A Prospective Cross-Sectional Study on the Correlation of Adenosine Deaminase and HbA1c With Microvascular Complications in Type 2 Diabetes Mellitus at a Tertiary Care Hospital in Central India.

Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition characterized by hyperglycemia, which can lead to various microvascular complications, including diabetic nephropathy, neuropathy, and retinopathy. Identifying reliable biomarkers for early detection and risk stratification of these complications is crucial for improving patient outcomes. Adenosine deaminase (ADA) and HbA1c have emerged as potential markers associated with immune function, inflammation, and long-term glycemic control.

Extensive Physiotherapy Rehabilitation for Pulmonary Tuberculosis and Tuberculous Meningitis With Ventriculoperitoneal Shunting: A Case Report.

Tuberculous meningitis (TBM), an advanced form of extrapulmonary tuberculosis (TB), is caused by infection of the meninges surrounding the brain and spinal cord. If it is not promptly and effectively treated, it can result in serious inflammatory reactions and neurological problems. TBM frequently leads to joint stiffness, discomfort, respiratory difficulties, swallowing difficulties, neurological deficits, and muscular weakness.

Comparative Evaluation Between Conventional Earplugs and Modified Earplugs in Reducing the Severity of Gag Reflex While Making Impression in Completely Edentulous Patients: A Randomized Controlled Trial.

Background The gag reflex is a common problem encountered during impression-making in completely edentulous patients. The use of music therapy and earplugs reduces gag reflex severity. However, no comparative study has been reported to establish their effectiveness.

Biofilm Formation in Chronic Infections: A Comprehensive Review of Pathogenesis, Clinical Implications, and Novel Therapeutic Approaches.

Biofilms are intricate microbial communities on various surfaces, including medical devices and biological tissues, encased within a protective matrix of extracellular polymeric substances. Their formation and persistence are significant factors in the pathogenesis of chronic infections, contributing to the complexity of treatment and increased resistance to antimicrobial agents. This review explores the multifaceted nature of biofilms, focusing on their formation, structure, and the genetic and environmental factors that contribute to their resilience.

Effective Management of McKenzie Derangement VI With Urge Urinary Incontinence Through Surgical Intervention and Customized Physiotherapy: A Case Report.

Urge incontinence, often linked to prolapsed intervertebral disc (PIVD) due to nerve compression, involves sudden, involuntary urine leakage. Management includes behavioral therapy, bladder training, and pelvic floor muscle training (PFMT) to strengthen pelvic muscles and regulate voiding, effectively reducing symptoms and improving quality of life. A 40-year-old female patient presented with chief complaints of lower back pain radiating down the right lower limb below the knee, accompanied by a right-sided listing.

Role of Multidetector Computed Tomography Urography in Evaluating Obstructive Uropathy in a Tertiary Hospital in Rural India.

Introduction: This study aims to evaluate the role of multidetector computed tomography (MDCT) urography in cases of obstructive uropathy to determine the cause, side, site, and level of obstruction and to differentiate between acute and chronic cases of obstructive uropathy based on imaging features.

Methods: Using Cochran's formula, a sample size of 121 patients was calculated. The patients underwent computed tomography (CT) urography to assess the obstructing agents causing obstructive uropathy.

Innovative hybrid approach: digital and analog fabrication of orbital prosthesis for post-COVID-19 mucormycosis defects using photogrammetry technique.

In addition to anatomical loss, removal of the full or portion of the orbit results in a facial deformity and psychological distress for the patient. This article details a practical case of prosthetic rehabilitation using digital workflow for an orbital deformity caused by post-COVID-19 Mucor mycosis. The main goal of this case study was to create a maxillofacial orbital prosthesis that is well-retained, simple to use, and accurate in terms of appearance.

Role of Necrosectomy in Necrotizing Pancreatitis: A Narrative Review.

Necrotizing pancreatitis (NP) is a severe complication of acute pancreatitis, characterized by necrosis of pancreatic and peripancreatic tissues, leading to significant morbidity and mortality. The role of necrosectomy, the surgical removal of necrotic tissue, in the management of NP has evolved over the past few decades, moving from early aggressive surgical intervention to a more conservative and stepwise approach. This narrative review explores the historical perspectives, current practices, and future trends in the role of necrosectomy in NP.

Platelet-Rich Plasma With an Activator: A New Approach for Treating Thin Endometriums of Women Suffering From Infertility.

This case study reflects the primary infertility treatment which was in vitro fertilization (IVF) that lasted for four years. This case study involves a 37-year-old female who underwent intrauterine insemination (IUI), recurrent implantation failure, and frozen embryo transfers with a focus on platelet-rich plasma (PRP) for receptor endometrial thickness. The patient's report revealed a hormonal imbalance and a thin endometrium measuring 5 mm, while her husband's semen analysis findings were normal.

Prevalence of Transfusion-Transmissible Infections Among Voluntary Blood Donors in a Tertiary Care Hospital.

Background Transfusion-transmissible infections (TTIs) pose a significant risk to blood transfusion safety, especially in low-resource settings. TTIs include infections such as HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, and malaria. Over four years, this study assesses the seroprevalence of TTIs among voluntary blood donors at a tertiary care center.

Transforming Global Health: Dr. Gagandeep Kang's Legacy in Microbiology and Public Health.

Dr. Gagandeep Kang is a towering personality in the field of microbiology and is known for her groundbreaking work globally. She made seminal discoveries in areas of enteric infections, vaccine development, and public health that have created a sea of change in scientific understanding and healthcare, probably beyond the borders of India.

The Evolution of Phage Therapy: A Comprehensive Review of Current Applications and Future Innovations.

Phage therapy, using bacteriophages to target and destroy bacteria, has evolved significantly from its early 20th-century inception to its modern resurgence as a promising alternative to antibiotics. This review explores the historical development of phage therapy, detailing its initial successes, subsequent decline with the rise of antibiotics, and recent revival in response to increasing antibiotic resistance. We examine the fundamental mechanisms of phage therapy, including the specificity of phages for bacterial targets and their ability to combat resistant strains.

Dr. Ravindra Kolhe and Dr. Smita Kolhe: The Pioneers of Improving Tribal Healthcare in Maharashtra, India.

Dr. Ravindra Kolhe and Dr. Smita Kolhe are the pioneers of improving tribal healthcare in Maharashtra, dedicating more than three and a half decades of their lives for the sake of the people in the remote Bairagarh village of the Melghat area.

Understanding Gratification Disorder in Childhood: A Comprehensive Review of Diagnosis, Differential Diagnosis, and Management Approaches.

Gratification disorder (GD) in childhood is characterized by difficulty delaying immediate rewards and controlling impulsive behaviors. This disorder manifests as a persistent struggle to wait for longer-term rewards and a tendency toward impulsive decision-making, which can disrupt academic performance, social interactions, and daily functioning. The relevance of GD is highlighted by its potential to impede the development of crucial skills such as self-control, problem-solving, and social competence.

A Comprehensive Review of Advanced Biomarkers for Chronic Kidney Disease in Older Adults: Current Insights and Future Directions.

Chronic kidney disease (CKD) is a growing health concern, particularly in older adults, due to its high prevalence and association with increased morbidity and mortality. Early detection and effective management are crucial to slowing disease progression and reducing complications such as cardiovascular events and end-stage renal disease (ESRD). Traditional biomarkers, including serum creatinine and estimated glomerular filtration rate (eGFR), often have limitations in older populations, where age-related physiological changes can obscure early signs of kidney dysfunction.

Exploring the Usefulness of Tumor Budding as a Histopathological Marker Compared to Tumor-Node-Metastasis (TNM) Staging in Breast Cancer.

Background:  Tumor budding, defined as small clusters of tumor cells at the invasive front of carcinomas, has gained attention as a potential prognostic marker in various cancers. This study aimed to evaluate the utility of tumor budding as a histopathological marker in breast cancer and compare it to traditional prognostic markers such as histological grading, tumor-node-metastasis (TNM) staging, and molecular subtypes.

Methods:  A prospective, cross-sectional study was conducted over two years (June 2022 to May 2024) in the Department of Pathology at Jawaharlal Nehru Medical College, Wardha.

An Unusually Large Submandibular Sialolith: A Case Report.

Sialolithiasis is among the most common pathological conditions of the salivary glands. It is characterized by blockage of the salivary gland excretory duct or by the formation of calcareous concretions, resulting in salivary stasis and causing salivary gland swelling. Most sialoliths generally arise in the submandibular gland and duct.

Imaging of Pulmonary Miliary Tuberculosis With Multiple Intracranial Tuberculomas.

Tuberculosis, caused by , is a widely spread disease complex affecting multiple organs. It is a type of communicable disease disproportionately affecting low and middle-income countries. The imaging modality of choice for pulmonary tuberculosis is computed tomography, and for brain lesions, it is a contrast-enhanced magnetic resonance imaging study.