2,471 results match your criteria: "Datta Meghe Institute of higher education and research[Affiliation]"

Background: Gangliocapsular stroke is a specific type of hemorrhagic stroke that primarily affects the basal ganglia and internal capsule due to rupture of the lenticulostriate perforating arteries. Patients afflicted with this condition often present with contralateral motor deficits, particularly affecting the upper extremity. Additionally, these individuals may experience challenges in coordination and stability, largely due to the involvement of the shoulder and scapular girdle.

View Article and Find Full Text PDF

The intricate terrain of breast cancer (BC) in India is examined in this review, which also looks at screening techniques, geographical differences, epidemiological trends, and obstacles to early diagnosis. BC has a major impact in India, especially on women. The research examines data from 2014 to 2024 and finds that, although overall cancer rates are declining, there has been a noticeable increase in BC cases.

View Article and Find Full Text PDF

Introduction: Throughout history and up until the present, there has been a medicine shortage. In the early 1920s, there was a shortage of insulin, which is when drug scarcity first appeared in the records. Drug shortages are now more prevalent globally than they were back then.

View Article and Find Full Text PDF

Background: Developmental milestones are easily identifiable events during a child's development, and their thorough monitoring is of utmost importance till 6 years of age. Rural mothers are rarely explained these milestones, which may be a reason for the higher prevalence of developmental disorders in rural areas (≊18%). This study aimed to assess the knowledge of developmental milestones in rural mothers attending a rural, tertiary care hospital and further provides intelligence to the mothers on the same.

View Article and Find Full Text PDF

Windswept Deformity: A Rare Skeletal Manifestation in an Adolescent with Primary Hyperparathyroidism.

J ASEAN Fed Endocr Soc

December 2024

Department of General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India.

Article Synopsis
  • Primary hyperparathyroidism (PHPT) in adolescents is uncommon and typically leads to more severe symptoms than in adults, with skeletal issues being rare and mostly documented in case studies.
  • A unique case is reported of a 19-year-old male with a windswept deformity, characterized by the bending of his legs at the knee, who was diagnosed with PHPT after showing elevated calcium and parathyroid hormone levels.
  • After identifying and surgically removing a parathyroid adenoma, the patient's calcium and parathyroid hormone levels returned to normal, and he is now scheduled for corrective surgery once his alkaline phosphatase stabilizes.
View Article and Find Full Text PDF

Well-differentiated squamous cell carcinoma of the clitoris: a rare case report.

Pan Afr Med J

December 2024

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.

Article Synopsis
  • Squamous cell carcinoma (SCC) can affect various organs, including the vagina and vulva, with vulvar carcinoma being a rare occurrence, typically seen in those over 70 years old, with a low prevalence of 2.6 per 100,000 people.
  • This case study focuses on a 65-year-old woman diagnosed with well-differentiated squamous cell carcinoma (WDSCC) of the clitoris, highlighting an increasing trend of diagnoses in women aged 35 to 45.
  • Current treatment approaches are shifting from radical surgeries, such as vulvectomy and lymph node removal, to more personalized and less invasive strategies for managing vulvar carcinomas.
View Article and Find Full Text PDF

Synovial sarcoma under the lens: a case report.

Pan Afr Med J

December 2024

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.

Article Synopsis
  • A 56-year-old male patient presented with swelling above his right ankle, which was diagnosed as synovial sarcoma after imaging and histopathology.
  • Treatment involved surgical removal and chemotherapy; however, the 5-year survival rate is low, highlighting the challenge of accurately diagnosing this tumor due to its misleading characteristics.
View Article and Find Full Text PDF

Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating ocular diseases. This review explores its potential impact, recent advancements, and clinical uses. This minimally invasive technique offers precise control of drug delivery to the eye, with various microneedle types showing the potential to penetrate barriers in the cornea and sclera, ensuring effective drug delivery.

View Article and Find Full Text PDF

Fresh produce prone to microbial contamination is a potential reservoir for antimicrobial-resistant bacteria (ARB) and antimicrobial resistance genes (ARGs), posing challenges to food safety and public health. This systematic review aims to comprehensively assess the prevalence of bacterial pathogens and the incidence of ARB/ARGs in fresh produce and agro-ecosystems across South Asia. Twenty-two relevant studies published between 2012 and 2022 from three major scientific databases and the grey literature were identified.

View Article and Find Full Text PDF

Tuberculosis (TB) is a serious infectious disease accounting for a significant number of deaths due to the infectious nature of the disease on the global platform. Migrant workers need special attention as these population groups live in substandard and crowded environmental conditions with poor ventilation, which play a crucial role in augmenting the risk of acquisition of infection. The global vision to ensure the delivery of effective TB control-related services for migrant workers has been influenced by a wide range of barriers.

View Article and Find Full Text PDF
Article Synopsis
  • The gingivobuccal sulcus is the area where the gums meet the inside of the cheek, allowing movement during activities like talking and eating.
  • This area is important for oral function but can be affected by conditions such as oral cancer, which may require surgical intervention like segmental mandibulectomy, impacting speech and chewing.
  • Post-surgical rehabilitation, involving a multidisciplinary team, aims to relieve pain and restore functions like jaw and tongue movement as well as swallowing to improve the patient's quality of life.
View Article and Find Full Text PDF

Psychosis is a complex mental health condition that can have a profound impact on individuals and their families. It is characterized by a loss of contact with reality, including delusions, hallucinations, and disorganized thinking. While psychosis is most commonly associated with psychiatric disorders such as schizophrenia, it is crucial to consider other potential causes to ensure accurate diagnosis and appropriate treatment.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the clinical profile of people living with HIV (PLWH) in Maharashtra, India, focusing on sociodemographic factors and healthcare access impacting the epidemiology of the disease.
  • Out of 150 patients, the majority were men aged 30-50, with heterosexual transmission being the most common route; 68% were symptomatic at presentation.
  • Pulmonary tuberculosis emerged as the most frequent opportunistic infection, alongside data revealing that many patients had low BMI and varying CD4 counts, underlining the need for effective management according to National AIDS Control Organization (NACO) guidelines.
View Article and Find Full Text PDF

Thymic mass in an elderly male patient with myasthenia gravis: A rare presentation.

Radiol Case Rep

January 2025

Department of Radiodiagnosis, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India 442001.

Myasthenia gravis is an acquired neuromuscular disorder characterized by weakness of the extra-ocular muscles, which progresses to generalized weakness of the voluntary muscles and fatigability. The presented case is of a 70-year-old male patient who presented with complaints of drooping of bilateral eyelids and breathlessness and was diagnosed to have myasthenia gravis and thymic mass. It is uncommon for an elderly patient to present with thymic mass and myasthenia gravis concurrently.

View Article and Find Full Text PDF

Eosinophilic gastrointestinal disorders (EGIDs) are representative of eosinophilic invasion of various sections of the gastrointestinal tract and do not pertain to any secondary causes. To affirm the diagnosis of eosinophilic infiltration of the gastrointestinal tract, tissue biopsy evidence must be demonstrated. Both iron deficiency anemia and gastritis symptoms may be brought on by mucosal eosinophilic infiltration.

View Article and Find Full Text PDF

Background: Reconstruction of maxillofacial defects is challenging due to the region's complex anatomy. During the COVID-19 era, many patients lost their maxilla and chewing efficiency as a result of Mucormycosis. In such cases, custom-designed implants offer a graftless solution for seemingly hopeless situations.

View Article and Find Full Text PDF

Extension of impurity profiling on eltrombopag olamine to in-silico predictions: An effort to exploit correlated forced degradation products and known drug-related substances in drug discovery.

J Chromatogr B Analyt Technol Biomed Life Sci

November 2024

Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel, Belgium. Electronic address:

The recent pandemic has highlighted the impact of diseases on global health and the economy. The rapid discovery of new hit molecules remains a tough challenge. Pharmaceutical impurity profiling can be linked to drug discovery through the identification of new hits from compounds identified during the analytical profiling.

View Article and Find Full Text PDF

Maternal and Child Health (MCH) programs have long been integral to global public health initiatives, aiming to safeguard the well-being of both mothers and their offspring. However, amidst the comprehensive approach to physical health, the mental well-being of mothers has often been overlooked, representing a critical gap in these programs. This paper examines the importance of addressing maternal mental health within the framework of MCH programs, highlighting its significance and the repercussions of its neglect.

View Article and Find Full Text PDF
Article Synopsis
  • A 7-year-old boy presented with severe seizures and neurological decline, initially showing symptoms like visual changes and cognitive deterioration over six months.
  • MRI scans indicated white matter lesions and elevated serum levels of certain fatty acids, leading to a provisional diagnosis of X-linked cerebral adrenoleukodystrophy (ALD).
  • Despite treatment, the patient's condition worsened to blindness and a vegetative state, underscoring the need for early diagnosis and intervention to manage ALD more effectively.
View Article and Find Full Text PDF