The role of artificial intelligence in pandemic responses: from epidemiological modeling to vaccine development.

Integrating Artificial Intelligence (AI) across numerous disciplines has transformed the worldwide landscape of pandemic response. This review investigates the multidimensional role of AI in the pandemic, which arises as a global health crisis, and its role in preparedness and responses, ranging from enhanced epidemiological modelling to the acceleration of vaccine development. The confluence of AI technologies has guided us in a new era of data-driven decision-making, revolutionizing our ability to anticipate, mitigate, and treat infectious illnesses.

Synergizing GA-XGBoost and QSAR modeling: Breaking down activity aliffs in HDAC1 inhibitors.

The work being presented now combines severe gradient boosting with Shapley values, a thriving merger within the field of explainable artificial intelligence. We also use a genetic algorithm to analyse the HDAC1 inhibitory activity of a broad pool of 1274 molecules experimentally reported for HDAC1 inhibition. We conduct this analysis to ascertain the HDAC1 inhibitory activity of these molecules.

Systems delay in women with breast cancer - A sequential explanatory mixed-methods study from central rural India.

Background: Globally, breast cancer is the most common malignant tumor in both developed and developing nations, with an incidence of 2 million cases every year and around 6 lakh deaths. Even after the availability of healthcare facilities, delays in the management of breast cancer are seen in both developed and developing countries.

Objectives: To assess the patient and system-level delays and to determine the factors that cause the identified delays in women with breast cancer from central rural India.

Unveiling cyclodextrin conjugation as multidentate excipients: An exploratory journey across industries.

The discovery of branched molecules like dextrin by Schardinger in 1903 marked the inception of cyclodextrin (CD) utilization, catalyzing its journey from laboratory experimentation to widespread commercialization within the pharmaceutical industry. CD, a cyclic oligosaccharide containing glucopyranose units, acts as a versatile guest molecule, forming inclusion complexes (ICs) with various host molecules. Computational studies have become instrumental in elucidating the intricate interactions between β-CD and guest molecules, enabling the prediction of binding energy, forces, affinity, and complex stability.

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery.

Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating ocular diseases. This review explores its potential impact, recent advancements, and clinical uses. This minimally invasive technique offers precise control of drug delivery to the eye, with various microneedle types showing the potential to penetrate barriers in the cornea and sclera, ensuring effective drug delivery.

Extensive Physiotherapy Rehabilitation for Pulmonary Tuberculosis and Tuberculous Meningitis With Ventriculoperitoneal Shunting: A Case Report.

Tuberculous meningitis (TBM), an advanced form of extrapulmonary tuberculosis (TB), is caused by infection of the meninges surrounding the brain and spinal cord. If it is not promptly and effectively treated, it can result in serious inflammatory reactions and neurological problems. TBM frequently leads to joint stiffness, discomfort, respiratory difficulties, swallowing difficulties, neurological deficits, and muscular weakness.

An Unusually Large Submandibular Sialolith: A Case Report.

Sialolithiasis is among the most common pathological conditions of the salivary glands. It is characterized by blockage of the salivary gland excretory duct or by the formation of calcareous concretions, resulting in salivary stasis and causing salivary gland swelling. Most sialoliths generally arise in the submandibular gland and duct.

Primary and residual cardiometabolic risk factors among young adults in a Russian city.

Background: Cardiovascular diseases are a leading cause of mortality and a significant contributor to temporary and permanent disabilities worldwide. This study aimed to investigate the burden of primary and residual cardiometabolic risk factors in a sample of young adults in the Russian city of Kazan.

Methods: This case-control study used the Cardiometabolic Disease Staging (CMDS) classification system, which has been validated in several countries.

Informed Strategies Based on Education Research to Enhance the Learning Ecosystem.

Educational institutions must change to create a learning ecosystem that prioritizes skills crucial for the 21st-century learners in the current global context that is quickly evolving. With an emphasis on evidence-based education, global citizenship, the integration of Sustainable Development Goals (SDGs), translatory practice, active learning strategies, improved clinical placement experiences, and peer learning, this paper explores the strategies for enhancing the efficacy of learning ecosystems. These elements are essential for encouraging continuous education in students and preparing them to meet their personal and professional needs.

Feminizing Genitoplasty in Congenital Clitoromegaly: A Case Report.

Congenital clitoromegaly, also known as macroclitoris, is a rare congenital disorder. It is a cause of poor self-esteem, anxiety, and gender self-perception. It negatively affects social, romantic, and emotional domains.

Exploring the Impact of Personalized Physical Therapy on a Patient With Motor Neuron Disorder: A Case Study.

This case study examines the effect of a tailor-made physiotherapy regimen on an 85-year-old male patient who was suffering from bulbar motor neuron disease (MND) and had a history of stroke and COVID-19. The physiotherapy plan was designed to strategically address the patient's respiratory issues, generalized weakness affecting limb muscles, and speech and swallowing difficulties. Frequent evaluations made it possible to adjust the treatment plan, emphasizing a holistic strategy to improve the patient's overall quality of life.

A Case Report on Advanced Hip Tuberculosis: Outcomes of Combined Surgical and Rehabilitative Intervention.

Although rare, musculoskeletal involvement of tuberculosis (TB) sustains this disease as a global health problem. Hip TB presents some unique challenges to its diagnosis and cure because of its specific anatomical and biomechanical properties. Herein, we would like to highlight an integrated approach in the surgical intervention and rehabilitation towards the management of an advanced symptom-bearing 25-year-old female hip TB patient.

Unlocking the Potential: Probiotics as a Promising Frontier in Oral Health.

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The role of probiotics in promoting oral health has gained attention in recent times Current literature aims to provide an outline of the application of probiotics in dentistry, focusing on their various formulations and potential benefits in oral health. The rationale for using probiotics in dental care, their different applications, and the future prospects of probiotics in dentistry will be discussed.

A Pioneer in Revolutionizing Physiotherapy in India: Dr. M. G. Mokashi's Journey of Compassion, Innovation, and Dedication.

Dr. Madhav Gajanan Mokashi is a remarkable individual in physiotherapy, and he is celebrated for his exceptional blend of educational and clinical excellence. His innovative research and influential roles in prominent conferences have shaped the physiotherapy landscape in India.

Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study.

Background: A stroke is described by the World Health Organization as "a clinical syndrome with rapidly developing symptoms that consist of a focal (or global, in a situation of coma) disruption of cerebral function that lasts more than 24 hours or leads to mortality without a known cause other than a vascular origin". Stroke is the most prevalent cause of impairment and mortality on a global scale. Modified constraint-induced movement therapy (mCIMT) is an approach to therapy for motor disabilities that involves constraining the movements of the nonparetic limb, diligent practice and behaviour modification to extend the time the paretic limb is utilized for daily tasks.

Self-Directed Learning Versus Traditional Teaching in Learning Gross Anatomy Among First-Year Medical Students: A Comparative Study.

Introduction: Gross anatomy is the first subject to be grasped by budding medicos before learning a long series of skills and competencies required to bloom as a physician or surgeon. In recent years, the teaching time for anatomy has been reduced. The number of anatomy teachers is much less in comparison to the increasing number of students.

A Review on Osteopathic Manipulation in Patients With Headache.

Headaches are a common neurological disorder, significantly impacting patients' quality of life. Traditional treatments include pharmacological and nonpharmacological approaches. Osteopathic manipulative treatment (OMT) is a holistic, hands-on technique used by osteopathic physicians to alleviate pain and improve function by addressing musculoskeletal dysfunctions.