1,878 results match your criteria: "Dartmouth Psychiatric Research Center & Dartmouth College[Affiliation]"

Evaluating age-related disparities in cannabis-related problems among LGBT+ versus non-LGBT+ adults.

Addict Behav

January 2024

Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Williamson Translational Research Building, Third Floor HB 7261, 1 Medical Center Drive, Lebanon, NH 03756, USA; Department of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address:

LGBT+ adults demonstrate greater cannabis-related problems (e.g., Cannabis Use Disorder [CUD]) compared to non-LGBT+ counterparts.

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Article Synopsis
  • The Brain Imaging Data Structure (BIDS) is a collaborative standard designed to organize various neuroscience data and metadata.
  • The paper details the history, principles, and mechanisms behind the development and expansion of BIDS, alongside the challenges it faces as it evolves.
  • It also shares lessons learned from the project to help researchers in other fields apply similar successful strategies.
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  • This paper explores the use of Facebook for recruiting breast cancer survivors for a clinical trial during the COVID-19 pandemic, highlighting limited prior evidence in this area.
  • The study found that Facebook was a highly effective recruitment tool, contributing to 59% of the total participants and reaching individuals from 24 states, while traditional clinic recruitment was less geographically diverse.
  • Despite some demographic differences between participants recruited through Facebook and clinics, the study emphasizes that social media can enhance recruitment efforts for cancer research while considering potential biases.
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Background: Screening for substance use in rural primary care clinics faces unique challenges due to limited resources, high patient volumes, and multiple demands on providers. To explore the potential for electronic health record (EHR)-integrated screening in this context, we conducted an implementation feasibility study with a rural federally-qualified health center (FQHC) in Maine. This was an ancillary study to a NIDA Clinical Trials Network study of screening in urban primary care clinics (CTN-0062).

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Tele-Neuropsychology: From Science to Policy to Practice.

Arch Clin Neuropsychol

February 2024

American Psychological Association, Washington, DC, USA.

Objective: The primary aim of this paper is to accelerate the number of randomized experimental studies of the reliability and validity in-home tele-neuropsychological testing (tele-np-t).

Method: We conducted a critical review of the tele-neuropsychology literature. We discuss this research in the context of the United States' public and private healthcare payer systems, including the Centers for Medicare & Medicaid Services (CMS) and Current Procedural Terminology (CPT) coding system's telehealth lists, and existing disparities in healthcare access.

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  • Seasonal variations at birth can influence DNA methylation, which may affect health outcomes over a person’s lifetime.
  • A study involving multiple cohorts discovered specific DNA methylation patterns linked to different birth seasons, revealing 26 differentially methylated regions (DMRs) at birth and 32 in childhood.
  • Results suggested that geographic latitude plays a role in these associations, linking certain genes to conditions like schizophrenia and asthma, particularly in infants born in higher latitudes (≥50°N).
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Culturally tailored digital therapeutic for substance use disorders with urban Indigenous people in the United States: A randomized controlled study.

J Subst Use Addict Treat

December 2023

Department of Psychology and Center on Alcohol Substance use & Addiction (CASAA), University of New Mexico, 1 University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA.

Introduction: Indigenous people experience health disparities, including higher rates of substance use disorders (SUDs). Digital therapeutics are a growing platform for treatment services and have the potential to expand access to culturally responsive interventions for Indigenous people. As one of the first randomized controlled trials for SUDs for American Indian and Alaska Native (AI/AN) adults, the aim of this study was to pilot test the efficacy of a culturally tailored intervention among urban Indigenous adults.

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Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.

Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples.

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Article Synopsis
  • Social anxiety disorder (SAD) makes people really scared of how others see them, leading to negative thoughts about themselves.
  • The study looked at how adults with SAD respond to good and bad feedback after a stressful speaking task and found they focus more on the negative stuff.
  • Researchers believe that the brain’s response to feedback plays a key role in these negative feelings, which could help figure out how to better support people with SAD.
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Background: There is little guidance for conducting health equity-focused economic evaluations of evidence-based practices in resource-constrained settings, particularly with respect to staff time use. Investigators must balance the need for low-touch, non-disruptive cost data collection with the need for data on providing services to priority subpopulations.

Methods: This investigation took place within a pilot study examining the implementation of a bundled screening intervention combining screening for social determinants of health and colorectal cancer at four federally qualified health centers (FQHCs) in the Boston metropolitan area.

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A reproducible and generalizable software workflow for analysis of large-scale neuroimaging data collections using BIDS Apps.

bioRxiv

August 2023

Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Neuroimaging research faces a crisis of reproducibility. With massive sample sizes and greater data complexity, this problem becomes more acute. Software that operates on imaging data defined using the Brain Imaging Data Structure (BIDS) - BIDS Apps - have provided a substantial advance.

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Local field potential (LFP) recording is a valuable method for assessing brain systems communication. Multiple methods have been developed to collect LFP data to study the rhythmic activity of the brain. These methods range from the use of single or bundled metal electrodes to electrode arrays that can target multiple brain regions.

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It is well-known that food-cue reactivity (FCR) is positively associated with body mass index (BMI) and weight change, but the mechanisms underlying these relationships are incompletely understood. One prominent theory of craving posits that the elaboration of a desired substance through sensory imagery intensifies cravings, thereby promoting consumption. Olfaction is integral to food perception, yet the ability to imagine odours varies widely.

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Background: The extent to which physical and social attributes of neighborhoods play a role in childhood asthma remains understudied.

Objective: To examine associations of neighborhood-level opportunity and social vulnerability measures with childhood asthma incidence.

Design, Setting, And Participants: This cohort study used data from children in 46 cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) Program between January 1, 1995, and August 31, 2022.

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Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium.

Mol Autism

August 2023

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, South Tower, Room 8310, Nashville, TN, 37232, USA.

Article Synopsis
  • The study examined how autistic individuals respond to sensory stimuli, focusing on three main traits: hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK).
  • Using data from 3,868 autistic youth, the researchers applied advanced statistical methods to explore the relationships between these traits across different sensory modalities.
  • Results showed that while a general pattern of HYPER responses could be validated, HYPO responses were less consistent, and SEEK had a more limited version, indicating that sensory responses in autism vary significantly and require nuanced assessment.
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The Advanced Research Institute (ARI) in Mental Health and Aging is a NIMH-funded mentoring network to help transition early-career faculty to independent investigators and scientific leaders. Since 2004, ARI has enrolled 184 Scholars from 61 institutions across 34 states. We describe the ARI components and assess the impact and outcomes of ARI on research careers of participants.

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The course of posttraumatic stress disorder (PTSD) symptoms varies among veterans of war zones, but sources of variation in long-term symptom course remain poorly understood. Modeling of symptom growth trajectories facilitates the understanding of predictors of individual outcomes over time. Although growth mixture modeling (GMM) has been applied to military populations, few studies have incorporated both predeployment and follow-up measurements over an extended time.

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Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients.

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Article Synopsis
  • - Genomic medicine can improve disease prevention and treatment by using polygenic risk scores (PRSs) to evaluate disease risk and guide tailored treatments, making the pathway from discovery to real-world application an ongoing process.
  • - The text highlights examples like lung cancer screening and tobacco treatment as areas where genomics could significantly enhance preventative measures and treatment efficacy, which are currently not fully utilized.
  • - It addresses the challenges in implementing genomic interventions, including the need for more inclusive research across diverse populations, lack of established treatment guidelines, and practical hurdles in applying genomic data in clinical settings.
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Purpose: Prior research has noted treatment inequalities in the care of rural veterans with posttraumatic stress disorder (PTSD). This project sought to increase the delivery, or reach, of recommended PTSD treatments in 2 rural health care systems of the Department of Veterans Affairs (VA) using implementation facilitation.

Methods: The quality improvement project involved 6 months of facilitation to 2 low-reach PTSD clinics within 2 VA health care systems.

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Gender and sex can influence cannabis behaviors and consequences (Cannabis Use Disorder [CUD]). Research typically examines sex and gender independently. Gender analyses often exclude transgender and gender diverse (TGD) populations.

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Dysregulated Emotion and Trying Substances in Childhood: Insights from a Large Nationally Representative Cohort Study.

Subst Use Misuse

September 2023

Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

Objective: Transdiagnostic perspectives on the shared origins of mental illness posit that dysregulated emotion may represent a key driving force behind multiple forms of psychopathology, including substance use disorders. The present study examined whether a link between dysregulated emotion and trying illicit substances could be observed in childhood.

Method: In a large ( = 7,418) nationally representative sample of children (M = 9.

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