9,987 results match your criteria: "Dartmouth Hitchcock Medical Center.[Affiliation]"

Background: Subtotal cholecystectomy is advocated in patients with severe inflammation and distorted anatomy preventing safe removal of the entire gallbladder. Not well documented in this surgically complex population is the feasibility of intraoperative imaging and management of common bile duct (CBD) stones. We evaluated these operative maneuvers in our subtotal cholecystectomy patients.

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Purpose Of Review: We evaluate available evidence for the role of inflammation in depression. We reappraise literature involving systemic inflammation, neuroinflammation and neurotransmission and their association with depression. We review the connection between depression, autoimmunity and infectious diseases.

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This study evaluates the Pittsburgh Sleep Quality Index (PSQI) in terms of factor structure and measurement invariance (MI). The sample included postmenopausal breast cancer (BC) survivors ( = 101) and matched healthy controls ( = 60). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed on PSQI's seven component scores.

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Article Synopsis
  • * A 50-year-old man came to a clinic with a painful lump on his forehead and was diagnosed with a frontal sinus mucocele that had eroded his frontal bone, necessitating surgical treatment.
  • * Immediate CT imaging is crucial for diagnosing frontal sinus mucoceles due to their potential complications, like damage to the eyes or brain, making it vital for doctors to recognize related symptoms.
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Background: Congenital heart defects (CHD) are the most common birth defects and previous estimates report the disease affects 1% of births annually in the United States. To date, CHD prevalence estimates are inconsistent due to varied definitions, data reliant on birth registries, and are geographically limited. These data sources may not be representative of the total prevalence of the CHD population.

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Food allergy yardstick: Where does omalizumab fit?

Ann Allergy Asthma Immunol

January 2025

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.

Article Synopsis
  • Food allergy management has shifted from avoiding allergens to active treatments, highlighted by the approval of peanut immunotherapy in 2020 and the recent approval of omalizumab in 2024 for IgE-mediated food allergies.
  • Clinicians now have multiple treatment options and must understand the benefits, risks, and optimal use of these therapies to effectively manage patients.
  • A comprehensive review and expert opinion is provided to help clinicians incorporate omalizumab and other therapies into patient care through shared decision-making.
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Objectives: Dilated cardiomyopathy (DCM) is often hereditary, with 20% to 40% of nonischemic cases showing familial linkage, yet genetic testing is underused. This report describes an unreported pathogenic nonsense variant in the Titin (TTN) gene (NM_001267550.2:c.

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In Response.

Anesth Analg

November 2024

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

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Appropriateness of care: Asymptomatic carotid stenosis including transcarotid artery revascularization.

Semin Vasc Surg

June 2024

Geisel School of Medicine at Dartmouth, Hanover, NH; Section of Vascular Surgery, 3V, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03766; Veterans Affairs Medical Center, White River Junction, VT.

Carotid artery stenosis is one of the most common diagnoses treated by vascular specialists in the United States. The optimal management of carotid stenosis remains controversial, however, with notable variation surrounding diagnostic imaging modalities, longitudinal surveillance, medical therapies, and procedural interventions. Data from high-quality randomized controlled trials and observational studies form the foundation for current management paradigms and societal guidelines that inform clinical practice.

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Article Synopsis
  • Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi), like trametinib, show potential as a treatment for pediatric patients with low-grade gliomas, a type of brain tumor linked to abnormal MAP kinase pathway signaling.
  • There is limited knowledge about the long-term effectiveness and side effects of these therapies specifically for children.
  • The article discusses a unique case involving a young patient with a low-grade glioma who developed a rare skin infection caused by Mycobacterium chelonae while being treated with trametinib.
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  • The Delphi consensus aimed to clarify management practices for abdominal aortic aneurysms (AAAs) due to conflicting data in previous literature.
  • A group of 44 experts anonymously discussed six key topics over three rounds, achieving a 100% response rate.
  • Key findings included the agreement on minimum case volume for AAA repairs, the effectiveness of screening programs, lifelong surveillance after repair, and the consideration of screening for women smokers at 65, but no consensus on certain repair thresholds or thrombosis prevention was reached.
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Development and validation of a machine learning-based, point-of-care risk calculator for post-ERCP pancreatitis and prophylaxis selection.

Gastrointest Endosc

January 2025

Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. Electronic address:

Article Synopsis
  • - A new machine learning tool was developed to predict the risk of post-ERCP pancreatitis (PEP) using data from 12 clinical trials, aiming to improve decision-making regarding patient care.
  • - The tool was trained on 7389 patients, considering various risk factors and interventions, achieving a predictive accuracy (AUC) of 0.70 in the training phase and 0.74 in a pilot study with 135 patients.
  • - This study shows that the model can effectively help identify patients at low risk for PEP, potentially reducing unnecessary post-procedural monitoring.
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  • - The presence of multiple skin lesions in infants may indicate underlying health issues, requiring dermatopathologists to differentiate between conditions that have different treatment outcomes.
  • - The article focuses on three rare conditions: congenital disseminated pyogenic granuloma, multifocal infantile hemangioma, and multifocal lymphangioendotheliomatosis with thrombocytopenia, highlighting how to distinguish them using histopathology and immunohistochemistry.
  • - A case study is presented about an infant with congenital disseminated pyogenic granuloma affecting both skin and liver, showing that the lesions can resolve naturally over time without treatment, which underscores the importance of diagnosis and monitoring.
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Article Synopsis
  • The study focuses on a rare superficial variant of deep penetrating/plexiform melanocytomas/nevi (DPN) that includes a junctional component, complicating diagnosis.
  • It includes 11 cases from 10 patients (5 men and 5 women) aged 27 to 78, with lesions found in various locations, and most cases being associated with a conventional nevus.
  • Immunohistochemical analysis shows strong nuclear beta-catenin and LEF1 staining in all DPN cases, while conventional nevi displayed the opposite pattern, highlighting the need for careful differentiation to avoid misdiagnosis as melanoma.
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