Introduction of Lazy Luna an automatic software-driven multilevel comparison of ventricular function quantification in cardiovascular magnetic resonance imaging.

Cardiovascular magnetic resonance imaging is the gold standard for cardiac function assessment. Quantification of clinical results (CR) requires precise segmentation. Clinicians statistically compare CRs to ensure reproducibility.

A single center experience in 90 cases with nonimmune hydrops fetalis: diagnostic categories ‒ mostly aneuploidy and still often idiopathic.

Objectives: The prognosis of nonimmune hydrops fetalis (NIHF) is still poor with a high mortality and morbidity rate despite progress in perinatal care. This study was designed to investigate etiology and outcome of NIHF.

Methods: A retrospective review of 90 NIHF cases from 2007 to 2019 was conducted at University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Expectation of others' cooperation, efficacy beliefs, and willingness to sacrifice personal interests for the environment.

This paper departs from the view that the social dilemma literature provides a useful framework to delineate possible barriers to the adoption of environmentally friendly lifestyles. One domain in which tensions between personal and collective interests might occur are travel decisions in the context of tourism, where it has been shown that even those people who are very committed to environmental practices at home tend to reduce respective commitments on vacation. Data from a cross-sectional survey N = 771 were analyzed to investigate if the expectation that other tourists travel environmentally friendly can in part explain individual travel decisions with environmental implications.

Fault Handling in Industry 4.0: Definition, Process and Applications.

The increase of productivity and decrease of production loss is an important goal for modern industry to stay economically competitive. For that, efficient fault management and quick amendment of faults in production lines are needed. The prioritization of faults accelerates the fault amendment process but depends on preceding fault detection and classification.

Correlation between Scratch Behavior and Tensile Properties in Injection Molded and Extruded Polymers.

This study investigates the validity and applicability of the correlation between scratch and tensile properties for extruded polymer strands. The mechanical properties could be predicted for extruded samples, which allows skipping the step of injection molding and therefore enables a faster material development. Extruded polymer strands and tensile test specimens out of PMMA, PS, POM, PP and PE have been investigated.

Cascaded neural network-based CT image processing for aortic root analysis.

Purpose: Careful assessment of the aortic root is paramount to select an appropriate prosthesis for transcatheter aortic valve implantation (TAVI). Relevant information about the aortic root anatomy, such as the aortic annulus diameter, can be extracted from pre-interventional CT. In this work, we investigate a neural network-based approach for segmenting the aortic root as a basis for obtaining these parameters.

OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study.

We investigated stability and change of plasma and urinary oxytocin as well as OXTR DNA methylation patterns through psychotherapy. Furthermore, we explored the potential impact of inpatient psychotherapy on oxytocin-related biomarkers and vice versa by differentiating patients who remitted from depression versus non-remitters. Blood and urine samples were taken from 85 premenopausal women (aged 19-52), 43 clinically depressed patients from a psychosomatic inpatient unit, and 42 healthy control subjects matched for age and education at two points of time.

The articulatory in-out effect: replicable, but inexplicable.

People prefer inward over outward articulation dynamics, a phenomenon referred to as the articulatory in-out effect. It is empirically robust and generalizes across languages, settings, and stimuli. However, the theoretical explanation of the effect is still a matter of lively debate and in need of novel research directions.

Revealing the formation mechanism and band gap tuning of SbS nanoparticles.

SbS is a promising nanomaterial for application in solar cells and in the fields of electronics and optoelectronics. Herein, SbS nanoparticles were prepared via the hot-injection approach. In contrast to earlier work, the reaction temperature was decreased to 150 °C so that the reaction was slowed down and could be stopped at defined reaction stages.

Weakly Supervised Learning for Categorization of Medical Inquiries for Customer Service Effectiveness.

With the growing unstructured data in healthcare and pharmaceutical, there has been a drastic adoption of natural language processing for generating actionable insights from text data sources. One of the key areas of our exploration is the Medical Information function within our organization. We receive a significant amount of medical information inquires in the form of unstructured text.

Understanding the Decision-Making Process Between Presenteeism and Absenteeism.

Due to their impact on various stakeholder groups, research on the global phenomena of sickness presenteeism (working despite illness) and sickness absenteeism (absence due to illness) is constantly growing. Most studies focus on identifying factors associated with the attendance behaviors. In contrast, there have been few theoretical approaches to explain the individual decision-making process for or against working while ill.

A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials.

In heart failure (HF) trials efficacy is usually assessed by a composite endpoint including cardiovascular death (CVD) and heart failure hospitalizations (HFHs), which has traditionally been evaluated with a time-to-first-event analysis based on a Cox model. As a considerable fraction of events is ignored that way, methods for recurrent events were suggested, among others the semiparametric proportional rates models by Lin, Wei, Yang, and Ying (LWYY model) and Mao and Lin (Mao-Lin model). In our work we apply least false parameter theory to explain the behavior of the composite treatment effect estimates resulting from the Cox model, the LWYY model, and the Mao-Lin model in clinically relevant scenarios parameterized through joint frailty models.

Working While Ill Is Not Always Bad-Positive Effects of Presenteeism.

Presenteeism-going to work while ill-is a widespread phenomenon worldwide. Previous research has concentrated mainly on its negative effects. This study investigates the positive consequences of presenteeism derived from a comprehensive content model of presenteeism that was developed on the basis of negative effects.

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells.

Upconversion nanoparticles (UCNPs), consisting of NaYF doped with 18% Yb and 2% Er, were coated with microporous silica shells with thickness values of 7 ± 2 and 21 ± 3 nm. Subsequently, the negatively charged particles were functionalized with -(6-aminohexyl)-3-aminopropyltrimethoxysilane (AHAPS), which provide a positive charge to the nanoparticle surface. Inductively coupled plasma optical emission spectrometry (ICP-OES) measurements revealed that, over the course of 24h, particles with thicker shells release fewer lanthanide ions than particles with thinner shells.

Coating of upconversion nanoparticles with silica nanoshells of 5-250 nm thickness.

A concept for the growth of silica shells with a thickness of 5-250 nm onto oleate-coated NaYF:Yb/Er upconversion nanoparticles (UCNP) is presented. The concept enables the precise adjustment of shell thicknesses for the preparation of thick-shelled nanoparticles for applications in plasmonics and sensing. First, an initial 5-11 nm thick shell is grown onto the UCNPs in a reverse microemulsion.

Computational issues in fitting joint frailty models for recurrent events with an associated terminal event.

Background And Objective: Joint frailty regression models are intended for the analysis of recurrent event times in the presence of informative drop-outs. They have been proposed for clinical trials to estimate the effect of some treatment on the rate of recurrent heart failure hospitalisations in the presence of drop-outs due to cardiovascular death. Whereas a R-software-package for fitting joint frailty models is available, some technical issues have to be solved in order to use SAS software, which is required in the regulatory environment of clinical trials.

Millennials: sickness presenteeism and its correlates: a cross-sectional online survey.

Objective: Sickness presenteeism (SP) is a well-documented phenomenon in the current workforce. However, little is known about the SP of future employees (Millennials). We investigated rate and propensity of presenteeism and health-related and work-related correlates in university students to obtain information about the relevance of SP in the future workforce.

Cultural Variation in Reactions to a Group Member's Vicarious Choice and the Role of Rejection Avoidance.

Extending the literature on culture and the personal or interpersonal construction of choices, this research investigates consequences of an ingroup member's vicarious decision for the entire group and the mechanism behind cultural variation. In Study 1, Japanese people showed, compared to Germans, greater acceptance of vicarious choice and evaluated the ingroup member who had chosen on their behalf more positively. Using mediation analyses and priming methods, Studies 2 and 3 identified rejection avoidance to partly explain culturally diverse reactions to vicarious choices.

Marginal hazard ratio estimates in joint frailty models for heart failure trials.

This work is motivated by clinical trials in chronic heart failure disease, where treatment has effects both on morbidity (assessed as recurrent non-fatal hospitalisations) and on mortality (assessed as cardiovascular death, CV death). Recently, a joint frailty proportional hazards model has been proposed for these kind of efficacy outcomes to account for a potential association between the risk rates for hospital admissions and CV death. However, more often clinical trial results are presented by treatment effect estimates that have been derived from marginal proportional hazards models, that is, a Cox model for mortality and an Andersen-Gill model for recurrent hospitalisations.

Lessons Learned From Applications of the Stage Model of Self-Regulated Behavioral Change: A Review.

Stage models are becoming increasingly popular in explaining change from current behavior to more environmentally friendly alternatives. We review empirical applications of a recently introduced model, the stage model of self-regulated behavioral change (SSBC). In the SSBC, change toward pro-environmental behavior takes place in four, qualitatively different stages (predecisional, preactional, actional, and postactional) which are each influenced by constructs taken from theories previously established to describe and predict pro-environmental behavior.

Using Card Sorting to Explore the Mental Representation of Energy Transition Pathways Among Laypeople.

Meeting international emission targets will require major changes in the energy system. This paper addresses the public perception of different pathways to energy transition, and their mental representation in particular. A study is reported that employed card sorting to explore how laypeople categorize possible pathway components with respect to their perceived similarity (Norwegian sample, = 61; German sample, = 71).