Prevalence and clinical implications of anti-drug antibody formation and serum drug levels among patients with IBD receiving anti-TNF therapy: A cross-sectional study.

Background: The emergence of tumor necrosis factor inhibitors (anti-TNF) has considerably changed the management of inflammatory bowel disease (IBD) in patients who do not respond to traditional therapies. This study assesses the prevalence of anti-TNF drug levels (DLs) and antibodies (ATAbs) in patients with IBD in Saudi Arabia and explores their associations with IBD type and prior anti-TNF failure.

Methods: This cross-sectional study included patients aged 14-75 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC), treated with anti-TNF medications at King Fahad Medical City over January 2016 to December 2022.

Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.

The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.

Primary Dentin Conditioning with Methylene Blue Activated Photodynamic Therapy, Phytic Acid, and Er,Cr:YSGG to Resin-Modified Glass Ionomer Cement in Comparison to Conventional Polyacrylic Acid.

Impact of surface conditioner phytic acid (IP6) Er,Cr:YSGG laser (ECYL) methylene blue photodynamic therapy (MB-PDT) on the microleakage and shear bond strength (SBS) of resin-modified glass ionomer cement (RMGIC) to primary sound dentin. Overall, 80 extracted sound primary molars were collected followed by their submergence in self-cure acrylic resin. The dentin surface was exposed and made flat and was assigned into four groups based on the surface conditioning.

Navigating Toxicity: Investigating the Interplay Between Workplace Gaslighting, Workaholism, and Agility Among Nurses.

Toxic workplace environments, especially those involving gaslighting, are known to contribute to stress and excessive work habits, such as workaholism, which may hinder a nurse's agility-an essential skill in adapting to fast-paced healthcare environments. However, the interplay between workplace gaslighting, workaholism, and agility in nursing remains underexplored. This study aims to investigate the relationship between workplace gaslighting, workaholism, and agility among nurses, focusing on how gaslighting moderates this relationship.

Knowledge and Compliance with Infection Prevention and Control Practices in Prosthodontic Procedures Among Dental Students and Professionals.

: Infection prevention and control (IPC) is essential to ensure the safety of dental personnel and patients. This study aimed to assess the knowledge and compliance of dental undergraduate students, interns, and postgraduate students with IPC measures in prosthodontic procedures. : A cross-sectional observational study was conducted at the College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, involving 216 participants selected using stratified random sampling.

Coexisting autoimmune disorders among patients with inflammatory bowel disease at a tertiary center in Saudi Arabia: A cross-sectional study.

Background: Approximately 25% of individuals with inflammatory bowel disease (IBD) concurrently experience immune-mediated inflammatory diseases (IMIDs), while the overall prevalence of these conditions in the general population is 5-7%. Individuals with IBD and concurrent IMIDs tend to have a more aggressive disease profile. We aimed to assess the prevalence of coexisting autoimmune disorders among patients with IBD and their association with inflammatory bowel disease type.

Did Primary Healthcare Patients in Riyadh Experience Their First Migraine Episodes After a Stressful Event, and What Triggers and Relievers Do They Commonly Report?

Objective: This study aimed to investigate whether the first onset of migraine episodes among primary healthcare patients in Riyadh, Saudi Arabia, is preceded by a highly stressful event, as well as to identify common potential triggers and relievers reported by these patients.

Background: Migraine is a prevalent and debilitating neurological disorder. The pathophysiology of migraine involves complex interactions between genetic, neurological, and environmental factors, including the trigeminovascular system and neuropeptides such as calcitonin gene-related peptide (CGRP).

Knowledge, Attitude, and Perception Toward Evaluation of Acute Heart Failure Among Emergency Medicine Residents in Riyadh, Saudi Arabia.

Background: Acute heart failure (AHF) poses significant challenges in clinical practice due to its varied clinical presentations and complex management strategies. Adequate confidence levels among medical residents in diagnosing and managing AHF are crucial for timely and effective patient care.

Study Aim: This cross-sectional study aimed to assess medical residents' knowledge, attitude, and perception levels in diagnosing and managing AHF and explore factors influencing their confidence levels.

Exploring the Nature and Challenges Among Physicians in Saudi Arabia Responding to an Inflight Medical Emergency: A Cross-Sectional Survey.

Background  Inflight medical emergencies (IMEs) present a challenging situation due to the availability of limited medical resources and a complex cabin environment. The physicians have an ethical responsibility to aid in such situations. This study aims to assess the attitudes of Saudi physicians regarding IMEs.

Prevalence, Incidence and Risk Factors of White Spot Lesions Associated With Orthodontic Treatment - A Systematic Review and Meta-Analysis.

The primary objective was to systematically assess the prevalence, incidence and risk factors of WSLs with orthodontic treatment. The secondary objective was to compare the prevalence of WSLs between conventional fixed appliances (CFA) and other appliances, as well as with no treatment. PubMed, Scopus, Web of Science, LILACs, Virtual Health Library and Cochrane CENTRAL were searched.

Evaluation of modified essay questions (MEQs) as an assessment tool in third-year medical students' modular summative assessment.

Aim: Whether case-based modified essay questions (MEQs) are crucial to summative assessment in medical curriculum is still debatable. The current study aimed to evaluate third-year medical students' performance in case-based MEQs and multiple-choice questions (MCQs) in summative assessment in the endocrine module.

Methods: Students' scores in mid and final module MEQs and MCQs were analyzed over four successive years from 2018/2019 to 2021/2022, where comparisons were made between students' scores in MEQs and MCQs, and between scores of students of different categories.

The Influence of Early Maladaptive Schemas on Recovery and Psychological Capital in Borderline Personality Disorder Clients: Findings From Rural Dwelling Sample.

Introduction: Early maladaptive schemas (EMSs) are among the key vulnerability factors explaining the development and persistence of symptoms in borderline personality disorder (BPD). Furthermore, it was suggested that EMSs might impact recovery-related outcomes, including psychological and recovery capital, among individuals with BPD.

Aims: To investigate the relationship among EMSs, psychological and recovery capital in individuals with BPD disorder.

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as mortality predictors in acute Aluminum phosphide (grain pills) poisoning: clinical insights and risk assessment.

Background: Aluminum phosphides (AlP) is a solid fumigant pesticide known for its high toxicity and mortality. Diagnosis of AlP is based on the history and clinical examination. The literature on the early prediction of adverse outcomes following AlP exposure is limited.

Assessment of Stress Distribution Around Traditional and Sleeve Fixed Partial Denture Designs: Finite Element Analysis.

Objectives:  The aim of this research is to evaluate/compare the use of traditional versus sleeve fixed partial denture (PD) designs made from different materials on supporting structures. The comparison included three- and four-unit PD cases.

Materials And Methods:  Four finite element models are used in the research.

The role of artificial intelligence literacy and innovation mindset in shaping nursing students' career and talent self-efficacy.

Background: As artificial intelligence (AI) transforms nursing education, AI literacy is becoming a critical necessity for increasing the career potential and talent of nursing students. Additionally, fostering an innovation mindset promotes adaptability, creativity and openness to new approaches, further boosting students' confidence in their careers. However, few studies have examined the impact of these competencies on nursing students' career and talent self-efficacy, underscoring the need for further investigation.

Mutagenicity and DNA damage assessment of locally produced nano-hydroxyapatite-silica-glass ionomer cement on human periodontal ligament fibroblasts using Ames and Comet assays.

Aim: This research assessed the mutagenicity and DNA damage of a novel type of nano-hydroxyapatite-silica glass ionomer cement (nano-HA-SiO-GIC) and a conventional GIC (cGIC) using Ames and Comet assays.

Methods: Cell viability was tested on human periodontal ligament fibroblasts (HPLFs) using 3.125 mg/ml, 6.

Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.

: SARS-CoV-2 is one of the viruses that caused worldwide health issues. This effect is mainly due to the wide range of disease prognoses it can cause. The aim of this study is to determine protein profiles that can be used as potential biomarkers for patients' stratification, as well as potential targets for drug development.

International nursing students' culture shock and academic engagement: The moderating role of resilience.

Background: The nursing profession has experienced a growing influx of international nursing students pursuing nursing degrees in the current era. Predicting and controlling culture shock among this special group is a critical issue as it shapes their academic engagement. Building resilience capabilities among this set of students is a pivotal necessity to buffer the effect of culture shock on their academic engagement.

Navigating transition shock: The role of system thinking in enhancing nursing process competency among early career nurses.

Background: Building nursing process competency among beginner nurses is a pivotal need in contemporary, complex, fast-paced nursing practice. However, transitioning from the educational phase to practicing as a nurse can be a significant adjustment. New practitioners often experience a period of shock, which may present challenges in developing nurse competency.

Efficiency of bulk-fill versus conventional resin-based composite in class II restorations: A dental student perspective.

Purpose/objectives: The aim of the study was to evaluate the effect of two distinct light-polymerization protocols, used by dental students, on the placement time and polymerization efficiency of bulk-fill (BF) and conventional (CRC) resin-based composites (RBCs).

Methods: Thirty dental students participated in this study. Each student was asked to complete four Class II RBC restorations using two different types of RBCs (BF and CRC) paired with two distinct light-polymerization protocols: one using 1200 mW/cm irradiance (P1200) and one using 800 mW/cm irradiance (P800).

Associations between BCL-2 expression and different histopathological prognostic factors in different molecular subtypes of invasive breast carcinoma of no special type.

Background: Breast cancer is heterogeneous and the existing prognostic classifiers are limited in accuracy, leading to the unnecessary treatment of numerous women. B-cell lymphoma 2 (BCL-2), an anti-apoptotic protein, has been proposed as a marker of poor prognosis, associated with resistance to therapy in most tumor types expressing BCL-2. In breast cancer, however, BCL-2 expression has been reported to be a favorable prognostic factor.