Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition by inhibiting microRNA-192 expression: and studies.

The aim of this study was to investigate the effect of Astragaloside IV (AS-IV) on renal fibrosis and , and further to explore the underlying mechanism. To investigate the effect of AS-IV treatment on renal fibrosis , mouse renal fibrosis model was established by performing unilateral ureteral occlusion (UUO). The mice in the intervention group of AS-IV were given AS-IV 20 mg/(kg/d) on the day after surgery for 7 consecutive days.