Vitamin D (1,25-(OH)D) regulates the gene expression through competing endogenous RNAs networks in high glucose-treated endothelial progenitor cells.

Vitamin D (vit-D) supplementation can improve endothelial cell function in type 2 diabetes mellitus patients with vit-D insufficiency or deficiency. In the present study, we aimed to compare the expression profiles of circRNAs, lncRNAs, miRNAs, and mRNAs between 1,25-(OH)D-treated endothelial progenitor cells (EPCs) and control cells, and to further construct the 1,25-(OH)D-regulated ceRNA networks in EPCs. RNA sequencing was performed on the 1,25-(OH)D-treated EPCs and control cells derived from the bone marrow (BM).

GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer.

Purpose: Successful treatment of colorectal cancer (CRC) is greatly impeded by metastasis and chemoresistance, particularly to 5-fluoruracil (5-Fu), one of the staples of clinical intervention in advanced CRC. The purpose of this study is to determine whether the gene glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) contributes to CRC cell metastasis and 5-Fu resistance. Ultimately, we evaluated the ability of microRNA 195-5p (miR-195-5p) to reduce GDPD5 expression and thus to enhance CRC cell susceptibility to chemotherapy.