A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients.

Background: Nemonoxacin malate is a novel non-fluorinated quinolone for oral and intravenous (IV) administration. This phase 3, multicentre, randomised, double-blind, double-dummy, parallel-controlled clinical trial (NCT02205112) evaluated the efficacy and safety of IV nemonoxacin vs. levofloxacin for the treatment of community-acquired pneumonia (CAP) in adult patients.

Value of [Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis.

Purpose: Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations.

Multiple-site bleeding at pleural adhesions and massive hemothorax following percutaneous coronary intervention with stent implantation: A case report.

An elderly male patient with coronary heart disease underwent coronary angiography, which revealed bilateral severe coronary artery stenosis. Four stents were implanted, and at 5 h post-surgery, typical hemorrhagic shock appeared. Echocardiography verified heavy bleeding in the right thoracic cavity.

Thoracoscopic Surgery Versus Thoracotomy for Lung Cancer: Short-Term Outcomes of a Randomized Trial.

Background: Safety and short-term efficacy of video-assisted thoracoscopic surgery (VATS) for early-stage non-small lung cancer (NSCLC) has been demonstrated by observational studies previously. However, these outcomes have never been verified by a large randomized controlled trial (RCT). The aim of our RCT was to confirm that VATS is not inferior or even superior to open operation for early-stage NSCLC in terms of short-term and oncologic efficacy.

Demethylation of miR-495 inhibits cell proliferation, migration and promotes apoptosis by targeting STAT-3 in breast cancer.

In breast cancer (BC), silencing of miRNA genes due to miRNA gene promoter methylation are the important mechanisms directly contributing to tumorigenesis and tumor progression. miRNA-495 (miR-495) has been reported to be a tumor suppressor gene in various cancers, but its role and regulation in BC remains unclear. In the present study, the level of miR-495 was inversely correlated with the expression of STAT-3 in BC tissues and cell lines.

Assessment of the diagnostic value of a urinary adipsin rapid strip test for pre-eclampsia: A prospective multicenter study.

Aim: The purpose of the present study was to evaluate the clinical value of the rapid strip test of urinary adipsin for the quick diagnosis of pre-eclampsia.

Methods: In a multicenter diagnostic test study, we studied the diagnostic accuracy of the rapid strip test of urinary adipsin in women presenting with pre-eclampsia. A total of 204 pre-eclampsia patients and 254 healthy pregnant women were recruited for this study, respectively.

p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells.

Objectives: The aim of this study was to investigate whether p75NTR (p75 neurotrophin receptor) regulates differential mineralization capacity of rEMSCs (rat ectomesenchymal stem cells) and underlying mechanisms associated with Mage-D1 (melanoma-associated antigens-D1).

Materials And Methods: Immunohistochemical staining of p75NTR in developing tooth germs was performed on E12.5d (embryonic 12.

A comparison of ultrasound-guided high intensity focused ultrasound for the treatment of uterine fibroids in patients with an anteverted uterus and a retroverted uterus.

Objective: The aim of this study was to compare the treatment outcomes of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids in patients with an anteverted uterus versus a retroverted uterus.

Materials And Methods: Based on the principles of statistics we enrolled 221patients with an anteverted uterus and 221 with a retroverted uterus. All patients had a solitary uterine fibroid and every fibroid was identified as hypointense on the T2 weighted images (T2WI) on magnetic resonance.

The molecular mechanisms between metabolic syndrome and breast cancer.

Metabolic syndrome, which is extremely common in developed and some developing countries, is a clustering of at least three of five of the following medical conditions: abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein levels. It has been proved that there is a strong association between metabolic syndrome and breast cancer. Metabolic syndrome could increase the risk of breast cancer and influence the prognosis of the breast cancer patients.

Association study of circulating endothelial progenitor cells and plasma prostacyclin levels in pulmonary hypertension rats.

The aim of this study was to investigate the correlation between circulating endothelial progenitor cell (EPC) levels and plasma prostacyclin (PGI2) concentrations in pulmonary hypertension (PH) rat models. Monocrotaline was used to induce PH, and the number of CD34/Flk-1-double-positive mononuclear cells in peripheral CD45-negative blood was counted by flow cytometry, which reflected EPC circulation. The Greiss method was used to detect the plasma PGI2 concentration.

Knockdown of eukaryotic translation initiation factors 3B (EIF3B) inhibits proliferation and promotes apoptosis in glioblastoma cells.

Eukaryotic initiation factors 3 (EIF3) complex is essential for initiation of protein synthesis for both cells and virus. It consists of 13 subunits (EIF3A to M), among which EIF3B serves as a major scaffolding subunit. However, its functions in human glioblastoma have not been explored yet.

Vagal activities are involved in antigen-specific immune inflammation in the intestine.

Background And Aims: The mechanism of intestinal immune inflammation, such as food allergy, remains to be further understood. The present study aims to investigate the role of the vagal nerve in the pathogenesis of skewed T-helper 2 (Th2) responses in the intestine.

Methods: The expression of the immunoglobulin E (IgE) receptor on the vagus nerve in the mouse intestine was observed by immunohistochemistry.

[Clinical application of AcrySof ReStor multifocal intraocular lens].

Objective: To study the results of using AcrySof ReStor multifocal intraocular lens (MIOL) after the cataract operation.

Methods: It was a non-random comparative clinical study. After the small incision phacoemulsification, AcrySof ReStor MIOL was inserted into the eye in 22 cases (30 eyes, observed group); single focal intraocular lens (SIOL) was inserted in 20 cases (30 eyes, control group).

[The observation of palatopharyngeal histopathologic characteristic on the patients with obstructive sleep apnea-hypopnea syndrome].

Objective: To observe the histopathologic characteristic of the palatopharyngeal tissue and study the effect of ectopic accumulation of lipid on the pathogenesis and development of OSAHS.

Method: Thirty-eight cases were selected from the patients in hospital and divided into two groups. Each group had 19 cases, coupled according to Body Mass Index (BMI).

[Study on the gene mutation of TIGR in primary open angle glaucoma, their relatives and normal controls in Chongqing].

Objective: To study trabecular meshwork induced glucocorticoid response protein (TIGR) gene mutation in primary open angle glaucoma (POAG), their relatives and normal controls in Chongqing.

Methods: (1) The coding sequence of TIGR was screened for sequence alterations using polymerase chain reaction (PCR) followed by single-strand conformation polymorphism (SSCP). (2) Samples corresponding to bands of altered mobility were sequenced.

[Development of conductance measurement technique for permeability of monolayer endothelial cells].

The conductance measurement method of endothelial permeability has been established by the principle that there is direct ratio between conductance and filter area, and has been compared with the albumin filter method. The results show that there is close correlation between conductance and filter area, the conductance measurement can be used for the detection of the monolayer endothelial cells permeability. The combination of the conductance measurement and the albumin filter measurement method can accurately reflect the permeability change in severity and scope.