1,918 results match your criteria: "Dankook University College of Medicine.[Affiliation]"

Article Synopsis
  • * A case is presented where a 35-year-old man with metabolic acidosis and mild carbon monoxide poisoning was suspected of having cyanide poisoning, prompting the administration of an antidote, which led to improvement.
  • * The patient later experienced sudden airway obstruction requiring emergency intubation, with inhalation damage detected only in the lower airway, highlighting the importance for physicians to recognize both cyanide poisoning and inhalation burns for effective treatment.
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Backgroud: Internal fixation has been established as a treatment of choice in relatively young patients with femoral neck fractures. Due to the characteristics of femoral neck anatomy and blood supply, complications such as malunion, nonunion, avascular necrosis, and femoral neck shortening can occur after internal fixation of femoral neck fractures. Unlike other complications such as avascular necrosis or nonunion, femoral neck shortening has not been relatively well studied.

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Article Synopsis
  • Global warming and air pollution significantly harm the health of vulnerable populations, especially older adults, children, and individuals with disabilities (PWDs).
  • A systematic review analyzed numerous studies from PubMed and Web of Science, revealing that PWDs face greater health risks from extreme temperatures and air pollution compared to non-disabled individuals.
  • The findings suggest that tailored policies and preparedness measures are necessary to better protect PWDs from the adverse effects of climate change and air pollution.
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Article Synopsis
  • The study investigates how the distance between the laser fiber tip and soft tissue affects the destruction of that tissue during holmium laser enucleation of the prostate (HoLEP).
  • By experimenting with a soft tissue phantom at various distances, the researchers evaluated the effects of laser pulses on tissue destruction and thermal impact.
  • Results show that as the distance increases, the laser's ability to destroy tissue decreases, but thermal effects can still be significant even at greater distances.
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Evaluation of inguinal and axillary lymph node size distribution for Intralymphatic injection.

Allergy

September 2024

Division of Respiratory Disease and Allergy, Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea.

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Article Synopsis
  • Hemoglobin (Hb) Chile is a rare variant caused by a specific point mutation in the Hb β locus gene, leading to an amino acid change and inherited in an autosomal dominant way.
  • A case study presented a 17-year-old male with symptoms like pale skin and cyanosis, who was found to have low oxygen saturation and elevated methemoglobin levels, indicating a health issue.
  • Genetic testing revealed a new mutation related to Hb Chile that wasn't present in his parents, emphasizing the importance of checking for Hb gene mutations in patients with unexplained chronic methemoglobinemia, regardless of their family history.
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Clinical Profiles of Multidrug-Resistant and Rifampicin-Monoresistant Tuberculosis in Korea, 2018-2021: A Nationwide Cross-Sectional Study.

Tuberc Respir Dis (Seoul)

January 2025

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea.

Article Synopsis
  • It analyzed data from over 24,000 TB cases, finding that MDR/RR-TB represented 2.1% of all TB cases, with specific subcategories including MDR-TB and rifampicin-monoresistant TB.
  • Key associated factors for MDR/RR-TB included younger age, being a foreigner, and having a history of prior TB, highlighting the need for targeted identification strategies in these high-risk groups.
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Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.

Neurology

October 2024

From the Department of Nuclear Medicine (H.J.S., Jai-Hyuen Lee), Dankook University College of Medicine, Cheonan, Chung Nam; Department of Nuclear Medicine (J.S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Neurology (R.J.B., J.J.L.-G., J.C.M., A.D.), Washington University School of Medicine, St. Louis, MO; Department of Clinical Epidemiology and Biostatistics (S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Neurology (G.S.D.), Mayo Clinic College of Medicine and Science, Jacksonville, FL; Department of Neurology (J.P.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (S.B.B.), University of Pittsburgh School of Medicine, PA; Neuroscience Research Australia (P.R.S.); School of Medical Sciences (P.R.S.), University of New South Wales, Sydney, Australia; Department of Cellular Neurology (M.J.), Hertie Institute for Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (M.J.), Tübingen; Department of Neurology (J.L.), Ludwig-Maximilians-Universität München; German Center for Neurodegenerative Diseases (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.), Germany; Department of Neurology (Jae-Hong Lee), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; Department of Pathology and Immunology (R.J.P.), Knight Alzheimer's Disease Research Center (R.J.P., J.H.), and Department of Neurology (R.J.P., J.H.), Washington University in St. Louis; Department of Psychiatry (C.C.), Washington University School of Medicine; Department of Psychological and Brain Sciences (J.H.), Washington University, St. Louis, MO; and Department of Neurology (S.P.S.), The Warren Alpert Medical School of Brown University, Butler Hospital, Providence, RI.

Article Synopsis
  • The study examines the link between protective lifestyle factors and the age at symptom onset of autosomal dominant Alzheimer disease (ADAD), which is largely influenced by genetics, focusing on how resilience-related experiences may impact this relationship.
  • The researchers analyzed data from the Dominantly Inherited Alzheimer Network, assessing both clinical and lifestyle factors in two groups: one looking at general resilience among people showing cognitive stability despite high pathology and another focusing on specific genetic timelines for ADAD.
  • Findings from 320 participants indicate variations in age at onset among carriers based on lifestyle and resilience factors, revealing potential avenues for understanding how these influences might delay the onset of symptoms in genetically predisposed individuals.
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Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study.

World Allergy Organ J

September 2024

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Anti-type 2 (T2) biologic therapies (biologics) improve exacerbation rates, lung function, and asthma-related quality of life (QoL) in patients with severe T2 asthma. However, studies comparing different biologics are lacking. We evaluated the QoL in patients with severe asthma comprehensively and compare the efficacy of different T2-directed biologics using QoL questionnaires.

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Background/aims: Fecal microbiota transplantation (FMT) is a promising therapy for inducing and maintaining remission in patients with ulcerative colitis (UC). However, FMT has not been approved for UC treatment in Korea. Our study aimed to investigate patient perceptions of FMT under the national medical policy.

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A phase II study of tepotinib in patients with advanced solid cancers harboring MET exon 14 skipping mutations or amplification (KCSG AL19-17).

ESMO Open

September 2024

Division of Hematology-Oncology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University School of Medicine, Choengju. Electronic address:

Background: We evaluated the efficacy and safety of tepotinib in patients with various solid cancers harboring MET exon 14 skipping mutation (METex14) or MET gene amplification.

Patients And Methods: A phase II, multicenter study was conducted in patients with advanced or metastatic solid cancers who progressed after standard treatment, harboring either METex14 or MET amplification detected in tissue-based next-generation sequencing (NGS). The primary endpoint was objective response rate (ORR).

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Photobiomodulation with near-infrared laser for tinnitus management: preliminary animal experiments and randomized clinical trials.

Lasers Med Sci

August 2024

Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 31116, Republic of Korea.

This study investigates the effectiveness of photobiomodulation therapy (PBMT) in treating chronic high-frequency tinnitus with the TINI device, a near-infrared (830 nm) laser. The study includes preliminary animal experiments with 28 mice and a randomized controlled trial with 56 participants to examine the functional and molecular changes in the auditory system that PBMT may cause. The animal model used sodium salicylate to induce tinnitus, followed by PBMT, which showed promising reductions in the behavioral evidence of tinnitus and a reversal of tinnitus-associated upregulation of vesicular glutamate transporters 2 expression in the ipsilateral dorsal cochlear nucleus (p < 0.

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Article Synopsis
  • The study aimed to evaluate the safety and effectiveness of a light-emitting diode (LED) device with four wavelengths for treating grade 2 sacral pressure ulcers (PUs).
  • A total of 38 patients participated in a double-blinded clinical trial, comparing the LED device's effects with a sham device over four weeks.
  • Results indicated that while LED treatment showed promise for reducing wound size in cases without eschar, overall evidence did not conclusively support its efficacy in treating grade 2 PUs.
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Background: Neuropilin-1 (NRP1) is expressed on the surface epithelium of respiratory tract and immune cells, demonstrating its possible function in regulating the immune response in airway disease. However, its role in patient with chronic rhinosinusitis (CRS) remains unknown. This study aimed to elucidate the role of NRP1 in CRS with nasal polyps (CRSwNP).

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Article Synopsis
  • - The study aimed to investigate how the location of gallbladder cancer (GBC) tumors affects patient outcomes, as previous research was limited and inconclusive.
  • - Researchers conducted a multicenter analysis of 372 patients who underwent surgery for GBC, categorizing them into two groups: those with tumors in the fundus/body (FB-GBC) and those in the neck/cystic duct (NC-GBC).
  • - Results indicated that NC-GBC patients experienced worse outcomes, including more advanced cancer stages, lower rates of successful tumor removal (R0), and higher recurrence and mortality rates, yet the specific location of the tumor was not identified as an independent factor influencing prognosis.
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Background: Patients with ST-elevation myocardial infarction (STEMI) tend to be excluded or under-represented in randomized clinical trials evaluating the effects of potent P2Y12 inhibitor monotherapy after short-term dual antiplatelet therapy (DAPT).

Methods: Individual patient data were pooled from randomized clinical trials that included STEMI patients undergoing drug-eluting stent (DES) implantation and compared ticagrelor monotherapy after short-term (≤3 months) DAPT versus ticagrelor-based 12-month DAPT in terms of centrally adjudicated clinical outcomes. The co-primary outcomes were efficacy outcome (composite of all-cause death, myocardial infarction, or stroke) and safety outcome (Bleeding Academic Research Consortium type 3 or 5 bleeding) at 1 year.

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Development and validation of a machine learning-based, point-of-care risk calculator for post-ERCP pancreatitis and prophylaxis selection.

Gastrointest Endosc

January 2025

Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. Electronic address:

Article Synopsis
  • - A new machine learning tool was developed to predict the risk of post-ERCP pancreatitis (PEP) using data from 12 clinical trials, aiming to improve decision-making regarding patient care.
  • - The tool was trained on 7389 patients, considering various risk factors and interventions, achieving a predictive accuracy (AUC) of 0.70 in the training phase and 0.74 in a pilot study with 135 patients.
  • - This study shows that the model can effectively help identify patients at low risk for PEP, potentially reducing unnecessary post-procedural monitoring.
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Licochalcone A attenuates NMDA-induced neurotoxicity.

Anim Cells Syst (Seoul)

August 2024

Department of Physiology, College of Medicine, Center for Human Risk Assessment, Dankook University, Cheonan, Republic of Korea.

Article Synopsis
  • This study explores the protective effects of Licochalcone A (Lico-A), a compound from licorice roots, against neurotoxicity induced by NMDA in rat hippocampal neurons.
  • Results showed that Lico-A improved cell survival and increased synaptic markers, indicating a reversal of NMDA's harmful effects on neurons.
  • Additionally, Lico-A reduced levels of proteins related to necroptosis and diminished the activated response of supportive glial cells, highlighting its potential as a neuroprotective agent against NMDA-related neurotoxicity.
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Allergy Wheal and Erythema Segmentation Using Attention U-Net.

J Imaging Inform Med

August 2024

Department of Biomedical Engineering, Gil Medical Center, Gachon University College of Medicine, 21 Namdong-Daero 774 beon-gil, Namdong-gu, Incheon, Korea.

The skin prick test (SPT) is a key tool for identifying sensitized allergens associated with immunoglobulin E-mediated allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, urticaria, angioedema, and anaphylaxis. However, the SPT is labor-intensive and time-consuming due to the necessity of measuring the sizes of the erythema and wheals induced by allergens on the skin. In this study, we used an image preprocessing method and a deep learning model to segment wheals and erythema in SPT images captured by a smartphone camera.

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During the healing process after intra-nasal surgery, the growth and repair of damaged tissues can result in the development of postoperative adhesions. Various techniques have been devised to minimize the occurrence of postoperative adhesions which include insertion of stents in the middle meatus, application of removable nasal packing, and utilizing biodegradable materials with antiadhesive properties. This study assesses the efficacy of two sodium hyaluronate (SH)-based freeze-dried hydrogel composites in preventing postoperative nasal adhesions, comparing them with commonly used biodegradable materials in nasal surgery.

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Background: Cancer is a leading cause of death worldwide, posing a significant threat to human health and life expectancy. Numerous existing studies explored the correlation between coal-fired power plants and cancer development. Currently, Chungcheongnam-do Province hosts 29 coal-fired power plants, constituting half of the total 58 plants across South Korea.

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Background: Osteochondral autologous transplantation (OAT) has been widely used in the treatment of osteochondral lesion of the talus (OLT). Previous studies have reported successful outcomes following the use of osteochondral autogenous grafts from the intercondylar notch of the knee or a non-weight-bearing region of the femoral condyle. However, donor-site morbidity of the knee joint has been observed in several cases.

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Article Synopsis
  • The study aimed to establish clear criteria for classifying the severity of alopecia areata (AA), as no universal guidelines existed prior to this research.! -
  • A consensus was reached among experts, resulting in a severity classification system that uses the severity of alopecia tool (SALT) and categorizes AA as mild, moderate, or severe based on specific thresholds.! -
  • The new criteria will assist clinicians in diagnosing AA more accurately, determining suitable treatments, and effectively monitoring the condition's progression.!
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Incidence of Tuberculosis Among Immigrants in Korea Who Participated in a Latent Tuberculosis Infection Screening Program.

J Korean Med Sci

July 2024

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: With a rapid decrease in tuberculosis (TB) incidence, the significance of latent tuberculosis infection (LTBI) has been underscored in South Korea. Although South Korea does not have a high proportion of immigrants compared to other countries, there is a growing argument that it should actively embrace immigrants as a solution to address issues of low birth rates and population aging. This study aimed to assess TB incidence among immigrants who participated a pilot LTBI screening program in South Korea.

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This research group (forensic research via omics markers in environmental health vulnerable areas: FROM) aimed to develop biomarkers for exposure to environmental hazards and diseases, assess environmental diseases, and apply and verify these biomarkers in environmentally vulnerable areas. Environmentally vulnerable areas-including refineries, abandoned metal mines, coal-fired power plants, waste incinerators, cement factories, and areas with high exposure to particulate matter-along with control areas, were selected for epidemiological investigations. A total of 1,157 adults, who had resided in these areas for over 10 years, were recruited between June 2021 and September 2023.

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