Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids.

This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the transdermal administration of cannabinoids. Cannabinoids have proven beneficial in the treatment of wide-ranging physical and psychological disorders.

Recycled PMMA prepared directly from crude MMA obtained from thermal depolymerization of mixed PMMA waste.

Recycled PMMA was prepared by directly polymerizing crude pyrolysis oils from lab-scale pyrolysis of collected industrial waste PMMA. The pyrolysis oils consisted mainly of methyl methacrylate (MMA, >85%), while the type and number of by-products from the thermal process were assigned through GC-MS analysis showing a clear correlation to the pyrolysis temperature. By-products can be removed by distillation; however, directly employing the crude oils to prepare PMMA through solution, suspension, emulsion, or casting polymerization was investigated to assess the potential for omitting this costly step.

A reliable quantitative method for determining CBD content and release from transdermal patches in Franz cells.

Introduction: There are several cannabidiol (CBD) transdermal patches available on the market. However, none are FDA-approved. Furthermore, not much evidence has been published about CBD release and skin permeation from such patches, so the effectiveness and reliability remain unclear.

Recycling of dielectric electroactive materials enabled through thermoplastic PDMS.

In the green transition, actuators and generators play an essential role in the development of sustainable solutions across a broad range of applications. In this context, dielectric transducers are advocated as one of the most promising solutions in terms of effectiveness, lifetime and running costs. However, they are classically produced as sandwich structures, whereby a cross-linked dielectric material is placed between two compliant electrodes.

One reaction to make highly stretchable or extremely soft silicone elastomers from easily available materials.

Highly stretchable, soft silicone elastomers are of great interest for the fabrication of stretchable, soft devices. However, there is a lack of available chemistries capable of efficiently preparing silicone elastomers with superior stretchability and softness. Here we show an easy curing reaction to prepare silicone elastomers, in which a platinum-catalyzed reaction of telechelic/multi-hydrosilane (Si-H) functional polydimethylsiloxane (PDMS) in the presence of oxygen and water leads to slow crosslinking.

Binary Silicone Elastomeric Systems with Stepwise Crosslinking as a Tool for Tuning Electromechanical Behavior.

Interpenetrating polymer networks (IPNs) represent an interesting approach for tuning the properties of silicone elastomers due to the possible synergism that may occur between the networks. A new approach is presented, which consists of mixing two silicone-based networks with different crosslinking pathways; the first network being cured by condensation route and the second network by UV curing. The networks were mixed in different ratios and the resulted samples yield good mechanical properties (improved elongations, up to 720%, and Young's modulus, 1 MPa), thermal properties (one glass transition temperature, ~-123 °C), good dielectric strength (~50 V/μm), and toughness (63 kJ/m).

Antimicrobial PDMS Surfaces Prepared through Fast and Oxygen-Tolerant SI-SARA-ATRP, Using NaSO as a Reducing Agent.

Poly(dimethylsiloxane) (PDMS) is an attractive, versatile, and convenient material for use in biomedical devices that are in direct contact with the user. A crucial component in such a device is its surface in terms of antimicrobial properties preventing infection. Moreover, due to its inherent hydrophobicity, PDMS is rather prone to microbial colonization.

Insights into the Complex Prebreakdown Actuation of Silicone Elastomers and its Influence on Breakdown Behavior.

Dielectric elastomer transducers can be applied in many different applications, but their current use is limited by either their electrical breakdown strength or by electromechanical instabilities in the case of soft elastomers. The breakdown process is never a single, simple process but rather-most likely-an ensemble of thermoelectric processes taking place in both elastomer and electrode materials, coupled with mechanical and potentially also chemical degradation. In this work, by using a high-speed camera, we follow silicone-based dielectric elastomers undergoing a ramp-up in voltage close to electrical breakdown strength, with differently constructed elastomers and electrodes.

Effect of Crystallinity on Water Vapor Sorption, Diffusion, and Permeation of PLA-Based Nanocomposites.

The effects of crystalline morphology and presence of nanoparticles such as cellulose nanofibers (CNFs), organically modified nanoclay (C30B), or a combination of both on water vapor sorption and diffusion in polylactide (PLA) were evaluated by a quartz spring microbalance (QSM). It was found that the large spherulite size induced by high-temperature processing leads to an increase in water sorption and a substantial reduction of diffusion with increasing crystallinity. Contrarily, small-sized spherulites, arising after low-temperature processing during solvent-casting, showed a different behavior with a slight decrease in both water vapor sorption and diffusion with increasing crystallinity.

Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate).

The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol % of the functional monomer in the copolymer.

Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris.

The accumulation of plastic litter in natural environments is a global issue. Concerns over potential negative impacts on the economy, wildlife, and human health provide strong incentives for improving the sustainable use of plastics. Despite the many voices raised on the issue, we lack a consensus on how to define and categorize plastic debris.

Anti-biofilm effects of gold and silver nanoparticles synthesized by the Rhodiola rosea rhizome extracts.

Bacterial biofilm represents a major problem in medicine. They colonize and damage medical devices and implants and, in many cases, foster development of multidrug-resistant microorganisms. Biofilm development starts by bacterial attachment to the surface and the production of extracellular polymeric substances (EPS).

Glycerol-Silicone Elastomers as Active Matrices with Controllable Release Profiles.

Drug release regimes must be controlled for the optimal therapeutic effect. Although it is relatively straightforward to create first-order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases but are even more difficult to formulate.

Molecular Strategies for Improved Dielectric Elastomer Electrical Breakdown Strengths.

Dielectric elastomer transducers (actuators and generators) possess great commercial potential because they allow for novel transducer designs and applications due to-amongst others-their flexibility and low weight. On the other hand, the flexibility and inherent softness of dielectric elastomers also pose restrictions on their use, since the thin elastomers may undergo destructive deformations under large loads or in large electrical fields. In order to design better dielectric elastomers, it is crucial to understand the underlying phenomena of how thin and elastic dielectric elastomer films undergo electrical breakdown.

Green synthesis of gold and silver nanoparticles from (industrial hemp) and their capacity for biofilm inhibition.

Background: (hemp) is a source of various biologically active compounds, for instance, cannabinoids, terpenes and phenolic compounds, which exhibit antibacterial, antifungal, anti-inflammatory and anticancer properties. With the purpose of expanding the auxiliary application of in the field of bio-nanotechnology, we explored the plant for green and efficient synthesis of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs).

Methods And Results: The nanoparticles were synthesized by utilizing an aqueous extract of stem separated into two different fractions (cortex and core [xylem part]) without any additional reducing, stabilizing and capping agents.

Enhancing the electro-mechanical properties of polydimethylsiloxane elastomers through blending with poly(dimethylsiloxane--methylphenylsiloxane) copolymers.

In this work, improved electro-mechanical properties of silicone-based dielectric elastomers are achieved by means of adding so-called "voltage-stabilisers" prepared from phenyl-functional copolymers prepared using oxyanionic ring-opening polymerisation of octamethylcyclotetrasiloxane (D4) and either tetramethyltetraphenylcyclotetrasiloxane (T4) or octaphenylcyclotetrasiloxane (O4). The concentration of the voltage stabiliser was varied both by changing the molar ratio between methyl and phenyl groups in the copolymer and also by varying the amount of copolymer mixed into a PDMS-based elastomer. The phenyl-functional copolymers were generally found to disperse homogeneously in the PDMS matrix and this resulted in networks with improved mechanical and electrical properties.

A thermo-reversible silicone elastomer with remotely controlled self-healing.

Soft thermoplastic elastomers with increased durability and reliability are in high demand for a broad spectrum of applications. Silicone elastomers are soft and durable, but they are not thermoplastic in nature, and under extreme conditions such as high voltage or large deformations, reliability may also suffer. Thus, as a solution to these shortcomings, which are typical of silicone elastomers, it is natural to propose a thermo-reversible, self-healing, and recyclable silicone-based elastomer.

Simple Preparation of Thiol-Ene Particles in Glycerol and Surface Functionalization by Thiol-Ene Chemistry (TEC) and Surface Chain Transfer Free Radical Polymerization (SCT-FRP).

Thiol-ene (TE)-based polymer particles are traditionally prepared via emulsion polymerization in water (using surfactants, stabilizers, and cosolvents). Here, a green and simple alternative is presented with excellent control over particle size, while avoiding the addition of stabilizers. Glycerol is applied as a dispersing medium for the preparation of off-stoichiometric TE microparticles, where sizes in the range of 40-400 µm are obtained solely by changing the mixing speed of the emulsions prior to crosslinking.

Development of a thiol-ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase.

Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform.

Self-Healing, High-Permittivity Silicone Dielectric Elastomer.

Currently used dielectric elastomers do not have the ability to self-heal after detrimental events such as tearing or electrical breakdown, which are critical issues in relation to product reliability and lifetime. In this paper, we present a self-healing dielectric elastomer that additionally possesses high dielectric permittivity and consists of an interpenetrating polymer network of silicone elastomer and ionic silicone species that are cross-linked through proton exchange between amines and acids. The ionically cross-linked silicone provides self-healing properties after electrical breakdown or cuts made directly to the material due to the reassembly of the ionic bonds that are broken during damage.

Highly Branched Bio-Based Unsaturated Polyesters by Enzymatic Polymerization.

A one-pot, enzyme-catalyzed bulk polymerization method for direct production of highly branched polyesters has been developed as an alternative to currently used industrial procedures. Bio-based feed components in the form of glycerol, pentaerythritol, azelaic acid, and tall oil fatty acid (TOFA) were polymerized using an immobilized lipase B (CALB) and the potential for an enzymatic synthesis of alkyds was investigated. The developed method enables the use of both glycerol and also pentaerythritol (for the first time) as the alcohol source and was found to be very robust.

Dynamic dilution exponent in monodisperse entangled polymer solutions.

We study and model the linear viscoelastic properties of several entangled semi-dilute and concentrated solutions of linear chains of different molar masses and at different concentrations dissolved in their oligomers. We discuss the dilution effect of the oligomers on the entangled long chains. In particular, we investigate the influence of both concentration and molar mass on the value of the effective dynamic dilution exponent determined from the level of the storage plateau at low and intermediate frequencies.

3D Printed Silicone-Hydrogel Scaffold with Enhanced Physicochemical Properties.

Scaffolds with multiple functionalities have attracted widespread attention in the field of tissue engineering due to their ability to control cell behavior through various cues, including mechanical, chemical, and electrical. Fabrication of such scaffolds from clinically approved materials is currently a huge challenge. The goal of this work was to fabricate a tissue engineering scaffold from clinically approved materials with the capability of delivering biomolecules and direct cell fate.

Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching.

Limitations in controlling scaffold architecture using traditional fabrication techniques are a problem when constructing engineered tissues/organs. Recently, integration of two pore architectures to generate dual-pore scaffolds with tailored physical properties has attracted wide attention in tissue engineering community. Such scaffolds features primary structured pores which can efficiently enhance nutrient/oxygen supply to the surrounding, in combination with secondary random pores, which give high surface area for cell adhesion and proliferation.