Ultrasound and computed tomography in differentiating between simple and complicated appendicitis in pediatric patients.

Objectives: This study aims to measure the diagnostic accuracy and reliability of US and CT in diagnosing complicated appendicitis among pediatric patients and to find the performance of the imaging modalities in detecting complication signs.

Methods: a systematic review and meta-analysis were done on 15 eligible studies from the Medline Database concerning pediatric appendicitis and its complications. Studies either provided an overall estimate of sensitivity and specificity of the imaging modality or addressed signs of complicated appendicitis The reference standard employed was either surgical findings or histopathology reports.

Evaluation of the Dislodgement Resistance of Traditional Adhesive Posterior Bridges Compared With Adhesive Posterior Bridges Prepared With Standard and Modified Slot-Back Dummies: An In Vitro Study.

Background Bridges with minimal preparation have received great acceptance in recent years. Since their first appearance, they have undergone many types of modifications and improvements. Aim This study aimed to compare three types of minimal preparation bridges in terms of force required for dislodgement and the type of deformation incurred for each of the abutments and prostheses.

A case of congenital cholesteatoma in adult patient with intermittent episodes of facial palsy.

Introduction And Importance: Congenital cholesteatoma is a rare entity that arises from epithelial cell rests in the middle ear, parts of temporal bone or even intracranially. However, it can go unrecognized for several years making the consideration of such diagnosis a bit tricky among otologists.

Case Presentation: We are reporting a case of a young female adult who presented with unilateral hearing loss for one year and intermittent episodes of facial twitching in addition to periods of recurrent unilateral facial palsy that happened about three times in the past two years.

Liver metastasized pancreatic neuroendocrine tumor in a 17-year-old female: A case report.

Key Clinical Message: Pancreatic neuroendocrine tumors (PNETs) are rare and often misdiagnosed due to their vague symptoms and tumor heterogeneity. Early detection using computed tomography (CT) is essential, particularly in regions without access to advanced diagnostic tools like immunohistochemistry and genetic testing.

Abstract: Neuroendocrine tumors (NETs) are rare tumors in adults and extremely rare in the pediatric population, as pancreatic NETs (pNETs) have an incidence rate of <0.

Pyridoxine-dependent epilepsy caused by an ALDH7A1 mutation in an infant girl: the first case report in Syria.

Background: Pyridoxine-dependent epilepsy is primarily characterized by early-onset refractory seizures. This condition can be caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency due to a mutation in the ALDH7A1 gene, leading to the accumulation of certain substances that impact the production of various brain neurotransmitters and enzymes.

Case Presentation: Our report presents the first documented case of pyridoxine dependency in Syria.

Pediatric Kidney Transplantation in an Under-resourced Country: A Single-Center Experience.

Objectives: Kidney transplant is the optimal method for managing children with end-stage kidney disease. This study aimed to present the experience and results of the pediatric kidney transplant program at our center.

Materials And Methods: A single-center observational study was conducted at Children's University Hospital in Damascus, Syria.

How Irrigants Affect Mineral Trioxide Aggregate (MTA) Sealing in Furcal Perforations: An In Vitro Study.

Objective This study aimed to evaluate the effect of 5.25% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX) on ProRoot mineral trioxide aggregate (MTA) used for treating furcal perforations, compared to no solution application, using the dye penetration (DP) method. Materials and methods The study included 36 intact mandibular molars in the furcal area (FA) with well-spaced roots.

Enhancing Academic Success: A mixed Study on the Influencing Factors among Pharmacy Students in Syrian Universities.

Background: Academic achievement is the result of both effort and perseverance exerted by the students. This mixed-methods study aims to investigate the factors affecting the academic achievement of pharmacy students in Syrian universities.

Methods: A convergent parallel mixed-methods study was utilized.

The multifaceted effects of migraine on Syrian society: insights from a multicenter cross-sectional study.

Background: Migraine is the most common primary headache. It's alone responsible for 1.3% of disability in the world.

A look at Zancolli-Lasso indications and surgical technique with a unique case.

Introduction: Forearm lacerations could lead to disastrous disabilities, nerve injuries led by the ulna nerve cause severe hand deformity and disfunction with little options to repair.

Case Presentation: A young male suffered a distal ulna nerve injury and underwent multiple surgeries over two years. Zancolli-Lasso procedure was done, and major improvement was obtained.

The Expression of PDL-1 and PD1 in the Microenvironment of Oral Squamous Cell Carcinoma.

Objective: Immune checkpoint proteins, especially PD-1/PD-L1, play a vital role in controlling the intensity and duration of the immune response. However, cancer cells often over-expression PDL-1 on their surfaces, which leads to the permanent activation of the PD-1/PDL-1 pathway and exhaustion of T cells and creates a resistant tumor microenvironment. This study aimed to analyze PD-1, PD-L1 expression in tumor cells (PDL-1/TC) and in Tumor-Infiltrating Lymphocytes (PDL-1/TILS) of OSCC patients and associated with and to correlate it with histologic grade of malignancy and clinicopathologic parameters.

Ketamine and chronic treatment-resistant depression: real-world practice and after relapse.

Background: Chronic treatment-resistant depression (TRD) poses a major challenge for clinicians. Ketamine has shown a rapid but short-lived antidepressant effect in several studies involving TRD patients with different demographic and clinical profiles. Our study aimed to assess the antidepressant effect of serial infusion sessions of ketamine in patients with chronic TRD and evaluate the severity of symptoms after relapse and the general psychiatric health of the responding patients.

A Comparison of Different Implant Site Preparation Techniques in Low-Density Bone: An Ex-Vivo Study.

Introduction: Osseointegration is considered a prerequisite for the long-term success of dental implants, and many researchers have considered the stability of the implant when placed in the bone. Many techniques include undersized drilling, densifying burs, magnetic mallets, and expanders. These methods have led to higher initial insertion torque values.

Pentoxifylline in COVID-19 and considerations for its research in long COVID.

Introduction: Pentoxifylline (PTX) affects most blood components and the blood vessels, potentially modulating various conditions. Due to its impact on markers linked to COVID-19 severity, research has explored PTX for acute COVID-19. Following the widespread administration of COVID-19 vaccinations, there has been a notable and consistently growing increase in research focusing on long COVID.

A Comparison Between Three Types of Scaffolds for Pulp Regeneration: A Histological Study on Dogs.

Objectives: This study aims to compare the application of three types of normal scaffolds-native chitosan, enzymatically modified chitosan, and blood clot (BC)-on pulp regeneration in the teeth of experimental dogs through histological examination, to determine the quantity and type of new tissues formed within the root canal.

Materials And Methods: The research sample consisted of 32 root canals from 20 premolars of two male local experimental dogs. The sample was randomly divided into a control group, in which no intervention was performed on the teeth, and three experimental groups based on the type of scaffold used: the BC group, the native chitosan combined with BC (NCS + BC) group, and the enzymatically modified chitosan combined with BC (EMCS + BC) group.

A Rare Case Report of Malignant Peripheral Nerve Sheath Tumor in the Infratemporal Fossa.

Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors that develop from peripheral nerve sheath cells and they account for approximately 5% to 10% of all soft-tissue sarcomas. MPNSTs in the head and neck region represent approximately 2% to 6% of all head and neck sarcomas and account for 12% to 19% of all MPNSTs, and the infratemporal fossa is a rare site for MPNSTs. MPNSTs originating from the trigeminal nerve are extremely rare.

D-dimer as a Predictive Biomarker of Response to Chemotherapy in Patients With Metastatic Breast Cancer.

Background: Tumor-induced coagulation is widely observed in cancer patients. Moreover, it is associated with tumorigenesis, tumor progression and metastasis, by creating a proliferative and proangiogenic microenvironment. Therefore, D-dimer, a fibrin degradation product, correlates with tumor prognosis in several cancer types.

Polymeric nanoparticles loaded with vincristine and carbon dots for hepatocellular carcinoma therapy and imaging.

Chemotherapy for hepatoblastoma is limited by organ toxicity and poor outcomes, prompting the search for new, more effective treatments with minimal side effects. Vincristine sulfate, a potent chemotherapeutic, faces challenges due to P-glycoprotein-mediated resistance and its systemic toxicity. Nanoparticles offer a promising solution by improving pharmacokinetics, targeting tumor cells, thus reducing side effects.

Intraoperative diagnosis of Amyand's hernia, a case report.

Introduction: Hernia forms when an organ or its fascia protrudes through the continuing cavity's wall. Amyand's hernia describes an inguinal hernia containing an appendix, regardless of inflammation.

Presentation Of Case: Our patient was complaining of an increasing lump in the inguinal area.

Successful vaginal delivery in a patient with reconstructed bladder exstrophy and vaginoplasty after cesarean section, a case report from Syria.

Introduction And Importance: Bladder exstrophy (BE) is a rare congenital anomaly in which the anterior wall of the bladder is absent. In females, sexuality and fertility may be negatively affected with the association with pubic diastasis, dysplasia of the pelvic floor muscles, clitoris bifurcated, short vagina or narrow introitus.

Presentation Of Case: We present a case of 26-year-old woman with treated BE, vaginoplasty, and bicornuate uterus that came at week 36 of gestation.