2 results match your criteria: "Dalian Medical UniversityDalian 116011[Affiliation]"

The global burden of malignant glioma is expected to increase and new therapy approaches are urgently required. Solasonine is a natural glycoalkaloid compound that has been used in cancer treatment for many years; however the precise mechanisms are poorly understood. Here we seek to explore the potential roles of solasonine in glioma that could add to the development of newer therapeutic approaches for the treatment of malignant glioma.

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Roles of PD-1, Tim-3 and CTLA-4 in immunoregulation in regulatory T cells among patients with sepsis.

Int J Clin Exp Med

January 2016

Department of General Surgery, Dalian Medical UniversityDalian 116011, P. R. China; Department of General Surgery, Integrated Chinese and Western MedicineDalian 116011, P. R. China.

Objective: This study aims to elucidate the roles of PD-1, Tim-3 and CTLA-4 in sepsis.

Methods: Sepsis patients (n = 182) were selected as sepsis group and divided into three subgroups: mild sepsis group, severe sepsis group and septic shock group; 185 healthy volunteers were enrolled as control group. Flow cytometry and blood routine examination were performed for T lymphocytes and surface co-stimulatory molecules expressions.

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