Development and validation of the UPLC-MS method for simultaneous determination of six new psychoactive substances.

The combined abuse of benzodiazepines and antipsychotics has become a global problem, and to develop a highly sensitive and selective method for monitoring of benzodiazepine hypnotics and antipsychotics is urgently necessary. In this work, we established a rapid method for the simultaneous determination of benzodiazepines (diazepam, alprazolam, triazolam, and estazolam) and antipsychotic drugs (clozapine, and chlorpromazine) based on ultra performance liquid chromatography-mass spectrometry (UPLC-MS). The accuracy, precision, limit of detection (LOD), limit of quantification (LOQ), specificity, matrix effect and carry-over effect were verified in detail.

Facile synthesis of carbon nitride quantum dots as a highly selective and sensitive fluorescent sensor for the tetracycline detection.

Enhanced blue fluorescent carbon nitride quantum dots (g-CNQDs) were synthesized by a simple solvothermal "tailoring" process from bulk g-CN and analyzed by various characterization methods. The as-obtained g-CNQDs were successfully applied in the determination of tetracycline (TC) with a good linear relationship in the range of 0.23-202.

Development and comparison of UPLC-ESI-MS and RP-HPLC-VWD methods for determining microcystin-LR.

Microcystin-LR (MC-LR) generated by cyanobacteria is a kind of potent hepatotoxin, which poses a considerable threat to human health. In the research field of MC-LR removal, the quantitative analysis in a wide concentration range of samples is inevitable. In this paper, we presented the pseudo united use of an Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS) and High Performance Liquid Chromatography system with a Variable Wavelength Ultraviolet Detector (HPLC-VWD) approach to detect MC-LR.