Facile deprotection of F-BODIPYs using methylboronic acid.

4,4-Difluoro-4-bora-3,4-diaza--indacenes (F-BODIPYs) are deprotected through removal of the -BF moiety upon treatment with methylboronic acid. The tolerance of various substitution patterns about the dipyrrinato core is demonstrated the deprotection of thirteen F-BODIPYs and an F-aza-BODIPY. Work-up with aq.

A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes.

Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate. We herein present a step-wise route to the preparation of nine folate conjugates of the tripyrrolic prodigiosene skeleton. The strict requirement for step-wise construction of the folate core is demonstrated, so as to achieve conjugation at only the desired γ-carboxylic acid and thus maintain the α-carboxylic site for folate receptor (FRα) recognition.