Intergenerational effects of maternal rate of body weight gain on the multi-omics hepatic profiles of bovine fetuses.

Maternal periconceptual nutrition affects the growth trajectory of developing fetuses by modulating gene expression. The regulatory mechanisms and their role in fetal development remain underexplored in livestock models. Herein, we investigated the effects of maternal rate of body weight (BW) gain during early gestation on the DNA methylation, microRNA profiles, and their interaction with the hepatic gene expression in female fetuses.

Telehealth adoption for substance use and mental health disorders in Minnesota and North Dakota: a quasi-experimental study.

Background: The coronavirus disease 2019 (COVID-19) pandemic necessitated rapid adoption of telehealth services to maintain healthcare access for treating substance use disorders (SUDs) and mental health care (MHC). However, the impacts of telehealth expansion policies adopted in 2020 on access to addiction treatment in North Dakota (ND) and Minnesota (MN) remain unclear. This study examines the impact of the COVID-19 pandemic on utilization of telehealth services for SUDs and MHC in ND and MN.

Genetic mapping of QTLs for resistance to bacterial leaf streak in hexaploid wheat.

Robust QTLs conferring resistance to bacterial leaf streak in wheat were mapped on chromosomes 3B and 5A from the variety Boost and on chromosome 7D from the synthetic wheat line W-7984. Bacterial leaf streak (BLS), caused by Xanthomonas translucens pv. undulosa poses a significant threat to global wheat production.

The Scutulum and the Pre-Auricular Aponeurosis in Bats.

The external ear in eutherian mammals is composed of the annular, auricular (pinna), and scutellar cartilages. The latter extends between the pinnae, across the top of the head, and lies at the intersection of numerous auricular muscles and is thought to be a sesamoid element. In bats, this scutulum consists of two distinct regions, (1) a thin squama that is in contact with the underlying temporalis fascia and (2) a lateral bossed portion that is lightly tethered to the medial surface of the pinna.

Art and Inspiration: Edouard Benedictus and the Invention of Laminated Safety Glass.

The invention of laminated safety glass is attributed to the French chemist and artist Edouard Benedictus (1878-1930), who developed the innovation known as Triplex glass after inspiration struck via a fortuitous laboratory accident. Licensed first to the English Triplex Safety Glass Company in 1912, with production later carried out in the US, Triplex glass was first applied to automobiles during the first World War. While the story of his lab accident can be found in many sources, it has become more legend than historical fact.

From block to shred: Understanding the factors influencing shreddability of mozzarella cheese.

Mozzarella cheese is widely used for pizza applications, and it is generally shredded either in conversion plants or in pizzerias. The shreddability of mozzarella cheese is influenced by a variety of factors, and it is critical to understand how different mozzarella cheese types and storage conditions (temperature and age) affect this property. Three batches each of 3 types of mozzarella cheese (low-moisture mozzarella [LMM], low-moisture part-skim mozzarella [LMPS], and reduced-fat mozzarella [RFM]) representing 3 different fat levels were procured directly from a commercial manufacturer and stored at 2 different temperatures (1.

Psychiatric learning experiences in PGY1 pharmacy residency training: A 5-year analysis.

Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Mechanical and Thermal Characteristics of Films from Glycerol Mixed Emulsified Carnauba Wax/Polyvinyl Alcohol.

Poly(vinyl alcohol) (PVA)-based films have drawn significant attention owing to their potential applications in various industries. The application of wax to PVA films enhanced their resistance to dissolution and water infiltration. Nevertheless, waxed PVA films often exhibit inadequate mechanical properties owing to crack formation.

Adjustment of Mechanical Properties of 3D Printed Continuous Carbon Fiber-Reinforced Thermoset Composites by Print Parameter Adjustments.

Reinforcing thermoset polymers with continuous carbon fiber (CF) tow has emerged as a promising avenue to overcome the thermal and mechanical performance limitations of 3D printed polymeric structures for load-bearing applications. Unlike traditional methods, manufacturing continuous fiber-reinforced composites by 3D printing has the unique capability of locally varying the mechanical properties of the composites. In this study, continuous CF thermoset composite specimens were printed with varying line spacing, resin flow rate, and nozzle sizes.

Sugar beet root susceptibility to storage rots and downregulation of plant defense genes increases with time in storage.

Storage rots are a significant cause of postharvest losses for the sugar beet crop, however, intrinsic physiological and genetic factors that determine the susceptibility of roots to pathogen infection and disease development are unknown. Research, therefore, was carried out to evaluate the disease development in sugar beet roots caused by two common storage pathogens as a function of storage duration and storage temperature, and to identify changes in the expression of defense genes that may be influencing the root susceptibility to disease. To evaluate root susceptibility to disease, freshly harvested roots were inoculated with Botrytis cinerea or Penicillium vulpinum on the day of harvest or after 12, 40, or 120 d storage at 5 or 12 °C and the weight of rotted tissue present in the roots after incubation for 35 d after inoculation were determined.

Heart rate variability during pregnancy moderates the impact of depressive symptoms on fetal growth.

Depression occurs in up to 13 % of all pregnancies and is associated with adverse pregnancy outcomes. However, the literature regarding associations between depression and lower birth weight or fetal growth has been inconsistent. Here, we consider if high frequency heart rate variability (HF-HRV) may moderate the association between depression and birth weight.

Metabolomics reveals a differential attitude in phytochemical profile of black tea ( Var. ) during processing.

Black tea's quality and flavor are largely influenced by its processing stages, which affect its volatile and non-volatile phytochemicals. This study aimed to optimized black tea manufacturing by investigating withering time, fermentation time, and temperature's impact on sensory quality. Using a U* (15) uniform design, optimal conditions were determined: 14 h of withering, 5.

Brain-targeting liposome-based gene delivery exacerbates soluble amyloid-β accumulation in mice.

Alzheimer's disease (AD) is the most common cause of late-life dementia characterized by progressive neurodegeneration and brain deposition of amyloid-β (Aβ) and phosphorylated tau. The ε2 encoding apolipoprotein E () is a protective allele against AD among the three genotypes ( ε2, ε3, ε4), while is the strongest genetic factor substantially increasing AD risk. APOE regulates brain lipid homeostasis and maintaining synaptic plasticity and neuronal function, where has a superior function compared to and .

Effect of protease supplementation on amino acid digestibility of soybean meal fed to growing-finishing pigs in two different ages.

This study was conducted to investigate the effect of protease inclusion level in two different ages on the apparent (AID) and standardized (SID) ileal digestibility of crude protein (CP) and amino acids (AAs) in soybean meal (SBM) fed to growing-finishing pigs. Ten cannulated pigs (21 ± 2 kg) were assigned to experimental diets in a duplicate 5 × 5 Latin square design. In phase I (23 to 30 kg-pigs, 90 ± 17 d of age), ileal digesta was collected in five periods of 7 d (5 d adaptation and 2 d ileal digesta collection).

Mannose receptor (MRC1) mediates uptake of dextran by bone marrow-derived macrophages.

Macrophages survey their environment using receptor-mediated endocytosis and pinocytosis. Receptor-mediated endocytosis allows internalization of specific ligands, whereas pinocytosis nonselectively internalizes extracellular fluids and solutes. CRISPR/Cas9 whole-genome screens were used to identify genes regulating constitutive and growth factor-stimulated dextran uptake in murine bone marrow-derived macrophages (BMDM).

Validity and Reliability Assessment of a Food and Physical Activity Questionnaire for Adolescents From Low-Income Communities.

Objective: Develop and validate an evaluation questionnaire for sixth-12th grade Expanded Food and Nutrition Education Program (EFNEP) participants.

Design: Five-step process: domain concept prioritization, question generation, question pretesting, reliability testing, and criterion validity testing.

Setting: Community sites in 4 states and New Jersey EFNEP secondary program data.

Early changes in the gut microbiota are associated with weight outcomes over 2 years following metabolic and bariatric surgery.

Objective: Metabolic and bariatric surgery (MBS) is associated with substantial, but variable, weight outcomes. The gut microbiome may be a factor in determining weight trajectory, but examination has been limited by a lack of longitudinal studies with robust microbiome sequencing. This study aimed to describe changes in the microbiome and associations with weight outcomes more than 2 years post surgery.

The Role of Heating Treatments on Bioactive Compounds, Fatty Acid Compositions, Phenolic Compounds and Mineral Contents of Peanut Kernels.

In this study, the role of boiling and roasting on chemical properties, fatty acid compositions, polyphenols and mineral contents of peanut kernels provided from Mersin (Silifke) province in Turkey was investigated. The oil yields of peanut kernels treated were specified between 48.92% (boiled) and 52.

Development of a MALDI-TOF MS model for differentiating haemorrhagic septicaemia-causing strains of Pasteurella multocida from other capsular groups.

Pasteurella multocida capsular types A, D, and F cause disease in many animal hosts, including bovine respiratory disease in cattle, which is one of the most globally significant animal diseases. Additionally, P. multocida capsular types B and E cause haemorrhagic septicaemia, a devastating disease primarily of cattle, water buffalo, and bison that develops rapidly with high mortality.

Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care.

Cellular senescence, the irreversible arrest of cell division, is a hallmark of aging and a key contributor to age-related disorders. Targeting senescent cells represents a promising therapeutic approach to combat these ailments. This review explores the potential of Garcinia species, a genus rich in flavonoids with established antioxidant and anti-inflammatory properties, as a source of natural anti-senescence agents.

Blood pressure variability associated with falls in nursing home residents.

Background: High variations in serially measured blood pressures (BPs) portend a variety of adverse clinical events including dementia, cardiovascular sequelae and frailty. In this study, systolic blood pressure variability (BPV) was examined for its association with fall frequency and time to next fall among older adults living in nursing homes.

Methods: BP values and falls over time were extracted from medical records of nursing home residents aged ≥65 years over a 10-month period.