Long-term cardiovascular risk reduction after gastric cancer surgery: a nationwide cohort study.

Background: Gastrectomy for gastric cancer is associated with postoperative changes in cardiovascular risk factors, however, the impact of gastrectomy on cardiovascular events remains unclear. The authors assessed the incidence of cardiovascular events between patients undergoing gastrectomy or endoscopic resection for gastric cancer, and the general population.

Materials And Methods: This retrospective nationwide cohort study included patients with gastric cancer undergoing gastrectomy ( n =37 698), endoscopic resection ( n =2773), and matched control population ( n =161 887) between 2004 and 2013.

Capsaicin induces ATP-dependent thermogenesis via the activation of TRPV1/β3-AR/α1-AR in 3T3-L1 adipocytes and mouse model.

Capsaicin (CAP) is a natural bioactive compound in chili pepper that activates the transient receptor potential vanilloid subfamily 1 (TRPV1) and is known to stimulate uncoupling protein 1 (UCP1)-dependent thermogenesis. However, its effect on ATP-dependent thermogenesis remains unknown. In this study, we employed qRT-PCR, immunoblot, staining method, and assay kit to investigate the role of CAP on ATP-dependent thermogenesis and its modulatory roles on the TRPV1, β3-adrenergic receptor (β3-AR), and α1-AR using in vitro and in vivo models.

Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management.

This paper delves into the diverse and significant roles of curcumin, a polyphenolic compound from the Curcuma longa plant, in the context of cancer and inflammatory diseases. Distinguished by its unique molecular structure, curcumin exhibits potent biological activities including anti-inflammatory, antioxidant, and potential anticancer effects. The research comprehensively investigates curcumin's molecular interactions with key proteins involved in cancer progression and the inflammatory response, primarily through molecular docking studies.

Development of Field Tests for Cardiovascular Fitness Assessment in Wheelchair.

It is essential to consider both physique and physical fitness factors to minimize the risk of injuries and optimize athletic performance among elite athletes. Athletes with disabilities face limitations in fitness assessments compared to their healthy counterparts. The aim of this study was to revalidate established cardiovascular fitness assessment methods and develop field tests for wheelchair athletes.

Thr-to-Ala Mutation Leads to a Larger Aromatic Pair and Reduced Packing Density in α1,α3-Helices during Thioredoxin Cold Adaptation.

This study investigates the impact of aromatic-aromatic interactions on the cold adaptation of thioredoxin (Trx), a small redox protein with a conserved Trx-fold structure. Two Trx orthologs, one from the psychrophilic Arctic bacterium sp. (SpTrx) and the other from the mesophilic (EcTrx), display distinct aromatic interactions in their α1,α3-helices.

Deep learning solutions for smart city challenges in urban development.

In the realm of urban planning, the integration of deep learning technologies has emerged as a transformative force, promising to revolutionize the way cities are designed, managed, and optimized. This research embarks on a multifaceted exploration that combines the power of deep learning with Bayesian regularization techniques to enhance the performance and reliability of neural networks tailored for urban planning applications. Deep learning, characterized by its ability to extract complex patterns from vast urban datasets, has the potential to offer unprecedented insights into urban dynamics, transportation networks, and environmental sustainability.

Exploring the Role of Surface and Mitochondrial ATP-Sensitive Potassium Channels in Cancer: From Cellular Functions to Therapeutic Potentials.

ATP-sensitive potassium (KATP) channels are found in plasma membranes and mitochondria. These channels are a type of ion channel that is regulated by the intracellular concentration of adenosine triphosphate (ATP) and other nucleotides. In cell membranes, they play a crucial role in linking metabolic activity to electrical activity, especially in tissues like the heart and pancreas.

Incidence of tuberculosis disease in individuals diagnosed with tuberculosis infection after screening: A population-based cohort study in South Korea.

Objectives: Limited evidence exists regarding the impact of adherence to diverse tuberculosis (TB) preventive therapy (TPT) regimens on TB risk in individuals with TB infections (TBIs). This study aimed to examine the association between adherence to three TPT regimens and TB incidence.

Methods: This population-based retrospective cohort study used South Korean national health insurance data to identify individuals who were newly diagnosed with TBI between 2015 and 2020.

Material-common and material-specific neural activity during encoding of words and scenes: A neuroimaging meta-analysis.

This study examined the extent to which neural activity during memory encoding demonstrates material-commonness or material-specificity. A meta-analysis of functional magnetic resonance imaging studies was conducted to compare the brain regions associated with subsequent memory effects for word and scene stimuli. The main results were as follows.

Grouping of unused agricultural by-product biomass for fuel conversion in South Korea through multivariate analysis.

While biomass holds significance as a resource, its abundance in South Korea is limited. Therefore, in this study analyzed the chemical characteristics of agricultural by-products produced and evaluated their fuel potentiality. To achieve this objective, multivariate analysis was utilized to create biomass clusters with diverse feature.

Regional differences in the effects of healthy aging on depressive symptoms: a Korean longitudinal study of aging (2006-2020).

Background: Depression is a widely prevalent, often recurrent condition. To analyze the regional differences in depressive symptoms over time, we investigated urban-rural differences in change in depression over time in South Korea and the association between healthy aging and depressive symptoms among middle-aged and older adults.

Methods: Data collected in the Korean Longitudinal Study of Aging, from 2006 to 2020, of adult participants aged ≥45 years without depressive symptoms were analyzed.

Effect of rice milling, washing, and cooking on reducing pesticide residues.

The effects of milling, washing, and cooking on etofenprox, flubendiamide, and tebufenozide levels in brown and polished rice were investigated by HPLC using a UV detector. The reduction rates of etofenprox, flubendiamide, and tebufenozide after milling were 68.74-93.

Predicting Receiver Characteristics without Sensors in an LC-LC Tuned Wireless Power Transfer System Using Machine Learning.

Improvement of wireless power transfer (WPT) systems is necessary to tackle issues of power transfer efficiency, high costs due to sensor and communication requirements between the transmitter (Tx) and receiver (Rx), and maintenance problems. Analytical techniques and hardware-based synchronization research for Rx-sensorless WPT may not always have been available or accurate. To address these limitations, researchers have recently employed machine learning (ML) to improve efficiency and accuracy.

Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors.

A representative naturally occurring coumarin, 4-methylumbelliferone (), was exposed to 50 kGy of gamma ray, resulting in four newly generated dihydrocoumarin products - induced by the gamma irradiation. The structures of these new products were elucidated by interpretation of spectroscopic data (NMR, MS, [α], and UV). The unusual bisdihydrocoumarin exhibited improved tyrosinase inhibitory capacity toward mushroom tyrosinase with IC values of 19.

Simultaneous Enhancement of the Mechanical Properties, Performance and Insensitivity of an Energetic Elastomeric Polyurethane Binder by Kinetically Grafting Reactive Spiranes.

A series of robust energetic polyurethane binders was developed by in situ grafting reactive spiranes to achieve the migration-resistant processing aid and compensate for the energy output. The reactive grafting spiranes (RGSs), bearing two highly ring-strained spiranes, were synthesized sequentially to provide a promising ring strain energy up to a maximum value of 290 kJ mol. The thermodynamic compatibility of the RGS with uncured glycidyl azido polymer (GAP) was studied quantitatively by analyzing the glass transition temperature of their blendings.

Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors.

Recent studies have shown that some natural compounds from plants prevent obesity and related disorders, including the loss of skeletal muscle mass and strength. In this study, we investigated the effect of echinacoside (ECH), a caffeic acid glycoside from the phenylpropanoid class, on myogenesis and ATP-dependent thermogenesis in the skeletal muscle and its interaction with the dopaminergic receptors 1 and 5 (DRD1 and DRD5). We applied RT-PCR, immunoblot analysis, a staining method, and an assay kit to determine the effects of ECH on diverse target genes and proteins involved in skeletal muscle myogenesis and ATP-consuming futile processes.

NADPH Dynamics: Linking Insulin Resistance and β-Cells Ferroptosis in Diabetes Mellitus.

This review offers an in-depth exploration of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) in metabolic health. It delves into how NADPH affects insulin secretion, influences insulin resistance, and plays a role in ferroptosis. NADPH, a critical cofactor in cellular antioxidant systems and lipid synthesis, plays a central role in maintaining metabolic homeostasis.

Tools and tactics to define specificity of metabolic chemical reporters.

Metabolic chemical reporters (MCRs) provide easily accessible means to study glycans in their native environments. However, because monosaccharide precursors are shared by many glycosylation pathways, selective incorporation has been difficult to attain. Here, a strategy for defining the selectivity and enzymatic incorporation of an MCR is presented.

Assessment of a Novel Real-Time Bio-Liquor Circulation System for Manure Management and Mitigation of Odor Potential in Swine Farming.

Recently, circulating biologically treated manure in slurry pits has been used as an odor reduction technology, but few successful results have been reported, due to the lack of proper control strategies for bioreactors. This study was conducted to investigate the performance of the developed real-time controlled bio-liquor circulation system (BCS) at farm scale. The BCS was operated sequentially as per swine manure inflow (anoxic, aerobic, and settling) circulation to the slurry pit.

Curvature-based interface restoration algorithm using phase-field equations.

In this study, we propose a restoration algorithm for distorted objects using a curvature-driven flow. First, we capture the convex-hull shaped contour of the distorted object using the mean curvature flow. With the supplemented mass on the captured feature, we evolve the constraint mean curvature flow to a steady state, preserving the non-distorted region.

Association of skeletal muscle mass and risk of hypertension in Korean adults: secondary analysis of data from the community-based prospective cohort study.

Background: Cross-sectional studies have revealed a link between low muscle mass and hypertension. However, whether the degree of muscle mass predicts hypertension risk has not been confirmed. This study aimed to verify an association between skeletal muscle mass and incident hypertension in a longitudinal follow-up of middle-aged Korean adults.

Ochratoxin A triggers endoplasmic reticulum stress through PERK/NRF2 signaling and DNA damage during early embryonic developmental competence in pigs.

Ochratoxin A (OTA), a mycotoxin found in foods, has a deleterious effect on female reproduction owing to its endocrine-disrupting activity mediated through endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) production. However, the mechanisms of OTA-induced ER stress in pig embryos during in vitro culture (IVC) are not yet fully understood. In the present study, porcine embryos were cultured for two days in an IVC medium supplemented with 0.