720 results match your criteria: "DWI-Leibniz Institute for Interactive Materials[Affiliation]"
Adv Mater
October 2023
Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, China.
Thermoset plastics, highly desired for their stability, durability, and chemical resistance, are currently consumed in over 60 million tons annually across the globe, but they are difficult to recycle due to their crosslinked structures. The development of recyclable thermoset plastics is an important but challenging task. In this work, recyclable thermoset plastics are prepared by crosslinking a commodity polymer, polyacrylonitrile (PAN), with a small percentage of a Ru complex via nitrile-Ru coordination.
View Article and Find Full Text PDFBiomater Sci
August 2023
Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Imaging Diagnostic and Interventional Minimally Invasive Institute, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Heparin is a widely used anticoagulant agent in the clinic. After application, its anticoagulant effect must be reversed to prevent potential side effects. Protamine sulfate (PS) is the only clinically licensed antidote that has been used for this purpose in the last 80 years, which, however, provokes severe adverse effects, such as systemic hypotension and even death.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2023
DWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstr. 50, 52074, Aachen, Germany.
In pH-responsive drug carriers, the distribution of charges has been proven to affect delivery efficiency but is difficult to control and verify. Herein, we fabricate polyampholyte nanogel-in-microgel colloids (NiM-C) and show that the arrangement of the nanogels (NG) can easily be manipulated by adapting synthesis conditions. Positively and negatively charged pH-responsive NG are synthesized by precipitation polymerization and labelled with different fluorescent dyes.
View Article and Find Full Text PDFNanomaterials (Basel)
June 2023
Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Adv Healthc Mater
August 2023
Advanced Materials for Biomedicine (AMB), Institute of Applied Medical Engineering (AME), RWTH Aachen University Hospital, Center for Biohybrid Medical Systems (CMBS), Forckenbeckstraße 55, 52074, Aachen, Germany.
Recreating human tissues and organs in the petri dish to establish models as tools in biomedical sciences has gained momentum. These models can provide insight into mechanisms of human physiology, disease onset, and progression, and improve drug target validation, as well as the development of new medical therapeutics. Transformative materials play an important role in this evolution, as they can be programmed to direct cell behavior and fate by controlling the activity of bioactive molecules and material properties.
View Article and Find Full Text PDFAdv Healthc Mater
August 2023
Department of Biohybrid & Medical Textiles (BioTex), AME-Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Today's living world is enriched with a myriad of natural biological designs, shaped by billions of years of evolution. Unraveling the construction rules of living organisms offers the potential to create new materials and systems for biomedicine. From the close examination of living organisms, several concepts emerge: hierarchy, pattern repetition, adaptation, and irreducible complexity.
View Article and Find Full Text PDFAdv Healthc Mater
August 2023
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074, Aachen, Germany.
Drug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on-target therapeutic efficacy and off-target toxic side effects. DDS aid in overcoming biological barriers encountered by drug molecules upon applying them via various routes of administration.
View Article and Find Full Text PDFJ Am Chem Soc
June 2023
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52074 Aachen, Germany.
Herein, we present a DNA circuit programmed for the delivery of CpG oligodeoxynucleotides (CpG ODNs) with the pharmacological immunostimulation function. The circuit employs a complementary DNA (cDNA) strand to deactivate the biological function of CpG ODNs via hybridization, while T7 exonuclease mediates the activation by hydrolyzing the cDNA and releasing the CpG ODN as an active moiety. We investigated the influence of several factors on the kinetic profile and temporal behavior of the circuit.
View Article and Find Full Text PDFAdv Healthc Mater
July 2023
Department of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Therapeutic antibodies are the key treatment option for various cytokine-mediated diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. However, systemic injection of these antibodies can cause side effects and suppress the immune system. Moreover, clearance of therapeutic antibodies from the blood is limiting their efficacy.
View Article and Find Full Text PDFMaterials (Basel)
May 2023
Institute of Applied Powder Metallurgy and Ceramics (IAPK) at RWTH Aachen e.V., Augustinerbach 4, 52064 Aachen, Germany.
In order to enhance the range of processable alloys of laser-based powder bed fusion, reinforced alloys have gained focus. Satelliting is a recently introduced method for adding fine additives to larger parent powder particles using a bonding agent. Satellited particles prevent a local demixing due to size and density effects of the powder.
View Article and Find Full Text PDFSoft Matter
June 2023
Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam, Germany.
We report on triggering of p(NIPAM-AA) microgels' photo-responsiveness by making complexes with a spiropyran (SP) containing surfactant. Being dissolved in water, the SP surfactant in its merocyanine state bears three charges, while irradiation with UV and vis light leads to the partial or complete reversal of the SP state. The complexation of the photo-responsive amphiphile with swollen anionic microgels results in charge compensation within the gel interior and as a consequence its size reduces and the volume phase transition temperature (VPTT) decreases down to 32 °C.
View Article and Find Full Text PDFSci Rep
May 2023
Max Planck Institute for Medical Research (MPImF), Jahnstrasse 29, 69120, Heidelberg, Germany.
Functional unit of many organs like lung, kidney, intestine, and eye have their endothelial and epithelial monolayers physically separated by a specialized extracellular matrix called the basement membrane. The intricate and complex topography of this matrix influences cell function, behavior and overall homeostasis. In vitro barrier function replication of such organs requires mimicking of these native features on an artificial scaffold system.
View Article and Find Full Text PDFFEBS J
September 2023
Department of Biochemistry, Groningen Institute of Biomolecular Sciences & Biotechnology, University of Groningen, The Netherlands.
Formate dehydrogenases (Fdhs) mediate the oxidation of formate to carbon dioxide and concomitant reduction of nicotinamide adenine dinucleotide (NAD ). The low cost of the substrate formate and importance of the product NADH as a cellular source of reducing power make this reaction attractive for biotechnological applications. However, the majority of Fdhs are sensitive to inactivation by thiol-modifying reagents.
View Article and Find Full Text PDFSheng Wu Gong Cheng Xue Bao
May 2023
Institute of Biotechnology, RWTH Aachen University, Aachen 52074, Germany.
The large scale production and indiscriminate use of plastics led to serious environmental pollution. To reduce the negative effects of plastics waste on the environment, an approach of enzymatic degradation was put forward to catalyze plastics degradation. Protein engineering strategies have been applied to improve the plastics degrading enzyme properties such as activity and thermal stability.
View Article and Find Full Text PDFAcc Chem Res
June 2023
Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
Protein engineering has emerged as a powerful methodology to tailor the properties of proteins. It empowers the design of biohybrid catalysts and materials, thereby enabling the convergence of materials science, chemistry, and medicine. The choice of a protein scaffold is an important factor for performance and potential applications.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2023
DWI-Leibniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074, Aachen, Germany.
Mechanochemical approaches are widely used for the efficient, solvent-free synthesis of organic molecules, however their applicability to the synthesis of functional polymers has remained underexplored. Herein, we demonstrate for the first time that mechanochemically triggered free-radical polymerization allows solvent- and initiator-free syntheses of structurally and morphologically well-defined complex functional macromolecular architectures, namely stimuliresponsive microgels. The developed mechanochemical polymerization approach is applicable to a variety of monomers and allows synthesizing microgels with tunable chemical structure, variable size, controlled number of crosslinks and reactive functional end-groups.
View Article and Find Full Text PDFACS Chem Biol
June 2023
Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Street 2, 12489 Berlin, Germany.
ACS Appl Mater Interfaces
May 2023
Department of Nuclear Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Neural stem cells (NSCs) present attractive natural drug delivery systems (DDSs). Their migratory potential enables crossing of the blood-brain barrier and efficient and selective accumulation near malignant cells. Here, we present the potential of NSCs as DDSs for nucleoside analogue-conjugated nanogels (NGs).
View Article and Find Full Text PDFFlavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly, in 2022, icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma (HCC) by National Medical Products Administration (NMPA) of China. Moreover, recent studies demonstrate that icaritin can serve as immune-modulating agent to exert anti-tumor effects.
View Article and Find Full Text PDFStem Cell Rev Rep
August 2023
Department for Applied Cell Biology, Fraunhofer Institute for Production Technology, Steinbachstr. 17, 52074, Aachen, Germany.
The healing of neuronal injuries is still an unachieved goal. Medicine-based therapies can only extend the survival of patients, but not finally lead to a healing process. Currently, a variety of stem cell-based tissue engineering developments are the subject of many research projects to bridge this gap.
View Article and Find Full Text PDFComplex geometries for electrodes are a great challenge in electrochemical applications. Slurry electrodes have been one example, which use complex flow distributors to improve the charge transfer between the current collector and the slurry particles. Here we use titanium-based flow distributors produced by indirect 3D-printing to improve further the electron transfer from highly conductive flow distributors to the slurry particles for a vanadium redox flow application.
View Article and Find Full Text PDFSci Total Environ
July 2023
Goethe University Frankfurt, Department for Evolutionary Ecology & Environmental Toxicology, Max-von-Laue-Straße 13, 60438 Frankfurt am Main, Germany; Fraunhofer-Institute für Molecular Biology and Applied Ecology IME, Department Environmental Media-related Ecotoxicology, Frankfurt, Germany. Electronic address:
Textile production is one of the main sources of freshwater consumption by industries worldwide. In addition, according to the world bank, 20 % of the wastewater generated globally is caused by textile wet-processing. Textile wet-processing includes the processes in textile production where garments are dyed or given the final functions like water-repellency.
View Article and Find Full Text PDFiScience
April 2023
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52074 Aachen, NRW, Germany.
The intracellular milieu is crowded with biomacromolecules. Macromolecular crowding changes the interactions, diffusion, and conformations of biomacromolecules. Changes in intracellular crowding have been mostly ascribed to differences in biomacromolecule concentration.
View Article and Find Full Text PDFAntioxidants (Basel)
March 2023
Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Donor organ-shortage has resulted in the increased use of marginal grafts; however, normothermic machine perfusion (NMP) holds the potential for organ viability assessment and restoration of marginal grafts prior to transplantation. Additionally, cell-, oxygen carrier-free and antioxidants-supplemented solutions could potentially prevent adverse effects (transfusion reactions, inflammation, hemolysis), associated with the use of autologous packed red blood cell (pRBC)-based perfusates. This study compared 6 h NMP of porcine kidneys, using an established pRBC-based perfusate (pRBC, n = 7), with the novel cell- and oxygen carrier-free organ preservation solution Ecosol, containing taurine (Ecosol, n = 7).
View Article and Find Full Text PDFJ Phys Chem Lett
March 2023
Department of Molecular Chemistry & Materials Science, Weizmann Inst. of Science, Rehovot 7610001, Israel.
We demonstrate that the direction of current rectification via one of nature's most efficient light-harvesting systems, the photosystem 1 complex (PS1), can be controlled by its orientation on Au substrates. Molecular self-assembly of the PS1 complex using four different linkers with distinct functional head groups that interact by electrostatic and hydrogen bonds with different surface parts of the entire protein PS1 complex was used to tailor the PS1 orientation. We observe an orientation-dependent rectification in the current-voltage characteristics for linker/PS1 molecule junctions.
View Article and Find Full Text PDF