7,575,849 results match your criteria: "DE; Value Institute[Affiliation]"

Background: The proliferation of sexting among adolescents around the world today has woven a complex tapestry of sexual expression and exploration. However, its implications extend beyond consensual engagement, occasionally manifesting as a form of cyberviolence. Varied prevalence rates further complicate our understanding of the extent of youth sexting worldwide.

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Background: Although personality trait models have become consolidated as the hegemonic taxonomical models for describing personality and provide excellent capacity for predicting variables of psychological interest (i.e., mental disorders), there are still important gaps in our knowledge about personality traits predict those variables.

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Background: Background: This study investigates the effects of cognitive interventions on executive functions and attention in patients with moderate Alzheimer's, comparing traditional and technology-based methods with a control group.

Method: A randomized controlled trial was conducted with 112 participants, divided into three groups: traditional intervention, technology-based intervention, and control group. Sixteen sessions were carried out, assessed using standardized tests and applying hierarchical linear mixed models to adjust for confounding factors and random effects.

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Background: Understanding variables that influence therapy outcomes can improve the results of interventions and reduce socio-health costs. The current study examined possible predictors and moderators of outcome (age, gender, duration of panic disorder, motivation to change, conscientiousness, and experiential avoidance) in Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT).

Method: Eighty participants with a diagnosis of panic disorder, 56 women and 24 men, with an average age of 38 years, received 12 group sessions of CBT or ACT.

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Background: This study investigates the impact of social support on resilience and affect among Ukrainian individuals affected by war (non-displaced persons and refugees), one year after the onset of the conflict.

Method: A total of 344 participants were recruited and categorized into two groups: non-displaced individuals and refugees. Measures included the Scale of Positive and Negative Experience (SPANE), the Brief Resilient Coping Scale (BRCS), and the Multidimensional Scale of Perceived Social Support (MSPSS).

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Background: To date, no studies have shown validity evidence of a scale that measures the methodological quality of studies based on observational methodology (SBOM). This study presents validity evidence of the Methodological Quality Scale for Studies based on Observational Methodology (MQSOM) based on its internal structure.

Method: MQSOM was applied to 650 journal articles that used observational methodology.

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Introduction: As pharmacological strategies remain limited for relieving fatigue and associated cognitive symptoms, integrative modalities such as traditional Chinese medicine (TCM) could be explored as therapeutic strategies in cancer survivors. Here, we evaluate and report the efficacy and safety of a TCM concoction, modified Xiang Bei Yang Rong Tang (XBYRT), on quality of life (QOL), cancer-related fatigue (CRF), and cognitive symptoms, compared to placebo.

Methods: In a single-centered, randomized, double-blinded, placebo-controlled pilot trial conducted from 2019 to 2022, fatigued cancer survivors ≥21 years old were recruited to receive the XBYRT intervention or placebo (5% diluted) once daily for the duration of 8 weeks.

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[Diagnostic and therapeutic approach to unilateral posterior vertical insufficiency].

Orthod Fr

January 2025

Nantes Université, Université Angers, CHU Nantes, INSERM, CNRS, CRCI2NA, 44000 Nantes, France

Introduction: The aim of this article is to present the diagnostic and therapeutic approach to unilateral posterior vertical insufficiency.

Material And Methods: The authors describe the management protocol.

Results: Posterior vertical insufficiency (PVI) manifests clinically as obliquity of the maxillo-mandibular occlusal plane and bicommissural line, and deviation of the chin.

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Introduction: The cant of the occlusal plane in the frontal plane reflects facial asymmetry. Its treatment requires close collaboration between the orthodontist and the maxillofacial surgeon. In case of mild cant, treatment consists in coordination of dental arches followed by mandibular osteotomy.

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[Editorial].

Orthod Fr

January 2025

Co-Président de la journée multidisciplinaire 2024

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[Quantification of Facial Asymmetry : A Comprehensive Review of Methods and Applications].

Orthod Fr

January 2025

Laboratoire Forme et Croissance du Crâne, Institut Imagine, 24 boulevard du Montparnasse, 75015 Paris, France

Introduction: Facial asymmetry, present in all human faces at varying degrees, plays a critical role in clinical fields such as orthodontics, orthognathic and plastic surgeries, and craniofacial reconstruction. Accurate quantification of facial asymmetry is essential for diagnosis, treatment planning, and post-surgical evaluation.

Material And Methods: This article examines contemporary methods for quantifying facial asymmetry, including two-dimensional (2D) and three-dimensional (3D) landmark-based approaches, surface curvature analysis, and advanced image-based techniques.

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[The value of studying the cervical spine in craniofacial asymmetries].

Orthod Fr

January 2025

5 rue Georges Meynieu, 44300 Nantes, France

Introduction: The relationship between facial asymmetry and cervical anomaly is rarely mentioned in the diagnosis of dento-maxillo-facial orthopaedics. It is regrettable that the study of the cervical spine is often ignored in the etio-pathogenesis of these dysmorphoses, particularly in cases of facial asymmetry.

Objective: The aim is twofold: to encourage orthodontists and maxillofacial surgeons to make a systematic study of the cervical spine in craniofacial dysmorphoses and in particular craniofacial asymmetries, without claiming that they are becoming specialists in cervical spine pathology, and to introduce the necessary training in malformations of this anatomical region as part of the orthodontist specialisation curriculum.

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[Diagnosis and management of unilateral temporomandibular ankylosis].

Orthod Fr

January 2025

Service de Chirurgie maxillo-faciale, CHU de Caen Normandie, avenue de la Côte de Nacre, 14033 Caen, France

Introduction: Temporomandibular joint ankylosis is defined as permanent jaw constriction with an interincisal mouth opening of less than 30 mm, due to bony, fibro-osseous or fibrous fusion. Ankylosis may be uni- or bilateral. The complications of this ankylosis affect the functions of mastication, swallowing and phonation, sometimes facial morphology, and disturb dental hygiene.

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[Comparison of facial asymmetry assessment by frontal teleradiography and 3D imaging].

Orthod Fr

January 2025

Service de Médecine bucco-dentaire, AP-HP, Hôpital Pitié Salpêtrière, 83 boulevard de l’Hôpital, 75013 Paris, France

Introduction: The diagnostic approach to facial asymmetries is classically based, in addition to the clinical examination, on a cephalometric analysis carried out on a frontal radiography. Planning of orthognathic surgery requires a three-dimensional (3D) examination to visualize deformities. Nevertheless, the use of cephalometric analysis on 3D imaging remains clinically modest.

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How a gene fuels ear infections.

Elife

January 2025

Université Paris Cité, Institut Pasteur, AP-HP, Inserm, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reconnect, Progressive Sensory Disorders, Pathophysiology and Therapy Unit, Paris, France.

The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.

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Background: Extensive surgical resection of the thoracic aorta in patients with type A aortic dissection (TAAD) is thought to reduce the risk of late aortic wall degeneration and the need for repeat aortic operations.

Objectives: We evaluated the early and late outcomes after aortic root replacement and supracoronary ascending aortic replacement in patients with TAAD involving the aortic root.

Design: Retrospective, multicenter cohort study.

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Molecular Symphony of Mitophagy: Ubiquitin-Specific Protease-30 as a Maestro for Precision Management of Neurodegenerative Diseases.

CNS Neurosci Ther

January 2025

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, USA.

Introduction: Mitochondrial dysfunction stands as a pivotal feature in neurodegenerative disorders, spurring the quest for targeted therapeutic interventions. This review examines Ubiquitin-Specific Protease 30 (USP30) as a master regulator of mitophagy with therapeutic promise in Alzheimer's disease (AD) and Parkinson's disease (PD). USP30's orchestration of mitophagy pathways, encompassing PINK1-dependent and PINK1-independent mechanisms, forms the crux of this exploration.

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Background: Considerable epidemiological studies have examined the correlation between polymorphic single-nucleotide variants (SNPs) in miRNA genes and colorectal carcinoma (CRC) risk, yielding inconsistent results. Herein, we sought to systematically investigate the association between miRNA-SNPs and CRC susceptibility by combined evaluation using pairwise and network meta-analysis, the FPRP analysis (false positive report probability), and the Thakkinstian's algorithm.

Methods: The MEDLINE, EMBASE, WOS, and Cochrane Library databases were searched through May 2024 to find relevant association literatures.

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Carotenoids are a diverse group of pigments imparting red, orange, and yellow hues to many horticultural plants, also enhancing their nutritional properties and health benefits. In strawberry, the genetic and molecular mechanisms regulating the natural variation of fruit carotenoid composition remain largely unexplored. In this study, we use a population segregating in yellow/white flesh to detect a major quantitative trait locus (QTL), qYellow Flesh-4B, located on chromosome 4B and accounting for 82% of total phenotypic variation.

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When the kidneys are injured, uremic toxins (UTXs) accumulate in the body, affecting other tissues and causing a loss of essential body functions. This study investigated the adsorption of blood plasma-laden UTXs on the surface of PCL fibers to assess their potential as an alternative to membrane dialysis materials. Using plasma containing 26 UTXs at a concentration similar to that found in end-stage kidney disease patients, we analyzed the adsorbed proteins and examined clot formation in normal and toxin-treated plasma in the presence of PCL fibers.

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The Rous sarcoma virus (RSV) is an onco-retrovirus that infects avian species such as the chicken (Gallus gallus). RSV is the first oncovirus to be described, and the oncogenic activity of this virus is related to the expression of a tyrosine kinase that induces carcinogenic transformation. Interestingly, we have noted that the RSV genome contains various potential G4-forming sequences.

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RYR3 Variants Are Potentially Associated With Idiopathic (Non-Lesional) Partial Epilepsy/Susceptibility of Seizures, Toward Understanding the Gene-Disease Association by Genetic Dependent Nature.

Am J Med Genet B Neuropsychiatr Genet

January 2025

Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

The RYR3 gene encodes a brain-type ryanodine receptor that functions to release calcium from intracellular storage and plays an essential role in calcium signaling. The associations between RYR3 variants and brain disorders remain unknown. We performed whole-exome sequencing in patients with idiopathic (non-lesional) partial epilepsy of unknown etiology.

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Functional genomic approaches have been effective at uncovering the function of uncharacterized genes and identifying new functions for known genes. Often these approaches rely on an in vivo screen or selection to associate genes with a phenotype of interest. These selections and screens are dependent upon the expression of proteins encoded in genomic DNA from an expression vector, such as a plasmid.

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Optimizing oil-water separation using fractal surfaces.

J Chem Phys

January 2025

Instituto de Física, Universidade Federal do Rio Grande do Sul, Caixa Postal 15051, CEP 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.

Oil has become a prevalent global pollutant, stimulating the research to improve the techniques to separate oil from water. Materials with special wetting properties-primarily those that repel water while attracting oil-have been proposed as suitable candidates for this task. However, one limitation in developing efficient substrates is the limited available volume for oil absorption.

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