835 results match your criteria: "DC A.K.; and Cincinnati Children's Hospital[Affiliation]"
Phase II trial of neoadjuvant sitravatinib plus nivolumab in patients undergoing nephrectomy for locally advanced clear cell renal cell carcinoma.
Nat Commun
May 2023
Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Article Synopsis
- Sitravatinib, in combination with nivolumab, was tested in a phase 2 study for patients with locally advanced clear cell renal cell carcinoma before surgery to see if it could improve tumor response rates.
- The study had 20 participants with an objective response rate (ORR) of 11.8%, falling short of the anticipated 30%, and a promising 24-month disease-free survival (DFS) rate of 88%.
- Despite not meeting the primary endpoint, the treatment showed no severe side effects and influenced the tumor microenvironment positively by surgery time.
Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy.
N Engl J Med
May 2023
From the Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (M.G., D.M.F.); the Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford (S.B.S.), the University of California, San Francisco, San Francisco (M.J.D.), the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (M.G.-L.), the University of California, San Diego, La Jolla (S.L.), and Rady Children's Hospital San Diego, San Diego (S.L.) - all in California; the Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York (J.W., H.A.S.); the Department of Immunology, Perth Children's Hospital, and Telethon Kids Institute, Nedlands, WA (M.O.), Westmead Children's Hospital, Westmead, NSW (L.S.F., D.E.C.), Queensland Children's Hospital, University of Queensland, South Brisbane (J.P.), Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC (K.P.P.), Women's and Children's Hospital, North Adelaide, SA (P.Q.), and Sydney Children's Hospital, Randwick, NSW (B.W.) - all in Australia; Guy's and St. Thomas' NHS Foundation Trust (G.T.), and the National Heart and Lung Institute, Imperial College London (P.J.T.), London, the Lydia Becker Institute of Immunology and Inflammation, University of Manchester and Royal Manchester Children's Hospital, Manchester (P.D.A.), University Hospital Southampton NHS Foundation Trust, Southampton (M.E.-L.), and Sheffield Children's NHS Foundation Trust, Sheffield (N.J.) - all in the United Kingdom; the Division of Pediatric Allergy and Immunology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill (E.H.K., A.W.B.); UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh (D.A., T.D.G.); Baylor College of Medicine, Houston (S.A.), UT Southwestern Medical Center and Children's Medical Center, Dallas (C.P.), and Dell Medical School at the University of Texas, Dell Children's Medical Center of Central Texas, Austin (P.V.) - all in Texas; Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands (N.A.); Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal (P.B.), British Columbia Children's Hospital, University of British Columbia, Vancouver (E.S.C.), the Translational Medicine Program, Research Institute, and the Department of Immunology (T.E.), and the Division of Immunology and Allergy, Department of Paediatrics (J.E.M.U.), Hospital for Sick Children, University of Toronto, Toronto - all in Canada; the Department of Children and Adolescent Medicine, Division of Pneumology, Allergology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, Frankfurt (K.B.), Philipps-Universität Marburg, Marburg (W.P.), and Universitätsklinikum Carl Gustav Carus, Dresden (C.V.) - all in Germany; Hôpitaux Pédiatriques de Nice CHU Lenval, Nice (T. Bourrier, L.G.-C.), Université de Lille, CHU Lille, Pediatric Pulmonology and Allergy Unit, Hôpital Jeanne de Flandre, Lille (A.D.), the Pediatric Allergy Unit, Children's Hospital, University Hospital of Nancy, and EA3450 Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, Nancy (A.D.-C.), the Department of Pediatric Pulmonology and Allergy, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, and University of Paris Cité, Paris (G.L.), and DBV Technologies, Montrouge (K.J.B., D.E.C., T.D.G., R.R., A.P., H.T.B., T. Bois, H.A.S.) - all in France; Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia (T.B.-W.); University of Arizona Medical Center, Tucson (H.C.); University of Chicago (C.E.C.), Northwestern University Feinberg School of Medicine (M.M.), and Ann and Robert H. Lurie Children's Hospital of Chicago (M.M., J.A.P., R.G.R.) - all in Chicago; the University of Tennessee Health Science Center, Memphis (J.A.L.); Vanderbilt University Medical Center, Nashville (S.L.D., R.G.R.); Karl Landsteiner University of Health Sciences, Krems, and the Department of Pediatric and Adolescent Medicine, University Hospital St. Pölten, St. Pölten - both in Austria (T.E.); Paediatrics and Child Health and the INFANT Center (J.O.H.) and the HRB Clinical Research Facility and the INFANT Research Center (J.T.), University College Cork, Cork University Hospital, Cork, and Paediatrics and Child Health, Royal College of Surgeons in Ireland, Dublin (J.O.H.) - both in Ireland; University of Arkansas for Medical Sciences and Arkansas Children's Hospital - both in Little Rock (S.M.J.); Cleveland Clinic, Cleveland (L.A.K.); the Division of Pulmonary, Allergy, and Sleep Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis (K.M.K.); University of Rochester, Rochester, NY (J.L., K.T.); Seattle Allergy and Asthma Research Institute, Seattle (D.P.); University of Michigan, Ann Arbor (G.S.); Boston Children's Hospital, Boston (L.S.); Children's National Health System, Washington, DC (H.P.S.); Emory University, Atlanta (B.P.V.); and Johns Hopkins Hospital, Baltimore (R.A.W.).
Background: No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown.
Methods: We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving children 1 to 3 years of age with peanut allergy confirmed by a double-blind, placebo-controlled food challenge. Patients who had an eliciting dose (the dose necessary to elicit an allergic reaction) of 300 mg or less of peanut protein were assigned in a 2:1 ratio to receive epicutaneous immunotherapy delivered by means of a peanut patch (intervention group) or to receive placebo administered daily for 12 months.
Association of Angiopoetin-2 and TNF-α With Bleeding During Left Ventricular Assist Device Support: Analysis From the PREVENT Biorepository.
ASAIO J
August 2023
Department of Medicine, Columbia University, New York, New York.
The purpose of this study was to describe the changes in plasma levels of angiogenic and inflammatory biomarkers, specifically Ang-2 and TNF-α, in patients receiving HeartMate II (HMII) left ventricular assist device (LVAD) and correlate them with nonsurgical bleeding. It has been shown that angiopoietin-2 (Ang-2) and tissue necrosis factor-α (TNF-α) may be linked to bleeding in LVAD patients. This study utilized biobanked samples prospectively collected from the PREVENT study, a prospective, multicenter, single-arm, nonrandomized study of patients implanted with HMII.
View Article and Find Full Text PDFRetail Food Equivalents for Post-Oral Immunotherapy Dosing in the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food-Allergic Children and Adults (OUtMATCH) Clinical Trial.
J Allergy Clin Immunol Pract
February 2023
Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
Background: Patients with food allergy may be advised to introduce specific foods into their diets, both to increase tolerance gradually and as next steps after completing oral immunotherapy or other therapeutic interventions. However, the safe use of retail foods depends on the ability to establish the specific allergen protein content of these foods.
Objective: To develop a systematic approach to estimate the protein content of peanut, milk, egg, wheat, cashew, hazelnut, and walnut in a variety of retail food equivalents for each allergen and associated patient education materials.
Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial.
Ann Intern Med
May 2023
Population Health Research Institute, Hamilton, Ontario, Canada (M.M., D.C., F.K.B., S.N.O., M.K.W., A.L., R.P.W., M.H.M., J.V., I.C., K.B., S.P., D.S., E.P.B., J.S., W.F.M., S.I.B., S.Y., P.J.D.).
Background: Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively.
Objective: To compare the effects of a hypotension-avoidance and a hypertension-avoidance strategy on major vascular complications after noncardiac surgery.
Contemporary management and outcomes of penetrating colon injuries: Validation of the 2020 AAST Colon Organ Injury Scale.
J Trauma Acute Care Surg
August 2023
From the Department of Surgery (A.Z.), Howard University Hospital, Washington, DC; Department of Surgery (A.Z., N.K.D., R.A.K.), Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland; Department of Surgery (M.A., K.M.S.), Yale University, New Haven, Connecticut; Department of Surgery (G.J., B.M.), University of New Mexico Health Science Center, Albuquerque, New Mexico; Department of Surgery (M.C., A.C.S.), College of Medicine, University of Florida, Jacksonville, Florida; Department of Surgery (B.S.R., M.L.M.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; Department of Surgery (N.D.M., C.L.J.), University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery (D.L., K.K.), Community Regional Medical Center, UCSF Fresno, Fresno, California; Department of Surgery (C.R.H., N.L.W.), Denver Health, Denver, Colorado; Department of Surgery (J.A.P.-Z., H.M.A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Surgery (W.A.M., L.N.H.), University of California San Diego Health, San Diego; Department of Surgery (G.T.T., K.B.S.), Scripps Memorial Hospital, La Jolla; and Department of Surgery (K.L.S.), Stanford University, Stanford, California.
Introduction: The American Association for the Surgery of Trauma Colon Organ Injury Scale (OIS) was updated in 2020 to include a separate OIS for penetrating colon injuries and included imaging criteria. In this multicenter study, we describe the contemporary management and outcomes of penetrating colon injuries and hypothesize that the 2020 OIS system correlates with operative management, complications, and outcomes.
Methods: This was a retrospective study of patients presenting to 12 Level 1 trauma centers between 2016 and 2020 with penetrating colon injuries and Abbreviated Injury Scale score of <3 in other body regions.
Outcomes among trauma patients with duodenal leak following primary versus complex repair of duodenal injuries: An Eastern Association for the Surgery of Trauma multicenter trial.
J Trauma Acute Care Surg
July 2023
From the Rutgers Robert Wood Johnson Medical School (R.L.C., A.L.T., C.G.B.), New Brunswick, New Jersey; Grady Memorial Hospital (J.D.S., R.N.S., D.S. Hanos), Atlanta, Georgia; Temple University Hospital (I.N.A., J.H.B.), Philadelphia, Pennsylvania; R Adams Cowley Shock Trauma Center (N.K.D., A.Z., M.G.), University of Maryland School of Medicine, Baltimore, Maryland; Vanderbilt University Medical Center (R.J.D., O.L.G.), Nashville, Tennessee; Louisiana State University Health Sciences Center (A.A.S., B.L.S.), New Orleans, Louisiana; University of Kentucky (C.S.C., J.K.R.), Lexington, Kentucky; Medical College of Wisconsin (L.A.H., D.N.H.), Wauwatosa, Wisconsin; Mount Sinai Hospital (G.C., M.J.), Chicago, Illinois; Cooper University Hospital (K.E., N.S.F.), Camden, NJ; Indiana Health Methodist Hospital (A.A., J.H.L.), Indianapolis, India; University of Texas Southwestern (R.P.D., C.A.F.), Dallas, Texas; MEDStar Washington Hospital Center (C.T.T., J.J.Y.), Washington, DC; Perelman School of Medicine (J.B.), University of Pennsylvania, Philadelphia, Pennsylvania; Penn State Hershey Medical Center (J.H., C.J. McLaughlin), Hershey, Pennsylvania; Washington University School of Medicine/Barnes-Jewish Hospital (R.A.-A., J.M.K.), St. Louis, Missouri; Boston Medical Center (D.S. Howard, D.R.S.), Boston, Massachusetts; University of Rochester (K.D., M.V.), Rochester, New York; McGill University (B.H., E.G.W.), Montreal, Quebec, Canada; WakeMed Health and Hospital (C.S., P.O.U.), Raleigh, North Carolina; University of Arizona (B.A.J.), Tuscon, Arizona; Jackson Memorial Hospital Ryder Trauma Center (H.L., W.R.), Miami, Florida; University of Arizona (C.H.S.), Tuscon, Arizona; University of California Irvine Medical Center (C.A., J.N.), Orange County, California; Broward Health Medical Center (J.D.B., I.P.), Fort Lauderdale, Florida; Henry Ford Hospital (J.H.P., I.R.), Detroit, Miami; Penn Medicine Lancaster General Hospital (L.L.P., O.R.P.), Lancaster, Pennsylvania; Yale New Haven Hospital (H.A., L.M.K.), New Haven, Connecticut; Hartford Hospital (J.K., J.W.), Hartford, Connecticut; Oregon Health and Science University (R.H., M.A.S.), Portland, Oregon; University of Chicago Medicine and Biological Science (A.J.B., A.K.), Chicago, Illinois; Spartanburg Medical Center (L.K.M., C.J. Mentzer), Spartanburg, South Carolina; General University Hospital of Patras (V.M., F.M.), Patras, Achaia, Greece; Thomas Jefferson University Hospital (S.R.-G., E.S., J.M.), Philadelphia, Pennsylvania; South Texas Health System McAllen Medical Center (C.F., C.H.P.), McAllen, Texas; Massachusetts General Hospital (D.A., H.K.), Boston, Massachusetts; Rutgers Robert Wood Johnson Medical School (S.C., M.M.), New Brunswick, New Jersey; Rutgers School of Public Health (M.T.B.M.), Piscataway, New Jersey; Rutgers Robert Wood Johnson Medical School (M.N.), New Brunswick, New Jersey; and Perelman School of Medicine (M.J.S.), University of Pennsylvania, Philadelphia, Pennsylvania.
Background: Duodenal leak is a feared complication of repair, and innovative complex repairs with adjunctive measures (CRAM) were developed to decrease both leak occurrence and severity when leaks occur. Data on the association of CRAM and duodenal leak are sparse, and its impact on duodenal leak outcomes is nonexistent. We hypothesized that primary repair alone (PRA) would be associated with decreased duodenal leak rates; however, CRAM would be associated with improved recovery and outcomes when leaks do occur.
View Article and Find Full Text PDFMicroneedles Facilitate Small-Volume Intracochlear Delivery Without Physiologic Injury in Guinea Pigs.
Otol Neurotol
June 2023
Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Hypothesis: Microneedle-mediated intracochlear injection through the round window membrane (RWM) will facilitate intracochlear delivery, not affect hearing, and allow for full reconstitution of the RWM within 48 hours.
Background: We have developed polymeric microneedles that allow for in vivo perforation of the guinea pig RWM and aspiration of perilymph for diagnostic analysis, with full reconstitution of the RWM within 48 to 72 hours. In this study, we investigate the ability of microneedles to deliver precise volumes of therapeutics into the cochlea and assess the subsequent consequences on hearing.
Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants.
N Engl J Med
April 2023
From the Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Fajara, Gambia (B.K.); the Institute for International Health Charité, Universitätsmedizin, Berlin (B.K.); the South African Medical Research Council (MRC) Vaccines and Infectious Diseases Analytics Research Unit, Infectious Diseases and Oncology Research Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (S.A.M.), and Family Centre for Research with Ubuntu, Department of Paediatrics and Child Health, University of Stellenbosch (S.L.B.), and the Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, South African MRC Unit on Child and Adolescent Health, University of Cape Town (H.J.Z.), Cape Town - all in South Africa; Vaccine Research and Development, Pfizer, Pearl River, NY (I.M., B.A.P., D.R., J. Glanternik, H.S., P.Z., K.K., K.S., E.V.K., D.C., K.U.J., A.S.A., K.A.S., W.C.G., A.G.); Children's Hospital Colorado, Aurora (E.A.F.S.); Instituto de Maternidad y Ginecología Nuestra Señora de Las Mercedes, San Miguel de Tucumán (C.L.), and iTrials-Hospital Militar Central (G.P.M., F.P.P.) and iTrials (S.L.V.), Buenos Aires - all in Argentina; Clinical Research Prime, Idaho Falls, ID (J. Baker); Vaccine Research and Development, Pfizer, Hurley, United Kingdom (E.S.); Vaccine Clinical Research, Pfizer, Sydney, NSW (J. Baber), and the University of Western Australia School of Medicine, Vaccine Trials Group, Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, and Perth Children's Hospital, Nedlands, WA (P.C.R.) - all in Australia; Boeson Research, Missoula, MT (M.F.); Meridian Clinical Research, Hastings, NE (T.A.); Asian Hospital and Medical Center, Manila, Philippines (N.P.); the Department of Pediatrics, Spaarne Gasthuis, Haarlem and Hoofddorp (M.A.V.H.), and the Departments of Pediatrics and Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, and Respiratory Syncytial Virus Network Foundation, Zeist (L.J.B.) - all in the Netherlands; Meilahti Vaccine Research Center, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki (A.K.); National Taiwan University Hospital, Taipei (L.-M.H.); the Department of Obstetrics and Gynecology, Sendai City Hospital, Sendai, Japan (T.O.); the Institute of Biomedical Sciences, University of Chile School of Medicine, Santiago, Chile (S.L.V.); University of Otago and New Zealand Clinical Research - both in Christchurch, New Zealand (J. Gullam); Centre Hospitalier Universitaire Sainte-Justine, Montreal (B.T.); Hospital Moinhos de Vento and Pontifícia Universidade Católica do Rio Grande do Sul - both in Porto Alegre, Brazil (R.T.S.); the Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark (N.B.S.); and Arké Study Management Organization, Mexico City (M.D.P.).
Background: Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)-associated lower respiratory tract illness in newborns and infants is uncertain.
Methods: In this phase 3, double-blind trial conducted in 18 countries, we randomly assigned, in a 1:1 ratio, pregnant women at 24 through 36 weeks' gestation to receive a single intramuscular injection of 120 μg of a bivalent RSV prefusion F protein-based (RSVpreF) vaccine or placebo. The two primary efficacy end points were medically attended severe RSV-associated lower respiratory tract illness and medically attended RSV-associated lower respiratory tract illness in infants within 90, 120, 150, and 180 days after birth.
Early VTE prophylaxis in severe traumatic brain injury: A propensity score weighted EAST multicenter study.
J Trauma Acute Care Surg
July 2023
From the Division of Trauma and Surgical Critical Care, Department of Surgery (A.M.R.), Drexel College of Medicine, Philadelphia; Department of Surgery (D.K., S.S.S.), Crozer Health, Upland; Department of Surgery (C.J., E.J.K.), University of Pennsylvania, Philadelphia PA, Pennsylvania; Department of Surgery (H.M.S., M.B.A.), Virginia Commonwealth University, Richmond, Virginia; Department of Surgery (L.L.P.), Penn Medicine Lancaster General Health, Lancaster; Department of Surgery (C.M.), Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania; Department of Surgery (I.S.), Surgical Intensive Care Unit, New York Medical College, Department of Surgery (A.J.), West Chester Medical Center, Valhalla, New York; Department of Surgery (V.S., A.M.), St. Joseph Mercy Ann Arbor, Ypsilanti, Michigan; Department of Surgery (E.T., M.R.), Loma Linda University Medical Center, Loma Linda, California; Department of Surgery (L.L., W.Z.), St. Mary's Medical Center, West Palm Beach; Florida Atlantic University (L.L., W.Z.), Boca Raton, Florida; Department of Surgery (A.K., M.H.), Trinity Health Oakland, Pontiac, Michigan; Department of Surgery (J.C., C.B.), Prisma Health Upstate, Greenville, South Carolina; Department of Surgery (T.E., A.M.), Cooper University Hospital, Camden New Jersey; Department of Surgery (M.K., S.D.), Ohio Health Grant Medical Center, Columbus; Department of Surgery (R.C.), Department of Research (S.S.), Promedica Toledo Hospital, Toledo Ohio; Department of Surgery (L.E.J., J.W.), Ascension St. Vincent Hospital, Indianapolis, Indiana; Department of Trauma and Acute Care Surgery (M.W., B.P.), Kettering Health Main Campus, Kettering Ohio; Department of Surgery (C.M., N.T.), Spartanburg Medical Center, Spartanburg South Carolina; Department of Surgery (T.H., T.D.), Memorial Healthcare System, Hollywood, Florida; Department of Surgery (S.M.), Conemaugh Memorial Medical Center, Johnstown, Pennsylvania; Department of Surgery (L.D.-S., A.R.), University Hospitals Cleveland Medical Center, Cleveland, Ohio; Department of Surgery (L.C.T., T.J.N.), Cook County Hospital, Chicago, Illinois; Department of Surgery (D.H., D.R.), Penrose Hospital, Colorado Springs, Colorado; Department of Surgery (D.C.C., C.F.), Maine Medical Center, Portland, Maine; Department of Surgery (M.M., C.D.), St. Anthony Hospital, Lakewood, Colorado; Department of Surgery (J.D., S.B.), University of California, San Francisco-Fresno, San Francisco, California; Department of Surgery (K.S.), Yale School of Medicine, New Haven, Connecticut; Department of Surgery (P.F.), INOVA Fairfax Health System, Fairfax, Virginia.
Background: Patients with traumatic brain injury (TBI) are at high risk of venous thromboembolism events (VTE). We hypothesized that early chemical VTE prophylaxis initiation (≤24 hours of a stable head CT) in severe TBI would reduce VTE without increasing risk of intracranial hemorrhage expansion (ICHE).
Methods: A retrospective review of adult patients 18 years or older with isolated severe TBI (Abbreviated Injury Scale score, ≥ 3) who were admitted to 24 Level I and Level II trauma centers from January 1, 2014 to December 31 2020 was conducted.
Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades.
Nat Commun
March 2023
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, D.C., 20375, USA.
Access to efficient enzymatic channeling is desired for improving all manner of designer biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self-assemble with nanoparticle scaffolds into nanoclusters that access substrate channeling and improve catalytic flux by orders of magnitude. Utilizing saccharification and glycolytic enzymes with quantum dots (QDs) as a model system, nanoclustered-cascades incorporating from 4 to 10 enzymatic steps are prototyped.
View Article and Find Full Text PDFCrossmodal plasticity in hearing loss.
Trends Neurosci
May 2023
Department of Speech Language and Hearing Science, Center for Neuroscience, Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA. Electronic address:
Crossmodal plasticity is a textbook example of the ability of the brain to reorganize based on use. We review evidence from the auditory system showing that such reorganization has significant limits, is dependent on pre-existing circuitry and top-down interactions, and that extensive reorganization is often absent. We argue that the evidence does not support the hypothesis that crossmodal reorganization is responsible for closing critical periods in deafness, and crossmodal plasticity instead represents a neuronal process that is dynamically adaptable.
View Article and Find Full Text PDFRelative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling.
Clin Transl Sci
June 2023
Genentech Inc., South San Francisco, California, USA.
Alectinib, approved as 150 mg capsules for the treatment of adults with advanced ALK-positive non-small cell lung cancer, is being assessed in children with ALK-positive solid and central nervous system tumors. An ad hoc pediatric-friendly suspension of alectinib, prepared from capsule contents, is under investigation as an alternative formulation for children who cannot swallow capsules. This randomized, crossover, relative bioavailability, and food effect study evaluated alectinib administered as an oral suspension versus capsule formulation following conventional venipuncture and capillary microsampling.
View Article and Find Full Text PDFAngina After Percutaneous Coronary Intervention: Patient and Procedural Predictors.
Circ Cardiovasc Interv
April 2023
West of Scotland Regional Heart & Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (D.C., R.M., M.D., M.A.R., P.M., M.L., A.S., P.R., R.B., S.W., M.M., R.G., K.R., P.O., A.D., A.K., S.H., H.E., C.B., K.G.O.).
Background: Twenty percent to 40% of patients are affected by angina after percutaneous coronary intervention (PCI), which is associated with anxiety, depression, impaired physical function, and reduced quality of life. Understanding patient and procedural factors associated with post-PCI angina may inform alternative approaches to treatment.
Methods: Two hundred thirty patients undergoing PCI completed the Seattle Angina Questionnaire (SAQ-7) and European quality of life-5 dimension-5 level (EQ-5D-5L) questionnaires at baseline and 3 months post-PCI.
Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation.
iScience
March 2023
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Transient receptor potential canonical type 6 (TRPC6) is a non-voltage-gated channel that principally conducts calcium. Elevated channel activation contributes to fibrosis, hypertrophy, and proteinuria, often coupled to stimulation of nuclear factor of activated T-cells (NFAT). TRPC6 is post-translationally regulated, but a role for O-linked β-N-acetyl glucosamine (O-GlcNAcylation) as elevated by diabetes, is unknown.
View Article and Find Full Text PDFMichigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine Program: First-Year Outcomes and Implementation Costs.
Am J Ophthalmol
July 2023
From the Department of Ophthalmology and Visual Sciences (P.A.N-C., L.M.N., A.R.E., A.K.B., O.K., D.J., S.D.W., D.C.M., J.Z., M.A.W.); the Institute for Healthcare Policy and Innovation (P.A.N-C., A.R.E., O.K., D.C.M., M.A.W.), University of Michigan, Ann Arbor.
Purpose: The Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (MI-SIGHT) program aims to engage people who are at high risk of glaucoma; we assess first-year outcomes and costs.
Design: Clinical cohort study.
Methods: Participants ≥18 years of age were recruited from a free clinic and a federally qualified health center in Michigan.
Early Brain Injury After Subarachnoid Hemorrhage: Incidence and Mechanisms.
Stroke
May 2023
Department of Neurological Surgery (D.C.L., K.J., J.Y.Y., D.D., A.K.V., J.W.O., A.R.C., G.J.Z.), Washington University School of Medicine, St. Louis, MO.
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying therapeutic targets for this disease. In particular, there has been a shift in emphasis toward secondary brain injury that develops in the first 72 hours after subarachnoid hemorrhage.
View Article and Find Full Text PDFKITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers.
Vet Sci
February 2023
Institut für Bioinformatik, Universität Würzburg, 97070 Würzburg, Germany.
Copy number variations (CNVs) of the KITLG gene seem to be involved in the oncogenesis of digital squamous cell carcinoma (dSCC). The aims of this study were (1) to investigate KITLG CNV in giant (GS), standard (SS), and miniature (MS) schnauzers and (2) to compare KITLG CNV between black GS with and without dSCC. Blood samples from black GS (22 with and 17 without dSCC), black SS (18 with and 4 without dSSC; 5 unknown), and 50 MS (unknown dSSC status and coat colour) were analysed by digital droplet PCR.
View Article and Find Full Text PDFIdentification of an Optimal COVID-19 Booster Allocation Strategy to Minimize Hospital Bed-Days with a Fixed Healthcare Budget.
Vaccines (Basel)
February 2023
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.
Healthcare decision-makers face difficult decisions regarding COVID-19 booster selection given limited budgets and the need to maximize healthcare gain. A constrained optimization (CO) model was developed to identify booster allocation strategies that minimize bed-days by varying the proportion of the eligible population receiving different boosters, stratified by age, and given limited healthcare expenditure. Three booster options were included: B, costing US $1 per dose, B, costing US $2, and no booster (NB), costing US $0.
View Article and Find Full Text PDFChanges in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries.
Nat Hum Behav
April 2023
Children's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Article Synopsis
- Preterm birth (PTB) is a major cause of infant mortality globally, and studies show mixed results regarding its rates during COVID-19 lockdowns, with changes ranging from -90% to +30%.
- Analysis of data from 52 million births in 26 countries indicates modest reductions in PTB rates during the first three months of lockdown, but no significant changes in the fourth month.
- High-income countries showed an increase in stillbirth risk during the first month of lockdown, with Brazil experiencing increased stillbirth rates throughout the entire lockdown period, highlighting the need for further investigation into these trends.
Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks.
Am J Ophthalmol
August 2023
Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon (J.P., R.M.), Lyon, France.
Purpose: To evaluate the effectiveness of plasma exchange (PLEX) for optic neuritis (ON).
Methods: We conducted an international multicenter retrospective study evaluating the outcomes of ON following PLEX. Outcomes were compared to raw data from the Optic Neuritis Treatment Trial (ONTT) using a matched subset.
Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Circ Res
March 2023
Molecular Cardiology Research Institute, Tufts Medical Center, Boston MA (L.A.B., Q.L., J.I., A.S., J.J.M., B.V.C., N.D.C., I.Z.J.).
Background: Preeclampsia is a syndrome of high blood pressure (BP) with end organ damage in late pregnancy that is associated with high circulating soluble VEGF receptor (sFlt1 [soluble Fms-like tyrosine kinase 1]). Women exposed to preeclampsia have a substantially increased risk of hypertension after pregnancy, but the mechanism remains unknown, leaving a missed interventional opportunity. After preeclampsia, women have enhanced sensitivity to hypertensive stress.
View Article and Find Full Text PDFCombination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.
Diabetes Care
March 2023
1Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Objective: Combined low-risk lifestyle behaviors (LRLBs) have been associated with a reduction in type 2 diabetes risk. This relationship has not been systematically quantified.
Research Design And Methods: A systematic review and meta-analysis was conducted to assess the association of combined LRLBs with type 2 diabetes.
Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment.
Sci Rep
February 2023
Bristol Myers Squibb, Princeton, NJ, USA.
Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source of EMT gene expression signals and a potential mechanism of resistance to immuno-oncology treatment.
View Article and Find Full Text PDFArticle Synopsis
- Discontinuation of biologic treatments in psoriasis is often due to ineffectiveness or side effects, leading to clinicians and patients considering switching therapies.
- The study evaluates the effectiveness and safety of switching to bimekizumab from three other biologics (adalimumab, ustekinumab, and secukinumab) over a period of up to 80 weeks.
- Results showed significant improvements in symptoms and quality of life for most patients who switched to bimekizumab, with a high percentage achieving substantial reductions in psoriasis severity, especially among those who initially did not respond well to their previous treatments.