SAFETY OF PROPOFOL ANESTHESIA DURING NEUROSURGICAL OPERATIONS.

Objective: The aim: The purpose of this study was to assess the safety of propofol use during neurosurgical operations of different durations.

Patients And Methods: Materials and methods: 72 patients were divided into three groups depending on the type of operations; it were group 1 (ventriculostomy), group 2 (hematoma removal), and group 3 (tumor removal), the anesthesia durations in these groups were 65±5 min, 145±7 min and 225±10 min, respectively. Total propofol doses in patients of groups 1, 2, and 3 were 452±22 mg, 710±42 mg, and 966±51 mg, respectively.

Correlation between adipokines and mediators of non-specific inflammation in type 2 diabetic patients depending on the glycaemic control.

Objective: Introduction: The relationship between glycaemic control in type 2 diabetes and the risk of its complications has been proven in many studies. However, the role of adipose tissue hormones and non-specific inflammatory mediators in type 2 diabetes compensation has not been studied completely. The aim: To evaluate the correlation between the content of selected adipose tissue hormones and mediators of nonspecific inflammation, depending on the glycemic control in type 2 diabetes.

Prognosis of ischaemic heart disease in patients with newly diagnosed dm type 2 by logistic regression.

Objective: Introduction: Diabetes Mellitus (DM) type 2 is an important medical and social problem all around the world. One of the most serious and widespread complications of DM type 2 is a damage to the cardiovascular system. The aim was to study the way of how to predict the IHD development in patients with the newly diagnosed DM type 2 by building a mathematical model with the help of statistical method, in particular, a logistic regression, which allows predicting the occurrence of IHD by the levels of proven biochemical and anthropometric indices.

[Clinical and laboratory features of cholelithiasis in patients with type 2 diabetes by gender].

Objective: Introduction: Today, diabetes is considered a factor that provokes the development of bile duct disease. Cholelithiasis is associated with such risk factors as aging, high body mass index, female sex, genetic predisposition, alcohol abuse, high concentration of triglycerides and cholesterol, low density lipoprotein in blood plasma The aim of the work is to analyze the clinical and laboratory features of the pathology of the gall bladder in patients with type 2 diabetes, depending on the sex.

Patients And Methods: Materials and methods: Complex examination of 126 patients with cholelithiasis and type 2 diabetes mellitus was performed.

Interval hypoxic training in complex treatment of Helicobacter pylori-associated peptic ulcer disease.

This study was aimed to demonstrate the efficacy of interval hypoxic training (IHT) in complex treatment of Helicobacter pylori-associated duodenal peptic ulcer disease (DPUD) by parameters of aerobic metabolism and indexes of heart rate variability (HRV). Eighty patients with H. pylori-associated DPUD were included into the study, mean age 32+/-1.

Persistent accumulation of 4-hydroxynonenal-protein adducts in gastric mucosa after Helicobacter pylori eradication.

Recent studies indicate that oxidative stress caused by Helicobacter pylori and insufficient host antioxidant defense could play important role in pathogenesis of gastrointestinal ulcerations. By specific monoclonal antibodies we have detected weak presence of the major lipid peroxidation bioactive marker 4-hydroxynonenal (HNE) in healthy human gastric mucosa, which strongly increased in case of H. pylori-associated peptic ulcer.