Prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children: A cross-sectional study.

Background: Thalassemia is a hemoglobinopathy-associated genetic disease resulting due to defective synthesis of globin chains, causing defects in the skeletal and oral structures.

Aim: This cross-sectional study was designed to analyze the prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children.

Materials And Methods: Institutional Ethical committee clearance was obtained before starting the study.

Association Between Neighborhood Deprivation and Gestational Diabetes: A Systematic Review and Meta-Analysis.

Gestational diabetes mellitus (GDM) is a major global health concern, affecting maternal and child health. Although genetic predispositions and individual medical histories are well-recognized risk factors, emerging research suggests a significant impact of external factors like neighborhood socioeconomic characteristics. This study systematically reviews and meta-analyzes the association between neighborhood deprivation and GDM incidence.

Mortality reduction with 23-valent pneumococcal polysaccharide vaccine: a systematic review and meta-analysis.

Background: Pneumococcal disease, caused by Streptococcus pneumoniae, imposes a significant global health burden, particularly affecting vulnerable groups such as the elderly and immunocompromised. The 23-valent pneumococcal polysaccharide vaccine (PPV23) is designed to protect against 23 serotypes of Streptococcus pneumoniae. However, there is ongoing debate about its effectiveness in reducing all-cause mortality.

Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia.

Background: Bibliometric analysis of highly cited papers in a particular discipline brings forward the impactful papers published, the significant journals and the researchers in the field. These studies help in identifying research trends and research lacunae in the field, thus guiding the future research works. Oral proliferative verrucous leukoplakia (OPVL) is a challenging lesion with no uniform diagnostic criteria.

Effectiveness of Tecovirimat in Mpox Cases: A Systematic Review of Current Evidence.

Mpox, formerly known as monkeypox, has re-emerged as a significant global health concern, particularly during the widespread outbreak of 2022. As an orthopoxvirus related to the eradicated smallpox virus, mpox has been primarily managed with smallpox vaccines and treatments, including the antiviral agent Tecovirimat. This systematic review aims to evaluate the effectiveness and safety of Tecovirimat in treating mpox, focusing on its use during the 2022 outbreak, especially among high-risk populations, including men who have sex with men and people living with HIV.

Burden of neurologic diseases in BRICS countries (1990 to 2021): an analysis of 2021 Global Burden of Disease Study.

Background: Neurological disorders are a major global health concern, especially in BRICS nations (Brazil, Russia, India, China, South Africa), where demographic and socio-economic changes have amplified their impact. This study evaluates trends in incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) associated with neurological diseases in these countries from 1990 to 2021, focusing on sex disparities and key risk factors.

Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 database.

Targeting H3N2 influenza: advancements in treatment and vaccine strategies.

Introduction: The emergence of the H3N2 influenza virus in 1968 marked a significant event as it crossed the species barrier. This shift led to a pandemic, resulting in the deaths of one million people globally and highlighting the virus's severe impact on older individuals due to antigenic drift.

Area Covered: This review comprehensively examines the virological characteristics, evolutionary trends, and global epidemiology of the Influenza A (H3N2) virus.

Prioritization of Surgical, Obstetric, Trauma, and Anesthesia Care in South and Southeast Asian Countries' Health Planning and Policy‑making: SOTA Care Policies in South and Southeast Asia.

Lack of policy prioritization of surgical, obstetric, trauma and anesthesia (SOTA) care in South and Southeast Asian countries could be a potential contributor to limited access to care. To assess the SOTA care prioritization in National Health Policies, Strategies, and Plans (NHPSPs). We analyzed NHPSPs from twelve South and Southeast Asian countries.

Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990-2021).

Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.

Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.

Pancreatic β cell models for screening insulin secretagogues and cytotoxicity.

In the past 2-3 decades, numerous attempts have been made to create an insulin-secreting β cell line that maintains normal insulin secretion. However, primary β cell cultures have finite life and, therefore, cannot be used for long-term experiments. The most widely used insulin-secreting cell lines are Insulinoma-1, rat insulinoma cell line, hamster pancreatic β cell line, mouse insulinoma, and β tumor cell line.

Quercetin Nano-formulations as a Potential Approach for Skin Cancer.

Quercetin, a natural flavonoid, is well-proven for anticancer properties in a variety of cancers. Quercetin's anticancer action is driven by its anti-inflammatory and antioxidant properties. It inhibits pro-inflammatory cytokines (e.

Long non-coding RNA H19 as a prognostic biomarker for oral squamous cell carcinoma.

Background: H19, a 2.3 kb lncRNA, has been linked to tumor metastasis and progression, but its significance in oral squamous cell carcinoma (OSCC) remains unclear. H19 was initially thought to have a tumor-suppressive function, but recent studies have shown that it possesses both tumor-promoting and suppressive functions.

Early Orthodontic Treatment Needs of Children in High Caries Population Using Index for Preventive and Interceptive Orthodontic Treatment Needs.

Aim: Early identification and management of developing malocclusion can reduce or eliminate the need for future complicated treatment procedures. The present study was undertaken to assess early orthodontic treatment needs in 6- and 9-year-old children using the index for preventive and interceptive orthodontic treatment need (IPION) in Pune, India.

Materials And Methods: A total of 360 children reporting to the Department of Pediatric and Preventive Dentistry were evaluated clinically and on their respective dental casts according to the IPION requirement.