Synthesis of Bis(Carboranyl)amides 1,1'-μ-(CHNH(O)C(CH)-1,2-CBH) ( = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide).

Bis(carboranyl)amides 1,1'-μ-(CHNH(O)C(CH)-1,2-CBH) ( = 0, 1) were prepared by the reactions of the corresponding carboranyl acyl chlorides with ethylenediamine. Crystal molecular structure of 1,1'-μ-(CHNH(O)C-1,2-CBH) was determined by single crystal X-ray diffraction. Treatment of bis(carboranyl)amides 1,1'-μ-(CHNH(O)C(CH)-1,2-CBH) with ammonium or cesium fluoride results in partial deboronation of the -carborane cages to the -carborane ones with formation of [7,7'(8')-μ-(CHNH(O)C(CH)-7,8-CBH)].

Polycentric binding in complexes of trimethylamine--oxide with dihalogens.

Dihalogens readily interact with trimethylamine--oxide under ambient conditions. Accordingly, herein, stable 1 : 1 adducts were obtained in the case of iodine chloride and iodine bromide. The crystal and molecular structure of the trimethylamine--oxide-iodine chloride adduct was solved.

The First Nickelacarborane with - Structure.

The first nickelacarborane with structure [10',11'-(Py)-3,9'-Ni(1,2-CBH)(7',8'-CBH)] was isolated from the reaction of nickel(IV) bis(dicarbollide) with pyridine. The molecular structure of this complex was determined by single crystal X-ray diffraction. The nickel atom is a common vertex for the -NiCB cluster and the -NCB cluster where it is located together with carbon atoms in the open NiCB pentagonal face.

Bis(dicarbollide) Complexes of Transition Metals as a Platform for Molecular Switches. Study of Complexation of 8,8'-Bis(methylsulfanyl) Derivatives of Cobalt and Iron Bis(dicarbollides).

Complexation of the 8,8'-bis(methylsulfanyl) derivatives of cobalt and iron bis(dicarbollides) [8,8'-(MeS)-3,3'-M(1,2-CBH)] (M = Co, Fe) with copper, silver, palladium and rhodium leads to the formation of the corresponding chelate complexes, which is accompanied by a transition from the to the conformation of the bis(dicarbollide) complex. This transition is reversible and can be used in design of coordination-driven molecular switches based on transition metal bis(dicarbollide) complexes. The solid-state structures of {(PhP)ClPd[8,8'- (MeS)-3,3'-Co(1,2-CBH)-κ-S,S']} and {(COD)Rh[8,8'-(MeS)-3,3'-Co(1,2-CBH)-κ-S,S']} were determined by single crystal X-ray diffraction.

Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging.

Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.

[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration].

The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance.