Association of Telomere Length with Cognitive Impairment.

Telomere attrition is attributed to Alzheimer's disease (AD), major depressive disorder, stress levels, physical inactivity, short sleep duration, and reduced educational abilities. In this article, we tried to assess the association between the telomere length in peripheral blood leukocytes and level of cognitive impairment and its dependence on age and sex. Healthy subjects and patients with amnestic mild cognitive impairment (aMCI) and different AD stages were recruited in the study.

Epidemiology of Hip Fractures in Two Regions of Ukraine.

Worldwide, the number of hip fractures, the most important osteoporotic complication in the elderly, continues to increase in line with the ageing of the population. In some countries, however, including the Ukraine, data on the incidence of hip fracture are limited. This article describes the first analysis to characterize the incidence of hip fracture in the Ukrainian population from the age of 40 years.

[Marital status and place of living as social determinants of vertebral pain syndrome and disturbance of life quality in women of older age groups.].

In order to study the role of the marital status and place of residence, as the social determinants of the development of vertebral pain syndrome and related disorders of life activity, the results of a survey of 148 postmenopausal women aged 50-69 years were analyzed. Respondents were divided into groups depending on their marital status (living in a family with husbands and other relatives, only with husbands or alone) and places of residence (in rural or urban areas). The results of this study suggest that family status and place of residence in women of older age groups do not directly influence on the back pain, however they contribute to impairment of vital functions associated with back pain, in particular, psychological state, general activity, working capacity, and also stipulate a higher frequency of requests for medical care and hospitalizations.

[Features of vertebral pain syndromes in older women depending on the duration of postmenopausal period and bone mineral density indices].

We have analyzed the vertebral pain syndrome (VPS) rate in 2 844 women aged 40-89 years, divided into groups according to the period of life (reproductive, perimenopausal and postmenopausal (PMP)) and evaluated the relationship between VPS frequency and indices of bone mineral density (BMD). It was found that the frequency of VPS during different physiological periods of woman life ranges from 84,1 to 94,4 %, with significant increase when the PMP period is more than 20 years compared with women in reproductive and early postmenopausal periods. The significant increase of the VPS frequency in thoracic and lumbar spines starts from 1-3 years of PMP and is retained at higher level for all subsequent periods of PMP.

Epidemiology of hip fracture and the development of FRAX in Ukraine.

Unlabelled: A country-specific FRAX model has been developed for the Ukraine to replace the Austrian model hitherto used. Comparison of the Austrian and Ukrainian models indicated that the former markedly overestimated fracture probability whilst correctly stratifying risk.

Introduction: FRAX has been used to estimate osteoporotic fracture risk since 2009.

TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population.

Objective: To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population.

Materials And Methods: We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction.

The effect of gene therapy with the APOE3 Gene on structural and functional manifestations of secondary hippocampal damages in experimental traumatic brain injury.

Aim Of The Study: to study the efficiency of gene therapy following traumatic brain injury (TBI) by evaluating the influences of liposomal transfection of the brain tissue by APOE3-containing plasmid vector on the structural and functional manifestations of development of secondary brain injuries after acute experimental TBI in the rats of different age.

Material And Methods: Severe diffuse TBI in rats was inflicted under overall anesthesia by free load weighing 450 g, falling from a 1.5 m elevation.