The impact of war on people with type 2 diabetes in Ukraine: a survey study.

Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients' health to define key risk factors promoting disease progression.

Methods: A survey covering various aspects of T2D patients' experience and glycemic control data was conducted from June 2022 to February 2024.

Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults.

Vitamin D deficiency (VDD) is a global problem, however, there were no Ukrainian guidelines devoted to its screening, prevention, and treatment, which became the reason for the Consensus creation. This article aimed to present the Consensus of Ukrainian experts devoted to VDD management. Following the creation of the multidisciplinary Consensus group, consent on the formation process, drafting and fine-tuning of key recommendations, and two rounds of voting, 14 final recommendations were successfully voted upon.

FEATURES OF BONE REMODELING AROUND SURFACE-MODIFIED TITANIUM AND TANTALUM IMPLANTS.

Objective: The aim: To study the osseointegrative properties of titanium and tantalum implants with different surface structures in animal experiments.

Patients And Methods: Materials and methods: The histological and morphometric study was carried out on 60 male white rats after titanium implants with different surface structures made by 3D printed technology were inserted in the distal femur bone: presented by the multilayered layers of interlacing pores of 300 microns (series 1); rough (> 2 microns) (series 2); and tantalum implants with 300 microns pores and 80% porosity (series 3) as control material.

Results: Results: On the 30 days we found statistically significant differences in the bone-implant contact rate between the 2nd experiment series (44.

Association of Telomere Length with Cognitive Impairment.

Telomere attrition is attributed to Alzheimer's disease (AD), major depressive disorder, stress levels, physical inactivity, short sleep duration, and reduced educational abilities. In this article, we tried to assess the association between the telomere length in peripheral blood leukocytes and level of cognitive impairment and its dependence on age and sex. Healthy subjects and patients with amnestic mild cognitive impairment (aMCI) and different AD stages were recruited in the study.

Reaction of different cell types of the brain on neurotoxin cuprizone and hormone melatonin treatment in young and aging mice.

Introduction: The brain myelin and neurons destruction in multiple sclerosis may be associated with the production of neuroinflammatory cells (macrophages, astrocytes, T-lymphocytes) of pro-inflammatory cytokines and free radicals. The age-associated changes of the above cells can influence on the response of nervous system cells to toxic damaging and regulatory factors of humoral/endocrine nature, in particular pineal hormone melatonin. The study aim was (1) to evaluate changes of the brain macrophages, astrocytes, T-cells, neural stem cells, neurons, and central nervous system (CNS) functioning in the neurotoxin cuprizone-treated mice of different age; and (2) to assess in such mice the effects of exogenous melatonin and possible courses of its action.

Vitamin D deficiency in Ukraine: current evidence.

Background: Data from numerous studies demonstrate the high frequency of vitamin D deficiency (VDD) and insufficiency (VDI) in many countries worldwide that depend on age and sex, seasons, country, and concomitant pathology. This research aimed to study vitamin D status in the Ukrainian population during 2016-2022 years depending on age, sex, month, and year of the observation, and compare the results with the data of previous Ukrainian epidemiologic studies.

Methods: In a single-center cohort study, we analyzed the serum total 25-hydroxyvitamin D (25(OH)D) level in 7,418 subjects aged 20-99 years.

BONE MINERAL DENSITY AND PROBABILITY OF OSTEOPOROTIC FRACTURES IN WOMEN WITH TYPE II DIABETES MELLITUS.

Objective: The aim: To assess bone mineral density and 10-year probability of major osteoporotic and hip fractures using the Ukrainian FRAX® version for postmenopausal women with Type II diabetes mellitus and to determine the need for OP treatment according to the algorithm FRAX and BMD.

Patients And Methods: Materials and methods: 690 females aged 50-89 years (mean age 67.0±7.

Blood coagulation factors and platelet response to drug-induced hepatitis and hepatosis in rats.

Background: Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects. The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in rats.

Methods: We modeled diclofenac-induced hepatitis and tetracycline-induced hepatosis.

[Gerontological aspects of improving the quality of medical and social assistance to older displaced persons in the context of the COVID-19 pandemic in Ukraine.].

This work aimed to study the organization of medical-social services for the elderly internally displaced persons at the level of primary medico-sanitary aid (PMSA) in Ukraine, assessment of the main tasks and specifics of organization and provision of palliative and hospice care (PHC) under COVID-19 conditions. As a result of the sociological investigation, using the questionnaire methods and experts' evaluations, we have analyzed the socio-psychological characteristics of the elderly internally displaced persons, the specifics of their social adaptation, financing and medico-social servicing at the level PMSA, including structural modernization and optimization of organizational provision. The introduction of an affordable and economically viable system allows for the interaction of specialists from health care and social protection institutions, and optimizes compliance with the standards and principles of medical care.

Small molecules for cell reprogramming: a systems biology analysis.

If somatic stem cells would be able to maintain their regenerative capacity over time, this might, to a great extent, resolve rejuvenation issues. Unfortunately, the pool of somatic stem cells is limited, and they undergo cell aging with a consequent loss of functionality. During the last decade, low molecular weight compounds that are able to induce or enhance cell reprogramming have been reported.

Prenatal famine exposure and adult health outcomes: an epigenetic link.

Numerous human chronic pathological conditions depend on epigenetic modifications induced by environmental triggers throughout sensitive stages early in development. Developmental malnutrition is regarded as one of the most important risk factors in these processes. We present an overview of studies that the initiation and progression of many diseases are largely dependent on persisting epigenetic dysregulation caused by environmental insults early in life.

DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence.

Accumulating evidence suggests that exposure to unfavorable conditions early in life can substantially contribute to the risk of chronic disorders later in life ('developmental programming' phenomenon). The mechanistic basis for this phenomenon remains poorly understood so far, although epigenetic mechanisms such as DNA methylation, histone modifications and microRNA-mediated gene regulation apparently play a crucial role. The key role of epigenetic modifications triggered by unfavorable environmental cues during sensitive developmental periods in linking adverse early-life events to later-life health outcomes is evident from a large body of studies, including methylome-wide association studies and research of candidate genes.

FRAX-Based Intervention Thresholds for Osteoporosis Treatment in Ukraine.

Objectives: Osteoporosis, in addition to its consequent fracture burden, is a common and costly condition. FRAX is a well-established, validated, web-based tool which calculates the 10-year probability of fragility fractures. A FRAX model for Ukraine has been available since 2016 but its output has not yet been translated into intervention thresholds for the treatment of osteoporosis in Ukraine; we aimed to address this unmet need in this analysis.

EXPERIMENTAL STUDY OF BONE REBUILDING IN THE PERIIMPLANTATION AREA UNDER IMMEDIATE LOADING ON DENTAL IMPLANTS.

Objective: The aim: Study of the dynamics of morphological rearrangement of bone under conditions of immediate occlusive functional load and the effect of splinting of implants with temporary orthopedic structures with the analysis of the coefficient of stability of implants during immediate implantation in the experiment.

Patients And Methods: Materials and methods: A series of experiments was performed on 6 male Duroc pigs at the age of 6 months and weighing 40-60 kg. In the course of recent advances, the following methods have been used: the clinical protocol of immediate - implantation of time-consuming clothes, the definition of COEFICIENT, morphometry and light microscopy of the slides, statistical analysis.

Factors that regulate expression patterns of insulin-like peptides and their association with physiological and metabolic traits in Drosophila.

Insulin-like peptides (ILPs) and components of the insulin signaling pathway are conserved across different animal phyla. Eight ILPs (called DILPs) and two receptors, dInR and Lgr3, have been described in Drosophila. DILPs regulate varied physiological traits including lifespan, reproduction, development, feeding behavior, stress resistance and metabolism.

Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence.

Aging is a biological process with effects at the molecular, cellular, tissue, organ, system, and organismal levels and is characterized by decline in physical function and higher risks of age-related diseases. The use of anti-aging drugs for disease prevention has become a high priority for science and is a new biomedicine trend. Geroprotectors are compounds which slow aging and increase lifespan of the organism in question.

FEATURES OF BONE METABOLISM AND THEIR INFLUENCE ON ARTERIAL WALL STIFFNESS IN POSTMENOPAUSAL WOMEN WITH CONTROLLED UNCOMPLICATED HYPERTENSION.

The aim of this study was to investigate the features of bone metabolism and their influence on the arterial wall stiffness in postmenopausal women with a controlled uncomplicated arterial hypertension (AH). The study involved 44 women (main group) with the mean age of 69.04±0.

[10-YEAR MORTALITY IN PATIENTS AFTER HIP FRACTURES].

The aim is to study the indexes of short- and long-term mortality in patients after hip fractures (HF). In a retrospective study, the data of 146 women and 82 men with HF aged 50 years and older (mean age (Me [25Q-75Q]): 74.5 [64.

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting.

The development of interventions aimed at improving healthspan is one of the priority tasks for the academic and public health authorities. It is also the main objective of a novel branch in biogerontological research, geroscience. According to the geroscience concept, targeting aging is an effective way to combat age-related disorders.

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.

Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging.

Anise Hyssop Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in .

Anise hyssop, , is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress in . Dietary hyssop extended the lifespan in a sex and genotype independent manner over a broad range of concentrations up to 30 mg/ml.

Season-of-birth phenomenon in health and longevity: epidemiologic evidence and mechanistic considerations.

In many human populations, especially those living in regions with pronounced climatic differences between seasons, the most sensitive (prenatal and neonatal) developmental stages occur in contrasting conditions depending on the season of conception. The difference in prenatal and postnatal environments may be a factor significantly affecting human development and risk for later life chronic diseases. Factors potentially contributing to this kind of developmental programming include nutrition, outdoor temperature, infectious exposures, duration of sunlight, vitamin D synthesis, etc.

[Vertebral pain syndrome and quality of life in senior women with vertebral fractures depending on their quantity and localization.].

The features of vertebral pain (VP) and quality of life in postmenopausal women were analyzed depending on the number and location of vertebral fractures (VF). It was found that the intensity of pain in thoracic and lumbar spines, according to McGill pain index, was significantly higher in patients with two or more VF compared to women without any fractures, and absence of differences in subjects with a single VF. Most indices of 11-component Numerical Rating Scale at the thoracic spine were significantly higher only in females with two or more VF.

REACTIVE-ADJUSTABLE RESTRUCTURING OF STERNUM IN RATS AFTER MODELING OF MECHANICAL LOADING IN THE BIOMECHANICAL SYSTEM "STERNUM-RIBS-SPINE".

Aim of the research - to conduct histological analysis of the sternum immature rats after modeling mechanical loading in the biomechanical system "sternum - ribs - spine". The studies were conducted on 14 rats. In 8 rats a spinal deformity was simulated according to the method of Sarwark JF et al.