47 results match your criteria: "D.C.R. University of Science & Technology[Affiliation]"
A framework for advancing our understanding of cancer-associated fibroblasts.
Nat Rev Cancer
March 2020
Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit.
View Article and Find Full Text PDFNeer Type-II Distal Clavicle Fractures: A Cost-Effectiveness Analysis of Fixation Techniques.
J Bone Joint Surg Am
February 2020
Departments of Orthopaedics and Rehabilitation (H.M.F., D.C.R., A.R.T., A.J.M., and O.F.N.) and Medical Informatics and Clinical Epidemiology (C.J.H.), Oregon Health & Science University, Portland, Oregon.
Background: Neer type-II distal clavicle fractures are unstable and are generally appropriately managed with operative fixation. Fixation options include locking plates, hook plates, and suture button devices. No consensus on optimal technique exists.
View Article and Find Full Text PDFGeographic Differences in Phenotype and Treatment of Children with Sickle Cell Anemia from the Multinational DOVE Study.
J Clin Med
November 2019
Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 11-0236, Lebanon.
Background: DOVE (Determining Effects of Platelet Inhibition on Vaso-Occlusive Events) was a Phase 3, randomized, double-blind, placebo-controlled study conducted in children with sickle cell anemia at 51 sites in 13 countries across four continents.
Procedure: Data from DOVE were assessed for regional differences in subject phenotype and treatment. Demographics, baseline clinical and laboratory data, hydroxyurea (HU) use, vaso-occlusive crisis (VOCs; composite endpoint of painful crisis or acute chest syndrome (ACS, Beijing, China)), serious adverse events (SAEs, Florence, Italy), hospitalization, and treatments were compared across the Americas, Europe, North Africa/Middle East, and Sub-Saharan Africa (SSA).
Preferential and Enhanced Adsorption Ability of ZrO₂ Nanoparticles for the Removal of Cationic, Anionic and Azo Dyes: Isotherm and Kinetic Studies.
J Nanosci Nanotechnol
November 2019
Thin Film Laboratory, Department of Materials Science & Nanotechnology, D.C.R. University of Science & Technology, Murthal, Haryana 131039, India.
Adsorption of Coomassie Brilliant Blue R-250, Congo Red and Acridine Orange from aqueous solution has been examined using ZrO₂ nanoparticles, which proved to be a novel adsorbent. ZrO₂ nanoparticles have been prepared by simple chemical precipitation method. The characterization of ZrO₂ nanoparticles has been carried out by UV-vis spectroscopy, FTIR, XRD, TEM and FESEM.
View Article and Find Full Text PDFSilver embellished PANI/CNT nanocomposite for antimicrobial activity and sequestration of dye based on RSM modelling.
Environ Technol
September 2020
Thin Film Laboratory, Department of Materials Science & Nanotechnology, D.C.R. University of Science & Technology, Murthal, India.
Silver doped PANI/CNT (Ag-PANI/CNT) nanocomposite was synthesized and investigated as adsorbent for its possible application in the elimination of organic dye Brilliant Blue G (BBG). The morphological characteristics of Ag-PANI/CNT were studied using Fourier transform infrared, scanning electron microscopy, elemental mapping, transmission electron microscopy and X-ray diffraction. The response of operational parameters given as adsorbent dosage, concentration, pH and contact time for dye removal were investigated by using Response Surface Methodology (RSM).
View Article and Find Full Text PDFRight Ventricular Dysfunction and Long-Term Risk of Sudden Cardiac Death in Patients With and Without Severe Left Ventricular Dysfunction.
Circ Arrhythm Electrophysiol
June 2018
Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)
Background: Right ventricular systolic dysfunction (RVD) often coexists with various cardiopulmonary diseases. However, the association between RVD and risk of sudden cardiac death (SCD) has not been well studied. This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases.
View Article and Find Full Text PDFWhite matter integrity and processing speed in sickle cell anemia.
Neurology
June 2018
From Developmental Neurosciences (H.S., F.J.K., M.K., P.B., J.D.C., S. Sahota, S. Sakaria, C.A.C., J.M.K.), UCL Great Ormond Street Institute of Child Health, London; University Hospital Southampton NHS Foundation Trust (F.J.K.); Clinical and Experimental Sciences (F.J.K.), University of Southampton; Department of Radiology (D.E.S.), Great Ormond Street Hospital NHS Foundation Trust, London; Department of Haematology and Evelina Children's Hospital (J.H., R.K.-A., B.I., M.P.), Guy's and St Thomas' NHS Foundation Trust, London; King's College Hospital NHS Foundation Trust (S.C., D.C.R., M.A.), London; North Middlesex University Hospital NHS Foundation Trust (O.W.), London; and Department of Haematology (M.L.), Imperial College Healthcare NHS Foundation Trust, London, UK.
Objective: The purpose of this retrospective cross-sectional study was to investigate whether changes in white matter integrity are related to slower processing speed in sickle cell anemia.
Methods: Thirty-seven patients with silent cerebral infarction, 46 patients with normal MRI, and 32 sibling controls (age range 8-37 years) underwent cognitive assessment using the Wechsler scales and 3-tesla MRI. Tract-based spatial statistics analyses of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters were performed.
Aero-gel assisted synthesis of anatase TiO nanoparticles for humidity sensing application.
Dalton Trans
May 2018
Physical Chemistry Research Laboratory, Department of Chemistry, D.C.R. University of Science & Technology, Murthal, Haryana-131039, India.
Aero-gel based one-pot synthesis of anatase phase TiO2 nanoparticles having a high surface area of 125 m2 g-1 has been reported in this work. The humidity sensing perfomance of the obtained porous TiO2 nanoparticles exhibits a quick response (2 s) and fast recovery (1.5 s), negligible hysteresis (<1%) and good stability in the 11-98%RH range.
View Article and Find Full Text PDFN-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.
Proc Natl Acad Sci U S A
March 2018
Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Jongno-gu, 03080 Seoul, Korea;
The conjugation of amino acids to the protein N termini is universally observed in eukaryotes and prokaryotes, yet its functions remain poorly understood. In eukaryotes, the amino acid l-arginine (l-Arg) is conjugated to N-terminal Asp (Nt-Asp), Glu, Gln, Asn, and Cys, directly or associated with posttranslational modifications. Following Nt-arginylation, the Nt-Arg is recognized by UBR boxes of N-recognins such as UBR1, UBR2, UBR4/p600, and UBR5/EDD, leading to substrate ubiquitination and proteasomal degradation via the N-end rule pathway.
View Article and Find Full Text PDFAcute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.
N Engl J Med
January 2018
From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.
Background: Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction.
View Article and Find Full Text PDFGenome-Wide Gene-Potassium Interaction Analyses on Blood Pressure: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).
Circ Cardiovasc Genet
December 2017
From the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Background: Gene-environmental interaction analysis can identify novel genetic factors for blood pressure (BP). We performed genome-wide analyses to identify genomic loci that interact with potassium to influence BP using single-marker (1 and 2 joint tests) and gene-based tests among Chinese participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity).
Methods And Results: Among 1876 GenSalt participants, the average of 3 urine samples was used to estimate potassium excretion.
Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).
Hypertension
December 2017
From the Department of Epidemiology (J.L.N., C.L., J.H., T.N.K.) and Department of Medicine (J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens (C.L.); Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., X.L., J.L., X.W.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); and Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (C.C.G., D.C.R.).
We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of BP among participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). The GenSalt study was conducted among 1906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/d), 7-day high-sodium (307.
View Article and Find Full Text PDFDietary Patterns among Vietnamese and Hispanic Immigrant Elementary School Children Participating in an After School Program.
Nutrients
May 2017
Department of Sociology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30302, USA.
Article Synopsis
- Immigrant children in the U.S., specifically Vietnamese and Hispanic, face acculturation challenges affecting their dietary habits, as seen in a study of 63 kids in grades four to six.
- The study revealed that while children met fruit consumption recommendations, they significantly fell short in grains, protein, and dairy, with a high intake of discretionary foods like sweets and fast food.
- Boys generally consumed more grains, proteins, and fruits than girls, indicating potential areas for dietary improvement programs aimed at enhancing overall diet quality for these immigrant children.
Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.
Circ Cardiovasc Genet
April 2017
From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Korea (Y.K.K., J.L., S.H., B.-G.H., S.M., B.-J.K.); Genome Institute of Singapore, Agency for Science, Technology and Research (R.D., J.L., Y.-Y.T.); Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences (H.L., Y.H., Y.W., L.S., X.L.); National Yang-Ming University Hospital, Taipei, Taiwan (I-T.L.); National Yang-Ming University Hospital, Taipei, Taiwan; Singapore Eye Research Institute, Singapore National Eye Center (Y.C., Y.K., Y.Z., N.K., T.Y.W.); Duke-NUS Graduate Medical School, National University of Singapore, (Y.C., N.K., T.Y.W., E-S.T.); Department of Ophthalmology (Y.C., T.Y.W.), Department of Statistics and Applied Probability (Y.-Y.T.), Life Sciences Institute (Y.-Y.T.), NUS Graduate School for Integrative Science and Engineering (Y.-Y.T.), Department of Medicine, National University Health System, Singapore (E-S.T.); MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.H., H.H., L.G., Y.H., T.W.); Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan (I-T.L., W.H-h.S); School of Medicine, National Yang-Ming University, Taipei, Taiwan (W.H-h.S., K.-W.L.); Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., K.D.T., J.I.R., Y.-d.I.C.); Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, Ann Arbor (S.K.G.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.L., Y.-Y.T., X.S., E-S.T.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.); Department of Medical Genetics (F.-J.T.) and School of Chinese Medicine (C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Medicine, Columbia University Medical Center, New York, NY (W.P.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Department of Internal Medicine, Ditmanson Medical Foundation, Chiayi Christian Hospital, Taiwan (C.H.L.); Department of Business Administration, National Chung Cheng University, Chia-yi, Taiwan (C.H.L.); Department of Nursing, DaYeh University, Changhua, Taiwan (C.H.L.); Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (W.-J.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (C.-H.C., J.-Y.W.); Department of Ophthalmology and Visual Science, Khoo Teck Puat Hospital, Singapore, Singapore (N.K.); Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (L.J.R.); and Department of Epidemiology and Biostatistics, University of Georgia at Athens, Athens (C.L.); Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan (K.-W.L.).
Background: Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP.
Methods And Results: We conducted genome-wide analysis among 18 422 East Asian participants (stage 1) followed by replication study of ≤46 629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a <5.
A novel therapy to promote axonal fusion in human digital nerves.
J Trauma Acute Care Surg
November 2016
From the Department of Plastic Surgery (R.B., R.N., D.C.R., R.B.B., K.W.S., R.B.S., W.P.T.), Vanderbilt University, Nashville, TN; Department of General Surgery (R.B.), Georgetown University, Washington, DC; Department of Orthopaedics (T.W., C.B., S.N.), Thammasat University, Pathumthani, Thailand; Georgetown University School of Medicine (D.C.R.), Washington, DC; Department of General Surgery (K.W.S.), University of Arkansas, Little Rock, AR; Vanderbilt University Institute of Imaging Science (N.D.K., M.D.D., R.D.D.), Nashville, TN; Department of Radiology and Radiological Sciences (R.D.D.), Vanderbilt University, Nashville, TN; and Department of Biomedical Engineering (R.D.D.), Vanderbilt University, Nashville, Tennessee.
Background: Peripheral nerve injury can have a devastating impact on our military and veteran population. Current strategies for peripheral nerve repair include techniques such as nerve tubes, nerve grafts, tissue matrices, and nerve growth guides to enhance the number of regenerating axons. Even with such advanced techniques, it takes months to regain function.
View Article and Find Full Text PDFGenome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study.
Hypertension
August 2016
From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
We performed genome-wide analyses to identify genomic loci that interact with sodium to influence blood pressure (BP) using single-marker-based (1 and 2 df joint tests) and gene-based tests among 1876 Chinese participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. Among GenSalt participants, the average of 3 urine samples was used to estimate sodium excretion. Nine BP measurements were taken using a random zero sphygmomanometer.
View Article and Find Full Text PDFProceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014.
Biol Blood Marrow Transplant
April 2016
University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
Significant progress has been made over the past decade in haploidentical transplantation, with the development of novel methods to control intense alloreactive reactions generated in the major HLA-mismatched setting. Application of post-transplantation cyclophosphamide has gained worldwide acceptance as an effective and low-cost way to perform this type of transplantation, with outcomes now similar to those from HLA-matched unrelated donors. These advances have resulted in improved treatment-related mortality, whereas disease relapse has emerged as the most common cause of treatment failure.
View Article and Find Full Text PDFA Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events.
N Engl J Med
February 2016
From the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston (M.M.H.); UCSF Benioff Children's Hospital Oakland, Oakland, CA (C.C.H.); the Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon (M.R.A.); Evelina Children's Hospital (B.I.), Guy's and St. Thomas' Hospital (B.I.), Daiichi Sankyo Development (D.Z.), and King's College Hospital, Denmark Hill (D.C.R.) - all in London; the Department of Pediatrics, Division of Pediatric Hematology-Oncology, Medical University of South Carolina, Charleston (J.K.); U.S. Army Medical Research Unit-Kenya, Malaria Resistance (B.O.), Kenya Medical Research Institute-Walter Reed Project (J.N.O.), and the Center for Global Health Research and Public Health Collaboration (V.N.N.), Kenya Medical Research Institute - all in Kisumu, Kenya; Eli Lilly, Indianapolis (P.B.B., L.E.H., J.A.J., C.Z.); Kwame Nkrumah University of Science and Technology, Kumasi (T.A.), and the Department of Child Health, School of Medicine and Dentistry, Korle Bu Teaching Hospital, Accra (C.I.S.) - both in Ghana; the Clinic of Pediatric Hematology-Oncology, Azienda Ospedaliera-University of Padua, Padua, Italy (R.C.); Clinical Research Center, Alexandria University, Alexandria, Egypt (H.M.H.); and the Department of Pediatrics, Division of Hematology-Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montreal (N.R.).
Background: Sickle cell anemia is an inherited blood disorder that is characterized by painful vaso-occlusive crises, for which there are few treatment options. Platelets mediate intercellular adhesion and thrombosis during vaso-occlusion in sickle cell anemia, which suggests a role for antiplatelet agents in modifying disease events.
Methods: Children and adolescents 2 through 17 years of age with sickle cell anemia were randomly assigned to receive oral prasugrel or placebo for 9 to 24 months.
Malignant Transformation of Hymenolepis nana in a Human Host.
N Engl J Med
November 2015
From the Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (A.M., J.B., M.G.M., D.C.R., T.L.J., P.W.G., S.R.Z.), Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Center for Global Health (M.L.E., B.A.M.), Biotechnology Core Facility, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases (M.A.F.), Waterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases (G.S.V.), and Mycotic Diseases Branch (C.D.P.), Centers for Disease Control and Prevention (CDC), and Emory University School of Medicine (A.H.) - all in Atlanta; Universidad Pontificia Bolivariana School of Health Sciences (C.A.A., A.H., A.V.H., L.R.D.), Clínica Universitaria Bolivariana (C.A.A.), and Hospital Pablo Tobón Uribe (A.H., A.V.H.), Medellín, and Centros Especializados de San Vicente Fundación, Rionegro (C.A.A.) - all in Colombia; Asahikawa Medical University, Asahikawa, Japan (A.I.); and the Department of Life Sciences, Division of Parasites and Vectors, Natural History Museum, London (P.D.O.).
Article Synopsis
- Neoplasms can occur in invertebrates but not in tapeworms; however, a case was found where cells from a patient with HIV showed cancer-like features and were linked to tapeworm infection.
- These abnormal cells were identified as originating from Hymenolepis nana, though they did not resemble typical tapeworm tissue and were detectable through specific staining and genetic assays.
- The study reveals a new link between tapeworm infection and cancer, showing that genetically altered tapeworm cells can invade human tissue, presenting a novel mechanism for disease.
Risk factors for the development of heterotopic ossification in seriously burned adults: A National Institute on Disability, Independent Living and Rehabilitation Research burn model system database analysis.
J Trauma Acute Care Surg
November 2015
From the University of Michigan (B.L., A.G.), Ann Arbor, Michigan; Massachusetts General Hospital (P.J., J.B.J., D.C.R., J.C.S., C.M.R.), Harvard Medical School; and Spaulding Rehabilitation Hospital (J.C.S., C.M.R.), Boston, Massachusetts; University of Texas Southwestern (K.K.), Dallas, Texas; Harborview Medical Center (N.C.G.), University of Washington School of Medicine, Seattle, Washington.
Background: Heterotopic ossification (HO) is a debilitating complication of burn injury; however, incidence and risk factors are poorly understood. In this study, we use a multicenter database of adults with burn injuries to identify and analyze clinical factors that predict HO formation.
Methods: Data from six high-volume burn centers, in the Burn Injury Model System Database, were analyzed.
Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.
Neurology
September 2015
From the Departments of Neurology (F.W., D.C.R., S.M., A.M.F., N.J.C., J.C.M., R.J.B.), Radiology (B.A.G., D.S.M., T.L.S.B.), Biostatistics (C.X.), Psychology (J.H.), Neurological Surgery (T.L.S.B.), and Psychiatry (A.G.), Washington University School of Medicine, Saint Louis, MO; Department of Neurology (E.M.), University of Pittsburgh, PA; Mary S. Easton Center for Alzheimer's Disease Research at UCLA (J.M.R.), Los Angeles, CA; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; Department of Pathology and Laboratory Medicine (B.G.) and Department of Neurology (M.R.F.), Indiana University School of Medicine, Indianapolis; Center for Alzheimer Research and Treatment (R.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Boston, MA; Department of Neurology (S.S.), Butler Hospital and Warren Alpert Medical School, Brown University, Providence, RI; Neuroscience Research Australia (P.R.S.) and University of New South Wales, Sydney, Australia; Mental Health Research Institute (C.L.M.), University of Melbourne, Parkville, Australia; Centre of Excellence for Alzheimer's Disease Research and Care (R.N.M.), School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Australia; Dementia Research Centre (M.N.R., C.A.S.L.), UCL Institute of Neurology, London, UK; German Center for Neurodegenerative Diseases (M.J.) and Hertie Institute for Clinical Brain Research, Tübingen, Germany; Neurologische Klinik Ludwig-Maximilians-Universität Munich (A.D.) and German Center for Neurodegenerative Diseases (S.F.), Klinik und Poliklinik für Nuklearmedizin & TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; and Department of Neurology (F.W.), Xuan Wu Hospital, Capital Medical University, Beijing, China.
Objective: To investigate the associations of cerebral amyloidosis with concurrent cognitive performance and with longitudinal cognitive decline in asymptomatic and symptomatic stages of autosomal dominant Alzheimer disease (ADAD).
Methods: Two hundred sixty-three participants enrolled in the Dominantly Inherited Alzheimer Network observational study underwent neuropsychological evaluation as well as PET scans with Pittsburgh compound B. One hundred twenty-one participants completed at least 1 follow-up neuropsychological evaluation.
Genome-wide linkage and regional association study of blood pressure response to the cold pressor test in Han Chinese: the genetic epidemiology network of salt sensitivity study.
Circ Cardiovasc Genet
August 2014
From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Background: Blood pressure (BP) response to cold pressor test (CPT) is associated with increased risk of cardiovascular disease. We performed a genome-wide linkage scan and regional association analysis to identify genetic determinants of BP response to CPT.
Methods And Results: A total of 1961 Chinese participants completed the CPT.