Serum Raman spectroscopy: Prognostic applications in oral cancers.

Background: Loco-regional recurrences attributable to field cancerization and minimal residual cancer, remain prime causes of mortality in oral cancer (OC) subjects. The current study evaluates potential of serum Raman spectroscopy (SRS) to identify recurrence-prone OC subjects.

Methods: Raman spectra of serum from eight healthy subjects (H) and 57 OC subjects (with-recurrence [R], without-recurrence [NR], and with suspicious-lesions [S]), before (BS) and after (AS) surgical excision of tumor were recorded.

Morel-Lavallée Lesion: Uncommon Injury often Missed.

Introduction: Morel-Lavalleé lesion is an uncommon closed degloving injury usually affecting the lower extremity. Although these lesions have been documented in literature, yet there is no standard treatment algorithm for the same. A case of Morel-Lavallée lesion following blunt injury to the thigh is therefore presented to highlight the diagnostic and therapeutic challenges in managing such lesions.

Correlation between Aerosol Therapy and Other Associated Factors in Early Childhood with Molar Incisor Hypomineralization.

Context: The etiology of molar incisor hypomineralization (MIH) has been extensively explored. Recently, the effect of drugs used in aerosol therapy in childhood has been implicated as a possible factor in the development of MIH.

Aim: A case-control study was conducted in children aged 6-13 years to determine the association between aerosol therapy and other factors in the development of MIH.

Prevalence of molar incisor hypomineralization in India: A systematic review and meta-analysis.

Research Question: To estimate the pooled prevalence of molar incisor hypomineralization (MIH) in children from India.

Research Protocol: The PRISMA guidelines were followed.

Literature Search: An electronic search of the databases was performed to find prevalence studies of MIH in children above age 6 years in India.

Efficacy and Safety of Topical Tacrolimus in Comparison with Topical Corticosteroids, Calcineurin Inhibitors, Retinoids and Placebo in Oral Lichen Planus: An Updated Systematic Review and Meta-Analysis.

Background: Tacrolimus is a powerful macrolide calcineurin inhibitor that has low adverse effects which lead to a rapid response in the control of signs and symptoms in comparison to that of corticosteroids in Oral Lichen Planus(OLP). There have been increasing number of studies establishing the use of topical tacrolimus in oral lichen planus. Still, there is a need to find evidence of the successful use of tacrolimus in comparison to other drugs used in the treatment of OLP, by means of a systematic review and meta-analysis, so that an informed and accurate approach can be utilized.

Validation of a Deep Learning Model for Detecting Chest Pathologies from Digital Chest Radiographs.

Manual interpretation of chest radiographs is a challenging task and is prone to errors. An automated system capable of categorizing chest radiographs based on the pathologies identified could aid in the timely and efficient diagnosis of chest pathologies. For this retrospective study, 4476 chest radiographs were collected between January and April 2021 from two tertiary care hospitals.

Comparative analysis of IoT-based controlled environment and uncontrolled environment plant growth monitoring system for hydroponic indoor vertical farm.

Agriculture is a very important economic sector that contributes to a nation's overall economic development. According to the UN Food and Agriculture Organization, with a rising population, the cereals demand will reach 3 billion tons by 2050. Also, the mission of Sustainable Development Goals (SDGs) is to provide zero hunger and sustainable agriculture by 2030.

Is Paracetamol Better than Diclofenac Sodium in Management of Postoperative Pain and Edema Following Major Maxillofacial Surgeries?

Introduction: Paracetamol is an optimal non-opioid analgesic and holds considerable advantages over NSAIDs in managing post-operative pain. Literature to date doesn't provide substantial documentation of it's efficacy and safety in major oral and maxillofacial surgeries. The study is designed to compare the effectiveness of intravenous paracetamol with diclofenac sodium for controlling post-operative pain and edema in major oral and maxillofacial surgeries.

Odontoma - Basic Third Dimensional Histopathology Model Using 3D Animation Software and Clay Model.

Background: Oral lesions of the jaw has been well explained in the literature through high-quality 2D clinical, radiographic, and histopathological images. But the clinicians and most of the times students too, don't understand the histopathological aspect through the description of text and existing 2D images. This article is preliminary attempt to explain the key events of histopathological aspects of odontoma in third dimension and clay models in a life-like manner which author herself has designed, for better understanding not only by oral and general pathologists, and students but also by patients, which is the unique feature of this short manuscript.

Assessment of ergonomics to study the correlation between physical and psychological factors with prevalence of musculoskeletal disorders in practicing dentists.

Introduction: Musculoskeletal disorders are very commonly seen in dentists. These disorders can hinder their clinical practice and at times results in severe complications leading to an early retirement.

Aim: The aim of this study is to find a correlation between physical and psychological factors with the prevalence of musculoskeletal disorders in practicing dentists.

Comparison of pain perception between computer-controlled local anesthetic delivery and the conventional syringe for inferior alveolar nerve block in children.

Background: Local anesthesia (LA) is commonly used for pain control in clinical dental practice. However, it is often perceived as the most painful part of the treatment and the factor leading to the avoidance of dental care. Hence, research on better means of pain management is being conducted.

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study.

Background Poor sexual function is a widespread problem affecting about 40% of women and this may worsen their quality of life. Ashwagandha () an adaptogenic herb has been reported to improve sexual satisfaction, sleep, and quality of life in women. Objective The purpose of the study was to evaluate the efficacy and safety of standardized Ashwagandha root extract in improving sexual function in healthy females.

A Machine Learning Model for Detection of Coronary Artery Disease Using Noninvasive Clinical Parameters.

Coronary artery disease (CAD) is one of the most prevalent causes of death worldwide. The early diagnosis and timely medical care of cardiovascular patients can greatly prevent death and reduce the cost of treatments associated with CAD. In this study, we attempt to prepare a new model for early CAD diagnosis.

Tumor Microenvironment in Oral Squamous Cell Carcinoma: Special Stains and Scanning Electron Microscopic Study.

Background: Effect of the oral cancerous epithelial cells on the extracellular matrix (ECM) and vice versa is also responsible for the growth and progression of cancer. The effect of inflammation on the stroma and its association with progression has also been stated in literature.

Materials And Methods: The control group consisted of 10 patients with apparently normal mucosa with no history of habits, the study group consisted of 30 patients with oral squamous cell carcinoma (OSCC) confirmed by examination and incisional biopsy.

Sustained response on sequential anti-FGFR therapy in metastatic gall bladder cancer: a case report and literature review.

Purpose: Advanced gall bladder cancer (GBC) is an aggressive disease, and there is no consensus on treatment options beyond first-line chemotherapy. We report a case of an elderly male with FGFR2-altered advanced adenocarcinoma of the gallbladder who failed two prior lines of chemotherapy but had sustained response and stable disease on sequential FGFR-directed targeted therapy.

Design: We describe a case of FGFR2-altered metastatic adenocarcinoma of the gallbladder who failed two prior lines of chemotherapy.

Giant Pseudocyst of the Pancreas: A Case Report.

Pancreatic cysts are usually asymptomatic over 70% of the time. They can be benign or malignant. Enhanced imaging modalities and increased usage of routine imaging have increased the identification of pancreatic cysts.

Deep Learning Techniques for the Effective Prediction of Alzheimer's Disease: A Comprehensive Review.

"Alzheimer's disease" (AD) is a neurodegenerative disorder in which the memory shrinks and neurons die. "Dementia" is described as a gradual decline in mental, psychological, and interpersonal qualities that hinders a person's ability to function autonomously. AD is the most common degenerative brain disease.