Association between food security status and dietary patterns in a cohort of first-time food-aid users.

Objective: To examine the associations between food security status and dietary patterns among first-time food-aid users.

Methods: From September 2018 to January 2020, a sample of 1001 newly registered food-aid users from 106 community-based food donation organizations were recruited across urban, rural, and peri-urban areas in four administrative regions of the province of Quebec, Canada. The Household Food Security Survey Module (HFSSM) and the Short Diet Questionnaire (SDQ) were used to assess food security status and food intake, respectively.

"I know when to stop": sentinels and counterstrategies against drowsy driving in narcolepsy and idiopathic hypersomnia.

Study Objectives: To collect prodromal symptoms experienced by participants with narcolepsy and idiopathic hypersomnia (considered "hypersomnolence experts") prior to drowsy driving and counterstrategies used to maintain alertness.

Methods: Systematic, face-to-face interview (using a semi-structured questionnaire), including clinical measures, frequency of car accidents/near misses, and symptoms experienced before impending drowsy driving episodes and counterstrategies.

Results: Among 61 participants (32 with narcolepsy, 29 with idiopathic hypersomnia; 56 drivers), 61% of drivers had at least one lifetime accident/near miss.

Efficacy and safety of trimodulin in patients with severe COVID-19: results from a randomised, placebo-controlled, double-blind, multicentre, phase II trial (ESsCOVID).

Background: Trimodulin (human polyvalent immunoglobulin [Ig] M ~ 23%, IgA ~ 21%, IgG ~ 56% preparation) has previously been associated with a lower mortality rate in a subpopulation of patients with severe community-acquired pneumonia on invasive mechanical ventilation (IMV) and with clear signs of inflammation. The hypothesis for the ESsCOVID trial was that trimodulin may prevent inflammation-driven progression of severe coronavirus disease 2019 (COVID-19) to critical disease or even death.

Methods: Adults with severe COVID-19 were randomised to receive intravenous infusions of trimodulin or placebo for 5 consecutive days in addition to standard of care.

Exploring the Transport Path of Oceanic Microplastics in the Atmosphere.

Microplastics (MP) have been recognized as an emerging atmospheric pollutant, yet uncertainties persist in their emissions and concentrations. With a bottom-up approach, we estimate 6-hourly MP fluxes at the ocean-atmosphere interface, using as an input the monthly ocean surface MP concentrations simulated by the global oceanic model (NEMO/PISCES-PLASTIC, Nucleus for European Modeling of the Ocean, Pelagic Interaction Scheme for Carbon and Ecosystem Studies), a size distribution estimate for the MP in the micrometer range, and a sea salt emission scheme. The atmospheric dispersion is then simulated with the Lagrangian model FLEXPART.

De-indexed estimated glomerular filtration rates for the dosing of oral antidiabetic drugs in patients with chronic kidney disease.

Adjusting drug dose levels based on equations that standardize the estimated glomerular filtration rate (eGFR) to a body surface area (BSA) of 1.73 m can pose challenges, especially for patients with extremely high or low body mass index (BMI). The objective of the present study of patients with CKD and diabetes was to assess the impact of deindexing creatinine-based equations on estimates of kidney function and on the frequency of inappropriate prescriptions of oral antidiabetic drugs (OADs).

On the role of seamounts in upwelling deep-ocean waters through turbulent mixing.

Turbulent mixing in the ocean exerts an important control on the rate and structure of the overturning circulation. However, the balance of processes underpinning this mixing is subject to significant uncertainties, limiting our understanding of the overturning's deep upwelling limb. Here, we investigate the hitherto primarily neglected role of tens of thousands of seamounts in sustaining deep-ocean upwelling.

Terrestrial inputs boost organic carbon accumulation in Mexican mangroves.

Despite their ability to mitigate climate change by efficiently absorbing atmospheric carbon dioxide (CO) and acting as natural long-term carbon sinks, mangrove ecosystems have faced several anthropogenic threats over the past century, resulting in a decline in the global mangrove cover. By using standardized methods and the most recent Bayesian tracer mixing models MixSIAR, this study aimed to quantify source contributions, burial rates, and stocks of organic carbon (C) and explore their temporal changes (∼100 years) in seven lead-210 dated sediment cores collected from three contrasting Mexican mangrove areas. The spatial variation in C burial rates and stocks in these blue carbon ecosystems primarily depended on the influence of local rivers, which controlled C sources and fluxes within the mangrove areas.

[Non-invasive ventilation in acute respiratory failure of oncology-hematology patients: What are its current benefits and limitations?].

Acute respiratory failure (ARF) is a leading cause, along with sepsis, of admission to the intensive care unit (ICU) of patients with active cancer. Presenting variable clinical severity, ARF in onco-hematological patients has differing etiologies, primarily represented by possibly opportunistic acute infectious pneumonia (de novo hypoxemic ARF), and decompensation in chronic cardiac or respiratory diseases (e.g.

High risk of lung cancer in surfactant-related gene variant carriers.

Background: Several rare surfactant-related gene (SRG) variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. We aimed to study the epidemiology and phenotype of lung cancer in an international cohort of SRG variant carriers.

Methods: We conducted a cross-sectional study of all adults with SRG variants in the OrphaLung network and compared lung cancer risk with telomere-related gene (TRG) variant carriers.

Characterizing Trends in the Use of Food Donations and Other Food-Related Community-Based Social Assistance Programs in a Cohort of New Food Bank Users in Quebec, Canada.

To characterize 12-month trends in the use of food donations and other food-related community-based social assistance programs (CB-SAPs) during the first year following the enrollment of new food bank (FB) users in Quebec, Canada. A cohort of 1,001 newly registered FB-users in Quebec from the Pathways Study were followed-up during 12-month following baseline assessment. Outcomes were monthly use of food donations and other food-related CB-SAPs.

Optimal Heart Failure Medical Therapy and Mortality in Survivors of Cardiogenic Shock: Insights From the FRENSHOCK Registry.

Background: The effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied. Thus, this study investigated the association between guideline-directed heart failure (HF) medical therapy (GDMT) and one-year survival rate in patients who are post-CS.

Methods And Results: FRENSHOCK (French Observatory on the Management of Cardiogenic Shock in 2016) registry was a prospective multicenter observational survey, conducted in metropolitan French intensive care units and intensive cardiac care units.

Virtual Exercise in Medicine: A Proof of Concept in a Healthy Population.

Background: Science is beginning to establish the benefits of the use of virtual reality (VR) in health care. This therapeutic approach may be an appropriate complementary treatment for some mental illnesses. It could prevent high levels of morbidity and improve the physical health of patients.

Robust acceleration of Earth system heating observed over the past six decades.

Global heating of the Earth system is unequivocal. However, detecting an acceleration of Earth heating has remained elusive to date, despite suggestive evidence of a potential increase in heating rates. In this study, we demonstrate that since 1960, the warming of the world ocean has accelerated at a relatively consistent pace of 0.

Beneath the Antarctic sea-ice: Fine-scale analysis of Weddell seal () behavior and predator-prey interactions, using micro-sonar data in Terre Adélie.

Lactation is the most energy-demanding event in mammals' reproduction. In pinnipeds, females are the only food providers to the young and have developed numerous behavioral and physiological lactation strategies, from capital-breeding to income-breeding. Lactating females' fine-scale foraging strategy, and precise understanding of how females supplement their pup's needs as well as their own are important to understand the species' ecology and energetic balance.

Les pratiques de l'action intersectorielle locale pour l'équité en santé : étude du cas de la Corporation de développement communautaire Centre-Sud à Montréal.

Introduction: Afin d'agir sur les inégalités de santé et les ressources locales promotrices de santé, les praticiens et les décideurs doivent être outillés pour pratiquer l'action intersectorielle locale. Planifier et optimiser ces partenariats demeure pourtant un défi en raison du manque de connaissances sur les processus menant à l'atteinte de leurs objectifs - ce qu'ils et . Cette étude documente empiriquement, à l'aide d'une étude de cas, les pratiques de conception de l'action intersectorielle locale dans la démarche (QN) à Montréal.

Long-Term Efficacy and Safety of Pitolisant for Residual Sleepiness Due to OSA.

Background: In people with OSA, excessive daytime sleepiness is a prominent symptom and can persist despite adherence to CPAP, the first-line therapy for OSA. Pitolisant was effective in reducing daytime sleepiness in two 12-week randomized controlled trials (RCTs), one in patients adherent to CPAP (BF2.649 in Patients With OSA and Treated by CPAP But Still Complaining of EDS [HAROSA 1]) and the other in patients refusing or not tolerating CPAP (BF2.

Where to live? Landfast sea ice shapes emperor penguin habitat around Antarctica.

Predicting species survival in the face of climate change requires understanding the drivers that influence their distribution. Emperor penguins () incubate and rear chicks on landfast sea ice, whose extent, dynamics, and quality are expected to vary substantially due to climate change. Until recently, this species' continent-wide observations were scarce, and knowledge on their distribution and habitat limited.

In-hospital outcomes after acute myocardial infarction with obstructive coronary artery disease in critically ill patients hospitalized for non-cardiac disease.

Background: Acute myocardial infarction (AMI) is one of the major cardiac complications in patients hospitalized in the intensive care unit (ICU) for non-cardiac disease. A better knowledge of ischemic and bleeding risks in these patients is needed to identify those most likely to benefit from specific cardiac management. We therefore assessed the incidence and predictors of a composite outcome of severe ischemic event (AMI recurrence, ischemic stroke), major bleeding, or all-cause death in this setting.

Climate genomics-Geoscientists, ecologists, and geneticists must reinforce their collaborations to confront climate change.

Geoscientists and ecologists alike must confront the impact of climate change on ecosystems and the services they provide. In the marine realm, major changes are projected in net primary and export production, with significant repercussions on food security, carbon storage, and climate system feedbacks. However, these projections do not include the potential for rapid linear evolution to facilitate adaptation to environmental change.

Scaling-up RADseq methods for large datasets of non-invasive samples: Lessons for library construction and data preprocessing.

Genetic non-invasive sampling (gNIS) is a critical tool for population genetics studies, supporting conservation efforts while imposing minimal impacts on wildlife. However, gNIS often presents variable levels of DNA degradation and non-endogenous contamination, which can incur considerable processing costs. Furthermore, the use of restriction-site-associated DNA sequencing methods (RADseq) for assessing thousands of genetic markers introduces the challenge of obtaining large sets of shared loci with similar coverage across multiple individuals.