A new perspective on drug-resistant epilepsy in children with focal cortical dysplasia type 1: From challenge to favorable outcome.

Objective: We comprehensively characterized a large pediatric cohort with focal cortical dysplasia (FCD) type 1 to expand the phenotypic spectrum and to identify predictors of postsurgical outcomes.

Methods: We included pediatric patients with histopathological diagnosis of isolated FCD type 1 and at least 1 year of postsurgical follow-up. We systematically reanalyzed clinical, electrophysiological, and radiological features.

SOMA: SCREENING AND SOMATIC HEALTH INTERVENTION PROGRAM FOR PEOPLE WITH SEVERE MENTAL ILLNESS.

Progress in psychiatric treatment has led to important improvements in the quality of life of patients with severe mental illness (SMI). Nevertheless, the life expectancy of patients with SMI remains two decades shorter than that of the general population, and the most prevalent cause of death is cardiovascular disease. Given that the delivery of somatic care to a population of individuals with mental illness is specific, we developed a screening and intervention programme aimed at this vulnerable population.

Acupuncture Points in Medieval European Medicine to Treat Pain and Inflammation.

In the previous article, the author demonstrated the close relationship between bloodletting practices in medieval Europe and acupuncture in Traditional Chinese Medicine. This study aimed to explore how acupuncture-based treatment was applied in medieval Europe. The author hypothesizes that the physical stimulation of acupuncture points associated with bloodletting was one of the main methods of pain management at that time.

One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID-19 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, Czech Republic.

Aims: To evaluate antibody response to mRNA vaccine, identify subgroups with poor response and to determine long-term antibody durability in hematological patients.

Materials And Methods: We have vaccinated 292 patients with all hematological malignancies with a third dose of mRNA COMIRNATY vaccine with a 12-month follow-up period in our center in Ostrava, Czech Republic.

Results: Antibody response for the whole cohort exceeded 74% through the whole 12-month follow-up.

Practical, low-cost integrity testing of diesel particle filters using remote sensing measurement at the campus entrance gate.

This work investigates the detection of defunct or absent diesel particle filters by drive-through remote sensing measurement at the Czech University of Life Sciences main vehicular entrance gate. An exhaust sample was collected by a line attached to the road surface in the center of the travel lane. A non-volatile particle number (nvPN) counter and electric mobility particle size classifier were used to measure particle number concentrations, and an FTIR analyzer was used to measure CO, CO, and NO concentrations.

Myasthenia gravis: understanding treatment patterns and direct medical costs in the Czech Republic.

Background: Myasthenia gravis (MG) is a rare autoimmune disorder with significant clinical implications, including life-threatening myasthenic crises and exacerbations. Understanding real-world treatment patterns, especially associated direct medical costs, is essential for the effective management of healthcare delivery.

Methods: We conducted a descriptive cohort study using health administrative claims data from the Czech Republic covering more than 1,500 prevalent MG patients.

Design and development of spectrophotometric enzymatic cyanide assays.

Determination of free cyanide (fCN) is required for various industrial, environmental, food, and clinical samples. Enzymatic methods are not widely used in this field despite their selectivity and mild conditions. Therefore, we present here a proof of concept for new spectrophotometric enzymatic assays of fCN.

Wide-spread brain alterations early after the onset of Crohn's disease in children in remission-a pilot study.

Background: The research on possible cerebral involvement in Crohn's disease (CD) has been largely marginalized and failed to capitalize on recent developments in magnetic resonance imaging (MRI).

Objective: This cross-sectional pilot study searches for eventual macrostructural and microstructural brain affection in CD in remission and early after the disease onset.

Methods: 14 paediatric CD patients and 14 healthy controls underwent structural, diffusion weighted imaging and quantitative relaxation metrics acquisition, both conventional free precession and adiabatic rotating frame transverse and longitudinal relaxation time constants as markers of myelination, iron content and cellular loss.

Neurological symptoms and complications of influenza in the elderly.

Background: An in-depth study of neurological symptoms and complications of influenza in elderly patients. This population group is more susceptible to complications of the disease and these complications are more likely to end in death.

Methods: A retrospective analysis of patient data was performed.

Effect of the 1D/2D dimensionality in copper and silver thiolate coordination polymers on their photophysical properties.

A series of four new copper and silver-thiolate, [M(-SPhCOR)] (M = Cu, Ag and R = H, Me), coordination polymers is reported. The study shows that the hydrogen bonding between the carboxylic acids directs the formation of a 2D structure associated with poor photoemission, while the steric hindrance of the ester groups allows the assembly of a 1D network coupled with bright luminescence.

Transcriptomic Signatures of Antibody-mediated Rejection in Early Biopsies With Negative Histology in HLA-incompatible Kidney Transplantation.

Background: Presensitized patients with circulating donor-specific antibodies (DSAs) before transplantation are at risk for antibody-mediated rejection (AMR). Peritransplant desensitization mitigates but does not eliminate the alloimmune response. We examined the possibility that subthreshold AMR activity undetected by histology could be operating in some early biopsies.

Extension of the Side Distance Measurement Aspect Ratio in the Measurement of a Slot or Bore Using a Commercial Laser Triangulation Sensor.

We propose a new commercial laser triangulation sensor modification to enable the measurement of slots or bores side distance. The study showed the possibility of extending the sensor depth range for a slot or bore side distance measurement using a bypass of the illumination laser beam compared to a simple single mirror attachment to the sensor probe. We derived relations allowing for evaluation of the modified sensor side measurement range in desired depth based on the sensor parameters and the reflective mirror size and position.

Impact of COVID-19 Restrictions on Elderly Mobility and Emergency SOS Alarm Responses: A GPS-Based Study in the Czech Republic.

Background: Understanding the impact of pandemic measures on elderly mobility is crucial for shaping public health responses. This retrospective study assesses the changes in mobility of 216 elderly individuals (average age 84 years) in the Czech Republic before and during COVID-19 restrictions, using two years of GPS tracking data.

Methods: We conducted statistical analyses across various physical, demographic, and social factors.

Comparative Study of Water and Milk Kefir Grains as Biopolymeric Adsorbents for Copper(II) and Arsenic(V) Removal from Aqueous Solutions.

This study investigates the biosorption capabilities of kefir grains, a polysaccharide-based byproduct of the fermentation process, for removing copper(II) and arsenic(V) from contaminated water. Unlike traditional heavy-metal removal methods, which are typically expensive and involve environmentally harmful chemicals, biopolymeric materials such as kefir grains provide a sustainable and cost-effective alternative for adsorbing hazardous inorganic pollutants from aqueous solutions. Our experimental results revealed significant differences in the sorption capacities of two types of kefir grains.

LumaCam: a novel class of position-sensitive event mode particle detectors using scintillator screens.

A new type of position-sensitive detectors is gaining attention in the neutron community. They are scintillator based detectors that detect the scintillation light on an individual photon basis via an image intensifier and a fast image sensor. Their readout operates in event mode i.

Multipliers on bi-parameter Haar system Hardy spaces.

Let denote the standard Haar system on [0, 1], indexed by , the set of dyadic intervals and denote the tensor product , . We consider a class of two-parameter function spaces which are completions of the linear span of , . This class contains all the spaces of the form (), where and are either the Lebesgue spaces or the Hardy spaces , .

Spaced Hybrid TiO/Au Nanotube Arrays with Tailored Optical Properties for Surface-Enhanced Raman Scattering.

Controlling the overall geometry of plasmonic materials allows for tailoring their optical response and the effects that can be exploited to enhance the performance of a wide range of devices. This study demonstrates a simple method to control the size and distribution of gold (Au) nanoparticles grown on the surface of spaced titanium dioxide (TiO) nanotubes by varying the deposition time of magnetron sputtering. While shorter depositions led to small and well-separated Au nanoparticles, longer depositions promoted the formation of quasi-continuous layers with small interparticle gaps.

Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing.

Ageing is a complex phenomenon affecting a wide range of coexisting biological processes. The homogeneity of the studied population is an essential parameter for valid interpretations of outcomes. The presented study capitalises on the MRI data available in the Human Connectome Project-Aging (HCP-A) and, within individuals over 55 years of age who passed the HCP-A section criteria, compares a subgroup of 37 apparently neurocognitively healthy individuals selected based on stringent criteria with 37 age and sex-matched individuals still representative of typical ageing but who did not pass the stringent definition of neurocognitively healthy.

Exploring sperm cell motion dynamics: Insights from genetic algorithm-based analysis.

Accurate analysis of sperm cell flagellar dynamics plays a crucial role in understanding sperm motility as flagella parameters determine cell behavior in the spatiotemporal domain. In this study, we introduce a novel approach by harnessing Genetic Algorithms (GA) to analyze sperm flagellar motion characteristics and compare the results with the traditional decomposition method based on Fourier analysis. Our analysis focuses on extracting key parameters of the equation approximating flagellar shape, including beating period time, bending amplitude, mean curvature, and wavelength.

Epilepsy surgery in children with operculoinsular epilepsy: Results of a large unicentric cohort.

Objective: Epilepsy surgery in the operculoinsular cortex is challenging due to the difficult delineation of the epileptogenic zone and the high risk of postoperative deficits.

Methods: Pre- and postsurgical data from 30 pediatric patients who underwent operculoinsular cortex surgery at the Motol Epilepsy Center Prague from 2010 to 2022 were analyzed.

Results: Focal cortical dysplasia (FCD; n = 15, 50%) was the predominant cause of epilepsy, followed by epilepsy-associated tumors (n = 5, 17%) and tuberous sclerosis complex (n = 2, 7%).

Topical siRNA therapy of diabetic-like wound healing.

Non-healing wounds are a serious complication in diabetic patients. One of the detrimental factors contributing to limited wound healing is the accumulation of metalloproteinase-9 (MMP-9) in the wound. Selective inhibition of MMP-9 is one of the established therapeutic targets for diabetic wound healing.

Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry.

Introduction: The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends.

Methods: We selected all patients, both incident and prevalent, who were enrolled in the Czech MyReg registry between August 24, 2015 and November 19, 2021. For the descriptive analysis, all patients enrolled in the registry, regardless of their date of diagnosis or date of enrolment, were included.

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

This Letter reports a search for charge-parity (CP) symmetry violating nonstandard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from ν_{μ}(ν[over ¯]_{μ})→ν_{μ}(ν[over ¯]_{μ}) and ν_{μ}(ν[over ¯]_{μ})→ν_{e}(ν[over ¯]_{e}) oscillation channels are used to measure the effect of the NSI parameters ϵ_{eμ} and ϵ_{eτ}. With 90% CL the magnitudes of the NSI couplings are constrained to be |ϵ_{eμ}|≲0.

A dataset of µCT images of small samples of constructed Technosol from bioretention cells.

The dataset represents micro computed tomography (µCT) images of undisturbed samples of constructed Technosol, obtained by sampling from the top layer of the biofilter in two bioretention cells. A bioretention cell is a stormwater management system designed to collect and temporarily retain stormwater runoff and treat it by filtering it through a soil media called a biofilter. Soil samples were collected at 7, 12, 18, 23, and 31 months after the establishment of bioretention cells.