Highly stable lithium metal anodes enabled by bimetallic metal-organic frameworks derivatives-modified carbon cloth.

Lithium (Li) metal anodes hold great promise for next-generation secondary batteries with high energy density. Unfortunately, several problems such as Li dendrite growth, low Coulombic efficiency and poor cycle life hinder the commercialization of Li metal anodes. Herein, we design a highly lithiophilic carbon cloth host modified with Sn-doped zinc oxide (ZnO) (ZnSn-CC) directly derived from a bimetallic ZnSn metal-organic framework (ZnSn-MOF), which boosts uniform Li plating/stripping during charge-discharge and effectively protects the Li metal anode.

SPR is a fast and straightforward method to estimate the binding constants of cyclic dinucleotides to their binding partners, such as STING or poxin.

The development of small molecule drugs that target protein binders is the central goal in medicinal chemistry. During the lead compound development process, hundreds or even thousands of compounds are synthesized, with the primary focus on their binding affinity to protein targets. Typically, IC or EC values are used to rank these compounds.

Dragonfly larvae rearing: experimental insights and best practices.

Understanding and optimizing rearing conditions for dragonfly larvae is crucial for ecological research and conservation efforts, yet optimal rearing conditions and general rearing practices are lacking. In this study, we investigated the effect of temperature, amount of oxygen in water, presence of (artificial) plants, and age of eggs on hatchability, survival, and development of dragonfly larvae using the model species Sympetrum striolatum. We conducted three independent experiments and assessed variability between egg clutches of individual females, as well as the occurrence of cannibalism among larvae.

Survey of legislative frameworks and national recommendations governing paediatric maintenance haemodialysis in Europe.

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries.

Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted in all 42 European countries to complete two online questionnaires.

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Background And Objectives: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.

Methods: We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months.

Synthesis of Xenes: physical and chemical methods.

Since the debut of silicene in the experimental stage more than a decade ago, the family of two-dimensional elementary layers beyond graphene, called Xenes or transgraphenes, has rapidly expanded to include elements from groups II to VI of the periodic table. This expansion has opened pathways for the engineering of elementary monolayers that are inherently different from their bulk counterparts in terms of fundamental physical properties. Common guidelines for synthesizing Xenes can be categorized into well-defined methodological approaches.

Acute Effects of Fast vs. Slow Bench Press Repetitions with Equal Time Under Tension on Velocity, sEMG Activity, and Applied Force in the Bench Press Throw.

The tempo of resistance exercises is known to influence performance outcomes, yet its specific effects on post-activation performance enhancement (PAPE) remain unclear. This study aimed to investigate the effects of fast versus slow repetitions at a load of 70% of one-repetition maximum (1-RM) in the bench press exercise, focusing on velocity, surface electromyographic (sEMG) activity, and applied force while equating time under tension on bench press throw performance. Eleven men (age: 23.

Electrosynthesis of Ru (II)-Polypyridyl Oligomeric Films on ITO Electrode for Two Terminal Non-Volatile Memory Devices and Neuromorphic Computing.

Molecular electronics exhibiting resistive-switching memory features hold great promise for the next generation of digital technology. In this work, electrosynthesis of ruthenium polypyridyl nanoscale oligomeric films is demonstrated on an indium tin oxide (ITO) electrode followed by an ITO top contact deposition yielding large-scale (junction area = 0.7 × 0.

Systematic Review on 1,2,3-Oxadiazoles, 1,2,4-Oxadiazoles, and 1,2,5-Oxadiazoles in the Antimycobacterial Drug Discovery.

Tuberculosis remains a leading global health threat, exacerbated by the emergence of multi-drug-resistant strains. The search for novel therapeutic agents is critical in addressing this challenge. This review systematically summarizes the potential of oxadiazole derivatives as promising candidates in antimycobacterial drug discovery.

Oncological Feasibility of Limited Neck Dissection in cN0 Supraglottic Laryngeal Cancer.

Background: Supraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management of clinically negative necks (cN0) through selective neck dissection (SND) being debated due to potential morbidities and low metastasis rates in levels IIb and IV.

Methods: This study is a retrospective, multicenter examination of the potential feasibility of limited neck dissection (LND), including only levels IIa and III in cN0 supraglottic SCC patients. It analyzed occult metastasis rates and explored relapse occurrences alongside potential predictors of lymph node metastasis.

Maturing conditions of bimetallic nanocomposites as a new factor influencing Au-Ag synergism and impact of Cu(II) and/or Fe(III) on luminescence.

Gold-silver synergism has been well documented in many scientific works dealing with luminescent nanostructures that are exploitable in biomedical and environmental application. Frequently, the ratio of Au : Ag in synthetic mixtures was varied to influence the extent of Au-Ag synergism of the resulting luminescent gold-silver nanoclusters (GSNCs). However, in our approach, a new step, maturing under differing conditions using the same Au : Ag ratio (5 : 1), has been investigated systematically for the very first time.

Global burden of pneumoconiosis attributable to occupational particulate matter, gasses, and fumes from 1990~2021 and forecasting the future trends: a population-based study.

Background: This study aimed to quantify the global impact of pneumoconiosis resulting from occupational exposure to particulate matter, gasses, and fumes from 1990 to 2021, utilizing data from the Global Burden of Disease Study 2021.

Method: The analysis evaluated the global, regional, and national burden of pneumoconiosis attributable to workplace exposure to particulate matter, gasses, and fumes. It explored variations in disease impact across different demographics, including age and gender, and analyzed the relationship between disease burden and the Socio-Demographic Index (SDI).

Purging the Judiciary After a Transition: Between a Rock and a Hard Place.

Judges play a key role in the implementation of transitional justice mechanisms. Yet, less attention has been paid so far to the question of how to address their collaboration with non-democratic regimes. In theory, judges can be subjected to virtually all transitional justice mechanisms ranging from criminal prosecution and lustration to truth-seeking, or even amnesties.

SidF, a dual substrate N5-acetyl-N5-hydroxy-L-ornithine transacetylase involved in siderophore biosynthesis.

Siderophore-mediated iron acquisition is essential for the virulence of , a fungus causing life-threatening aspergillosis. Drugs targeting the siderophore biosynthetic pathway could help improve disease management. The transacetylases SidF and SidL generate intermediates for different siderophores in .

Sulfur isotope engineering in heterostructures of transition metal dichalcogenides.

Heterostructuring of two-dimensional materials offers a robust platform to precisely tune optoelectronic properties through interlayer interactions. Here we achieved a strong interlayer coupling in a double-layered heterostructure of sulfur isotope-modified adjacent MoS monolayers two-step chemical vapor deposition growth. The strong interlayer coupling in the MoS(S)/MoS(S) was affirmed by low-frequency shear and breathing modes in the Raman spectra.

GSAG:Ce scintillator: insights from yttrium admixture.

The GSAG:Ce scintillator represents a promising and cost-effective alternative to the expensive GGAG:Ce. Recent studies have attributed its low light yield to the thermal quenching effect. In this study, we employed the strategy of adding an yttrium (Y) admixture to the GSAG matrix to increase the thermal activation energy of thermal quenching.

Narrow Dietary Niche With High Overlap Between Snow Leopards and Himalayan Wolves Indicates Potential for Resource Competition in Shey Phoksundo National Park, Nepal.

Understanding species' dietary ecology and interspecific interactions is crucial for multi-species conservation planning. In Central Asia and the Himalayas, wolves have recolonized snow leopard habitats, raising considerable concern about resource competition between these apex predators. Using micro-histological analysis of prey species remains (e.

Multilevel Analysis of Ground Beetle Responses to Forest Management: Integrating Species Composition, Morphological Traits and Developmental Instability.

This study evaluates the response of ground beetle (Coleoptera: Carabidae) assemblage to forest management practices by integrating species composition, body traits, wing morphology and developmental instability. Traditional approaches that rely on averaged identity-based descriptors often overlook phenotypic plasticity and functional trait variability, potentially masking species-specific responses to environmental changes. To address this, we applied a three-layered analytical approach to address this gap, utilising ground beetle occurrence and morphological trait data from Podyjí National Park, Czech Republic.

Behavioral problems, dissociative symptoms, and empathic behaviors in children adopted in infancy from institutional and foster care in the Czech Republic.

This study examined if considerably different caregiving experiences in infancy influence socio-emotional development later in childhood. We included children aged 6-9 years who were, immediately after birth, placed in quality state-run institutions (N = 24) or quality state-run foster care with one family (N = 23). All children have lived in stable families since their adoption before 15 months of age.

Putting seedlings on the map: Trade-offs in demographic rates between ontogenetic size classes in five tropical forests.

All species must partition resources among the processes that underly growth, survival, and reproduction. The resulting demographic trade-offs constrain the range of viable life-history strategies and are hypothesized to promote local coexistence. Tropical forests pose ideal systems to study demographic trade-offs as they have a high diversity of coexisting tree species whose life-history strategies tend to align along two orthogonal axes of variation: a growth-survival trade-off that separates species with fast growth from species with high survival and a stature-recruitment trade-off that separates species that achieve large stature from species with high recruitment.

Efficacy and Safety Results With Rilzabrutinib, an Oral Bruton Tyrosine Kinase Inhibitor, in Patients With Immune Thrombocytopenia: Phase 2 Part B Study.

Current treatments for persistent or chronic immune thrombocytopenia (ITP) are limited by inadequate response, toxicity, and impaired quality of life. The Bruton tyrosine kinase inhibitor rilzabrutinib was evaluated to further characterize safety and durability of platelet response. LUNA2 Part B is a multicenter, phase 1/2 study in adults with ITP (≥ 3 months duration, platelet count < 30 × 10/L) who failed ≥ 1 ITP therapy (NCT03395210, EudraCT 2017-004012-19).

Comparative analysis of pediatric SHH medulloblastoma DAOY spheres and adherent monolayers: implications for medulloblastoma research.

Medulloblastoma, the most prevalent brain tumor among children, requires a comprehensive understanding of its cellular characteristics for effective research and treatment. In this study, we focused on DAOY, a permanent cell line of medulloblastoma, and investigated the unique properties of DAOY cells when cultured as floating multicellular aggregates called spheres, as opposed to adherent monolayers. Through our comprehensive analysis, we identified distinct characteristics associated with DAOY spheres.

Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients.

Background: The definition of minor ischemic stroke (MIS) is a topic of debate, however, the most accepted definition is a stroke with National Institutes of Health Stroke Scale (NIHSS) ≤ 5. Intravenous thrombolysis (IVT) is a crucial treatment option for acute ischemic stroke (AIS) including: alteplase, recombinant human tissue-type plasminogen activator (r-tPA), and the recently approved tenecteplase. However, there is a debate regarding its safety and efficacy.

Synthetic Browsing Histories for 50 Countries Worldwide: Datasets for Research, Development, and Education.

Browsing histories can be a valuable resource for cybersecurity, research, and testing. Individuals are often reluctant to share their browsing histories online, and the use of personal data requires obtaining signed informed consent. Research shows that anonymized histories can lead to re-identification, nullifying the anonymity promised by informed consent.