Aero-TiO three-dimensional nanoarchitecture for photocatalytic degradation of tetracycline.

One of the biggest issues of wide bandgap semiconductor use in photocatalytic wastewater treatment is the reusability of the material and avoiding the contamination of water with the material itself. In this paper, we report on a novel TiO aeromaterial (aero-TiO) consisting of hollow microtetrapods with ZnTiO inclusions. Atomic layer deposition has been used to obtain particles of unique shape allowing them to interlock thereby protecting the photocatalyst from erosion and damage when incorporated in active filters.

Impact of antiphospholipid syndrome on placenta and uterine NK cell function: insights from a mouse model.

Antiphospholipid syndrome (APS) is associated with recurrent pregnancy morbidity, yet the underlying mechanisms remain elusive. We performed multifaceted characterization of the biological and transcriptomic signatures of mouse placenta and uterine natural killer (uNK) cells in APS. Histological analysis of APS placentas unveiled placental abnormalities, including disturbed angiogenesis, occasional necrotic areas, fibrin deposition, and nucleated red blood cell enrichment.

The interplay between lying, sitting, standing, moving, and walking on obesity risk in older adults: a compositional and isotemporal substitution analysis.

Introduction: Obesity in older adults is linked to various chronic conditions and decreased quality of life. Traditional physical activity guidelines often overlook the specific postures and movements that older adults engage in daily. This study aims to explore the compositional associations between posture-specific behaviours and obesity risk in younger (M = 67.

Childhood trauma and dissociation in patients with panic disorder, obsessive-compulsive disorder, and borderline personality disorder. Part 2: Therapeutic effectiveness of combined cognitive behavioural therapy and pharmacotherapy in treatment-resistant inpatients.

Introduction: PAdverse Childhood Experiences (ACEs) are associated with an increased risk of mental health issues in general, but their relationship with panic disorder (PD) and obsessive-compulsive disorder (OCD) has received less attention compared to borderline personality disorder (BPD). Dissociative experiences are significant predictors of increased symptoms, reduced treatment adherence, and poor prognosis in several psychiatric conditions, including PD, OCD, and BPD; still, their impact remains underexplored. This part of the study focuses on the overall efficiency of psychotherapeutic programs on treatment-resistant patients diagnosed with PD, OCD, and BPD (or combined), as well as the relationship between ACEs, dissociation rates, and treatment results.

Childhood trauma and dissociation in patients with panic disorder, obsessive-compulsive disorder, and borderline personality disorder. Part 1: Relationships between demographic, clinical, and psychological factors.

Introduction: Panic disorder (PD), obsessive-compulsive disorder (OCD), and borderline personality disorder (BPD) are associated with various psychosocial factors that may influence their onset and psychopathology. Dissociation encompasses a wide range of manifestations, from benign experiences to severe mental health issues. Research comparing childhood trauma and dissociation, general psychopathology, and the onset of the disorder among patients with PD, OCD, and BPD has not yet been published.

The Behavior of Nasopharynx Malignancies: a Retrospective Study in a Ten-Year Sample.

Objectives: Malignant tumors of the nasopharynx make up 3% of malignancies in the ENT area. The most common nasopharyngeal malignancy is nasopharyngeal carcinoma (NPC), followed by lymphomas. Other nasopharyngeal tumors are very rare.

Cytidine analogs in plant epigenetic research and beyond.

Cytosine (DNA) methylation plays important roles in silencing transposable elements, plant development, genomic imprinting, stress responses, and maintenance of genome stability. To better understand the functions of this epigenetic modification, several tools have been developed to manipulate DNA methylation levels. These include mutants of DNA methylation writers and readers, targeted manipulation of locus-specific methylation, and the use of chemical inhibitors.

Perceived Riskiness and Problem Gambling Across Different Forms of Gambling: A Focus on 'Soft' Gambling.

Gambling encompasses a wide variety of activities, and the structural characteristics of each form contribute to its potential risk. However, the literature does not fully agree on the risk levels of certain gambling forms. In this study, we classify less risky gambling forms (soft forms) based on public perceptions of their riskiness.

Ultrathin ALD Coatings of Zr and V Oxides on Anodic TiO Nanotube Layers: Comparison of the Osteoblast Cell Growth.

The current study investigates and compares the biological effects of ultrathin conformal coatings of zirconium dioxide (ZrO) and vanadium pentoxide (VO) on osteoblastic MG-63 cells grown on TiO nanotube layers (TNTs). Coatings were achieved by the atomic layer deposition (ALD) technique. TNTs with average tube diameters of 15, 30, and 100 nm were fabricated on Ti substrates (via electrochemical anodization) and were used as primary substrates for the study.

Testing the Dispersal-Origin-Status-Impact (DOSI) scheme to prioritise non-native and translocated species management.

Assessing actual and potential impacts of non-native species is necessary for prioritising their management. Traditional assessments often occur at the species level, potentially overlooking differences among populations. The recently developed Dispersal-Origin-Status-Impact (DOSI) assessment scheme addresses this by treating biological invasions as population-level phenomena, incorporating the complexities affecting populations of non-native species.

Investigation of factors affecting the sound absorption behaviour of 3D printed hexagonal prism lattice polyamide structures.

The aim of this work is to investigate the sound absorption properties of open-porous polyamide 12 (PA12) structures produced using Selective Laser Sintering (SLS) technology. The examined 3D-printed samples, fabricated with hexagonal prism lattice structures, featured varying thicknesses, cell sizes, and orientations. Additionally, some samples were produced with an outer shell to evaluate its impact on sound absorption.

The Financial Burden of Localized and Metastatic Bladder Cancer.

Background And Objective: Bladder cancer (BCa) imposes a substantial economic burden on health care systems and patients. Understanding these financial implications is crucial for effective resource allocation and optimization of treatment cost effectiveness. Here, we aim to systematically review and analyze the financial burden of BCa from the health care and patient perspectives.

Safety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats.

Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L., in which there is currently growing interest for medicinal use. Here, we focused on the safety and pharmacokinetics of a CBD-rich (77 %, w/w) full-spectrum hemp extract in male and female rats.

Whole blood concentrations of fingolimod and its pharmacologically active metabolite fingolimod phosphate obtained during routine health care of patients with multiple sclerosis.

Background: Fingolimod is a first-in-class, orally administered drug indicated for the treatment of relapsing-remitting multiple sclerosis. It acts as an immunomodulator, is classified as a "disease-modifying therapy", and its main mechanism of action is the modulation of sphingosine-1-phosphate receptors. In this prospective pilot study, whole blood concentrations of fingolimod and fingolimod phosphate obtained during routine health care were measured.

Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II).

Background: Exposure of critically ill patients to antibiotics lead to intestinal dysbiosis, which often manifests as antibiotic-associated diarrhoea. Faecal microbiota transplantation restores gut microbiota and may lead to faster resolution of diarrhoea.

Methods: Into this prospective, multi-centre, randomized controlled trial we will enrol 36 critically ill patients with antibiotic-associated diarrhoea.

Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.

Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit from isoform-selective inhibitors, allowing studies on the role of these enzymes in normal physiology and disease pathogenesis. However, due to significant sequence homology within the catalytic domain, isoform selectivity is difficult to achieve with conventional small molecules.

Effect of Different Thawing Regimes on Cell Kinematics and Organelle Integrity of Nitrogen-Stored Wallachian Ram Spermatozoa.

Artificial insemination is an advanced reproductive technology used to increase the number of lambs born from elite sires to accelerate genetic gain in a flock [...

Application of Pulsed Electric Field During Malting: Impact on Species Growth and Mycotoxin Production.

The increasing contamination of cereals by micromycetes and mycotoxins during malting still poses an unresolved food safety problem. This study characterises the potential of the novel, rapidly developing food production technology of Pulsed Electric Field (PEF) to reduce the viability of fungi and the production of mycotoxins during malting. Barley, artificially inoculated with four species, was treated by PEF with two different intensities and then malted using a standard Pilsner-type technology.

"Head-to-Toe" Lipid Properties Govern the Binding and Cargo Transfer of High-Density Lipoprotein.

The viscoelastic properties of biological membranes are crucial in controlling cellular functions and are determined primarily by the lipids' composition and structure. This work studies these properties by varying the structure of the constituting lipids in order to influence their interaction with high-density lipoprotein (HDL) particles. Various fluorescence-based techniques were applied to study lipid domains, membrane order, and the overall lateral as well as the molecule-internal glycerol region mobility in HDL-membrane interactions (i.

Separation of Antibiotics Using Two Commercial Nanofiltration Membranes-Experimental Study and Modelling.

The widespread use of antimicrobial drugs has contributed to the increasing trace levels of contaminants in the environment, posing an environmental problem and a challenge to modern-day medicine seeking advanced solutions. Nanofiltration is one such breakthrough solution for the selective removal of antibiotics from wastewater due to their high efficiency, scalability, and versatility. This study examines the separation of antibiotics (sulfamethoxazole (SMX), trimethoprim (TMP), and metformin (MET), respectively) using commercially available membranes with an emphasis on AFC membranes (AFC 30 and AFC 80).

A Novel Organic-Inorganic-Nanocomposite-Based Reduced Graphene Oxide as an Efficient Nanosensor for NO Detection.

There are three components to every environmental protection system: monitoring, estimation, and control. One of the main toxic gases with considerable effects on human health is NO, which is released into the atmosphere by industrial activities and the transportation network. In the present research, a NO sensor is designed based on FeO piperidine-4-sulfonic acid grafted onto a reduced graphene oxide FeO@rGO-N-(piperidine-4-SOH) nanocomposite, due to the highly efficient detection of pollution in the air.

Evaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic.

Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) are environmental contaminants known for their persistence and bioaccumulation in fatty tissues. SCCPs are considered potential carcinogens and endocrine disruptors, with similar effects expected for MCCPs. This study investigated the body burden of SCCPs and MCCPs in residents of two regions of the Czech Republic with different levels of industrial pollution.

International Cardiovascular Development, Anatomy, and Regeneration (ICDAR) Community Meeting: Prague 2024.

The International Cardiovascular Anatomy, Development, and Regeneration meeting was held from 18-20 September 2024, in Prague, Czech Republic, supported by the European Society of Cardiology's Working Group on Development, Anatomy, and Pathology. Hosted at the Institute of Anatomy, First Faculty of Medicine, the event began with a hands-on workshop on normal and malformed human hearts, covering morphology, echocardiographic imaging, and rare congenital cases. The session allowed participants to examine and image both normal and malformed hearts.

Assessing Postural Stability in Gastrointestinal Endoscopic Procedures with a Belt-like Endoscope Holder Using a MoCap Camera System.

As musculoskeletal injuries in gastroenterologists related to the performance of endoscopic procedures are on the rise, solutions and new approaches are needed to prevent these undesired outcomes. In our study, we evaluated an approach to ergonomic challenges in the form of a belt-like endoscope holder designed to redistribute the weight of the endoscope across the whole body of the practitioner. The aim of the study was to determine how the use of this holder affected the body posture of practitioners during endoscopy.