1,725 results match your criteria: "Cystic Diseases of the Kidney"
J Am Soc Nephrol
July 2024
Molecular and Translational Kidney Research, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Key Points: Our study reveals segment-specific mechanisms in cystic kidney disease and suggests as a modifier of collecting duct–derived cyst progression. Our data demonstrate that genetic deletion of accelerates disease progression in a cystic mouse model.
Background: The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in maintaining the epithelial barrier properties of the kidney collecting duct and is important to osmoregulation.
Eur Urol Open Sci
April 2024
Division of Surgery and Interventional Sciences, University College London, London, UK.
Physiol Rep
April 2024
Department of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Kidney360
May 2024
Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China.
Intern Med
March 2024
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Japan.
Int J Surg Pathol
December 2024
Department of Pathology, ESIC Medical College & Hospital Faridabad, HR, India.
Liesegang rings are eosinophilic, concentric, lamellated structures that can assume a variety of shapes and sizes ranging from a few microns to hundreds of microns. To date, Liesegang rings have been reported in around 30 examples in the English literature, in the kidney, breast, female genital tract, and skin, and only a single report in the lung associated with allergic bronchopulmonary aspergillosis. Liesegang rings are usually incidental discoveries and have been associated with benign cystic lesions, inflammatory diseases, fibrosis, and tissue necrosis.
View Article and Find Full Text PDFCan J Kidney Health Dis
February 2024
Department of Medicine, McMaster University, Hamilton, ON, Canada.
J Avian Med Surg
January 2024
Arizona Exotic Animal Hospital, Mesa, AZ 85201, USA.
This report describes the diagnosis and treatment of a benign renal cyst in an adult, female golden eagle () presented for unilateral leg lameness. A cyst at the cranial division of the left kidney was diagnosed by computed tomography and was suspected of compressing the lumbosacral nerve plexus, resulting in limb lameness. The renal cyst was incompletely excised because the cyst wall was closely adhered to the kidney parenchyma and local blood supply.
View Article and Find Full Text PDFHum Pathol
March 2024
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. Electronic address:
Multiple tumors of different lineages merging into a single mass, termed collision tumors, are considered a rare phenomenon in the kidney. Tumor components, or partners, may be malignant (including metastatic disease), borderline, or benign. We report the largest cohort to date of 48 cases.
View Article and Find Full Text PDFAm J Kidney Dis
July 2024
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota; Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. Electronic address:
Am J Kidney Dis
June 2024
University of Melbourne Department of Medicine (Melbourne Health and Northern health), Royal Melbourne Hospital, Parkville, Australia. Electronic address:
J Diabetes Investig
January 2024
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai, China.
Aims/introduction: Simple renal cysts (SRC) are associated with age, hypertension and hyperuricemia, which are risk factors of renal impairment. This study aimed to investigate the prevalence of SRC and its association with measured glomerular filtration rate (mGFR) in patients with type 2 diabetes mellitus in China.
Methods: A total of 3,552 patients with type 2 diabetes mellitus admitted to Shanghai Sixth People's Hospital from January 2012 to December 2016 were investigated.
Front Physiol
November 2023
Department of Medicine, New Mexico Veterans Health Care Center, Albuquerque, NM, United States.
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disease caused by mutations in either or genes. Approximately, two million individuals suffer from this disorder worldwide. TSC1 and TSC2 code for the proteins harmartin and tuberin, respectively, which form a complex that regulates the mechanistic target of rapamycin complex 1 (mTORC1) and prevents uncontrollable cell growth.
View Article and Find Full Text PDFCureus
October 2023
Pathology, MetroHealth Medical Center, Cleveland, USA.
Hemangioblastoma, also known as capillary hemangioblastoma, is a rare benign mesenchymal tumor commonly found in the central nervous system (CNS). It can also manifest in various organs, including the kidney. Renal hemangioblastoma (RH) is often associated with Von Hippel-Lindau (VHL) disease, but sporadic occurrences are observed infrequently.
View Article and Find Full Text PDFAbdom Radiol (NY)
February 2024
Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892-1109, USA.
Objective: To determine the reliability of an MRI-based qualitative kidney imaging surveillance scoring system (KISSS) and assess which imaging features predict growth rate (GR) of renal tumors in patients with VHL.
Materials And Methods: We identified 55 patients with VHL with 128 renal tumors who underwent intervention from 2015 to 2020 at the National Cancer Institute. All patients had 2 preoperative MRIs at least 3 months apart.
Semin Nephrol
July 2023
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, FL. Electronic address:
Kidney Int
April 2024
Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:
Podocin is a key membrane scaffolding protein of the kidney podocyte essential for intact glomerular filtration. Mutations in NPHS2, the podocin-encoding gene, represent the commonest form of inherited nephrotic syndrome (NS), with early, intractable kidney failure. The most frequent podocin gene mutation in European children is R138Q, causing retention of the misfolded protein in the endoplasmic reticulum.
View Article and Find Full Text PDFVirchows Arch
January 2024
Department of Pathology, Stanford University, Stanford, CA, USA.
Development
December 2023
Department of Medicine, Division of Nephrology, Washington University in St Louis, St. Louis, MO 63110, USA.
Mutations that disrupt centrosome biogenesis or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet how centrosome dysfunction results in the kidney disease phenotypes remains unknown. Here, we examined the consequences of conditional knockout of the ciliopathy gene Cep120, essential for centrosome duplication, in the nephron and collecting duct progenitor niches of the mouse embryonic kidney.
View Article and Find Full Text PDFIntroduction: Renal cysts are a common disease that occurs at a rate of 7-10%. Currently there are no clinical recommendations for the treatment of patients with simple renal cysts. In the current literature there is some evidence that a simple renal cyst has negative effects on renal function.
View Article and Find Full Text PDFKidney Int Rep
October 2023
Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.
Front Med (Lausanne)
September 2023
Department of Obstetrics and Gynecology, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Nanjing, China.