Tetrahedrite Nanocomposites for High Performance Thermoelectrics.

Thermoelectric (TE) materials offer a promising solution to reduce green gas emissions, decrease energy consumption, and improve energy management due to their ability to directly convert heat into electricity and vice versa. Despite their potential, integrating new TE materials into bulk TE devices remains a challenge. To change this paradigm, the preparation of highly efficient tetrahedrite nanocomposites is proposed.

The Paediatric European Confederation of Medical Mycology (ECMM) Quality (Paed-EQUAL) Candida Score for the Management of Candidaemia in Children and Neonates.

Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug-resistant species such as Candida auris, which is associated with outbreaks. Guidelines on the management of candidaemia emphasise identification of species and determination of antifungal susceptibility to guide appropriate treatment, performing relevant investigations to rule out deep-seated infection, and removal of central venous catheters.

The influence of teachers' psychological capital on the quality of work life: exploring the mediating impact of emotions.

Introduction: The aim of this study is to investigate whether emotions play a mediating role in determining the effect of teachers' psychological capital (PsyCap) on the quality of work life (QWL).

Methods: The current study presents an investigation on the mediating role of emotions and their effect on teachers' PsyCap at their work life. The study used scales including Psychological Capital Scale (PsyCapS), Quality of Work Life Scale (QWLS) and Emotions Scale (ES).

Quality of life in heart failure. The heart of the matter. A scientific statement of the Heart Failure Association and the European Association of Preventive Cardiology of the European Society of Cardiology.

For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a range of physical and psychological symptoms, including shortness of breath, chest discomfort, fatigue, fluid congestion, trouble with sleeping, and depression. These symptoms reduce patients' capacity for daily social and physical activity.

Quality of life in heart failure. The heart of the matter. A scientific statement of the Heart Failure Association and the European Association of Preventive Cardiology of the European Society of Cardiology.

For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a range of physical and psychological symptoms, including shortness of breath, chest discomfort, fatigue, fluid congestion, trouble with sleeping, and depression. These symptoms reduce patients' capacity for daily social and physical activity.

3D Printing in Dental Education: A Review of Its Use across Disciplines.

Background: Dental education aims to equip students with the knowledge and skills required to competently manage clinical scenarios. It is critical that dental education evolves with technological advances to ensure quality student preparation. New technologies such as three-dimensional printing (3DP) have found their way into dental education and could overcome the limitations of traditional methods.

eDNA metabarcoding of marine invertebrate communities at RO desalination plant outfalls in Cyprus.

Seawater desalination has become an essential part of the drinking water supply of many arid countries in the world - including Cyprus and the wider Mediterranean - Middle Eastern region. In this study, the microinvertebrate fauna near the outfall sites of 2 seawater desalination plants, Dhekelia and Larnaca, in Cyprus was assessed by microscopy-based classical taxonomy and eDNA metabarcoding. The results show impact of desalination brine discharge on marine benthic communities.

Contribution of skeletal and dentoalveolar vertical components in the hypodivergent facial growth pattern : An observational study.

Purpose: This observational study aimed to explore the association of various vertical skeletal and dentoalveolar components with the hypodivergence facial growth pattern in a Middle Eastern population.

Methods: A total of 320 lateral cephalometric radiographs of Middle Eastern adults were selected and divided, based on their vertical facial growth pattern, equally into two groups: 1) hypodivergent (GoGn/SN ≤ 28°) and 2) normodivergent (28°  View Article and Find Full Text PDF

oncology: a mechanistic multiscale model of clinical prostate cancer response to external radiation therapy as the core of a digital (virtual) twin. Sensitivity analysis and a clinical adaptation approach.

Introduction: Prostate cancer (PCa) is the most frequent diagnosed malignancy in male patients in Europe and radiation therapy (RT) is a main treatment option. However, current RT concepts for PCa have an imminent need to be rectified in order to modify the radiotherapeutic strategy by considering (i) the personal PCa biology in terms of radio resistance and (ii) the individual preferences of each patient.

Methods: To this end, a mechanistic multiscale model of prostate tumor response to external radiotherapeutic schemes, based on a discrete entity and discrete event simulation approach has been developed.

Intermolecular interaction of AlO oxymetallic clusters in the detection of atmospheric pollutants: a DFT exploration of CO, CO, H, N, NO, NO, O, and SO, binding mechanisms.

Due to the lack of inherent geometric symmetry present in the structures of aluminum oxide clusters, determining their stable configuration becomes an exceedingly formidable task computationally. In this comprehensive analysis, we first propose the most stable state of AlO, determined through Density Functional Theory calculations at ωB97XD/Def2-TZVP level of theory. Multiple structural isomers were scrutinized for their stability and spin state, with the optimal structure determined using the bee colony algorithm for global optimization.

Reduction in locomotor activity and freezing time: A dual measure for more accurate fear response in rats.

Fear conditioning serves as a cornerstone behavioural test for modelling disorders, such as Post-Traumatic Stress Disorder (PTSD) and clinical anxiety, and for evaluating memory. The traditional measure of fear response, namely freezing time, might not encompass all expressions of fear behaviours, leading to potential exclusion of animals demonstrating 'resilient' responses. In this study, we sought to assess the combined utility of reduced locomotor activity and freezing time as a dual-measure for a more accurate evaluation of the fear response in Sprague-Dawley rats.

Critical care nurses' intention to leave and related factors: Survey results from 5 European countries.

Objectives: To determine the nursing intention to leave in critical care units and explore related factors along with work environment and sociodemographic variables.

Design And Setting: Quantitative cross-sectional study in five European countries (Spain, Poland, Croatia, Cyprus and Romania) through a self-administered survey in 2021.

Methods: The "AACN Critical elements of a healthy work environment scale.

The head position and cervical alignment in patients with Chiari malformation: A retrospective case-control study.

Aim And Background: This study aimed to investigate the relationship between cervical spinal alignment and the center of gravity (COG) of the head in patients with Chiari malformation (CM) compared to healthy individuals. CM is characterized by the herniation of posterior fossa structures through the foramen magnum, potentially affecting head positioning and craniovertebral junction biomechanics. Understanding these biomechanical changes is crucial for improving diagnostic and treatment strategies.

Aberrant enterocyte progenitor clustering as an early life biomarker of aging.

Stem cell accumulation and mutation-derived tumors are two hallmarks of midgut aging. They imply a decline in stem cell signaling homeostasis late in life and a robust homeostasis in young adults. Contrary to this, we find spontaneously developing stem-like cells that vary in size and ploidy, have a stem-enteroblast mixed identity, achieve higher mitotic rate per cell, exhibit DNA replication stress, and are inherently prone to clustering.

The protective role of self compassion in trauma recovery and its moderating impact on post traumatic symptoms and post traumatic growth.

This study examined the moderating effect of self-compassion on the relationship between post-traumatic symptoms (PTS) and post-traumatic growth (PTG) among adults with trauma exposure. A sample of 413 participants (254 women, 155 men) aged 18 to 81 years (M = 33.8; SD = 12.

Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project.

Background: Data standards are not only key to making data processing efficient but also fundamental to ensuring data interoperability. When clinical trial data are structured according to international standards, they become significantly easier to analyze, reducing the efforts required for data cleaning, preprocessing, and secondary use. A common language and a shared set of expectations facilitate interoperability between systems and devices.

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells.

Background: The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP).

Objective: To investigate the association between CNVs and structural forms on 17q.

Subtraction of Temporally Sequential Digital Mammograms: Prediction and Localization of Near-Term Breast Cancer Occurrence.

The objective is to predict a possible near-term occurrence of a breast mass after two consecutive screening rounds with normal mammograms. For the purposes of this study, conducted between 2020 and 2024, three consecutive rounds of mammograms were collected from 75 women, 46 to 79 years old. Successive screenings had an average interval of 2 years.

Determining Cognitive Performance in Athletes: A Systematic Review Focused on Methodology of Applying Cognitive Tests.

Although in recent years, there have been many studies to determine the cognitive performance of athletes, there are significant differences in the methodological approaches of these studies. Therefore, this methodology-focused systematic review aims to analyze the application methods of cognitive test studies with athletes and to provide standard recommendations for further studies. For this purpose, three electronic databases (Web of Science, PubMed, and Scopus) were searched using predetermined keywords.

Large Language Models in peri-implant disease: How well do they perform?

Statement Of Problem: Artificial intelligence (AI) has gained significant recent attention and several AI applications, such as the Large Language Models (LLMs) are promising for use in clinical medicine and dentistry. Nevertheless, assessing the performance of LLMs is essential to identify potential inaccuracies or even prevent harmful outcomes.

Purpose: The purpose of this study was to evaluate and compare the evidence-based potential of answers provided by 4 LLMs to clinical questions in the field of implant dentistry.

A dose escalation and safety study of AAVrh10-mediated Schwann cell-targeted gene therapy for CMT1X.

X-linked Charcot-Marie-Tooth disease (CMT1X) is an inherited demyelinating neuropathy caused by loss-of-function mutations in the GJB1 gene, encoding the gap junction protein connexin32 (Cx32). Cx32 plays a critical role in Schwann cell function and myelin formation in the peripheral nervous system. We have developed a gene replacement therapeutic approach using a humanized AAVrh10 vector construct expressing GJB1 under the control of the Schwann cell-specific human myelin protein zero (MPZ) promoter.

In vitro models: Can they unravel the complexities of cancer cell metastasis?

Metastasis still accounts for the majority of cancer-related deaths despite intense research efforts made worldwide to better understand the determinants involved and discover novel ways to halt it. However, studying the pathogenesis of metastasis in actual patients is indeed challenging which renders the need for the development of relevant experimental models urgent. Traditionally, several in vitro and in vivo models have been developed to study metastasis each of which having its own advantages and limitations.