Tedizolid for osteoarticular infections: evaluation of the published evidence.

Introduction: Tedizolid phosphate, an oxazolidinone antibiotic, has been approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). However, its off-label use has been reported in various infections, including osteoarticular infections.

Methods: A systematic review of data from PubMed, Scopus, and Web of Science was conducted to evaluate the antimicrobial activity, safety, and effectiveness of tedizolid in patients with bone and joint infections, including prosthetic joint infections, osteomyelitis, and septic arthritis.

A multi-omics analysis of effector and resting treg cells in pan-cancer.

Regulatory T cells (Tregs) are critical for maintaining the stability of the immune system and facilitating tumor escape through various mechanisms. Resting T cells are involved in cell-mediated immunity and remain in a resting state until stimulated, while effector T cells promote immune responses. Here, we investigated the roles of two gene signatures, one for resting Tregs (FOXP3 and IL2RA) and another for effector Tregs (FOXP3, CTLA-4, CCR8 and TNFRSF9) in pan-cancer.

Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition.

Peptide drug technologies offer powerful approaches to develop potent and selective lead molecules for therapeutic and research applications. However, new and optimized delivery approaches are necessary to overcome current pitfalls including fast degradation in cells and tissue. Extracellular signal-regulated kinases 1/2 (ERK1/2) exemplifies proteins that play crucial and varied roles within distinct cellular compartments.

Inherited rare epidermal growth factor receptor mutation and somatic mutations in patients with non-small cell lung cancer: a case report.

Background: Recent advances in molecular oncology have increasingly illuminated the role of germline EGFR mutations in non-small cell lung cancer (NSCLC). This case report presents the presence of a unique familial occurrence of EGFR mutations in patients with NSCLC.

Case Description: A mother and son, both never-smokers of Caucasian ethnicity, were diagnosed with advanced metastatic lung adenocarcinoma.

Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance.

The tumor microenvironment (TME) contains tumor cells, surrounding cells, and secreted factors. It provides a favorable environment for the maintenance of cancer stem cells (CSCs), the spread of cancer cells to metastatic sites, angiogenesis, and apoptosis, as well as the growth, proliferation, invasion, and drug resistance of cancer cells. Cancer cells rely on the activation of oncogenes, inactivation of tumor suppressors, and the support of a normal stroma for their growth, proliferation, and survival, all of which are provided by the TME.

Core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition disease: OMERACT delphi survey to establish consensus.

Objective: To agree on important domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition (CPPD) disease.

Methods: Patient research partners (PRPs) and other participants (mainly clinicians and researchers) contributed to three rounds of a consensus survey using Delphi methodology. Consensus was defined if ≥70% of both patients and other participants scored the domain as 'critically important domain to include'.

Placental interleukin 1β signaling in canine pregnancy: differential effects during and after decidualization in vitro.

Although implantation and parturition are associated with pro-inflammatory signals, inflammatory responses in the mature placenta frequently lead to pregnancy loss. Indeed, uterine inflammatory/infectious diseases are major causes of infertility and pregnancy loss in dogs. The pro-inflammatory interleukin (IL)-1β is increased during canine placentation and downregulated in mature placentae during healthy pregnancies, but is enriched in the placenta during infectious events.

Gingival thickness: effects on gingival wound healing.

Background: Although available evidence indicates that gingival thickness may affect periodontal surgical outcomes, there are no studies on the effect of gingival thickness on gingival excisional wound healing. This prospective study aimed to assess the effect of gingival thickness on the healing of standardized experimental gingival wounds.

Methods: Healthy non-smokers with thick or thin gingiva were recruited.

Tumor Asphericity in FDG PET Is an Independent Prognostic Parameter Improving Risk Stratification in Patients with Head and Neck Squamous Cell Carcinoma.

Tumor asphericity in F-FDG PET is a prognostic marker that has been investigated in small pilot studies of patients with head and neck squamous cell carcinoma (HNSCC). Here, we investigated the prognostic role of asphericity in a large multicenter database of patients with HNSCC treated with primary radiotherapy or chemoradiation and assessed its independent prognostic value. In total, 1,104 patients were included in this analysis.

Care pathways for patients with cognitive impairment and chronic kidney disease.

Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review the mutual consequences of CKD and CI on health outcomes and care pathways and highlight the complexities due to the involvement of different specialists. Our narrative review covers (i) the burden of CI among patients with CKD, (ii) the impact of CI on kidney health, (iii) access to kidney replacement therapy for people with CI, (iv) resources in cognitive care and (v) potential models for integrated 'nephro-cognitive' care.

Rings in Taylor Spatial Frame: Mechanical testing and finite element analysis.

Taylor Spatial Frame (TSF) is a type of hexapod external ring fixation system. TSF rings are supplied as half rings, whole full rings and two third rings in different sizes. In this work, these components as well as bolted full rings made of two half rings were tested in compression in two or three directions.

iBCS: 4. Application of the Inhalation Biopharmaceutics Classification System to the Development of Orally Inhaled Drug Products.

This is the fourth paper in a series describing an inhalation biopharmaceutics classification system (iBCS), an initiative supported by the Product Quality Research Institute. The paper examines the application of the inhalation Biopharmaceutics Classification System (iBCS) through the drug discovery, development, and postapproval phases for orally inhaled drug products (OIDP) and for the development of generic OIDPs. We consider the implication of the iBCS class in terms of product performance and identify the practical gaps that must be filled to enable the classification system to be adopted into day-to-day practice.

Comparison of the behaviour of pro-oxidant additive containing plastic degradation in the unmanaged natural environment and in the laboratory.

Pro-oxidant additive containing (PAC) plastics are designed to degrade in the unmanaged natural environment through oxidation and biological processes. In 2020, the British Standard Institution published the PAS 9017:2020 standard designed to ensure that PAC plastic tested under a specific set of protocols would successfully biodegrade in the environment. In this article, we compare the outcomes of laboratory tests carried out according to PAS 9017:2020 with field tests in an open unmanaged environment in the UK over 24 months.

Evaluating Risk in Kidney Living Donors.

Kidney donation is a safe procedure for carefully screened donors. The growing shortage of organs and improved survival rates among recipients of living donor transplants have broadened the criteria for acceptable living donors, including older individuals and those with pre-existing health conditions. Consequently, ensuring both the short- and long-term safety of living donors is of paramount importance.

Oral health protection and restorative approaches in the puerperal period.

There is a growing need for dental treatments in women during the puerperal period as a consequence of hormonal and physiological changes that occur. There are effective methods that dentists can apply while treating patients in the puerperal period and while ensuring the maintenance of treatment. The framework of these methods covers a wide range of subjects, from the examination and diagnosis process of the dentist to the treatment protocols and the oral hygiene motivation of the patient.

The Effect of Leisure-Time Exercise on Mental Health Among Adults: A Bibliometric Analysis of Randomized Controlled Trials.

Adequate levels of leisure-time exercise (LTE) are associated with mental health benefits. Despite increased research in recent years through randomized controlled trials (RCTs), a systematic literature review summarizing these findings is lacking. Here, we examined publication trends, impact, and research gaps regarding LTE's effects on mental health in the form of a bibliometric analysis.

The Implementation of a Blended Counseling Intervention in Undergraduate Engineering Students: The Effect on Mental Health.

The accelerating global concern for the mental health of university students necessitates delivering intervention programs. The purpose of this study is to evaluate the effectiveness of a 5-week blended counseling group program, with two integrated approaches, positive psychology intervention and cognitive therapy, toward undergraduate engineering students' depression, anxiety, and stress, from the Higher School of Pedagogical and Technological Education, Greece. Participants with a mean age of 21.

Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings.

T cells play diverse roles in cancer immunology, acting as tumor suppressors, cytotoxic effectors, enhancers of cytotoxic T lymphocyte responses and immune suppressors; providing memory and surveillance; modulating the tumor microenvironment (TME); or activating innate immune cells. However, cancer cells can disrupt T cell function, leading to T cell exhaustion and a weakened immune response against the tumor. The expression of exhausted T cell (Tex) markers plays a pivotal role in shaping the immune landscape of multiple cancers.

A project to define standards for radiology staffing, education and training across the European Union.

The European Union Radiation, Education, Staffing & Training (EU-REST) study was a European Commission-funded, 24-month project that analysed workforce availability, education and training needs to ensure quality and safety aspects of medical applications involving ionising radiation in the EU and developed staffing and education/training guidelines for key professional groups involved in ensuring radiation safety and quality of medical radiation applications in the EU Member States. This article outlines the origin, development, goals and overall structure of the project. CRITICAL RELEVANCE STATEMENT: This article provides a concise overview of the EU-REST project, which analysed the workforce availability of health professionals involved in the use of ionising radiation for diagnostic and therapeutic procedures and the corresponding education and training in radiation protection.

High temporal variability not trend dominates Mediterranean precipitation.

State-of-the-art climate models project a substantial decline in precipitation for the Mediterranean region in the future. Supporting this notion, several studies based on observed precipitation data spanning recent decades have suggested a decrease in Mediterranean precipitation, with some attributing a large fraction of this change to anthropogenic influences. Conversely, certain researchers have underlined that Mediterranean precipitation exhibits considerable spatiotemporal variability driven by atmospheric circulation patterns maintaining stationarity over the long term.

The relationship between diet, plasma glucose, and cancer prevalence across vertebrates.

Birds have higher plasma glucose concentrations but lower cancer prevalence than other vertebrates. However, this inverse relationship between glucose and cancer may not hold within vertebrate groups. Given that diet affects blood sugar levels, and carnivores have higher cancer risk than herbivores, we also examined whether diet correlates with plasma glucose concentrations.

Motor Learning-based Clinical Pilates Training for the Parkinson's Disease Rehabilitation @Parkinsonpilates: A Parallel Group, Randomised Controlled Trial with 3-Month Follow-up.

Objectives: To examine the effect of integrated motor learning clinical pilates protocol we developed for patients with Parkinson's Disease (pwPD) on providing enduring motor skills in walking, balance, reaction time, cadence, and functional mobility at 3-months follow-up.

Design: A parallel-group, randomized controlled trial (RCT).

Setting: XXX Medical Center, XXX, and XXX Physiotherapy and Rehabilitation Center, Nicosia.

Greening road transport: Comparison of technologies in conventional, hybrid, and electric vehicles.

The transportation sector is the primary catalyst for environmental deterioration on a global level. Growing concerns about environmental issues caused by the overuse of fossil fuels in this industry have prompted countries to prioritize eco-friendly and energy-efficient vehicles. Electric and hybrid vehicles offer a potential solution to the global challenge of meeting carbon neutrality objectives, especially in the transportation sector.

In memoriam: Carl J. Carrano : July 14, 1950-January 26, 2022.

This article is a celebration of the life and work of Carl J. Carrano who, from a childhood in Long Island, New York, built a career in bioinorganic chemistry, especially in the context of metal uptake and halogen metabolism in microbes and marine organisms.