Resources, support, and integration as potential barriers and facilitators to the implementation of blended therapy in the routine care of inpatients: a qualitative study.

While research on blended therapy (BT), i.e. the combination of face-to-face and digital treatment, has grown rapidly, integrating BT into routine practice remains limited, especially in inpatient settings.

Role of exosomes in dental and craniofacial regeneration - A review.

Background: The treatment of congenital deformities, traumatic injuries, infectious diseases, and tumors in the craniomaxillofacial (CMF) region is complex due to the intricate nature of the tissues involved. Conventional treatments such as bone grafts and cell transplantation face limitations, including the need for multiple surgeries, complications, and safety concerns.

Objective: This paper aims to provide a comprehensive analysis of the role of exosomes (EXOs) in CMF and dental tissue regeneration and to explore their potential applications in regenerative dental medicine.

Beyond Seizures: Psychiatric comorbidities in children with epilepsy.

Purpose: Children with epilepsy are at an increased risk of developing psychiatric comorbidities, which exacerbate the overall disease burden. However, these disorders are often underreported in developing countries. This study, conducted in a developing country, aims to evaluate the frequency of psychiatric disorders and associated factors in a large cohort of children with epilepsy.

Improved water resources management for smart farming: a case study for Cyprus.

Water-scarce areas are threatened by climate crisis and, thus, there is an urgent need for optimizing water resources management. Remote sensing has been widely used for calculating the evapotranspiration over large areas, which is an essential variable for calculating the actual irrigation needs of crops. The main objective of this work is to design an approach to optimize the irrigation needs for specific crops.

Recent methane surges reveal heightened emissions from tropical inundated areas.

Record breaking atmospheric methane growth rates were observed in 2020 and 2021 (15.2±0.5 and 17.

Associations between breastfeeding and self-reported experience of the "10 Steps to Successful Breastfeeding": a cross-sectional and longitudinal study of maternity clinic practices in Cyprus.

Objective: To assess the implementation of the "10 Steps for Successful Breastfeeding" and explore associations with any Breastfeeding (BF) and Exclusive Breastfeeding (EBF) initiation and continuation.

Methods: Implementation of the 10 Steps was assessed based on a consecutive sample of 568 mothers' self-reported experience across all public ( = 5) and 29 (of 35) private maternity clinics using the WHO/UNICEF BFHI questionnaire (Section 4) within the first 24-48 h after birth. BF and EBF were estimated within 48 h after birth as well as at 1st, 4th and 6th month based on a self-reported current status method.

Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.

Background: Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. It is the leading cause of dementia in older adults, marked by the pathological accumulation of amyloid-beta plaques and neurofibrillary tangles. These pathological changes lead to widespread neuronal damage, significantly impacting daily functioning and quality of life.

The effect of silymarin on diabetes mellitus-induced male rats reproductive impairment: Evidences for role of heat shock proteins 70 and 90.

Male fertility is adversely influenced by diabetes. The beneficial effects of antioxidant bioflavonoids in improving fertility have been reported. This study was conducted to evaluate the effects of silymarin on diabetes mellitus-induced male reproductive impairment in rats by investigating its role in Hsp70 and Hsp90 expression.

The Warburg Effect: Is it Always an Enemy?

The Warburg effect, also known as 'aerobic' glycolysis, describes the preference of cancer cells to favor glycolysis over oxidative phosphorylation for energy (adenosine triphosphate-ATP) production, despite having high amounts of oxygen and fully active mitochondria, a phenomenon first identified by Otto Warburg. This metabolic pathway is traditionally viewed as a hallmark of cancer, supporting rapid growth and proliferation by supplying energy and biosynthetic precursors. However, emerging research indicates that the Warburg effect is not just a strategy for cancer cells to proliferate at higher rates compared to normal cells; thus, it should not be considered an 'enemy' since it also plays complex roles in normal cellular functions and/or under stress conditions, prompting a reconsideration of its purely detrimental characterization.

Assigning (genus ) to Pseudoberkleasmiaceae (Dothideomycetes, Pleosporomycetidae, Pleosporales) and introducing as a novel species.

species are dematiaceous hyphomycetes that are characterised by acropleurogenous, dictyoseptate, campanulate or cheiroid, and brown to dark brown conidia that are composed of several layers of cells radiating from a protuberant basal cell, and mostly seen with appendages arising from the apical cells. The genus was introduced based on morphology to accommodate five of the six species that exhibited holoblastic conidial ontogeny. was referred to as Ascomycota genus as it was challenging to resolve its taxonomic placement based solely on the available morphological data (no DNA sequence data was previously available).

Description of two new species ( sp. nov and sp. nov.) (Tanaidacea: Crustacea) from the Mediterranean and a biogeographic overview of the genus.

The Mediterranean Sea is recognized as one of the most threatened marine environments due to pollution, the unintentional spread of invasive species, and habitat destruction. Understanding the biodiversity patterns within this sea is crucial for effective resource management and conservation planning. During a research cruise aimed at assessing biodiversity near desalination plants in the vicinity of Larnaca, Cyprus, conducted as part of the WATER-MINING project (Horizon 2020), specimens of the tanaidacean genus were collected.

Gatekeeping or Provider Choice for Sustainable Health Systems? A Literature Review on Their Impact on Efficiency, Access, and Quality of Services.

As early as 1978, the World Health Organization set primary healthcare as the basis on which health systems should be built worldwide. However, the health systems of the different countries show considerable variations in terms of the implementation of gatekeeping from primary to secondary healthcare and direct access to specialists and hospital care. This literature review attempts to present the gatekeeping system with references to the UK, Sweden, the Netherlands, and Germany compared to the situation in Greece, where no gatekeeping system exists.

Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a case report.

SANT is a rare, non-lymphoid, benign entity, originating from the red pulp of the spleen. It is characterized by the presence of vascular nodules surrounded by a stroma of collagen fibers. It was introduced as a distinct disease entity by Martel et al in 2004, after the histopathological examination of 25 cases.

Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.

Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.

Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.

from sheep herds around water tributaries of the Malakand region of Pakistan.

This study was designed to determine the prevalence of infections in sheep herds around tributaries in Pakistan and to evaluate the influence of potential risk factors. In total, 448 samples from 26 sheep herds were screened microscopically and then confirmed through polymerase chain reaction (PCR) amplification of the 18S SSU rRNA gene. Our result revealed that, out of 448 samples, 107 were found positive by microscopy and 77 positive by PCR, with prevalence rates of 23.

Factors contributing to road traffic accidents in the Gaza Strip a comprehensive analysis.

Road traffic crashes (RTCs) are considered one of the major public health issues in many countries worldwide. Investigating factors of traffic crashes, accidents, and disasters can facilitate and aid in identifying measures to mitigate their frequency and severity as well as occurrence and impact, thereby enhancing road safety. This study aims to investigate the factors that contribute to road traffic accidents in the Gaza Strip, Palestine.

Genetic epidemiology of amyotrophic lateral sclerosis in Cyprus: a population-based study.

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal degenerative disease of motor neurons, presenting with relentlessly progressive muscle atrophy and weakness. More than fifty genes carrying causative or disease-modifying variants have been identified since the 1990s, when the first ALS-associated variant in the gene SOD1 was discovered. The most commonly mutated ALS genes in the European populations include the C9orf72, SOD1, TARDBP and FUS.

Electro-bioremediation of wastewater: Transitioning the focus on pure cultures to elucidate the missing mechanistic insights upon electro-assisted biodegradation of exemplary pollutants.

Electro-bioremediation of exemplary water pollutants such as nitrogenous, phosphorous, and sulphurous compounds, hydrocarbons, metals and azo dyes has already been studied at a macro-scale level using mixed cultures. The technology has been generally established as a proof of concept at the technology readiness level (TRL) of 3, and there are already specific cases where the technology reached TRL 5. However, this technology is less utilized compared to traditional approaches.

Correction: The Cyprus Institute of Neurology and Genetics, an emerging paradigm of a gender egalitarian organisation.

[This corrects the article DOI: 10.1371/journal.pone.

Expression of GnRH, Kisspeptin, and Their Specific Receptors in the Ovary and Uterus in Deslorelin-Treated Late-Prepubertal Bitches.

In this study, the expression and localization of gonadotropin-releasing hormone (GnRH1) and kisspeptin (KISS1) and their specific receptors in canine ovarian and uterine tissues were investigated after the application of deslorelin acetate (Suprelorin, 4.7 mg, Virbac, France) in the late prepubertal period. We hypothesized that prolonged treatment of prepubertal dogs with deslorelin would alter the expression of GnRH and kisspeptin genes in the uterus and ovaries.

Three-Dimensional Thermal Tomography with Physics-Informed Neural Networks.

: Accurate reconstruction of internal temperature fields from surface temperature data is critical for applications such as non-invasive thermal imaging, particularly in scenarios involving small temperature gradients, like those in the human body. : In this study, we employed 3D convolutional neural networks (CNNs) to predict internal temperature fields. The network's performance was evaluated under both ideal and non-ideal conditions, incorporating noise and background temperature variations.

The Effect of Intraset Rest Periods on External and Internal Load During Small-Sided Games in Soccer.

The purpose of this study was to compare the internal and external load in continuous and intermittent small-sided games (SSG) formats. Eight semi-professional soccer players participated in the study, and they completed three protocols: (a) I-intermittent SSG protocol (Int-I, 4 sets of 4 min with a 3 min recovery); (b) Continuous SSG protocol (Con, 2 sets of 8 min with a 3 min recovery); (c) II-SSG protocol (Int-II, 4 sets of 4 min, where each set includes 1 min of exercise with varying recovery periods (10, 20, 30 s), with a 3 min recovery period between sets). A one-way analysis of variance (ANOVA) was used to analyze the dependent variables, with significance determined at < 0.