126 results match your criteria: "Cutaneous Manifestations of Smoking"

Article Synopsis
  • * A case study describes a 71-year-old man from Mexico with a history of smoking, diabetes, and hypertension, who developed a widespread skin condition that was later diagnosed as miliary cutaneous tuberculosis.
  • * Diagnosis was confirmed through histopathological exam showing specific cells and bacteria, and the patient began treatment, highlighting the need for quick and accurate diagnosis in those with weakened immune systems.
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Article Synopsis
  • The study focuses on differentiating perianal issues caused by hidradenitis suppurativa (HS) and perianal fistulizing inflammatory bowel disease (IBD), as they often present similar symptoms.
  • A retrospective review of patient data at the Mayo Clinic identified 15 key clinical features using machine learning to help distinguish between HS and IBD cases.
  • Findings revealed significant differences in symptoms, with HS patients showing more skin-related issues and IBD patients experiencing additional gastrointestinal symptoms, which may lead to better diagnosis and treatment strategies.
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Article Synopsis
  • Diffuse dermal angiomatosis (DDA) is a rare, benign skin condition that mainly affects middle-aged women, particularly on the breasts.
  • The case discussed involves a 56-year-old woman with bilateral DDA linked to risk factors like smoking that cause tissue hypoxia.
  • Addressing the hypoxic factors led to the healing of the ulcers associated with DDA, suggesting that managing these risks can improve the condition.
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  • - Atopic dermatitis (AD) is a common chronic skin condition that not only affects the skin but also leads to mental health issues and reduced quality of life, with a noted increased prevalence of addictive disorders among affected individuals.
  • - A study conducted with 208 AD patients in Munich aimed to assess the prevalence of various addictive behaviors while examining risk factors linked to these conditions.
  • - Findings indicated that younger AD patients were more prone to addictions, with notable percentages displaying issues like smoking (14.9%), critical alcohol use (15.4%), compulsive internet use (16.8%), and drug abuse (5.8%).
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  • - NF1 is a genetic disorder that primarily affects the skin and neurological systems, but it can also lead to severe pulmonary issues, such as lung cysts and emphysematous bullae, which increase the risk of spontaneous pneumothorax (SSP).
  • - A case study of an 18-year-old male with NF1 illustrates how he developed a right-sided pneumothorax due to ruptured lung bullae, which was successfully treated, highlighting the need for awareness of pulmonary complications in NF1.
  • - Recognizing and diagnosing lung problems early in NF1 patients is essential, as surgical removal of cysts and bullae can help prevent recurrent SSP and improve patient outcomes.
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Article Synopsis
  • * Common skin issues in RA patients include nodules, dermatoses, vasculitis, and vasculopathy, which can cause additional health challenges beyond joint pain.
  • * Treatment for these skin-related manifestations often includes medications like corticosteroids and biologics, tailored to the severity of the disease, with the goal of enhancing early diagnosis and patient quality of life.
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Article Synopsis
  • Lung cancer is very common and it causes many deaths, but it's rare for it to spread to the skin.
  • A 53-year-old man who smoked and had breathing problems found a lump under his skin, and tests showed it was from lung cancer.
  • Sadly, even with treatment, he only lived three more months, showing that skin spread from lung cancer is usually a sign that the disease is really serious.
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Article Synopsis
  • Systemic lupus erythematosus (SLE) often affects the lungs, and the study investigates the significance of diffusing capacity of the lungs for carbon monoxide (DLCO) in evaluating lung function in SLE patients.
  • A retrospective analysis of 232 SLE patients revealed that 66.4% experienced DLCO alterations, which were linked to factors such as smoking history, interstitial lung disease, and renal or neurological involvement.
  • The findings indicate that DLCO alterations may serve as a prognostic indicator for severe disease outcomes, including ICU admissions and increased mortality, suggesting a connection to SLE-related vascular damage.
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Article Synopsis
  • Some patients may show unusual symptoms that could be related to a condition called porphyria, which is inherited and affects how the body processes certain chemicals.
  • Acute intermittent porphyria (AIP) is a specific type of porphyria that can cause severe symptoms like stomach pain and confusion, especially triggered by certain stresses like drugs or trauma.
  • A case of AIP in a burn patient showed these symptoms, and after several tests, it was found that he had high levels of harmful substances, which contributed to his complications and eventual death.
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  • Birt-Hogg-Dubé syndrome (BHD) is a rare genetic disorder that can cause lung cysts and sometimes leads to lung problems, skin growths, and kidney cancer.
  • It's more common in some countries like China, but many people don't get diagnosed quickly or correctly.
  • Experts have made 15 recommendations to help with diagnosis and treatment, and genetic tests can help identify the cause of the syndrome in families.
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Rheumatoid vasculitis in 2023: Changes and challenges since the biologics era.

Autoimmun Rev

September 2023

Service de rhumatologie, INSERM UMR-S1109, Hôpital de Hautepierre, 1 Avenue Molière BP 83049, 67098 Strasbourg Cedex, France; Centre National de Référence des Maladies Auto-immunes Systémiques Rares Est Sud-Ouest (RESO)-LUPUS, European Reference Networks (ERN) ReCONNET and RITA, France.

Background: Significant changes in the epidemiology and natural history of rheumatoid vasculitis (RV) have occurred with the introduction of biological therapies such as TNF inhibitors (TNFi) and rituximab.

Purpose: This scoping review aims to address the key current challenges and propose updated criteria for RV. This will aid future descriptive observational studies and prospective therapeutic trials.

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Reticular Oral lichen planus (OLP) is a chronic autoimmune disease that presents as fine, white, linear and lace like lesions of the oral cavity referred to as Wickham striae. The clinical characteristics of 30 patients with reticular oral lichen planus is presented so that cases are not missed/misdiagnosed by ENT surgeons. The clinical records noted for each patient were gender, age and clinical presentation of reticular OLP (site affected, presence of symptoms and extraoral manifestations of the disease, smoking habit, and consumption of alcoholic beverages).

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Article Synopsis
  • The COVID-19 pandemic significantly impacted global health and economics, later discovered to cause a variety of symptoms beyond respiratory issues, including skin-related manifestations.
  • The study aimed to investigate the occurrence and types of skin issues in hospitalized moderate-to-severe COVID-19 patients, as well as the potential implications for their recovery or mortality.
  • Among 821 patients analyzed, 7.55% presented with skin rashes, with the majority developing these rashes post-admission, highlighting a range of reactions, particularly reactive erythemas and vascular issues related to the virus.
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Article Synopsis
  • Hidradenitis suppurativa (HS) is a chronic skin condition that causes painful abscesses and scarring in areas where skin rubs together, linked to immune system dysfunction.
  • The condition disproportionately affects women, with a female-to-male ratio of about 3:1, highlighting potential sex-related factors in its development.
  • The article explores how factors like hormones, genetics, the microbiome, and lifestyle choices like smoking might influence immunity differences between sexes and contribute to the prevalence of HS in women.
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Article Synopsis
  • A rare case is reported where an elderly male presented with a solitary scalp metastasis that turned out to be the first sign of underlying lung cancer.* -
  • The case highlights the need for physicians to recognize unusual clinical signs of visceral malignancies and the importance of prompt diagnostic testing for accurate diagnosis and treatment.* -
  • It is essential to consider skin lesions as potential indicators of lung cancer metastasis, especially in patients with a smoking history or known lung cancer, as these cases often predict a poor prognosis.*
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Article Synopsis
  • Cutaneous lupus erythematosus (CLE) is an autoimmune skin condition closely related to systemic lupus erythematosus (SLE), which can appear either alongside or separately from SLE symptoms.
  • There are three main types of CLE: acute cutaneous lupus erythematosus (ACLE), subacute cutaneous lupus erythematosus (SCLE), and chronic cutaneous lupus erythematosus, which includes discoid lupus erythematosus (DLE), each with distinct appearances and varying associations with SLE.
  • Diagnosis involves clinical evaluation and skin biopsy, with management strategies focusing on minimizing risk factors, using UV protection, and employing topical and systemic therapies as necessary.
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as a differential diagnosis for limb ulcers: case report.

J Vasc Bras

September 2022

Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP, Faculdade de Medicina, Campus de Botucatu, Botucatu, SP, Brasil.

Article Synopsis
  • Bullosis diabeticorum (BD) is a rare skin condition associated with diabetes, characterized by painless bloody blisters that can develop into necrotic ulcers, particularly affecting the upper limbs.
  • A case study of a 77-year-old man with poor diabetes control and hypertension showed lesions that progressed from blisters to ulcers, leading to a biopsy that confirmed BD.
  • Treatment involved smoking cessation, better blood sugar management, and topical corticosteroids, resulting in improvement and healing of the lesions.
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Article Synopsis
  • - Aortoiliac occlusive disease (AIOD) is a severe condition linked to factors like advanced atherosclerosis, diabetes, and smoking, often leading to obstructive blood flow issues in the lower limbs.
  • - Two Caucasian patients experienced painful ulcers on their legs and claudication, with severe blockages in their aorta and iliac arteries confirmed by angiography and ultrasonography.
  • - Early detection and surgical intervention significantly enhance patient outcomes by improving both quality of life and the chances of saving affected limbs.
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Article Synopsis
  • The study analyzed clinical data from 1,958 head and neck cancer patients to examine paraneoplastic syndromes (PNS) and their impact on diagnosis and prognosis.
  • Out of these, 40 patients had PNS, primarily dermatologic, with a mean age of 60.4 years, and the majority were in advanced cancer stages (III/IV).
  • Results indicated that early detection of PNS was associated with better overall survival and disease-free survival rates, highlighting the importance of recognizing these syndromes for improving patient outcomes.
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Article Synopsis
  • Cutaneous lupus erythematosus (CLE) is a skin-related condition linked to systemic lupus erythematosus (SLE), requiring evolving treatment approaches for moderate to severe cases.
  • Anifrolumab, a monoclonal antibody that targets the IFN-α receptor 1, has shown promise in treating patients with resistant CLE and has been approved based on positive clinical trial results.
  • A case series involving three patients treated with anifrolumab for at least 12 weeks revealed significant improvements in skin symptoms and appearance, highlighting its potential as an effective treatment for those unresponsive to standard therapies.
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[Association of skin lesion severity with clinical features of psoriatic arthritis].

Zhonghua Nei Ke Za Zhi

July 2022

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.

Article Synopsis
  • The study aimed to explore how the severity of psoriasis impacts various clinical features in patients with psoriatic arthritis (PsA) by analyzing data from the Chinese REgistry of Psoriatic ARthritis (CREPAR).
  • Out of 1,074 participants, 106 (9.9%) had severe psoriasis, which was linked to increased joint involvement, more frequent nail disease, higher smoking rates, and a greater occurrence of hypertension compared to those with non-severe psoriasis.
  • Patients with severe psoriasis also showed higher levels of inflammatory markers (ESR and CRP), as well as worse scores on disease activity assessments and health status, indicating a greater disease burden for those with severe skin
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Focus on the Contribution of Oxidative Stress in Skin Aging.

Antioxidants (Basel)

June 2022

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.

Article Synopsis
  • Skin aging shows up as wrinkles, less elasticity, and rough texture, while photoaged skin has uneven color and more deep wrinkles.
  • Aging skin gets damaged by things like pollution and sun exposure, which lead to an imbalance in the skin's natural defenses and healing abilities.
  • The review talks about how oxidative stress is a big reason for skin aging and highlights the role of both internal processes and outside factors in this natural process.
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