1,453 results match your criteria: "Cutaneous Horn"
Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.
Cancer Cell
December 2024
Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
Immunosuppression commonly disrupts the homeostasis of mutated normal skin, leading to widespread skin dysplasia and field cancerization. However, the immune system's role in maintaining the normal state of mutated tissues remains uncertain. Herein, we demonstrate that T cell immunity to cutaneotropic papillomaviruses promotes the homeostasis of ultraviolet radiation-damaged skin.
View Article and Find Full Text PDFArticle Synopsis
- Cutaneous melanoma (CM) and non-melanoma skin cancer (NMSC) rates are increasing in postmenopausal women, but the impact of vitamin A on their risk remains unclear.
- A study of 52,877 White women found no link between total vitamin A intake and melanoma risk; however, higher dietary vitamin A and beta-cryptoxanthin were correlated with an increased risk of NMSC.
- The findings suggest that while vitamin A does not lower CM or NMSC risk, higher dietary intakes may actually increase NMSC risk in this demographic.
A Case of Basal Cell Carcinoma Exacerbated with Akatsuki Disease.
Dermatopathology (Basel)
November 2024
Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku 783-8505, Kochi, Japan.
Akatsuki disease (also known as pomade crust) is characterized by skin lesions resulting from inadequate skin hygiene. It is sometimes influenced by underlying psychological factors. Akatsuki disease sometimes mimics cutaneous horn or skin cancer.
View Article and Find Full Text PDFClinical and histopathological features of advanced cutaneous squamous cell carcinoma with varying responses to cemiplimab.
J Dtsch Dermatol Ges
November 2024
Department of Dermatology, Venereology und Allergology, University Medical Center Leipzig, Leipzig, Germany.
Background: Most patients with unresectable locally advanced cutaneous squamous cell carcinoma (cSCC) benefit from cemiplimab, but some do not respond. Our study aims to identify clinical and histopathological features predicting response to cemiplimab.
Patients And Methods: We analyzed 15 patients treated with cemiplimab, assessing clinical, demographic, histopathological, and immunohistochemical characteristics and correlating them with treatment response.
Nodular Melanoma Presenting with Cutaneous Horn and Displaying Rhabdoid Features: An Unusual Presentation.
J Coll Physicians Surg Pak
November 2024
Department of Pathology, Faculty of Medicine, Duzce University, Duzce, Turkiye.
Article Synopsis
- Null can signify the absence of a value or a concept in programming and mathematics.
- It often indicates that a variable has no assigned data or an object is uninitialized.
- In philosophical terms, null might refer to the idea of non-existence or emptiness.
Pediatric Eyelid Cutaneous Horns: A Case Series and Literature Review.
Am J Ophthalmol
January 2025
From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children (R.B., A.M.A., K.M., A.A.), Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto (R.B., A.M.A., K.M., A.A.), Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- - The study examines the clinical and histopathologic characteristics of eyelid cutaneous horns in five pediatric patients, with a focus on information from patient records and literature review.
- - Results showed that all lesions resolved either surgically or conservatively, with the average patient age being 6.6 years, and no signs of malignancy were found during histologic evaluations.
- - The findings suggest that pediatric eyelid cutaneous horns are linked to inflammatory conditions like hordeolum or chalazion and are generally benign, differing from adult cases that often involve neoplastic changes.
Digital Cutaneous Horn.
Am J Med
January 2025
Olympic Medical Center, Port Angeles, Wash; Washington State University Elson S. Floyd School of Medicine, Spokane. Electronic address:
Pilomatricoma presenting as a giant cutaneous horn in an 8-year-old child: A case report and literature review.
SAGE Open Med Case Rep
September 2024
Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- A case study involved an 8-year-old boy who had a large, recurrent skin horn on his neck, which was successfully treated through surgery.
- The findings suggest that "perforating pilomatricoma," characterized by skin horn formation, should be recognized as a possible diagnosis for kids showing similar symptoms.
Cutaneous Horn Over the Nose.
J Cutan Med Surg
August 2024
Department of Dermatology, MGMCRI Campus, Sri Balaji Vidyapeeth Deemed University, Puducherry, India.
Verrucous Cyst with Cutaneous Horn.
Indian Dermatol Online J
April 2024
Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Cutaneous Metaplastic Synovial Cyst Presenting as a Cutaneous Horn.
Am J Dermatopathol
November 2024
Department of Dermatology, Minhang Hospital, Fudan University, Shanghai, China.
Photobiomodulation inhibits neuronal firing in the superficial but not deep layer of a rat spinal dorsal horn.
Biochem Biophys Res Commun
May 2024
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.
Article Synopsis
- Photobiomodulation (PBM) is being investigated as a treatment for chronic pain, particularly its effects on neuronal firing in different layers of the spinal dorsal horn.
- Previous studies showed PBM effectively inhibits pain-related neuronal activity in the superficial layers but its impact on deeper layers receiving innocuous stimuli was not well understood.
- This study found that while PBM reduced pain-related firing in the superficial layers significantly, it did not alter firing rates in the deep layers, indicating PBM's potential to alleviate pain without compromising the sense of touch.
Increased Systemic Levels of Centrally Acting B-Type Natriuretic Peptide Are Associated with Chronic Itch of Different Types.
J Invest Dermatol
October 2024
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, Miller School of Medicine, University of Miami, Miami, Florida, USA. Electronic address:
Article Synopsis
- B-type natriuretic peptide (BNP) is a neuropeptide associated with various types of itch, showing elevated levels in patients undergoing hemodialysis.
- A study evaluated BNP and N-terminal pro-BNP levels in patients with chronic itch and found a correlation between these levels and itch severity, particularly in those with chronic pruritus of unknown origin.
- Experiments in mice confirmed that increased BNP levels lead to significant scratching, supporting the idea that BNP could play a central role in itch signaling in the spinal cord.
Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.
Neuron
April 2024
Cell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; W.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA. Electronic address:
Article Synopsis
- Sensory feedback is crucial for motor control, but the specific neural circuits involved are not well understood; this study focuses on the medial deep dorsal horn of the mouse spinal cord as a key area for integrating proprioceptive and cutaneous signals.
- Researchers identify glycinergic inhibitory neurons that express parvalbumin in this region and demonstrate their role in processing converging sensory inputs to shape neural activity.
- By targeting these parvalbumin-expressing interneurons, the study shows they inhibit motor networks and affect limb movements, suggesting they play a significant role in coordinating smooth and contextually appropriate motor responses.
Comparative study of permeation effects between vibrating microneedle and low-frequency sonophoresis systems.
Drug Deliv Transl Res
November 2024
College of Pharmacy, Hangzhou Medical College, Hangzhou, 310014, China.
Article Synopsis
- Microneedles and low-frequency ultrasound are two methods used to enhance drug penetration through the skin, and this study compares their effectiveness using the drug tetramethylpyrazine hydrochloride (TMPH).
- In laboratory experiments with rat skin, results showed that vibrating microneedles significantly increased TMPH permeability, achieving up to a 41.92-fold increase with optimal settings.
- Although low-frequency ultrasound also enhanced TMPH penetration, it only produced a 4.34-fold increase under specific conditions, indicating that vibrating microneedles are the more effective method for transdermal drug delivery.
Treated Primary Cutaneous Malignant Melanoma With Later Metastasis Found in Clinical Presentation of Left Axilla Lymphadenopathy: A Case Report.
Cureus
February 2024
Interventional Radiology, St. Vincent's Medical Center, Jacksonville, USA.
Article Synopsis
- The patient had a noticeable mass in her armpit, which was identified as metastasis, and distinguishing it from a primary breast cancer was challenging.
- Key diagnostic tools like biopsy and specific immunohistochemical markers (S100 and Sox10) were vital in confirming the cancer's origin, highlighting the need for thorough assessments for melanoma patients, as breast metastases often lead to a worse prognosis.
A Posteromedial Portal Allows Access to the Posteromedial Knee, While a Posterolateral Portal Risks Common Fibular Nerve Injury: A Cadaveric Analysis.
Arthrosc Sports Med Rehabil
February 2024
Burjeel Hospital for Advanced Surgery, Dubai, United Arab Emirates.
Article Synopsis
- The study aimed to explore the safety and accessibility of direct posterior arthroscopy portals in the knee using cadaveric specimens.
- Of 95 formalin-embalmed and 9 fresh-frozen knees tested, the risk of neurovascular damage was found to be 9.6%, primarily associated with the lateral cannula.
- While the medial portal was generally safe, the lateral portal posed significant risks, particularly affecting the common fibular nerve, making its use not recommended at this time.
Actinic keratoses and squamous cell carcinoma limited to photo-exposed skin in vitiligo vulgaris in pigmented skin type.
BMJ Case Rep
January 2024
Dermatology and Venereology, All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Orissa, India
Article Synopsis
- Vitiligo patients typically have fewer melanocytes, which theoretically increases their risk for non-melanoma skin cancers, but studies in Caucasians have shown lower incidences of such cancers in these patients.
- A rare case in India describes an older woman with long-standing vitiligo who developed actinic keratoses and squamous cell carcinoma in sun-exposed vitiligo patches, highlighting a need for more local research.
- The patient received treatment for her lesions and was advised on lifestyle changes, emphasizing the importance of sunscreen use and protective clothing, especially considering many Indian patients may not prioritize sun protection due to financial limitations.
Single-Photon Emission Computed Tomography/Computed Tomography Utilization for Extremity Melanomas at a High-Volume Center.
J Surg Res
April 2024
Huntsman Cancer Institute, Salt Lake City, Utah; Department of Surgery, University of Utah, Salt Lake City, Utah. Electronic address:
Article Synopsis
- Planar lymphoscintigraphy (PL) is used to map sentinel lymph nodes (SLNs) before a biopsy in melanoma patients, with a new protocol adding SPECT/CT imaging for better anatomical detail.
- A study analyzed data from 380 patients with extremity melanoma, comparing outcomes between those who received both SPECT-CT and PL versus those who received only PL.
- The results showed that SPECT-CT significantly increased the chances of detecting SLNBs in "nontraditional" nodal basins without affecting the number of SLNs removed or the positivity rate.
Novel Pathogenic C5 Gene Variants in a Patient with Neisseria Meningitis and Diffuse Cutaneous HSV-1 Infection.
J Clin Immunol
January 2024
Department of Allergy and Immunology, Walter Reed National Military Medical Center, 4944 North Palmer Road, Bethesda, MD, 20814, USA.
Specific and Nonuniform Brain States during Cold Perception in Mice.
J Neurosci
March 2024
Physics for Medicine Paris, INSERM, ESPCI Paris, CNRS, PSL Research University, Paris 70015, France
Article Synopsis
- Researchers are studying how the brain processes temperature signals, focusing on the spinal cord's dorsal horn as the initial point for encoding this thermal information.
- Using functional ultrasound imaging, the study observed brain activity in awake male mice exposed to different temperatures, uncovering a unique response pattern between the somatomotor-cingulate cortices and the hypothalamus.
- The findings suggest that the brain has a shared hub for processing temperature sensations, with the cingulate areas linked to emotional responses, especially during colder temperatures, which disrupts connectivity with the hypothalamus.
Cutaneous Horn Presentation in Porokeratotic Eccrine Ostial and Dermal Duct Nevus. A Brief Review and Case Report.
Am J Dermatopathol
March 2024
Department of Pathology, IMSS Hospital de Especialidades, Centro Médico Nacional "Manuel Ávila Camacho", Puebla.
Article Synopsis
- Porokeratotic eccrine ostial and dermal duct nevus is a rare skin growth that features a cornoid lamella specifically over eccrine sweat glands.
- The article discusses a case study of a 6-year-old girl who was diagnosed with this condition, confirmed through a histopathologic examination.
- The girl exhibited unusual white, wart-like growths on the front side of her right hip, resembling a cutaneous horn.
Characterization of T-Helper Immune Phenotype in Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) Endorses a Delayed-Type Hypersensitivity Reaction.
Am J Dermatopathol
February 2024
Pathologist, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Article Synopsis
- SDRIFE is a unique skin reaction to drugs, characterized by red patches mainly in the groin and buttock areas, but its exact cause is not well understood.
- This study compared the immune responses in SDRIFE with those in psoriasis and eczema by analyzing specific immune cell types using skin samples.
- Results showed that SDRIFE has a distinctive immune response, with lower Th2 levels and a Th1-dominated profile, suggesting it may help guide future treatments and understanding of SDRIFE as a type of allergic reaction.
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus.
J Headache Pain
December 2023
Université Clermont Auvergne, CHU Clermont-Ferrand, Inserm/UCA U1107, Neuro-Dol: Trigeminal Pain and Migraine, Faculté de Chirurgie Dentaire, 2 Rue de Braga, 63100, Clermont-Ferrand, France.
Article Synopsis
- Migraine is a neurological disorder causing recurrent headaches and sensory symptoms, with central sensitization linked to pain modulation from the locus coeruleus (LC), which can be normalized by propranolol, a common preventive migraine medication.
- In a study with rats, researchers observed that the LC and trigeminocervical complex (TCC) show synchronized activity, but this connection is disrupted during trigeminal sensitization triggered by inflammation.
- Propranolol's action involves microinjections into the LC, which help reduce trigeminal sensitization by altering the activity patterns in these brain regions, indicating a significant role of their interaction in migraine pathology.