103 results match your criteria: "Cutaneous Cholesterol Emboli"
An 80-year-old man presented to our hospital with worsening renal function and ambulation difficulties due to lower extremity symptoms that included livedo reticularis, gangrene, cyanosis, and ulcers in his legs. The patient was diagnosed with a cholesterol crystal embolism. Treatment with prednisolone and rosuvastatin was initiated; however, no improvements were observed in the patient's cutaneous symptoms or renal function.
View Article and Find Full Text PDFOcclusive cutaneous vasculopathies as cause of chronic ulcers.
J Dtsch Dermatol Ges
April 2024
Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Article Synopsis
- Occluding vasculopathies are a group of conditions that often cause skin ulcers, particularly leg ulcers.
- This article focuses on livedoid vasculopathy and calciphylaxis as important types of occlusive vasculopathies relevant for diagnosing leg ulcers.
- Diagnosis involves identifying specific skin signs, like livedo racemosa, and confirming through tissue samples and lab tests to differentiate from other skin conditions.
Dermatological Lesions of Cholesterol Embolisation Syndrome and Kaposi Sarcoma Mimic Primary Systemic Vasculitis: Case report study.
Sultan Qaboos Univ Med J
May 2023
College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Article Synopsis
- Primary systemic vasculitis can show a variety of symptoms, including general issues like fever and body aches, as well as specific organ damage.
- The text describes two cases that mimic primary systemic vasculitis: cholesterol embolisation syndrome and Kaposi sarcoma, both displaying symptoms like blue toe syndrome and skin rashes.
- The report emphasizes the difficulty of diagnosing these conditions accurately and aims to provide guidance on how to differentiate them from primary systemic vasculitis.
A case of cholesterol embolization syndrome mimicking rapidly progressive renal failure causing end-stage kidney disease.
Saudi J Kidney Dis Transpl
May 2022
Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India.
Article Synopsis
- Cholesterol embolization syndrome is a rare issue that can happen after a heart procedure called coronary angioplasty.
- It can cause symptoms that look like other illnesses, making it hard to diagnose unless doctors do a tissue biopsy.
- In this case, a middle-aged man developed serious problems with his skin and kidneys shortly after the procedure, leading to toe amputation and needing regular dialysis for his kidneys.
Incidence, Risk Factors, and Prognosis of Cholesterol Crystal Embolism Because of Percutaneous Coronary Intervention.
Am J Cardiol
March 2022
Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan.
Article Synopsis
- Cholesterol crystal embolism (CCE) is a rare but serious complication that can occur after percutaneous coronary intervention (PCI), with an incidence rate of 0.38% among 23,184 patients studied from 2000 to 2019.
- The study identified age ≥70 years, presence of aortic aneurysm, and a femoral approach as positive risk factors for developing CCE, while using an inner sheath was found to be a protective factor.
- CCE leads to a significant risk of mortality (10% within a year) and the need for chronic hemodialysis (11%), highlighting the importance of recognizing high-risk patients before PCI to mitigate these risks.
Fatal Course of Cutaneous Cholesterol Embolization Syndrome: A Case Report.
Int J Low Extrem Wounds
December 2023
Medisch Spectrum Twente, Netherlands.
Article Synopsis
- - Cholesterol embolization syndrome is a serious and often overlooked complication that can occur after procedures like endovascular interventions or thrombolytic therapies, leading to serious health issues involving abdominal organs and skin.
- - In this reported case, the patient experienced severe skin ulceration and necrosis following treatment, eventually resulting in the amputation of both legs after unsuccessful initial interventions.
- - Despite treatment efforts, including prednisone, the patient died from sepsis and renal failure, highlighting the need for timely diagnosis and management of cholesterol embolization syndrome in patients with increasing skin necrosis even after successful arterial revascularization.
Cutaneous Cholesterol Embolization to the Lower Trunk: An Underrecognized Presentation.
Cutis
March 2021
Virginia Commonwealth University, Richmond. Dr. Brinster is from the Departments of Dermatology and Pathology; Dr. Levy is from the Department of Surgery, Division of Vascular Surgery; and Dr. Awadalla is from the Department of Dermatology.
Cutaneous Polymer-Coating Embolism After Endovascular Procedures: Report of Two Cases and a Literature Review.
Am J Dermatopathol
September 2021
Departments of Pathology.
Article Synopsis
- * The most frequently affected organs from this complication are the lungs and central nervous system, while skin embolization is rare and usually presents as asymptomatic skin lesions.
- * The study highlights two cases of skin lesions resulting from polymer embolization after vascular surgeries, where biopsies confirmed the presence of foreign material, and the lesions healed without special treatment.
Article Synopsis
- Acute Peripheral and/or Cutaneous Ischemic Syndrome (APCIS) refers to limb and skin necrosis that can arise from various underlying health issues or sometimes from unknown causes.
- The condition can be linked to mechanisms such as vessel wall diseases, embolic events, local blood clots, and certain blood disorders, which complicate diagnosis and treatment.
- The text discusses five cases of APCIS, particularly interesting for rheumatologists, and suggests an initial diagnostic approach along with a treatment plan that includes full-dose anticoagulation and immunosuppressive therapy.
Mimics of vasculitis.
Rheumatology (Oxford)
January 2021
Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, USA.
Article Synopsis
- - Prompt diagnosis of vasculitis is crucial, but it's equally important to identify conditions that can mimic it, as some have similar symptoms and effects.
- - Mimicking conditions can include infections, genetic disorders, and specific vascular issues that affect different-sized blood vessels and may lead to complications like aneurysms or skin and brain problems.
- - A systematic approach is needed to accurately differentiate between true vasculitis and its mimics, as misdiagnosis can lead to severe consequences for patient health.
Cholesterol Embolization Syndrome After Carotid Artery Stenting Associated with Delayed Cerebral Hyperperfusion Intracerebral Hemorrhage.
World Neurosurg
October 2020
Neuroendovascular Therapy Center, Aichi Medical University, Aichi, Japan; Department of Neurosurgery, Aichi Medical University, Aichi, Japan.
Article Synopsis
- Cholesterol embolization syndrome (CES) occurs when cholesterol crystals from atheromatous plaques in large vessels are released, leading to damage in multiple organs.
- A patient with CES exhibited skin symptoms like blue toes, along with kidney and neurological issues after receiving carotid artery stenting.
- Early identification and treatment of CES are crucial to lower the risks of severe complications, including intracerebral hemorrhage caused by delayed cerebral hyperperfusion syndrome.
[Cholesterol crystal embolism mimicking a DRESS].
Rev Med Interne
April 2020
Service de dermatologie, hôpital René Dubos-Pontoise, 6, avenue de l'île de France, 95300 Pontoise, France.
Article Synopsis
- Cholesterol crystal embolism (CCE) can cause skin issues when cholesterol crystals block small arteries, leading to ischemia, and this case was misdiagnosed as a drug reaction known as DRESS.
- A 66-year-old woman developed severe skin redness (erythroderma) and kidney failure shortly after starting allopurinol, along with high eosinophil counts, which initially suggested DRESS.
- Ultimately, tests ruled out DRESS, revealing instead that her skin symptoms were linked to chronic hypereosinophilia rather than artery blockage, marking this case as unique in presenting CCE with symptoms reminiscent of DRESS.
[Benign Presentation of a Potentially Fatal Disease].
Rev Port Cir Cardiotorac Vasc
July 2019
Medicina Geral e Familiar, Unidade de Saúde Familiar São Martinho, Penafiel, Portugal.
Article Synopsis
- * The abdominal aorta is the primary source of these cholesterol emboli, while peripheral arteries are less commonly involved.
- * This paper discusses three spontaneous cases of atheroembolism with skin symptoms and emphasizes the importance of recognizing its signs for timely diagnosis and treatment.
Successful treatment of a cutaneous ulcer due to cholesterol crystal embolization with topical basic fibroblast growth factor.
Eur J Dermatol
April 2017
Department of Dermatology Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Showa-ku Nagoya 466-8550, Japan.
Occlusive Nonvasculitic Vasculopathy.
Am J Dermatopathol
September 2017
*Associate Staff of the Department of Dermatology, Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autónoma, Madrid, Spain; †Associate Staff of the Department of Dermatology, Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain; ‡Director of Dermatopathology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain; §Director of Dermatopathology, Dermatopathology Research Unit, Medical University of Graz, Graz, Austria; ¶Director of Dermatopathology, Dermatopathologie Laboratory, Friedrichschafen, Germany; and ‖Chairman of the Department of Dermatology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain.
Article Synopsis
- The text reviews key clinical and histopathologic features of cutaneous manifestations related to occlusive nonvasculitic vasculopathic disorders, noting that retiform purpura is a common clinical symptom.
- Histopathologically, these disorders are characterized by the occlusion of vessel lumina without signs of vasculitis, stemming from various causes such as cholesterol embolization, malignancies, and other systemic or vascular coagulopathies.
- Accurate diagnosis of these conditions relies on correlating histopathologic findings with the patient's clinical history and understanding the various underlying disorders that can lead to occlusive vasculopathy.
Multisystem diseases affecting the skin and eye.
Clin Dermatol
December 2016
Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:
Article Synopsis
- There are many multisystem diseases that can impact both the eyes and skin, which may serve as early indicators for a systemic illness or can influence treatment decisions.
- Physicians need to be knowledgeable in recognizing these conditions, assessing the extent of the disease in patients, and initiating the right therapies to address these serious health issues.
- This discussion focuses on diseases like reactive arthritis and Behçet disease, highlighting the importance of understanding their skin and eye symptoms to effectively evaluate and manage patients, ultimately preventing significant long-term health problems.
Cutaneous cholesterol embolization syndrome.
Indian J Dermatol Venereol Leprol
March 2016
Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
Limited cutaneous pseudovasculitis: a mild variant of cholesterol emboli syndrome.
Circulation
February 2015
From Harvard Medical School, Boston, MA (O.A.O.); Harvard Combined Dermatology Residency Program, Boston, MA (K.W.M., D.S., V.E.N.); Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA (V.E.N.); and Departments of Dermatology (M.M.S., A.P.S.) and Pathology (M.P.H.), Massachusetts General Hospital, Boston.
Lesson of the month 1: sudden onset postural livedo reticularis, cyanotic toes and multiorgan failure.
Clin Med (Lond)
June 2014
Department of Dermatology, School of Medicine, Acibadem University, Istanbul, Turkey
Article Synopsis
- Cholesterol embolisation syndrome (CES) is a rare and serious disease caused by cholesterol crystals breaking off from atherosclerotic plaques, leading to high mortality rates.
- Its symptoms are often non-specific and can be subtle, making it difficult to recognize and treat in time.
- The article highlights a fatal case of CES to raise awareness about its severity and the importance of early diagnosis.
Simultaneous combined superficial peroneal nerve and peroneous brevis muscle biopsy, via the same cutaneous incision, allows examination of several tissue specimens and significantly improves the diagnosis of systemic diseases with peripheral nerve involvement. Vasculitides are certainly the most frequently diagnosed on neuro-muscular biopsies, but this procedure is also well advised to asses a diagnosis of sarcoidosis or amyloidosis. More occasionally, combined nerve and muscle biopsy may reveal an unpredicted diagnosis of cholesterol embolism, intra-vascular lymphoma, or enables complementary diagnosis investigations on mitochondrial cytopathy or storage disease.
View Article and Find Full Text PDFCholestrol emboli syndrome: acute renal insufficiency after a procedure or a thrombolytic therapy or anticoagulant therapy.
Indian J Surg
June 2013
Department of Nephrology, Apollo Hospital, Jubilee Hills, Hyderabad, India.
Article Synopsis
- Cholesterol emboli syndrome occurs when cholesterol crystals from atherosclerotic plaques break free and block small arteries, leading to serious health issues.
- The case described highlights severe symptoms affecting the skin and kidneys after a coronary angiography, pointing out how the syndrome is frequently overlooked or misdiagnosed.
- Improved assessment of risk factors for patients undergoing invasive procedures may help prevent the occurrence of this serious complication.
Cutaneous cholesterol embolization syndrome: A case report.
Dermatol Online J
July 2012
Department of Dermatology, Christian Medical College, Vellore, Tamilnadu, India.
Article Synopsis
- An 81-year-old woman with existing health issues underwent a surgical procedure to repair an abdominal aortic aneurysm and experienced several complications afterward.
- She developed calf muscle pain, confusion, and worsening kidney function, and displayed distinctive skin symptoms on her gluteal region and toes.
- A histological examination confirmed a condition called cutaneous cholesterol embolization syndrome, which she managed to recover from with hemodialysis and supportive care.
[Cholesterol embolism syndrome: a rare, but severe complication in patients with atherosclerosis].
Dtsch Med Wochenschr
May 2012
Klinik für Innere Medizin, St.-Antonius-Hospital Eschweiler.
Article Synopsis
- - Cholesterol embolization occurs when cholesterol crystals are released into the bloodstream during vascular procedures, leading to small artery blockage and inflammation, often resulting in renal failure and skin symptoms like blue toes.
- - Diagnosis is confirmed through biopsies or fundoscopy, as classic symptoms may not always be present, and vasculitis must be ruled out as a differential diagnosis.
- - Treatment focuses on managing symptoms, with statins recommended for their protective effects; however, prognosis is poor, with a significant portion of affected patients requiring renal replacement therapy and a high mortality rate within the first year.
Spontaneous cutaneous cholesterol crystal embolism with focal clinical symptomatology: report of a case in an unusual location with secondary histological changes reminiscent of atypical decubital fibroplasia.
Am J Dermatopathol
October 2011
Department of Clinical Dermatology, Ospedali Riuniti, Foggia, Italy.
Article Synopsis
- Cholesterol crystal embolization (CCE) is a complication of atherosclerosis that can occur after procedures like vascular surgery or in the absence of clear causes, sometimes affecting multiple organs.
- A unique case study presented a 65-year-old man with a painful, nonhealing skin ulcer on his elbow, linked to isolated CCE, which exhibited unusual histological changes.
- After a biopsy confirmed the presence of cholesterol emboli and surrounding reactive tissue, the ulcer was surgically treated, and the patient showed no signs of disease after an 18-month follow-up.
Subcutaneous thrombotic vasculopathy syndrome: an ominous condition reminiscent of calciphylaxis: calciphylaxis sine calcifications?
Am J Dermatopathol
December 2011
Department of Pathology, Lahey Clinic, Burlington, MA 01805, USA.
Article Synopsis
- Ischemic skin necrosis is a serious condition that can result from various systemic issues like thrombotic vasculopathy and calciphylaxis, and it poses a high risk of morbidity and mortality.
- A study presented three obese patients with ischemic skin necrosis, all showing extensive microvascular thrombosis in skin biopsies without calcifications typically seen in calciphylaxis.
- The findings suggest that subcutaneous thrombotic vasculopathy could be either a rare variant of calciphylaxis or an early stage leading to it, emphasizing the role of thrombosis in these vascular-related skin conditions.