Repurposing neuroleptics: clozapine as a novel, adjuvant therapy for melanoma brain metastases.

The blood-brain barrier and the distinct brain immunology provide challenges in translating commonly used chemotherapeutics to treat intracranial tumors. Previous reports suggest anti-tumoral effects of antipsychotics, encouraging investigations into potential treatment effects of neuroleptics on brain metastases. For the first time, the therapeutic potential of the antipsychotic drug clozapine in treating melanoma brain metastases (MBM) was investigated using three human MBM cell lines.

Social representations of dementia. A qualitative inquiry into perspectives of people with dementia, professionals, and informal caregivers.

Using a theoretical framework that underscores the social dimension of meaning-making processes, this study delved into the social representations of dementia in the Italian context and the personal meanings expressed by three distinct groups of participants. The study involved ninety-two episodic interviews with people living with dementia and those who had provided care as professionals or informal caregivers. The collected data underwent various types of analysis.

Dermanyssus gallinae as a pathogen vector: Phylogenetic analysis and associated health risks in pigeons.

Dermanyssus gallinae (D. gallinae) is a nocturnal, blood-feeding ectoparasite that primarily infests poultry, causing significant economic losses. This study aimed to identify poultry red mites and detect associated pathogens using morphological and molecular techniques.

Complete genome sequence of Sulfitobacter pontiacus WPMT18310, a dimethylsulfoniopropionate (DMSP) degradation bacterium isolated from the Mariana Trench.

Bacteria of the genus Sulfitobacter are widely distributed across various marine environments and play a vital role in the sulfur cycle. Sulfitobacter pontiacus WPMT18310 was isolated from water samples collected at a depth of 10,890 m in the Mariana Trench. In this study, we report the complete genome of S.

Establishing a Pan-European, multi-disciplinary taphonomic research Infrastructure: The 'UK-Netherlands decomposition experimental research (UNDER) Group'.

This study unveils the establishment of the United Kingdom-Netherlands Decomposition Experimental Research (UNDER) working group, marking a pioneering initiative in practical Forensic Taphonomy within the UK. Our primary objective was to craft a cohesive multidisciplinary framework, designed to ethically orchestrate, execute, and assess human decomposition. Concurrently, we aimed to amass data through human burials, fostering collaboration among diverse forensic experts across Europe.

Ecopsychosocial strategies for the self-exploration of professional family caregivers to manage the behavioural and psychological symptoms of Alzheimer patients in Iran: a qualitative study.

Objective: The aim of the present study was to explore the experiences and viewpoints of professional family caregivers in the management of behavioural and psychological symptoms of dementia (BPSDs) to identify the ecopsychosocial strategies applied by them.

Design: Qualitative study.

Setting: Kerman, Iran.

Feasibility, Acceptability and Preliminary Effectiveness of a Manualized Lay-Led Food Literacy Intervention for Women in a Community Setting.

Food literacy (FL) is the capability to make healthy food choices in different settings, contexts, and situations. Addressing factors such as competencies, self-efficacy and social norms enables sustainable positive change in nutrition behaviour. This study assesses the feasibility, acceptability, and preliminary effectiveness of a lay-led FL intervention for Arabic and Hebrew-speaking women in community settings, utilizing a train-the-trainer model.

Investigating chemical risk in green and loggerhead turtles foraging in Moreton Bay using species-specific cell-based bioassays.

Differences in trophic level may result in differences in chemical exposure between species of sea turtles, as pollutants may bioaccumulate differentially in diet items. It is, therefore, crucial to understand species-specific differences in exposure and effect to accurately assess chemical risk to individual species. This study used blood collected from green and loggerhead turtles foraging in Moreton Bay, Queensland, Australia, to assess differences in chemical exposure and effect of two species foraging in the same area at different trophic levels.

Influence of environmental attitudes and time horizons on the valuation of lagoon ecosystem services: A choice experiment approach using principal component analysis.

Coastal lagoon habitats provide multiple ecosystem goods and services that contribute to people's well-being. However, owing to degradation from both anthropogenic and natural causes, these areas require conservation and protection that involve considerable public investment. To help determine this investment, this study estimates the nonmarket economic value of habitat, regulation, and cultural ecosystem services (ESs) using people's environmental attitudes and temporal preferences.

Caregiving burden for adults with epilepsy and coping strategies, a systematic review.

Objectives: Caregiving for adults with epilepsy (AWE) imposes a different degree and scope of challenges than for children and teenagers with epilepsy, and it remains understudied. This study aimed to identify the types of caregiver burdens, needs, and coping strategies in caregiving for AWE.

Methods: Previous studies relevant to this topic were identified from 7 databases.

Formative research and development of a referral toolkit for sexual health services linkages within chicago public high schools.

Objective: Linking adolescent students to sexual health services has been recommended to promote overall adolescent health and wellbeing. Support at the school level is needed to develop such linkages, particularly in large, urban districts.

Data Collection Methods: A series of focus groups and interviews were conducted in three high schools piloting sexual health services linkage efforts in Chicago Public Schools.

First report of MDR virulent Pseudomonas aeruginosa in apparently healthy Japanese quail (Coturnix japonica) in Bangladesh.

Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen associated conditions like septicaemia, respiratory disorders, and diarrhoea in poultry, particularly in Japanese quail (Coturnix japonica). The infection causes huge economical losses due to its high transmissibility, mortality and zoonotic potential.

The extent of western lowland gorilla social relationships within and between groups.

The nature of western lowland gorilla social relationships within and between groups is largely understudied, partly due to the challenges of monitoring associations between individuals who live in neighboring groups. In this study, we examined the social relationships of four western lowland gorilla groups in the Ndoki landscape of northern Republic of Congo. To do so, we compiled all-occurrence social interaction and silverback nearest neighbor social networks from data collected during daily group follows conducted over several years.

Real sounds influence postural stability in people with vestibular loss but not in healthy controls.

Objective: What we hear may influence postural control, particularly in people with vestibular hypofunction. Would hearing a moving subway destabilize people similarly to seeing the train move? We investigated how people with unilateral vestibular hypofunction and healthy controls incorporated broadband and real-recorded sounds with visual load for balance in an immersive contextual scene.

Design: Participants stood on foam placed on a force-platform, wore the HTC Vive headset, and observed an immersive subway environment.

Relationships for Social Change: The Value of the Promotora Framework in Navigating Systems of Employment.

In the United States, socioeconomic disparities are a reality that shapes the challenges many communities of color experience. Throughout the globe, community-based initiatives have been explored as a way to reduce several barriers that contribute to social inequalities. One in particular, the Promotora framework, has been widely used to improve health outcomes.

Trichomoniasis in Men: A Neglected Factor in Male Infertility?

Purpose: This study is aimed to detect the frequency of trichomoniasis, a sexually transmitted infection caused by an anaerobic protozoan Trichomonas vaginalis, in men referred to the Fertility and Infertility Research Center Hamadan University of Medical Sciences.

Methods: In this cross-sectional study, a group of 197 male volunteers who sought medical attention for issues related to infertility participated. The urine and semen samples were collected in sterile conditions.

Genetic diversity and environmental adaptation in Ethiopian tef.

Orphan crops serve as essential resources for both nutrition and income in local communities and offer potential solutions to the challenges of food security and climate vulnerability. Tef [Eragrostis tef (Zucc.)], a small-grained allotetraploid, C4 cereal mainly cultivated in Ethiopia, stands out for its adaptability to marginal conditions and high nutritional value, which holds both local and global promise.

Multiplex Polymerase Chain Reaction Versus Standard Bacterial Culture in Critically Ill Children With Suspected Pneumonia.

Background: Bacterial lower respiratory tract infection, particularly ventilator-associated pneumonia (VAP), is a significant cause of morbidity and mortality in children who require mechanical ventilation (MV). Microbiologic diagnosis has relied on bacterial culture, but reverse transcriptase polymerase chain reaction (RT-PCR) with bacterial targets is now available for clinical use. We compared the diagnostic performance of tracheal aspirate (TA) multiplex RT-PCR to culture in children requiring MV with suspected lower respiratory tract infection.

New Plastitar Record for the Mediterranean Sea: Characterization of Plastics and Tar from the Salento Peninsula (Ionian Sea).

The various forms of anthropogenic pollution are regarded as a serious threat to marine coastal areas. The overproduction and mismanagement of petroleum derivatives, such as tar and plastics, have resulted in a significant correlation between these two pollutants. The aggregation of tar, microplastics (MPs), and natural materials can create plastitar blocks, which are common in coastal areas.

The First Large Identification of 3ANX and NX Producing Isolates of in Manitoba, Western Canada.

Fusarium head blight, caused by , continues to be one of the most important and devastating fungal diseases on cereal grains including wheat, barley, and oat crops. produces toxic secondary metabolites that include trichothecene type A and type B mycotoxins. There are many variants of these toxins that are produced, and in the early 2010s, a novel type A trichothecene mycotoxin known as 3ANX (7-α hydroxy,15-deacetylcalonectrin) and its deacetylated product NX (7-α hydroxy, 3,15-dideacetylcalonectrin) were identified in Minnesota, USA.

Isolation, Identification, and Antimicrobial Susceptibilities of Bacteria from the Conjunctival Sacs of Dogs with Bacterial Conjunctivitis in Different Regions of Wuhan, China.

In order to investigate the bacterial species present in the conjunctival sacs of dogs with bacterial conjunctivitis in Wuhan (Hongshan District, Wuchang District, Jiangxia District, and Huangpi District) and their resistance to aminoglycoside antibiotics, samples of conjunctival sac secretions were collected from 56 dogs with bacterial conjunctivitis in various regions of Wuhan. Drug susceptibility testing for aminoglycoside antibiotics was performed on the most commonly isolated gram-positive and gram-negative bacteria. The expression of two aminoglycoside modifying enzyme genes, and , and three 16S rRNA methyltransferase genes, , and , were analyzed by PCR.

Identification of Health Needs in Ukrainian Refugees Seen in a Primary Care Facility in Tenerife, Spain.

Background: Ukrainian refugees fleeing the conflict between Russia and Ukraine may face significant challenges to their physical, psycho-emotional, social, and spiritual wellbeing.

Aim: To identify the health needs of Ukrainian refugees seen in primary care facilities in Tenerife, Canary Islands, Spain.

Methods: A mixed-methods design was employed.

Correlation Between Infection and the Nasal Mycobiota in a Population of Free-Ranging Koalas () in New South Wales, Australia.

Cryptococcosis is a fungal disease in humans and animals, caused by the and species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. Nasal colonisation and subclinical cryptococcosis are common in koalas () due to their shared environmental niche with : trees.

Ex Situ Conservation, DNA Barcoding and Enzymatic Potential Evaluation of Macrofungi (Basidiomycota, Ascomycota) from Vietnam.

The diversity and resource potential of macroscopic fungi in tropical regions remain understudied. Vietnam, being in a biodiversity hotspot, has a large number of new fungal species that are of interest for biotechnology and medicine. The presence of a large number of protected areas in Vietnam creates favorable opportunities for the study and ex situ conservation of tropical biodiversity.

Relationship Between Participative Decision-Making Within an Organization and Employees' Cognitive Flexibility, Creativity, and Voice Behavior.

The existing literature predominantly examines the direct effects of participative decision-making, often overlooking the mechanisms and processes that mediate or moderate its outcomes. This study addresses this gap by investigating the impact of participative decision-making on employees' cognitive flexibility, creativity, and voice behavior. Specific contradictions and gaps in prior research are highlighted, particularly the limited understanding of how these variables interact.