Effects of partial replacement of soybean meal with and lysozyme on diarrheal incidence, plasma biochemical parameters, and immunity of weaned piglets.

Introduction: The study aimed to investigate the effects of and lysozyme on growth performance, diarrhea rate, immune function, plasma biochemical parameters, and gut microbiota and metabolites of weaned piglets.

Methods: Thirty weaned Xiangcun black piglets (BW, 11.47 ± 1.

AI-assisted neurocognitive assessment protocol for older adults with psychiatric disorders.

Introduction: Evaluating neurocognitive functions and diagnosing psychiatric disorders in older adults is challenging due to the complexity of symptoms and individual differences. An innovative approach that combines the accuracy of artificial intelligence (AI) with the depth of neuropsychological assessments is needed.

Objectives: This paper presents a novel protocol for AI-assisted neurocognitive assessment aimed at addressing the cognitive, emotional, and functional dimensions of older adults with psychiatric disorders.

An efficient heuristic for geometric analysis of cell deformations.

Sickle cell disease causes erythrocytes to become sickle-shaped, affecting their movement in the bloodstream and reducing oxygen delivery. It has a high global prevalence and places a significant burden on healthcare systems, especially in resource-limited regions. Automated classification of sickle cells in blood images is crucial, allowing the specialist to reduce the effort required and avoid errors when quantifying the deformed cells and assessing the severity of a crisis.

, , and : An Emerging Triad of Vector-Borne Co-Infections?

Canine leishmaniosis (CanL), caused by the protozoan and transmitted primarily by phlebotomine sand flies, poses significant challenges for zoonotic disease management [...

Optimisation of Using Low-Grade Kaolinitic Clays in Limestone Calcined Clay Cement Production (LC3).

LC3 (limestone calcined clay cement) is poised to become the construction industry's future as a so-called low-carbon-footprint cement. Research into this subject has determined the minimum kaolinite content in calcined clays to guarantee good mechanical performance. This study examines the use of clay from the Valencian Community (Spain), which has a lower kaolinite content than the recommended amount (around 30%) for use in LC3 and how its performance can be enhanced by replacing part of that clay with metakaolin.

Microbiome of (Ixodida: Ixodidae) Ticks: Variation in Community Structure with Regard to Sex and Host Habitat.

ticks are the main hematophagous ectoparasites of camels, harboring a variety of microbes that can affect tick vector competence and pathogen transmission. To better understand the tick microbiome influenced by sex and host habitat, we analyzed the bacterial community of male and female ticks collected from camel farms, livestock markets, and slaughterhouses, representing the range of major habitats in the UAE, by sequencing the 16S rRNA gene. Tick samples were collected during 2022 and 2023.

Neurological Performance and Clinical Outcomes Related to Patients With Oropouche-Associated Guillain-Barré Syndrome.

Background And Aims: A recent study reported that Oropouche virus (OROV) infection may play a role in the etiology of Guillain-Barré syndrome. We aimed to identify the neurological performance, disease-modifying therapies, and clinical outcomes related to patients with Oropouche-associated Guillain-Barré syndrome admitted to the critical care unit.

Methods: This was an analysis of 210 patients diagnosed with Guillain-Barré syndrome and suspicion of Oropouche viral infection admitted to the critical care units from June 2024 to September 2024 using the national administrative healthcare data.

Secondhand Smoke Exposure and Brain Health Indicators in Cuban Preschoolers.

Secondhand smoke affects nearly 40% of children worldwide, leading to serious health and behavioral problems. Being neurotoxic, it poses potential risks for child health and learning. In Cuba, there is limited research on the association of secondhand smoke with children's brain health, especially in vulnerable populations like young children at home.

Cyclic Lipopeptides as Selective Anticancer Agents: In vitro Efficacy on B16F10 Mouse Melanoma Cells.

Objective: In this study, 25 synthetic cyclic lipopeptides (CLPs) were investigated for their anticancer potential against mouse melanoma (B16F10) cells, human prostate cancer (PC-3), human colorectal adenocarcinoma (HT-29) and mouse embryonic fibroblast (NIH3T3) cells.

Methods: The cytotoxic activity of investigated compounds was evaluated using MTT and CV assays. In order to examine the mechanism of action of the most potent compound cell cycle analysis, apoptosis assay, caspase activity, CFSE and DHR staining, DAF-FM, autophagy and immunocytochemistry caspase-3 assays were performed.

Optimized hydrothermal carbonization of chicken manure and anaerobic digestion of its process water for better energy management.

Modern poultry production is faced with the challenge of properly managing its associated wastes, in particular chicken manure (CM). There is a need to improve the management of CM through conversion processes that allow the production of value-added products, particularly for energy purposes, such as hydrothermal carbonization (HTC) and anaerobic digestion (AD). The objectives of this study were: i) to optimize the CM-HTC, using response surface methodology with simultaneous optimization of mass yield and higher heating value (HHV), and ii) to evaluate the biomethane potential of the process water generated from hydrochar production under the optimized condition.

The Brussels consensus for non-invasive ICP monitoring when invasive systems are not available in the care of TBI patients (the B-ICONIC consensus, recommendations, and management algorithm).

Background: Invasive systems are commonly used for monitoring intracranial pressure (ICP) in traumatic brain injury (TBI) and are considered the gold standard. The availability of invasive ICP monitoring is heterogeneous, and in low- and middle-income settings, these systems are not routinely employed due to high cost or limited accessibility. The aim of this consensus was to develop recommendations to guide monitoring and ICP-driven therapies in TBI using non-invasive ICP (nICP) systems.

Techno-economic dataset for energy market and capacity payment co-optimization in the Dominican Republic's power market.

The electric power industry has an impact on fossil fuel consumption, which must be considered in decarbonization strategies. Energy systems optimization modelling can be applied to evaluate policy scenarios in the power sector to accelerate energy transitions. These modelling tools need data to simulate different scenarios in the power system to clarify the design of energy policies.

Strategy to mitigate aggregation during Protein A chromatography and low pH virus inactivation for a nivolumab biosimilar candidate.

Protein A chromatography represents the most prevalent methodology for the capture of monoclonal antibodies. The use of a low pH elution buffer from Protein A has been observed to contribute to product aggregation, particularly in the case of IgG4 antibodies, such as nivolumab. This paper presents a well-defined strategy for addressing this issue.

Places to be young: The dispossession of public space in Old Havana.

The touristification of Old Havana is resulting in unique patterns of gentrification that rely on a new spatial imaginary, the enforcement of which is resulting in the loss of places for residents to be young. The Cuban state's preservation of significant proportions of social housing as part of its investments in the heritage tourism industry is disrupting common housing-led displacement in the city. The neighbourhood's economic transition is concentrated instead in public spaces, as squares and streets are taken over by new tourist-serving businesses.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

Secondary metabolites and extracellular proteases contribute to the antagonistic action of indigenous Trichoderma strains against Botrytis cinerea.

The aim of this work is to evaluate different molecular strategies deployed by indigenous isolates of Trichoderma in their interaction with the phytopathogen Botrytis cinerea. In vitro antagonism assays, determination of volatile and diffusible compounds, and the relative expression of the prb1 gene, which codes for an extracellular protease, before and during the stage of direct contact between the two fungi, were carried out; the characterization of this protease was also performed. All 17 Trichoderma strains tested showed high levels of inhibition against B.

Isotope effects in Eley-Rideal abstraction of hydrogen from tungsten surfaces: the role of dissipation.

Molecular dynamics simulations are performed to investigate the influence of isotope substitutions on the Eley-Rideal recombination dynamics of hydrogen isotopes from the (100) and (110) surfaces of tungsten. Dissipation of electrons and phonons is taken into account by, respectively, the local density friction approximation and the general Langevin oscillator, effective models which have been intensively used in recent years. As the coupling to surface phonons and electrons might be altered by the mass combination, the main objective of the paper is to assess the role of dissipation to the surface in the course of abstraction.

Characterization by LC-MS/MS analysis of KLH vaccine conjugated with a tick antigen peptide.

Keyhole limpet haemocyanins (KLH1 and KLH2) from , are multi-subunit oxygen-carrying metalloproteins of approximately 3900 amino acids, that are widely used as carrier proteins in conjugate vaccines and in immunotherapy. KLHs and their derived conjugate vaccines are poorly characterized by LC-MS/MS due to their very stable supramolecular structures with megadalton molecular mass, and their resistance to efficient digestion with standard protocols. KLH1 and KLH2 proteins were conjugated to the conserved P0 peptide (pP0), derived from the P0 acidic ribosomal protein of sp.

Cardio-Obstetrics Practice in Latin America: A Regional Survey of General Cardiologists.

Background: Cardiovascular (CV) disease is a leading cause of death in pregnant women globally, especially in low- and middle-income countries including Latin America (LATAM), where there is lack of data on how cardiologists are trained in cardio-obstetrics (CO) and the practice patterns in the care of pregnant patients.

Objectives: The authors aimed to identify CO competency and practice patterns among LATAM general cardiologists.

Methods: An anonymous cross-sectional Google-based electronic survey was sent via email to clinical cardiologists through local American College of Cardiology chapters and CV societies.

Development of a StIW111C-based bioresponsive pore-forming conjugate for permeabilizing the endosomal membrane.

Gene expression manipulation is pivotal in therapeutic approaches for various diseases. Non-viral delivery systems present a safer alternative to viral vectors, with reduced immunogenicity and toxicity. However, their effectiveness in promoting endosomal escape, a crucial step in gene transfer, remains limited.

Shell colour luminance of Cuban painted snails, Polymita picta and Polymita muscarum (Gastropoda: Cepolidae).

Climate change is a global environmental threat, directly affecting biodiversity. Terrestrial gastropods are particularly susceptible to alterations in temperature and humidity and have develop morph-physiological and behavioural adaptations in this regard. Shell colour polymorphism and its potential implication for thermoresistance constitute an unexplored field in Neotropical land snails.

Evaluating the effect of denoising submillimeter auditory fMRI data with NORDIC.

Functional magnetic resonance imaging (fMRI) has emerged as an essential tool for exploring human brain function. Submillimeter fMRI, in particular, has emerged as a tool to study mesoscopic computations. The inherently low signal-to-noise ratio (SNR) at submillimeter resolutions warrants the use of denoising approaches tailored at reducing thermal noise-the dominant contributing noise component in high-resolution fMRI.

Efficiency Analysis of Healthcare Systems in Latin American and Caribbean Countries: An Application Based on Data Envelopment Analysis.

Objectives: Despite the increasing investments in Latin American healthcare, the corresponding improvement in population health is not proportional. This discrepancy may be attributed to the efficiency of resource utilization. This study used the data envelopment analysis (DEA) methodology to assess the efficiency of healthcare systems in 23 Latin American and Caribbean countries.