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Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.

JAMA Surg

September 2021

Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland.

Article Synopsis
  • The incidence of early-onset colorectal cancer (diagnosed in individuals under 50) is on the rise globally, with distinct clinical and molecular characteristics compared to late-onset cases.
  • Factors contributing to this increase may include diet, obesity, antibiotic use, and changes in gut microbiome, with most cases occurring sporadically rather than being genetically inherited.
  • There is a need for tailored preventive and therapeutic approaches for early-onset colorectal cancer, as younger patients often present with more severe disease stages but similar outcomes to older patients after treatment.
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