1,264 results match your criteria: "Craniofacial Center.[Affiliation]"

Management of alar webbing using a CAD-CAM splint: A case report.

J Prosthodont

January 2025

Pediatric Plastic Surgery and Laurence C. Wright Craniofacial Center, John R. Oishei Children's Hospital, Buffalo, New York, USA.

Alar webbing is a functional and aesthetic defect of the nasal structure noted in cleft lip and palate patients (CLP), which is thought to be due to a deficiency in nasal lining tissue. Surgical procedures have previously focused on the removal of lining or alar cartilage leading to worse post-operative defects. This case demonstrates a novel technique of releasing the tissue, followed by using a CAD-CAM splint to help mold the tissue during the healing process to better control esthetics, symmetry, and prevent relapse.

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There are many factors to consider regarding the orthodontic treatment of an individual with cleft lip and palate in relation to the alveolar bone graft procedure. Some of these are: the sequence and timing of treatment, indications for pre-graft orthodontics, the appropriate appliances that should be used, and considerations in post-graft orthodontics. A review of some of the current concepts, management, and protocols are described.

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Background: Goldenhar syndrome is a clinically heterogeneous disorder defined by a rare combination of congenital anomalies-an eye abnormality, in addition to two of the following three: ear anomalies, mandibular malformations, and vertebral defects. Notably, children with Goldenhar syndrome present with a high incidence of cervical spine malformations.

Clinical Case: In this report, we present an unusual case of a 15-year-old child with Goldenhar syndrome, who additionally presents with some clinical features of VACTERL syndrome.

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Discussion: Travel Burden to American Cleft Palate and Craniofacial Association-Approved Cleft and Craniofacial Teams: A Geospatial Analysis.

Plast Reconstr Surg

January 2025

From the Craniofacial Center, Division of Plastic and Craniofacial Surgery, Seattle Children's Hospital; and Division of Plastic Surgery, Department of Surgery, University of Washington.

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Velopharyngeal insufficiency (VPI) is common in patients with a repaired cleft palate. 18% to 20% of patients who undergo superiorly based pharyngeal flap for VPI may require a revision procedure due to persistent hypernasality. One solution to persistent VPI is flap revision, but there is a paucity of revision techniques described in the literature.

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Application of Virtual Planning and 3-Dimensional Printing Guide in Surgical Management of Craniosynostosis.

World Neurosurg

December 2024

Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: This study aims to elaborate on the application of virtual surgical planning (VSP) and 3-dimensional printing (3DP) guides in the surgical management of craniosynostosis and compare their surgical outcomes with traditional surgical planning.

Methods: A retrospective review of patients who underwent cranial vault and cranio-orbital remodeling procedures for craniosynostosis was performed. VSP was accomplished by establishing a 3D model from Digital Imaging and Communications in Medicine format computed tomography data.

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True Median Cleft With Sinus Tract in the Nasal Septum: A Case Report.

Cleft Palate Craniofac J

November 2024

Department of Plastic Surgery, Cleft and Craniofacial Center, Shizuoka Children's Hospital, Shizuoka, Japan.

A true median cleft is an extremely rare congenital anomaly characterized by a midline vertical cleft and various deformities, also known as Tessier number 0 cleft. Here we report a case of a 5-year-old Asian boy with true median cleft associated with sinus tracts in the nasal septum, a phenomenon not previously reported in the literature. The tracts were identified as the cause of recurrent infections around the oral vestibule and upper lip.

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Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.

Hum Mol Genet

November 2024

Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.

Article Synopsis
  • Puumala virus (PUUV) can lead to serious illnesses like Hemorrhagic Fever with Renal Syndrome, but the genetic factors affecting disease severity in humans are not well understood.
  • A genome-wide association study using data from 2227 cases helped identify significant associations at the Human Leukocyte Antigen (HLA) locus and the ERAP1 gene, which are important for immune response.
  • The study found a specific genetic variant (rs26653) in the ERAP1 gene and identified associations with several HLA alleles that suggest how these genetic factors may influence susceptibility to severe PUUV infections.
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Speech Aid Prostheses For Patients With Cleft and Other Craniofacial Birth Conditions.

J Craniofac Surg

November 2024

Department of Surgery, The University of Illinois College of Medicine, Shriners Hospital for Children-Chicago, UIHealth UIC Craniofacial Center, Chicago, IL.

Normal speech production is a complex mechanism requiring the coordination of several organs of the oral cavity. The lip, hard and soft palates, and teeth all play a role in normal speech production. In cases of craniofacial birth conditions such as cleft lip and palate or ectodermal dysplasia, one or more of these areas may be compromised.

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Article Synopsis
  • In Finland, isolated cleft palate (CP) occurs more frequently than cleft lip with or without cleft palate (CL/P), which is the opposite trend seen in other European countries.
  • A genome-wide association study revealed a specific single nucleotide polymorphism (rs570516915) strongly linked to CP in the Finnish population, showing significant statistical results and confirmed in other cohorts.
  • The risk allele for rs570516915 disrupts a binding site for the IRF6 transcription factor, leading to decreased IRF6 expression, indicating that this genetic alteration may be a key factor in the mechanism causing CP.
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Objective: Remote teaching strategies have been widely adapted in recent years but their impact on dental students' learning outcomes is less well understood. The aim of this mixed-method pilot study was to examine the impact of remote teaching on undergraduate dental student's learning outcome as assessed by examination performance and student feedback in an orthodontics course.

Methods: Out of the lectures (19 in total), 10 were delivered remotely (live online lecture or video recording) and 9 as traditional classroom teaching in 2023.

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Objective: Secondary rhinoplasty is a frequently requested revision procedure in patients with a history of cleft lip and palate (CLP). The satisfaction of patients with the esthetic outcome of the procedure has been infrequently studied.

Design: Adult patients with CLP who had undergone a secondary rhinoplasty between 2009 and 2019 were identified in a cross-sectional cohort that had filled the FACE-Q rhinoplasty module.

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Planning the Cut: Gender-Affirming Considerations in Orthognathic Surgery.

J Oral Maxillofac Surg

November 2024

Assistant Professor of Surgery, Service Chief, Craniofacial Surgery, Medical Director, Burn and Plastic Surgery Clinic, Harborview Medical Center, Division of Plastic and Craniofacial Surgery, Department of Surgery, Seattle Children's Hospital, Seattle, WA.

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Current Situation of Non-cleft Craniofacial Anomalies in Thailand: A Multicenter Study.

J Craniofac Surg

January 2025

Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Article Synopsis
  • - The study investigates the impact of non-cleft craniofacial anomalies on patients and their caregivers, focusing on experiences and challenges faced by caregivers across four major hospitals in Thailand over three years, involving 224 participants.
  • - Findings indicate a regional prevalence of anomalies, with craniosynostosis and clefts being the most common, and reveal a lack of family history for these conditions. Many patients faced multiple hospital stays, and despite frequent visits, a notable portion had not received necessary surgeries.
  • - Caregivers reported significant stress but largely did not view it as a burden, highlighting issues such as inadequate access to specialized care and a lack of support networks, indicating the need for improved healthcare strategies and resources tailored to regional
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Indicator of tongue pressure to estimate the mastication pattern in an aging population.

J Prosthet Dent

October 2024

Professor, Department of Craniofacial Orthodontics, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC; Professor, Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; Professor, Craniofacial Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC; and Professor, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.

Statement Of Problem: The mastication ability of the elderly greatly affects their health-related quality of life. However, studies investigating the impact of peri-oral muscular strength on the performance of mastication in older adults are lacking.

Purpose: The purpose of this cross-sectional clinical study in older adults was to formulate an equation relating to the mastication pattern and tongue pressure to estimate the correlation between tongue pressure and habitual mastication patterns, including mastication strokes and mastication time.

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Objective: To evaluate the extent of naso-alveolar molding (NAM) in pushing the premaxilla posteriorly in patients with bilateral cleft lip and palate (BCLP).

Background: Naso-alveolar molding application in cleft lip and palate cases bridges the cleft gap and increases nasal tip projection. In BCLP, NAM potentially mobilizes the premaxilla posteriorly to allow tension-free primary lip closure.

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Article Synopsis
  • This study looked at how ear and hearing care is done for kids with cleft palates across different teams in the US.
  • It involved over 1,200 children born between 2015 and 2022, checking how many got the right follow-up care by 18 months old.
  • Results showed that kids got more ear care if the doctors were part of their main team instead of being referred to separate specialists.
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Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown.

Methods: We conducted the largest genome-wide association study of cNCS followed by replication, fine mapping, and functional validation of the most significant region using zebrafish animal model.

Results: Genome-wide association study identified 6 independent genome-wide-significant risk alleles, 4 on chromosome 7q21.

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Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate.

Sci Rep

September 2024

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Article Synopsis
  • Non-syndromic cleft lip with or without palate (NSCL/P) is a common birth defect, potentially influenced by abnormal DNA methylation in pregnant mothers.
  • The study involved 39 NSCL/P patients and 33 mothers, analyzing Alu methylation and cellular aging markers in blood and tissue samples.
  • Findings showed specific patterns of Alu methylation changes in patients with cleft lip and palate, indicating the mother's methylation status may contribute to the severity of the child's cleft condition.
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Craniotubular Dysplasia Ikegawa Type: Further Delineation of the Phenotype.

Am J Med Genet A

February 2025

Department of Genetics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Craniotubular Dysplasia Ikegawa type is a sclerosing bone disorder recently identified in five patients from four independent Indian families. It is caused by homozygous or compound heterozygous mutations in TMEM53. Deficient TMEM53 leads to overactive BMP signaling which promotes bone formation.

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Prompt engineering to increase GPT3.5's performance on the Plastic Surgery In-Service Exams.

J Plast Reconstr Aesthet Surg

November 2024

The Craniofacial Center, Division of Plastic, Reconstructive, and Cosmetic Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA; Shriners Children's Chicago Hospital, Chicago, IL 60707, USA. Electronic address:

This study assesses ChatGPT's (GPT-3.5) performance on the 2021 ASPS Plastic Surgery In-Service Examination using prompt modifications and Retrieval Augmented Generation (RAG). ChatGPT was instructed to act as a "resident," "attending," or "medical student," and RAG utilized a curated vector database for context.

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Reduction Cranioplasty in Cases of Hydrocephalic Macrocephaly: Pearls and Pitfalls of Computer-Assisted Surgery.

Cleft Palate Craniofac J

September 2024

Department of Oral and Maxillofacial Surgery, Associate Dean for Hospital Affairs, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA.

Reduction cranioplasty may be indicated to address functional or cosmetic sequelae of hydrocephalic macrocephaly. With the advent of CAD/CAM digital workflow, surgeons can design and fabricate craniotomy guides, templates, and models that allow for precise cranial reconstruction. Although there are several advantages of virtual planning, pre-determined surgical plans may limit intraoperative flexibility, requiring surgeons to troubleshoot errors in pre-operative planning or model design.

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