4,323 results match your criteria: "Craiova; County Emergency University Hospital[Affiliation]"

Fruit processing by-products could represent a sustainable ingredient for developing innovative dairy products. The present study was conducted to develop a novel functional yogurt by adding bilberry pomace powder (BPP) at 0.5%, 1.

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Background: Systemic sclerosis (SSc) is a complex connective tissue disease characterized by microangiopathy, immune dysregulation, and fibrosis. Early detection of microvascular abnormalities using nailfold videocapillaroscopy (NVC) is crucial in assessing disease progression and associated disease's involvement such as interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH).

Objective: This study aims to explore the relationships correlation between NVC patterns, clinical manifestations, and systemic complications in SSc.

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The COST EU-PoTaRCh Action establishes a network focused on the past, present, and future significance, production, and use of major forest by-products in Europe and beyond. The Action centers around forest by-products-primarily potash, tar, resin, and charcoal (PoTaRCh), along with plant extracts-which have been produced and utilized for over 100,000 years due to their unique chemical, biological, and therapeutic properties. The primary goal of the Action is to demonstrate the importance of these products for the socio-economic development of European countries and beyond, as well as their impact on biodiversity and the natural environment.

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Long non-coding RNAs (lncRNAs) have been in the spotlight for the past two decades due to their extensive role in regulating a wide range of cellular processes. Development, differentiation, regulation, and modulation are some of the vital cellular cascades coordinated by these molecules. Despite their importance, there has been limited literature on their practical implications in cancer prevention.

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Bacillus Calmette-Guérin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau.

Vaccine

December 2024

Bandim Health Project, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Studiestræde 6, 1455 Copenhagen C, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, Fioniavej 34, 5230 Odense, Denmark.

Article Synopsis
  • BCG (Bacillus Calmette-Guérin) has shown non-specific immune benefits against infections, and this study investigates its effects in older adults in a TB-endemic area.
  • A single-blinded trial in Guinea-Bissau involved 40 adults over 50, with half receiving BCG and the other half a placebo, measuring cytokine production after vaccination.
  • Results showed that BCG improved immune responses, particularly in those previously exposed to TB, indicating its potential for enhancing immunity in older populations and warranting further research.
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Background: Pseudoexfoliation syndrome (PEX) is a common age-related ocular condition characterized by the accumulation of a fibrillar, pseudoexfoliative material on the anterior segment of the eye. This study aims to investigate the histopathological characteristics of pseudoexfoliative material within different ocular structures, including the eyelid, conjunctiva, and anterior lens capsule.

Methods: A total of 32 anterior lens capsules, 3 eyelid fragments, and 12 conjunctival specimens were obtained from patients clinically diagnosed with PEX during ocular surgeries at the Onioptic Hospital of Ophthalmology.

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  • - A 66-year-old man with a long history of smoking was diagnosed with rheumatoid arthritis in 2018 and later developed interstitial pulmonary fibrosis in 2020, treated with nintedanib in 2022.
  • - Despite showing some clinical improvement, his condition remained serious and progressive, ultimately leading to death from pulmonary thromboembolism.
  • - An autopsy revealed severe complications related to rheumatoid arthritis including lung interstitial lesions, bronchiectasis, and vascular damage caused by chronic inflammation.
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Background/objectives: Fibromyalgia (FM) affects up to 5% of the global population and is a leading cause of significant social and economic consequences. Higher health literacy leads to better understanding of treatment plans, improved self-care, and adherence to recommendations, enhancing overall quality of life. This study aims to determine whether different aspects of the disease are influenced by patients' education level and literacy when applying the same therapy and to assess how patients' perceptions of therapy outcomes vary over time based on their educational level.

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Assessing the Relationships between Physical Activity, a Healthy Life, and Personal Happiness in European Union Countries.

Healthcare (Basel)

September 2024

Department of Economics, Accounting and International Business, Faculty of Economics and Business Administration, University of Craiova, 13 AI Cuza Street, 200585 Craiova, Romania.

Maintaining a physically active lifestyle is a determinant factor of a healthy life and personal happiness. Meanwhile, physical inactivity remains a significant issue, resulting in negative consequences for public health. This paper investigates the relationships between physical activity, physical inactivity, a healthy life, life expectancy, and personal happiness in European Union (EU) countries.

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  • JCO CheckMate 274 is a phase III trial comparing adjuvant nivolumab to placebo for high-risk muscle-invasive urothelial carcinoma (MIUC) post-surgery, showing improved disease-free survival (DFS) metrics with nivolumab treatment.
  • The study documented results at a median follow-up of 36.1 months, with larger survival benefits noted for patients with positive PD-L1 expression.
  • No new safety issues were discovered, reinforcing the role of nivolumab as standard treatment for high-risk MIUC following radical resection.
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According to the World Health Organization, burns represent a major global public health issue, causing approximately 180,000 deaths annually. The article presents the case of a 17-year-old patient with burns after electric shock (27,000 volts), with a burned area of approximately 72%, 3rd degree, segment IIB, with ABSI score=12, who was treated in a centre dedicated to paediatric burn patients. The use of treatment of paediatric burns not only enhances the quality of healthcare but also has the potential to reduce suffering and improve the chances of recovery for children who go through such traumatic experiences.

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Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated significant anticancer properties in a range of malignancies. However, its therapeutic efficacy is limited by its hydrophobicity, poor bioavailability, and systemic toxicity. Derivatives, analogues, and nanoformulations of CPT have been synthesized to overcome these limitations.

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  • Cardiac resynchronization therapy (CRT) has greatly improved heart failure treatment, but conventional lead placement can sometimes fail, prompting the need for alternative techniques.
  • One such technique is trans-septal left ventricle (TSLV) endocardial lead implantation, which was successfully used in a patient after a failed conventional implant.
  • The follow-up after TSLV implantation showed positive results, with no complications, improved heart function, and indicates that TSLV can be a viable option for certain patients when traditional methods fail.
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Psychotropic drugs are vital in psychiatry, aiding in the management of mental health disorders. Their use requires an understanding of their pharmacological properties, therapeutic applications, and potential side effects. Ongoing research aims to improve their efficacy and safety.

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  • * Despite advancements in HIV treatment, the leading causes of death have shifted from AIDS-related issues to liver disease and cardiovascular problems, partly due to the hepatotoxic effects of certain antiretroviral medications.
  • * The review stresses the importance of monitoring liver health in PLWH, especially those co-infected with hepatitis B or C, and suggests adjusting antiretroviral treatments to lower the risk of liver damage and fibrosis.
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  • The study focuses on hip osteoarthritis (OA), a degenerative condition affecting the hip joint due to cartilage damage, and its surgical treatment through hip arthroplasty at a specific hospital in Romania.
  • Researchers aimed to analyze the incidence of OA patients, their demographics (age and gender), living conditions, and types of hip surgeries performed over a five-year period.
  • The findings revealed that out of 485 patients, a significant majority (87.83%) were over 60 years old, and the disease predominantly affected women, with a female-to-male ratio of 2:1.
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  • Gallstones have become increasingly common, affecting around 6% of men and 9% of women in the U.S., with 10-20% of adults in Western countries suffering from this condition.
  • The onset of gallstone symptoms is happening at younger ages than previously observed, leading to increased pain and functional disability among younger populations.
  • A review of 28 articles assessed imaging techniques like ultrasound, CT, and MRI for gallstones, finding notable differences in sensitivity (p < 0.001) but less conclusive results regarding specificity (p = 0.474).
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  • A retrospective study was conducted on 55 patients diagnosed with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at The Clinical Emergency County Hospital Craiova, focusing on epidemiological and clinical aspects.
  • The majority of patients were older adults, with a mean age of 66.4 years, and GEP-NETs were most commonly found in the colon, specifically the ascending colon.
  • Notable findings included a higher prevalence of arterial hypertension in patients with colon neuroendocrine tumors (C-NET) and an overall increase in GEP-NET cases in recent years.
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  • * Diagnosis of AD relies on subjective assessments, with ongoing efforts to establish reliable biomarkers for improved accuracy; severity scores help tailor treatments based on individual patient needs.
  • * This study highlights four unique adult-onset AD cases, two of which had no previous history of the condition, emphasizing the atypical nature of adult presentations and investigating biomarkers like IL-4, IL-13, and IgE for diagnostic potential.
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  • * Lifestyle choices, such as adopting healthier behaviors, can significantly lower the risk of cognitive decline, while genetic factors further influence susceptibility to conditions like Alzheimer's.
  • * Long-term use of substances like opioids and cocaine is associated with memory and executive function deterioration, highlighting the need for strategies to address cognitive decline and potential treatment options.
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Background: Obstructive ventilatory dysfunctions have an increased incidence, and through functional assessment determined by the International Classification of Functioning, Disability and Health (ICF), appropriate treatment can be established.

Aims: The objectives of our research are represented by the application of respiratory rehabilitation sessions according to the ICF in patients with obstructive ventilatory dysfunctions-with COPD or asthma, using a unique, international language and the evaluation of the results obtained before and after completion pulmonary rehabilitation.

Methods: We conducted a randomized prospective study between November 2022-April 2023, which included 84 patients diagnosed with obstructive ventilatory dysfunctions and who performed respiratory rehabilitation.

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Knee osteoarthritis (KOA) represents a progressive and painful disease that in time can lead to loss of function and disability. Early diagnosis and correct treatment are essential in preventing the advancement of the condition to a stage where it can affect the quality of life. The development of new imagistic methods and devices can help detect changes in the structure of the join before the onset of symptoms.

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  • Juvenile Idiopathic Arthritis (JIA) encompasses various chronic inflammatory conditions that can lead to different health issues in children, notably growth retardation and delayed puberty.
  • Complications such as these are linked to the severity and duration of the disease, with reports indicating growth impairment in 8% to 41% of affected children, while data on puberty delays is limited.
  • Optimizing treatment for JIA, including the use of biological therapies, is crucial for improving growth outcomes and minimizing long-term health impacts, highlighting the need for early detection and preventive measures in affected children.
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  • A study involving 65 gout patients and 40 healthy individuals investigated the presence of subclinical carotid atherosclerosis, which is a risk factor for cardiovascular disease, through ultrasound examinations.
  • The findings showed a significantly higher prevalence of increased carotid intima-media thickness (CCAIMT) and carotid plaques in gout patients compared to the controls, indicating a potential connection between gout and cardiovascular risks.
  • Various factors, such as serum uric acid levels, age, disease duration, and low-density lipoprotein cholesterol, were found to independently contribute to the increased carotid thickness and plaque formation in gout patients, emphasizing the usefulness of carotid ultrasound as a diagnostic tool.
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  • Dental fatigue fractures are linked to increased occlusal stress, likely exacerbated during the COVID-19 pandemic, leading to a rise in cases.
  • A retrospective study analyzed dental fracture cases from a clinic, comparing data from March 2019 to March 2021, and found a significant increase in fractures during the pandemic.
  • The number of fractured teeth tripled during the pandemic, with the most affected being maxillary premolars and permanent first molars, and most cases required extraction.
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