707 results match your criteria: "Cowpox Infection Human"
Rev Esp Salud Publica
October 2023
Cátedra Balmis de Vacunología UA-ASISA. Alicante. España.
Acta Naturae
January 2023
State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, Koltsovo, Novosibirsk region, 630559 Russian Federation.
Front Microbiol
September 2023
Diagnostic Systems Division, United States Army Medical Research Institute of Diseases, Frederick, MD, United States.
mBio
October 2023
Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Viruses
August 2023
Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA.
Sci Total Environ
October 2023
Centre for Infectious diseases, National Institute for Public Health and the Environment, Bilthoven, Utrecht, the Netherlands. Electronic address:
Urban greening has benefits for both human and environmental health. However, urban greening might also have negative effects as the abundance of wild rats, which can host and spread a great diversity of zoonotic pathogens, increases with urban greenness. Studies on the effect of urban greening on rat-borne zoonotic pathogens are currently unavailable.
View Article and Find Full Text PDFJ Comp Pathol
July 2023
Institute of Infection, Veterinary and Ecological Science (IVES), University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK. Electronic address:
Cowpox virus is considered to be a re-emerging zoonotic pathogen and a public health threat due to increasing numbers of cases in humans and animals in Europe over the past decade, including within the United Kingdom (UK). We present epidemiological data and diagnostic features of 27 recent, naturally occurring cowpox cases in zoo and wild animals across the UK, including the first reports of cowpox in two snow leopards (Panthera uncia), a Bengal tiger (Panthera tigris tigris), three Chilean pudus (Pudu puda), a Malayan tapir (Tapirus indicus) and a Eurasian otter (Lutra lutra), and the first reports of Orthopoxvirus infection in a lar gibbon (Hylobates lar), a Southern tamandua (Tamandua tetradactyla) and an aardvark (Orycteropus afer). This study provides a detailed overview of cowpox infections in a wide range of non-domestic animal species, presents a range of methods for diagnosis and demonstrates the value of retrospective analysis of pathology surveillance in revealing epidemiological links.
View Article and Find Full Text PDFAntiviral Res
August 2023
Department of Veterinary Pathobiology, School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address:
Many poxviruses are significant human and animal pathogens, including viruses that cause smallpox and mpox (formerly monkeypox). Identifying novel and potent antiviral compounds is critical to successful drug development targeting poxviruses. Here we tested two compounds, nucleoside trifluridine, and nucleotide adefovir dipivoxil, for antiviral activities against vaccinia virus (VACV), mpox virus (MPXV), and cowpox virus (CPXV) in physiologically relevant primary human fibroblasts.
View Article and Find Full Text PDFJ Infect Public Health
August 2023
Faculty of Medicine, Yarmouk University, P.O Box 566, 21163 Irbid, Jordan. Electronic address:
Transpl Infect Dis
June 2023
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: The use of vaccination to prevent infection has a long history, starting in the 1700s with Jenner. New innovations have led to improvements in the safety and efficacy of vaccines, from live attenuated viruses to subunit vaccines, to RNA-based vaccination for SARS-CoV-2. Despite this progress, however, solid organ transplant (SOT) recipients on immunosuppression demonstrate an impaired vaccine response compared with healthy controls.
View Article and Find Full Text PDFJ Med Chem
April 2023
Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.
The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in orthopoxvirus antivirals. Monkeypox belongs to the genus of the Poxviridae family, which also includes the variola virus, vaccinia virus, and cowpox virus. Two orally bioavailable drugs, tecovirimat and brincidofovir, have been approved for treating smallpox infections.
View Article and Find Full Text PDFmSphere
April 2023
Bioinformatics, IRCCS E. Medea Scientific Institute, Bosisio Parini, Lecco, Italy.
Clin Dermatol
November 2023
Private Practice, Pembroke Pines, Florida, USA. Electronic address:
The word "pox" indicated, during the late 15th century, a disease characterized by eruptive sores. When an outbreak of syphilis began in Europe during that time, it was called by many names, including the French term "la grosse verole" ("the great pox"), to distinguish it from smallpox, which was termed "la petite verole" ("the small pox"). Chickenpox was initially confused with smallpox until 1767, when the English physician William Heberden (1710-1801) provided a detailed description of chickenpox, differentiating it from smallpox.
View Article and Find Full Text PDFRev Francoph Lab
March 2023
Service des agents infectieux et d'hygiène, Hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex, France.
Animal viruses are present in most human environments. Their viability in these media is very variable and the most important element that conditions this viability is the existence or not of a phospholipid envelope surrounding the nucleocapsid. After some general considerations on the structure of viruses, their multiplication cycle and their resistance to different physico-chemical agents, some examples of the impact of animal viruses present in the environment on human health will be presented.
View Article and Find Full Text PDFArch Pathol Lab Med
July 2023
The Departments of Obstetrics and Gynecology and Global Health, University of Washington School of Medicine, Seattle (Adams Waldorf).
Context.—: Before its eradication, the smallpox virus was a significant cause of poor obstetric outcomes, including maternal and fetal morbidity and mortality. The mpox (monkeypox) virus is now the most pathogenic member of the Orthopoxvirus genus infecting humans.
View Article and Find Full Text PDFViruses
January 2023
Tonix Pharmaceuticals, Dartmouth, MA 02748, USA.
Biomolecules
February 2023
Department of Medial Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA 95616, USA.
Cowpox viruses (CPXVs) exhibit the broadest known host range among the family and have caused lethal outbreaks in various zoo animals and pets across 12 Eurasian countries, as well as an increasing number of human cases. Herein, we review the history of how the cowpox name has evolved since the 1700s up to modern times. Despite early documentation of the different properties of CPXV isolates, only modern genetic analyses and phylogenies have revealed the existence of multiple species that are currently constrained under the CPXV designation.
View Article and Find Full Text PDFAnalyst
February 2023
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
In 2022, the outbreak of the monkeypox virus occurred in many non-endemic countries, and the World Health Organization (WHO) assessed that this outbreak was "atypical". The establishment of a rapid and effective assay that can be used for the early diagnosis of monkeypox virus infection is crucial for outbreak prevention and control. In this study, the monkeypox virus A29 protein and the homologous vaccinia virus A27 protein and cowpox virus 162 protein were expressed in for screening.
View Article and Find Full Text PDFActa Naturae
January 2022
State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, Koltsovo, Novosibirsk region, 630559 Russia.
Int J Mol Sci
January 2023
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, Scotland, UK.
Cowpox is caused by a DNA virus known as the cowpox virus (CPXV) belonging to the genus in the family Poxviridae. Cowpox is a zoonotic disease with the broadest host range among the known poxviruses. The natural reservoir hosts of CPXV are wild rodents.
View Article and Find Full Text PDFJ Clin Virol
February 2023
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, 98195, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. Electronic address:
Background: In spring of 2022, an outbreak of monkeypox (mpox) spread worldwide. Here, we describe performance characteristics of monkeypox virus (MPXV)-specific and pan-orthopoxvirus qPCR assays for clinical use.
Methods: We validated probe-based qPCR assays targeting MPXV-specific loci F3L and G2R (genes MPXVgp052/OPG065 and MPXVgp002 and gp190/OPG002, respectively) and a pan-orthopoxvirus assay targeting the E9L locus (MPXVgp057/OPG071).
Viruses
December 2022
Oxford Wildlife Trade Research Group, School of Social Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Southeast Asia is considered a global hotspot of emerging zoonotic diseases. There, wildlife is commonly traded under poor sanitary conditions in open markets; these markets have been considered 'the perfect storm' for zoonotic disease transmission. We assessed the potential of wildlife trade in spreading viral diseases by quantifying the number of wild animals of four mammalian orders (Rodentia, Chiroptera, Carnivora and Primates) on sale in 14 Indonesian wildlife markets and identifying zoonotic viruses potentially hosted by these animals.
View Article and Find Full Text PDFViruses
November 2022
State Research Center of Virology and Biotechnology "Vector", Novosibirsk Region, Koltsovo 630559, Russia.
The aim of the work was an experimental evaluation of the characteristics of the kit for the rapid immunochemical detection of orthopoxviruses (OPV). The kit is based on the method of one-stage dot-immunoassay on flat protein arrays using gold conjugates and a silver developer. Rabbit polyclonal antibodies against the vaccinia virus were used as capture and detection reagents.
View Article and Find Full Text PDFBioorg Med Chem Lett
January 2023
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue, 9, 630090 Novosibirsk, Russia.
Smallpox was eradicated >40 years ago but it is not a reason to forget forever about orthopoxviruses pathogenic to humans. Though in 1980 the decision of WHO to cease vaccination against smallpox had seemed logical, it led to the decrease of cross immunity against other infections caused by orthopoxviruses. As a result, in 2022 the multi-country monkeypox outbreak becomes a topic of great concern.
View Article and Find Full Text PDF