Investigating the Mechanisms of Antibody Binding to Alpha-Synuclein for the Treatment of Parkinson's Disease.

Parkinson's disease (PD) is an idiopathic neurodegenerative disorder with the second-highest prevalence rate behind Alzheimer's disease. The pathophysiological hallmarks of PD are both degeneration of dopaminergic neurons in the substantia nigra pars compacta and the inclusion of misfolded α-synuclein (α-syn) aggregates known as Lewy bodies. Despite decades of research for potential PD treatments, none have been developed, and developing new therapeutic agents is a time-consuming and expensive process.

Narrativity and Referential Activity Predict Episodic Memory Strength in Autobiographical Memories.

Narrativity has been proposed as an indicator of episodic memory strength when people discuss their past (Nelson and Horowitz in Discourse Processes 31:307-324, 2001. https://doi.org/10.

An online repository of solvation thermodynamic and structural maps of SARS-CoV-2 targets.

SARS-CoV-2 recently jumped species and rapidly spread via human-to-human transmission to cause a global outbreak of COVID-19. The lack of effective vaccine combined with the severity of the disease necessitates attempts to develop small molecule drugs to combat the virus. COVID19_GIST_HSA is a freely available online repository to provide solvation thermodynamic maps of COVID-19-related protein small molecule drug targets.

An online repository of solvation thermodynamic and structural maps of SARS-CoV-2 targets.

SARS-CoV-2 recently jumped species and rapidly spread via human-to-human transmission to cause a global outbreak of COVID-19. The lack of effective vaccine combined with the severity of the disease necessitates attempts to develop small molecule drugs to combat the virus. COVID19_GIST_HSA is a freely available online repository to provide solvation thermodynamic maps of COVID-19-related protein small molecule drug targets.

Incorporating Innovative Simulation Activities Into Campus Lab to Enhance Skill Competence and Critical Thinking of Second-Semester Associate Degree Nursing Students.

Decreasing access to clinical sites, inconsistency in student learning experiences, and lack of faculty have compelled nursing schools to incorporate more simulation into their curricula. Professional organizations, regulating bodies, and schools of nursing support its use. The Nursing 2 Challenge simulation activity was designed to give second-semester nursing students an opportunity to improve skill competence and critical thinking utilizing a systematic, preplanned station rotation format in the safe setting of the nursing campus lab.

Successful Integration of an Academic Electronic Health Record Into the Curriculum of an Associate Degree Nursing Program.

The use of electronic data management systems is rapidly expanding. Nurses need to be competent in the use of electronic health records (EHRs) and understand their contribution to safe, effective, high quality patient care. Faculty must incorporate learning experiences in the application of EHRs into undergraduate nursing programs in order to adequately prepare students for employment.

Using the human patient simulator to foster critical thinking in critical situations.

New registered nurses are expected to utilize critical thinking when providing care to their patients, especially in critical situations. Using mini-scenarios on the human patient simulator, faculty members can foster critical thinking and expose students to critical situations in a nonthreatening environment. An example of one such scenario, using an oncology patient with hypercalcemia and ventricular tachycardia, is outlined in the article.

Pharmacologic management of obesity.

Obesity is a major health problem in the United States. It is not only a problem in itself, but it is a predisposing factor for many chronic illnesses. Pharmaceutical houses have devoted much research in the development of drugs to combat the problem.

Tuberculosis drugs.

Tuberculosis is an old disease, and for some time thought to be almost eliminated in industrial societies. With the advent of the AIDS epidemic, it has made a comeback and often in a form more virulent than was seen in the past. This article summarizes the drugs used to treat the disease and suggests ways nurses may help keep this once underestimated problem in control.

Historical developments in the drug therapy of diabetes.

It is suggested that some 16 million Americans have diabetes, although about only one-half of them are diagnosed. Type I or IDDM diabetics must take insulin in some form to maintain their life. A larger number of Americans have Type II or NIDDM, and many can be treated with a combination of diet and exercise.

Antiviral medications.

As the numbers of identified viruses increase, it is expected that one of the classifications of medications receiving a great deal of attention is the antivirals. To understand the difficulty in developing these medications, the nurse must understand some of the basic principles underlying the way viruses develop, multiply, and cause disease. This article discusses some of those principles and presents the medications now available to treat viral diseases.

Herbs: multicultural folk medicines.

Herbs have been used by man since antiquity for the prevention and treatment of illness. In the past few years, an increased interest in herbs seems to parallel the back-to-nature movement in the United States. While many herbs can be helpful, others pose potential threats.

Women's multiple roles and psychological well-being.

Examination of the relationships of multiple roles and internal-external locus of control with psychological well-being among 162 middle-class women aged 23 yr. and over, returning to school at a community college, showed women occupying two or three of the roles of partner, mother, and paid employee were happier than those occupying one or none. Internal locus of control was important in adding significantly to the prediction of both happiness and self-esteem, beyond that predicted by number of roles and control variables.