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Biomarkers of brain injury in foals with hypoxic-ischemic encephalopathy.
J Vet Intern Med
May 2011
Countryside Equine Hospital, Louisville, TN, USA.
Article Synopsis
- Neonatal hypoxic-ischemic encephalopathy (NHIE) in foals lacks a diagnostic test before death, leading researchers to investigate potential biomarkers.
- The study focused on two biomarkers, UCHL1 and phosphorylated neurofilament H (pNF-H), measuring their plasma concentrations in 33 diagnosed foals compared to 17 healthy foals.
- UCHL1 showed strong diagnostic performance with an AUC of 0.86 and higher concentrations in NHIE foals, suggesting it could be a reliable marker for brain injury in this condition.