Copper Prevention Values in Brazilian Subtropical Soils.

The Brazilian National Environmental Council (CONAMA) Resolution 420/2009 establishes soil quality guideline values for copper, as the prevention value (PV). It defines the maximum concentrations of chemical substances permitted in the soil. Thus, the aim of the present research was to evaluate the effectiveness of the copper PV adopted at the national level by conducting exposure assays with enchytraeids (Enchytraeus crypticus, Enchytraeus bigeminus and Enchytraeus dudichi) and springtails (Folsomia candida, Proisotoma minuta and Sinella curviseta) in two Brazilian subtropical soils: a Latosol and an Argisol.

Target product profile for cell-based and gene-based therapies to achieve a cure for HIV.

This target product profile (TPP) highlights the minimal and optimal characteristics for ex-vivo and in-vivo cell and gene therapy-based products aimed at achieving an HIV cure (ie, durable antiretroviral-free viral control). The need for an effective, safe, scalable, affordable, accessible, and acceptable cure for HIV infection remains a major global priority. The possibilities for cell and gene therapy-based products for an HIV cure are rapidly expanding.

Developing an Evidence- and Theory-Informed Mother-Daughter mHealth Intervention Prototype Targeting Physical Activity in Preteen Girls of Low Socioeconomic Position: Multiphase Co-Design Study.

Background: Preteen girls of lower socioeconomic position are at increased risk of physical inactivity. Parental support, particularly from mothers, is positively correlated with girls' physical activity levels. Consequently, family-based interventions are recognized as a promising approach to improve young people's physical activity.

A Core Outcome Set for Adult General ICU Patients.

Objectives: Randomized clinical trials informing clinical practice (e.g., like large, pragmatic, and late-phase trials) should ideally mostly use harmonized outcomes that are important to patients, family members, clinicians, and researchers.

Constraining the history of water and climate on Mars through light element stable isotope analysis of volatiles in returned martian samples.

Much has been learned about Mars through data returned from space missions and analyses of martian meteorites. There are, however, many questions still outstanding which cannot currently be answered-including the issue of whether there is, or was, life on Mars. The return of a cache of samples-including of the atmosphere-from separate locations in Jezero Crater and with differing petrogeneses will provide the international community with the opportunity to explore part of the evolutionary history of Mars in great detail.

Revising the definition of "demand satisfied for modern methods of family planning:" A cross-sectional study to explore incorporating person-centered constructs of demand, choice, and satisfaction.

Several challenges to validity have been identified with standard approaches used to measure "demand satisfied for modern methods of family planning." This study explored construct validity of the widely used indicator for "demand satisfied" by comparing the standard definition to alternative definitions of the indicator highlighting dimensions of women's own perceived demand, choice, and satisfaction. This cross-sectional study of women aged 15-49 years was conducted in Argentina (n = 1492), Ghana (n = 1600), and India (n = 1702) using a two-staged random sampling design.

Toward a More General Consent for the Use of Patients' Biological Material and Health Information for Medical Research-The Patient Perspective.

Biological material and health information from patients are valuable for medical research. Under a "broad" consent model, hospital patients in Norway can consent to their biological material and health information being stored in research biobanks and used for "specific, broadly defined research purposes" within a specified medical research area but not for medical research in general. Patients are asked to provide new consent each time researchers wish to use their material in a different medical research area.

Development and Content Validity of a Questionnaire on Peripheral Intravenous Catheter Maintenance and Knowledge of Nursing Professionals Regarding Best Practices.

The aims of this study were to develop a questionnaire on peripheral intravenous catheter (PIVC) maintenance, evaluate its content validity, and assess factors influencing the level of knowledge of nursing professionals regarding best practices.The study was conducted in 3 stages: (1) development of a questionnaire on PIVC maintenance; (2) content validity assessment by experts with assessment of comprehensiveness, relevance, and clarity; and (3) application of the questionnaire to 1493 nursing professionals. Relationships between personal characteristics and knowledge levels were evaluated.

Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB.

Aluminium is a common metallic toxicant that easily penetrates the brain and exerts severe pathological effects e.g., oxidative stress, inflammation and neurodegeneration.

Novel High-Quality Amoeba Genomes Reveal Widespread Codon Usage Mismatch Between Giant Viruses and Their Hosts.

The need for high-quality protist genomes has prevented in-depth computational and experimental studies of giant virus-host interactions. In addition, our current knowledge of host range is highly biased due to the few hosts used to isolate novel giant viruses. This study presents 6 high-quality amoeba genomes from known and potential giant virus hosts belonging to 2 distinct eukaryotic clades: Amoebozoa and Discoba.

Right data, wrong data: Statistical sampling and the making of modern agriculture in India.

The size of India's food deficit became a pressing question for the Indian state in the early years of independence. As different organizations, government bodies, and individuals debated over the ways, means, and expertise needed to tide over the food crisis, policymakers realized that the primary requirement was to have a numerical understanding of the problem. Data became crucial to accurately assess production trends and compare them with requirements.

Promoting Equitable Engagement in Attention-Deficit/Hyperactivity Disorder Care.

Attention-deficit/hyperactivity disorder (ADHD) is a treatable pediatric condition, but children with racial-ethnic minority backgrounds often do not receive timely or consistent treatment. Understanding how systemic racism impacts care and learning from families of color about their experiences can provide critical insights for improving clinical practice and engaging patients equitably in ADHD care. We interweave a mother's experience navigating ADHD care for her son with commentary from an interprofessional team about what clinicians can do for families to reduce the impact of systemic racism on care.

Elevated developmental temperatures below the lethal limit reduce Aedes aegypti fertility.

Aedes aegypti mosquitoes are the principal vectors of dengue and continue to pose a threat to human health, with ongoing urbanization, climate change, and trade all impacting the distribution and abundance of this species. Hot periods are becoming increasingly common and their impacts on insect mortality have been well established, but they may have even greater impacts on insect fertility. In this study, we investigated the impacts of high temperatures on Ae.

Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock.

Molecular chaperones play critical roles in post-translational maintenance in protein homeostasis. Previous studies have shown that loss of Smyd1b function results in defective myofibril organization and dramatic upregulation of heat shock protein gene (hsp) expression in muscle cells of zebrafish embryos. To investigate the molecular mechanisms and functional importance of this stress response, we characterized changes of gene expression in smyd1b knockdown and knockout embryos using RNA-seq.

Effects of an Extreme Weather Event on Primate Populations.

Objectives: With contemporary, human-induced climate change at a crisis point, extreme weather events (e.g., cyclones, heatwaves, floods) are becoming more frequent, intense, and difficult to predict.

Prognostic evaluation of nutrition risk screening tools in hospitalized adults with normal weight range, overweight, or obesity: A comparative analysis.

Background: Many nutrition risk screening tools include low body mass index (BMI). It remains uncertain whether it affects the validity of these tools in patients with overweight or obesity. We aimed to determine the frequency of malnutrition risk and evaluate its association with hospital length of stay in hospitalized adults according to BMI classification.

Clot signature in patients with large vessel occlusion stroke and concomitant active cancer.

Background And Purpose: Patients with active cancer face an increased risk of ischemic stroke. Also, stroke may be an initial indicator of cancer. In patients with large vessel occlusion (LVO) stroke treated with thrombectomy, analysis of the clot composition may contribute new insights into the pathological connections between these two conditions.

Comparison of Ceramic Bonding to Cobalt-Chromium, Zirconia and Nickel-Chromium Alloys Fabricated Using of Various Techniques.

The purpose of this study was to evaluate the characteristics of the ceramic bonding to cobalt-chromium (Co-Cr) alloys fabricated by casting, milling, and additive manufacturing, compared with zirconia and nickel-chromium. One hundred specimens (N = 100), prepared with the dimensions of 25 × 3 × 0.5 mm, were assigned to five groups (n = 20): presintered milled Co-Cr (Group M), additively manufactured Co-Cr (Group SLM), cast Co-Cr (Group C), presintered zirconia (Group Zi), and cast Ni-Cr (Group Ni).

Runs of Homozygosity and Inferences in Wild Populations.

Long homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here, we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic analyses in wild populations.

CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer.

The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) at the National Institute of Chemistry (NIC) in Ljubljana represents a significant step forward, as it is the first centre of its kind in Slovenia. The CTGCT is poised to spearhead advances in cancer immunotherapy and personalised therapies for neurological and other rare genetic diseases.

The problem of multiple adjustments in the assessment of minimal clinically important differences.

Introduction: Anthropometric, demographic, genetic, and clinical features may affect cognitive, behavioral, and functional decline, while clinical trials seldom consider minimal clinically important differences (MCIDs) in their analyses.

Methods: MCIDs were reviewed taking into account features that may affect cognitive, behavioral, or functional decline in clinical trials of new disease-modifying therapies.

Results: The higher the number of comparisons of different confounders in statistical analyses, the lower values will be significant.

Corrigendum to " antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids" [Heliyon Volume 10, Issue 19, October 2024, Article e38434].

[This corrects the article DOI: 10.1016/j.heliyon.

Cost-effectiveness of lazertinib as first-line treatment in patients with -mutated advanced lung cancer.

Background: Lazertinib demonstrates efficacy similar to that of osimertinib in the first-line treatment of epidermal growth factor receptor ()-mutated advanced lung cancer. However, its cost-effectiveness has not yet been evaluated.

Objective: To study the cost-effectiveness of lazertinib as a first-line treatment for patients with -mutated advanced lung cancer.

Knowledge, Attitude, and Practices Regarding Leprosy Among Nurses Employed at a Tertiary Healthcare Centre in Central India: An Epidemiological Study.

Introduction: Leprosy is a common infectious disease in India that can lead to nerve damage and disability. There is a dearth of knowledge regarding leprosy not only among the general public but also among healthcare workers. This knowledge gap leads to the generation of stigma and delay in the detection of new cases.