Anti-wrinkle activity of the ethanol extract of Aronia melanocarpa for development of the cosmeceutical ingredients.

Despite the abundance of natural biological resources in Aronia melanocarpa, there is still insufficient research specifically exploring the potential for developing cosmeceutical compositions utilizing this plant. To develop the ingredient with the cosmeceutical function, the anti-wrinkle effect of the ethanol extract of A. melanocarpa was investigated.

Exploring the Biological Activity of Phytocannabinoid Formulations for Skin Health Care: A Special Focus on Molecular Pathways.

Recent advancements have highlighted the potential of cannabis and its phytocannabinoids (pCBs) in skin health applications. These compounds, through their interaction with the endocannabinoid system (ECS), show promise for skin health products. Their ability to regulate inflammation, oxidative stress and cell proliferation makes them useful in addressing skin problems such as inflammation, scarring, healing, acne and aging, positioning them as valuable tools for innovative skincare solutions.

Algae a Potential Source in Cosmetics: Current Status, Challenges, and Economic Implications.

Recently, many studies have revealed the association between environmental stresses and skin disorders. Skin protects the inner body organs as a first line of defence against various environmental detriments. The physical, chemical, biological, and environmental stresses and internal factors, including reactive oxygen species, can lead to skin aging, laxity, wrinkles, dryness, and coarse texture.

Contribution of mushroom farming to mitigating food scarcity: Current status, challenges and potential future prospects in Pakistan.

Food insecurity, pollution, and malnutrition are some critical issues tackled by the modern world in the recent era. However, edible mushrooms are nutritionally, economically, and biotechnologically valuable groups of macro fungi. Besides being an essential source of edible food, it is also exploited in pharmacological industries as a potential source of anticancer, antioxidant and immunomodulating agents.

Photoprotective Effect of Taurine-Rich Protamex Extract From Salmon (Oncorhynchus keta) Byproduct Against Ultraviolet B-Induced Skin Damage in Human Dermal Fibroblasts and Zebrafish Model.

Background: Exposure to ultraviolet (UV) light promotes reactive oxygen species (ROS) production and metalloproteinase (MMP) 1 expression, leading to skin damage. Several studies have reported that protein-rich fish byproducts from enzymatic hydrolysis exhibited a variety of health benefits such as antioxidant and anti-inflammation. In the current study, we investigated the protective effect of protein hydrolysate from salmon byproduct (SBPH) in ultraviolet B (UVB)-irradiated human dermal fibroblasts (HDFs) and zebrafish.

Oranges, potatoes and phytonutrients; why are they good for human health.

Dietary chemoprevention has emerged as a cost-effective approach to control most prevalent chronic diseases including cancer. Changes in dietary patterns and lifestyle, such as increasing the consumption of fruits and vegetables and more balanced intakes of meat and plant foods, are a practical and effective strategy for reducing the incidence of chronic diseases. Phytonutrients (or phytochemicals) are found in eatable fruits and vegetables that, daily ingested, may exhibit a potential for modulating human metabolism in a manner favourable for the prevention of chronic and degenerative diseases.

Antioxidant and anti-inflammatory properties of water kefir microbiota and its bioactive metabolites for health promoting bio-functional products and applications.

Inflammation and oxidative stress are implicated in several chronic disorders, while healthy foods and especially fermented beverages and those containing probiotics can provide anti-inflammatory and antioxidant protection against such manifestations and the associated disorders. Water kefir is such a beverage that is rich in both probiotic microbiota and anti-inflammatory bioactives, with an increasing demand as an alternative to a fermented product based on non-dairy matrix with potential health properties. Within this study, the health-promoting properties of the most representative species and strains of microorganisms present in water kefir grains, as well as the health benefits attributed to the bioactive metabolites produced by each individual strain in a series of their cultures, were thoroughly reviewed.

Exploring dipeptidyl peptidase-IV inhibitory peptides from Tartary Buckwheat protein: A study of hydrolysis, fractionation, and molecular interactions.

Tartary buckwheat, a protein-rich pseudocereal with anti-diabetic effects, has not yet been fully explored as a source of dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides. This study aims to discover novel DPP-IV inhibitory peptides from tartary buckwheat protein (TBP). Five hydrolysis methods were employed, with simulated gastrointestinal digestion (SGID) releasing the most active DPP-IV inhibitory hydrolysates, showing both the highest degree of hydrolysis (22.

Chemical characterization of wheat-based waste derived from a pharmaceutical process for its potential valorization.

Introduction: We report the analysis and characterization and the preliminary biological evaluation, of both liquid and solid wastes obtained from the processing of wheat () to produce the most iconic phytostimulin-based pharmaceutical products. The study aims to verify whether the waste can be reused in another process and not destined to its simple destructive disposal.

Methods: In this perspective, we first carried out an in-depth chemical-physical analysis of the waste together with a biocompatibility evaluation to plan the feasible final choice of waste destination.

Decelerated skin aging effect of rubber (Hevea brasiliensis) seed oil in cell culture assays.

Rubber seeds, the abundant by-products of rubber tree (Hevea brasiliensis), have been studied for sustainable utilization. Nevertheless, there is no information available regarding activity against skin aging. The study aimed to prepare rubber seed oil (RSO) and evaluate fatty acid compositions by gas chromatography - mass spectrometry (GC/MS), linamarin contamination by ultra-high performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS).

Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides.

Sphingolipids are vital membrane components in in mammalian cells, plants, and various microbes. We aimed to explore and exploit the sphingolipid biosynthesis pathways in an oleaginous and dimorphic yeast Yarrowia lipolytica by constructing and characterizing mutant strains with specific gene deletions and integrating exogenous genes to enhance the production of long-chain bases (LCBs) and glucosylceramides (GlcCers). To block the fungal/plant-specific phytosphingosine (PHS) pathway, we deleted the SUR2 gene encoding a sphinganine C4-hydroxylase, resulting in a remarkably elevated secretory production of dihydrosphingosine (DHS) and sphingosine (So) without acetylation.

Postbiotic Metabolite Derived from PD18 Maintains the Integrity of Cell Barriers and Affects Biomarkers Associated with Periodontal Disease.

: Periodontal disease is caused by oral infections, biofilms, persistent inflammation, and degeneration of cell barrier integrity, allowing pathogens to invade host cells. Probiotics have been extensively studied for the treatment of periodontal disease. However, research on the involvement of beneficial substances produced by probiotics, called "postbiotics," in periodontal diseases remains in its early stages.

Photoprotective Effect of Ultrasonic-Assisted Ethanol Extract from on UVB-Exposed HaCaT Keratinocytes.

The present study investigated the photoprotective effect of the ultrasonic-assisted ethanol extract (USHE) from , a brown seaweed containing fucosterol (6.22 ± 0.06 mg/g), sulfoquinovosyl glycerolipids (CHOS, CHOS, CHOS, CHOS), and polyphenols, against oxidative damage in ultraviolet B (UVB)-exposed HaCaT keratinocytes.

Moisturizing Effects of Alcalase Hydrolysate Fractions from Viscera, a Marine Organism, on Human Dermal Fibroblasts, HaCaT Keratinocytes, and Reconstructed Human Skin Tissues.

, an abalone, is a marine gastropod mollusk that has been cultivated globally owing to its nutritional value and high market demand. However, the visceral parts of are typically discarded as by-products, highlighting the need to explore their potential value in developing cosmeceuticals and pharmaceuticals. This study investigated the potential moisturizing effects of visceral tissues.

Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation.

Hyperpigmentation, a dermatological concern caused by increased melanin production, affects many people worldwide. Traditional skin-brightening products target inhibition of cellular tyrosinase activity but often contain harmful toxicants. Oxyresveratrol (OXR) is a robust tyrosinase inhibitor, but its instability, poor water solubility, and low skin permeation limit its use.

Conditioned medium of human umbilical cord-mesenchymal stem cells cultivated with human cord blood serum enhances stem cell stemness and secretome profiles.

The proteins secreted by human umbilical cord mesenchymal stem cells (hUC-MSCs) may enhance tissue regeneration and wound healing. Traditional hUC-MSC cultures may not be enough since they undergo recurrent cellular senescence during large-scale production. This decreases the therapeutic ability of hUC-MSCs by altering genes and proteins that control stemness, proliferation, and protein release.

Enhancing D-pantothenate production in Escherichia coli through multiplex combinatorial strategies.

D-pantothenate, universally acknowledged as vitamin B5, has garnered considerable interest owing to its crucial functionality in the feed, pharmaceutical, and cosmeceutical sectors. Development of microbial strains for D-pantothenate hyperproducer has emerged as a prominent research direction in recent years. Herein, we converted an engineered Escherichia coli with low yield to a plasmid-free hyperproducer of D-pantothenate using multiplex combinatorial strategies.

Comparative metabolic profiling and quantitative analysis of metabolites in different tissues of Ajuga turkestanica by ESI-UHPLC-QqTOF-MS and NMR.

Ajuga turkestanica preparations are used as anti-aging cosmeceuticals and for medicinal purposes. Herein we describe the characterization and quantification of its metabolites in different organs using UHPLC-MS and NMR spectroscopy. A total of 51 compounds belonging to various phytochemical classes (11 flavonoids, 10 ecdysteroids, 9 diterpenes, 6 fatty acids, 5 iridoids, 3 phenylpropanoids, 3 sugars, 2 phenolics, 1 coumarin, 1 triterpene) were annotated and tentatively identified by UHPLC-ESI-QqTOF-MS/MS of methanolic extracts obtained separately from the organs.

A Comprehensive Review of Plant-Based Cosmetic Oils (Virgin Coconut Oil, Olive Oil, Argan Oil, and Jojoba Oil): Chemical and Biological Properties and Their Cosmeceutical Applications.

Plant-based oils, such as coconut, olive, argan, and jojoba, are abundant in natural emollients and vital fatty acids that hydrate and moisturize the skin. They shield the surface, stop moisture loss, and maintain suppleness of, the skin. They are rich in vitamins, nutrients, and antioxidants that nourish the skin.

Synthesis and Evaluation of a ZnO-Chitosan Adduct for Safe and Sustainable Enhanced Ultra-Violet (UV) Sunscreens Protection.

Chitosan (Ch), a natural polysaccharide, is known for its biocompatibility, biodegradability, and various beneficial properties, including antioxidant and antibacterial activities. The objective of this study is to investigate the functionalization of zinc oxide (ZnO) with chitosan to develop a novel ZnO@Ch adduct for use in cosmetic formulations, specifically as a sun protection agent. The functionalization was achieved through ionotropic gelation, which enhanced the stability and reduced the photocatalytic activity of ZnO, thereby improving its safety profile for skin applications.