Sham feeding in rats with chronic, reversible gastric fistulas.

Sham feeding occurs when ingested food is prevented from accumulating in the stomach and small intestine by surgical intervention. Sham feeding permits the investigation of the orosensory controls of meal size in the absence of postingestive controls. This unit details preoperative preparation, surgery, postoperative care and maintenance, and test procedures for the simplest and most widely used method, which involves implantation of a gastric cannula in a rat to provide a chronic, reversible gastric fistula.

Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1alpha inhibit signaling by KSHV G protein-coupled receptor.

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes two proteins that are similar to human CC chemokines and a G protein-coupled receptor (KSHV-GPCR) that is constitutively active. KSHV-GPCR binds a number of human CXC and CC chemokines. We showed that interferon gamma-inducible protein-10 (IP-10), a human CXC chemokine, inhibits KSHV-GPCR signaling (Geras-Raaka et al.

Nifedipene in the Treatment of Blood Pressure Rise After ECT.

Extreme rise of blood pressure may increase the risk associated with electroconvulsive therapy (ECT) in patients with cardiovascular disease, cerebrovascular disease, and aortic and intracranial aneurysms. A case is presented in which sublingual nifedipene was used in the treatment of a high-risk patient with severe rise of blood pressure. The therapeutic alternatives of managing severe ECT-related blood pressure increases are presented.

ECT in the High-Risk Geriatric Patient.

Electroconvulsive therapy (ECT) is an important therapeutic modality in geriatric patients because its safety, high efficacy and rapid onset of action are suited to the special needs of this population. It appears that ECT can be effective in the acute treatment of depression, mania, paranoid disorders and various psychiatric syndromes occurring in the context of brain disease. Certain cardiovascular and neurological disorders or use of drugs increase the risk of ECT in geriatric patients.

CHANGES IN BLOOD VESSELS (CAPILLARY FRAGILITY) WITH INFLAMMATION.

Suction with a partial vacuum of -70 mm. Hg applied to normal skin of rabbits causes intracutaneous hemorrhage after an average time of 8 minutes. Inflammation produced by various agents, including turpentine, killed streptococci, staphylococci, pneumococci or meningococci, and filtrates from cultures of meningococci or typhoid bacilli, produces a series of changes that are almost uniform.